Dispersive solid-phase extraction of buprenorphine from biological fluids using metal-organic frameworks and its determination by ultra-performance liquid chromatography

In this work, various types of metal-organic frameworks were synthesized, and their affinities toward buprenorphine were evaluated using dispersive solid-phase extraction. The extracted buprenorphine was determined by ultra high performance liquid chromatography-ultraviolet detection system. The highest extraction recovery was observed by employing zeolitic imidazole framework-67. Then, a facile and fast extraction method was designed for the extraction and purification of the target drug. Optimization of the extraction method was carried out by the design of experiment approach. A linearity range of 1�1000 μg/L with the limit of detection of 0.15 μg/L and relative standard deviations (50 μg/L, n = 5) of 3.4 was obtained for standard sample analysis. Under optimized experimental and instrumental conditions, the relative recoveries were in the range of 95 to 111. Eventually, zeolitic imidazole framework-67 was successfully employed for the extraction and determination of buprenorphine in the biological fluids with satisfactory results. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinhei

A simple and fast method based on new magnetic ion imprinted polymer as a highly selective sorbent for preconcentration and determination of cadmium in environmental samples

Background: The analysis of heavy metals at trace level is one of the main toxicologists concern, due to their vital rules in human`s life. Cadmium is one of these toxic heavy metals, which released to the environment from various industries. Methods: In order to determine Cd (II) ions in various matrices magnetic ion-imprinted polymer (IIP) method has been developed and applied. This nano-sorbent has been synthesized by coating an IIP compound on Fe3O4nanopar-ticles core to achieve highest surface area. This polymer has been used to evaluate Cd (II) levels in food, river, and wastewater in Tehran, Iran. Results: Fe3O4@Cd-IIP was stable up to 300 °C. The various factors such as sample pH (optimized as 7), elution/sorption time (5 min), eluent amount (4 mL HCL), and its concentration (2 mol L-1) were optimized. Analysis instrument in all steps was Flame Atomic Abortion Spectrophotometer (FAAS). In this study, the detection limit was determined down to 0.6 μg L-1. Conclusion: This method was applied successfully for the preconcentration and determination of Cd (II) ions in environmental samples obtained from rivers, various foods and wastewater. In addition, the accuracy of the method was confirmed by analyzing a certified reference material (Seronorm LOT NO2525) and spiked real samples. © 2016, Iranian Journal of Public Health. All rights reserved

Development of a selective sorbent based on a magnetic ion imprinted polymer for the preconcentration and FAAS determination of urinary cadmium

In this study, an ion imprinted polymer (IIP), based on coating of a polymer on a Fe3O4 nanoparticle (NP) core, is used as a magnetic sorbent for the preconcentration and determination of the Cd(ii) ion level in human urine samples. The synthesized polymer was characterized by IR spectroscopy, scanning electron microscopy (SEM), X-ray diffraction analysis (XRD) and thermal analysis (TG/DTA). The optimum conditions, such as pH of the sample, eluent volume, concentration and duration of sorption and elution, were investigated. In addition, the effect of some potentially interfering cations on the sorption of Cd(ii) was confirmed. In all samples, Cd(ii) was determined using a flame atomic absorption spectrophotometer. Under optimal conditions, the limit of detection (LOD) of cadmium was 0.6 μg L-1. The optimized method has been validated using day-to-day and within-day reproducible experiments and achieved appropriate accuracy and precision. The accuracy of the method was confirmed by analyzing a certified reference material (Seronorm LOT NO2525) and spiked real samples. Ultimately, this method was applied successfully for the preconcentration and determination of Cd(ii) ions in urine samples obtained from exposed individuals. This journal is © The Royal Society of Chemistry