Lateral phase separation of confined membranes

We consider membranes interacting via short, intermediate and long stickers. The effects of the intermediate stickers on the lateral phase separation of the membranes are studied via mean-field approximation. The critical potential depth of the stickers increases in the presence of the intermediate sticker. The lateral phase separation of the membrane thus suppressed by the intermediate stickers. Considering membranes interacting with short and long stickers, the effect of confinement on the phase behavior of the membranes is also investigated analytically

Adhesion-induced lateral phase separation of multi-component membranes: the effect of repellers and confinement

We present a theoretical study for adhesion-induced lateral phase separation for a membrane with short stickers, long stickers and repellers confined between two hard walls. The effects of confinement and repellers on lateral phase separation are investigated. We find that the critical potential depth of the stickers for lateral phase separation increases as the distance between the hard walls decreases. This suggests confinement-induced or force-induced mixing of stickers. We also find that stiff repellers tend to enhance, while soft repellers tend to suppress adhesion-induced lateral phase separation

Seroprevalence of contagious caprine pleuropneumonia in Borana and Guji lowlands, Southern Ethiopia

A multistage cross sectional serological study and questionnaire survey were conducted on contagious caprine pleuropneumonia in selected districts of Borana and Guji lowlands, Southern Ethiopia, to determine the prevalence of the disease and identify risk factors associated with the occurrence of the disease. A total of 900 sera samples were collected and tested using Complement Fixation Test (CFT). Questionnaire surveys were conducted with 69 randomly selected households. Out of the 900 goat sera samples tested, 119 (13.2%) were seropositive for CCPP, giving an overall seroprevalence of 13.2 % (95% CI=11.0%-15.4%) in the study areas. A seroprevalence of 18.3% (95% CI=14.3%-22.7%), 11.7% (95% CI=8%-15.2%) and 9.7% (95% CI=6.3%-12.6%) were recorded in Liban, Teltale and Moyale districts respectively. The seroprevalence recorded in Liban district was significantly different from that of Moyale district (

Segregation of receptor-ligand complexes in cell adhesion zones: Phase diagrams and role of thermal membrane roughness

The adhesion zone of immune cells, the 'immunological synapse', exhibits characteristic domains of receptor-ligand complexes. The domain formation is likely caused by a length difference of the receptor-ligand complexes, and has been investigated in experiments in which T cells adhere to supported membranes with anchored ligands. For supported membranes with two types of anchored ligands, MHCp and ICAM1, that bind to the receptors TCR and LFA1 in the cell membrane, the coexistence of domains of TCR-MHCp and LFA1-ICAM1 complexes in the cell adhesion zone has been observed for a wide range of ligand concentrations and affinities. For supported membranes with long and short ligands that bind to the same cell receptor CD2, in contrast, domain coexistence has been observed for a rather narrow ratio of ligand concentrations. In this article, we determine detailed phase diagrams for cells adhering to supported membranes with a statistical-physical model of cell adhesion. We find a characteristic difference between the adhesion scenarios in which two types of ligands in a supported membrane bind (i) to the same cell receptor or (ii) to two different cell receptors, which helps to explain the experimental observations. Our phase diagrams fully include thermal shape fluctuations of the cell membranes on nanometer scales, which lead to a critical point for the domain formation and to a cooperative binding of the receptors and ligands.Comment: 23 pages, 6 figure

Miocene faunal remains from the Burji-Soyama area, Amaro Horst, southern sector of the main Ethiopian Rift

The Palaeoanthropological Inventory of Ethiopia is dedicated to the discovery and documentation of palaeoanthropologically significant study areas in the Main Ethiopian Rift and Afar Depression. Fieldwork in the area at the southern end of the Amaro Horst during the 1989 field season was focused on a fossiliferous sedimentary succession with intercalated volcanic horizons. Potassium-argon dating sets a minimum age of 11.1 my for sediments bearing vertebrate remains. The partial skeleton of a fossil proboscidean recovered at Burji is described, illustrated and assessed comparatively. The remains are those of a primitive species of choerolophodont mastodon. Biochronological considerations place this specimen in the time range of 15-17 my. The presence of fossiliferous sediments in the Burji area suggest that a rift-related basin had developed in this part of Ethiopia by Middle or Early Miocene times.National Geographic Society 4134-89; National Science Foundation Anthropology Program: BSN 88-19735; Centre for Research and Conservation of the Cultural Heritage, Ethiopian Ministry of Culture and Sports Affair

Combining ability of highland tropic adapted potato for tuber yield and yield components under drought

Open Access Journal; Published online: July 25, 2017Recurrent drought and late blight disease are the major factors limiting potato productivity in the northwest Ethiopian highlands. Incorporating drought tolerance and late blight resistance in the same genotypes will enable the development of cultivars with high and stable yield potential under erratic rainfall conditions. The objectives of this study were to assess combining ability effects and gene action for tuber yield and traits related to drought tolerance in the International Potato Centre’s (CIP’s) advanced clones from the late blight resistant breeding population B group ‘B3C2’ and to identify promising parents and families for cultivar development. Sixteen advanced clones from the late blight resistant breeding population were crossed in two sets using the North Carolina Design II. The resulting 32 families were evaluated together with five checks and 12 parental clones in a 7 x 7 lattice design with two water regimes and two replications. The experiment was carried out at Adet, in northwest Ethiopia under well-watered and water stressed conditions with terminal drought imposed from the tuber bulking stage. The results showed highly significant differences between families, checks, and parents for growth, physiological, and tuber yield related traits. Traits including marketable tuber yield, marketable tuber number, average tuber weight and groundcover were positively correlated with total tuber yield under both drought stressed and well-watered conditions. Plant height was correlated with yield only under drought stressed condition. GCA was more important than SCA for total tuber yield, marketable tuber yield, average tuber weight, plant height, groundcover, and chlorophyll content under stress. This study identified the parents with best GCA and the combinations with best SCA effects, for both tuber yield and drought tolerance related traits. The new population is shown to be a valuable genetic resource for variety selection and improvement of potato’s adaptation to the drought prone areas in northwest Ethiopia and similar environments

Onsager coefficients of a Brownian Carnot cycle

We study a Brownian Carnot cycle introduced by T. Schmiedl and U. Seifert [Europhys. Lett. \textbf{81}, 20003 (2008)] from a viewpoint of the linear irreversible thermodynamics. By considering the entropy production rate of this cycle, we can determine thermodynamic forces and fluxes of the cycle and calculate the Onsager coefficients for general protocols, that is, arbitrary schedules to change the potential confining the Brownian particle. We show that these Onsager coefficients contain the information of the protocol shape and they satisfy the tight-coupling condition irrespective of whatever protocol shape we choose. These properties may give an explanation why the Curzon-Ahlborn efficiency often appears in the finite-time heat engines

Agricultural technology adoption, seed access constraints and commercialization in Ethiopia

This article examines the driving forces behind farmers’ decisions to adopt agricultural technologies and the causal impact of adoption on farmers’ integration into output market using data obtained from a random cross-section sample of 700 farmers in Ethiopia. We estimate a Double-Hurdle model to analyze the determinants of the intensity of technology adoption conditional on overcoming seed access constraints. We estimate the impact of technology adoption on farmers’ integration into output market by utilizing treatment effect model, regression based on propensity score as well as matching techniques to account for heterogeneity in the adoption decision, and for unobservable characteristics of farmers and their farm. Results show that knowledge of existing varieties, perception about the attributes of improved varieties, household wealth (livestock and land) and availability of active labor force are major determinants for adoption of improved technologies. Our results suggest that the adoption of improved agricultural technologies has a significant positive impact on farmers’ integration into output market and the findings are consistent across the three models suggesting the robustness of the results. This confirms the potential direct role of technology adoption on market participation among rural households, as higher productivity from improved technology translates into higher output market integration

Impact of modern agricultural technologies on smallholder welfare: Evidence from Tanzania and Ethiopia

This paper evaluates the potential impact of adoption of improved legume technologies on rural household welfare measured by consumption expenditure in rural Ethiopia and Tanzania. The study utilizes cross-sectional farm household level data collected in 2008 from a randomly selected sample of 1313 households (700 in Ethiopia and 613 in Tanzania). The causal impact of technology adoption is estimated by utilizing endogenous switching regression. This helps us estimate the true welfare effect of technology adoption by controlling for the role of selection problem on production and adoption decisions. Our analysis reveals that adoption of improved agricultural technologies has a significant positive impact consumption expenditure (in per adult equivalent terms) in rural Ethiopia and Tanzania. This confirms the potential role of technology adoption in improving rural household welfare as higher consumption expenditure from improved technologies translate into lower poverty, higher food security and greater ability to withstand risk. An analysis of the determinants of adoption highlighted inadequate local supply of seed, access to information and perception about the new cultivars as key constraints for technology adoption

Review of empirical and emerging breeding methods and tools for yam (Dioscorea spp.) improvement: status and prospects

Open Access Article; Published online: 05 Dec 2019Yam (Dioscorea spp.) is an important tuber crop with tremendous potential as a functional food in the tropics and subtropics. However, the crop has not shown progressive productivity gain over decades due to various production constraints. This paper reviews the progress achieved in empirical breeding endeavours and the development, status and application of emerging breeding tools and technologies to translate genetic gains in yam improvement. Significant progress has been made in yam genetic improvement over the years which has led to the identification and development of several improved clones and sources of variability for various economically important traits. Substantial efforts have also been made to develop diverse molecular markers, transcriptome and metabolome profiles of crucial traits, trait mapping and generate reference genome sequences of the key species. However, there seems to be a slow translation of research improvements into widespread applications. These advances and the integration of empirical and emerging methods and technologies into the breeding process will enhance yam breeding efforts and ensure the quick delivery of improved varieties that possess superior agronomic and quality traits