Peningkatkan Ketrampilan Menggunakan Media Pianika dengan Metode Driil SMP 1 Teriak Bengkayang

The purpose of this research is to study the art of music is expected to improve students' skills in using media pianika. The method used in this research is descriptive, with a qualitative approach. Pennelitian shape is action research (action research) with action research procedures including planning, implementation, observation and reflection. Driil method is something to do the same activity over and over again in earnest with the aim to strengthen the skills to be a permanent thing.Learning outcomes in this study is the knowledge and abilities of learners. The conclusions of this study is the use driil method can improve skills in using media pianika seventh grade students of SMP Negeri 1 Shouts Bengkayang. Improved learning outcomes in mind of the average value of student learning outcomes during the first cycle that is 66.28 students' skills in using media pianika musical instruments have not been successful because the average value of students under the KKM is 70. In the second cycle increased to 77, 87 in both categories

Network insights on oxaliplatin anti-cancer mechanisms

Abstract Oxaliplatin has been a crucial component of combination therapies since admission into the clinic causing modest gains in survival across multiple malignancies. However, oxaliplatin functions in a non-targeted manner, posing a difficulty in ascertaining precise efficacy mechanisms. While previously thought to only affect DNA repair mechanisms, Platinum-protein adducts (Pt-Protein) far outnumber Pt-DNA adducts leaving a big part of oxaliplatin function unknown. Through preliminary network modeling of high throughput data, this article critically reviews the efficacy of oxaliplatin as well as proposes a better model for enhanced efficacy based on a network approach. In our study, not only oxaliplatin’s function in interrupting DNA-replication was confirmed, but also its role in initiating or intensifying tumorigenesis pathways was uncovered. From our data we present a novel picture of competing signaling networks that collectively provide a plausible explanation of chemotherapeutic resistance, cancer stem cell survival, as well as invasiveness and metastases. Here we highlight oxaliplatin signaling networks, their significance and the clinical implications of these interactions that verifies the importance of network modeling in rational drug design

Penerapan Modifikasi Model Pembelajaran Team Share Tournamet terhadap Kemampuan Komunikasi Siswa Terintegrasi Ada Pappaseng Bugis Makassar

Abstract: Communication skills are very important to be mastered by students in facing the 21st century. It can help and facilitate students to express ideas, and exchange information both verbally and non-verbally. The purpose of this study was to determine the improvement of high school students' communication skills by applying the team share tournament learning model to the material of majas which has local wisdom, namely Pappaseng Bugis Makassar. This type of research is descriptive quantitative which aims to describe systematically the students' communication skills. The sampling technique used purposive sampling and selected students of class XI at one of the public high schools in Bone Regency with a total of 30 students. The instruments used in the study included tests of students' communication skills which were then analyzed using descriptive statistics. The results showed that the communication skills of high school students on figurative language material (folklore) had increased in each indicator after the integration of Makassar Bugis Pappaseng was applied in the learning process. The increase that occurred reached a percentage of up to 89% which was at high.Abstrak: Kemampuan komunikasi merupakan hal yang sangat penting dikuasai oleh siswa dalam menghadapi abad ke-21 karena dapat membantu dan memfasilitasi siswa untuk mengutarakan gagasan, serta bertukar informasi baik secara verbal maupun nonverbal. Tujuan penelitian ini adalah untuk mengetahui peningkatan kemampuan komunikasi siswa SMA dengan penerapan model pembelajaran team share tournament pada materi majas yang dikaitkan dengan kearifan lokal ada pappaseng bugis makassar. Jenis penelitian ini adalah deskriptif kuantitatif yang bertujuan untuk menggambarkan secara sistematis mengenai kemampuan komunikasi siswa. Teknik penentuan sampel digunakan purposive sampling dan dipilih siswa kelas XI pada salah satu SMA Negeri yang terdapat di Kabupaten Bone dengan jumlah 30 siswa. Instrumen yang digunakan dalam penelitian meliputi tes kemampuan komunikasi siswa yang selanjutnya dianalisis menggunakan statistik deskriptif. Hasil penelitian menunjukkan bahwa kemampuan komunikasi siswa SMA pada materi majas (cerita rakyat) mengalami peningkatan pada setiap indikatornya setelah diterapkan integrasi ada pappaseng Bugis Makassar dalam proses pembelajaran. Peningkatan yang terjadi mencapai persentase hingga 89% yang berada pada kategori tinggi

Acquired factor V inhibitor in a context of sepsis and disseminated intravascular coagulation

International audienc

Target blood pressure for septic and vasodilatory shock: what is optimal?

International audienc

Analysis of Ultramafic Rocks Weathering Level Using the Magnetic Susceptibility in Konawe Regency, Southeast Sulawesi, Indonesia

The Konawe region is part of the Sulawesi Southeast Arm ophiolite belt where ultramafic rocks are exposed in the form of dunite and peridotite. The formation of nickel deposits is closely related to the weathering process of ultramafic rocks as a source rock. Ultramafic rocks exposed to the surface will experience weathering which is influenced by many factors, including in the form of climate change, topography, and existing geological structures. The weathering process in the source rock can influence variations in chemical elements and magnetic properties in laterite soil profiles. For example, the chemical weathering might affect magnetic mineralogy and the physical weathering could affect granulometry as well as the quantity of magnetic minerals in the soil. Condition of weathering of ultramafic rocks (initial, moderate and advanced) can affect nickel content in laterite sediments. The weathering profile study of serpentine mineral is an indication of the lateralization process that occurs in ultramafic rocks and is carried out through petrographic analysis of thin cuts and polish cuts. Determination of weathering level like this is based on the level of weathering of the mineral serpentine. In this study, the determination of the weathering level of ultramafic rocks (initial, moderate, and continued) uses magnetic susceptibility parameter. A total of 232 ultramafic rock core samples obtained from 34 hand samples were taken from different places and weathered levels were analyzed. The results of the research have shown that the magnetic susceptibility of ultramafic rocks in the study area varies, from 580 x 10-6 SI to 4.724 x 10-6 SI. Based on the value of magnetic susceptibility, magnetic minerals contained in ultramafic rock samples are hematite and geotite minerals. This means that the weathering level of ultramafic rock samples is the continued weathering level. The level of continued weathering that occurs in ultramafic rocks in the study area produces nickel laterite deposits with a nickel content of 1.65 - 2.40% in the saprolite zone, 0.42% in the saprock zone, and 0.20 - 0.51% in the basic rock zone (bedrock)

Compared effects of inhibition and exogenous administration of hydrogen sulphide in ischaemia-reperfusion injury

INTRODUCTION: Haemorrhagic shock is associated with an inflammatory response consecutive to ischaemia-reperfusion (I/R) that leads to cardiovascular failure and organ injury. The role of and the timing of administration of hydrogen sulphide (H2S) remain uncertain. Vascular effects of H2S are mainly mediated through K+ATP-channel activation. Herein, we compared the effects of D,L-propargylglycine (PAG), an inhibitor of H2S production, as well as sodium hydrosulphide (NaHS), an H2S donor, on haemodynamics, vascular reactivity and cellular pathways in a rat model of I/R. We also compared the haemodynamic effects of NaHS administered before and 10 minutes after reperfusion. METHODS: Mechanically ventilated and instrumented rats were bled during 60 minutes in order to maintain mean arterial pressure at 40 +/- 2 mmHg. Ten minutes prior to retransfusion, rats randomly received either an intravenous bolus of NaHS (0.2 mg/kg) or vehicle (0.9% NaCl) or PAG (50 mg/kg). PNU, a pore-forming receptor inhibitor of K+ATP channels, was used to assess the role of K+ATP channels. RESULTS: Shock and I/R induced a decrease in mean arterial pressure, lactic acidosis and ex vivo vascular hyporeactivity, which were attenuated by NaHS administered before reperfusion and PNU but not by PAG and NaHS administered 10 minutes after reperfusion. NaHS also prevented aortic inducible nitric oxide synthase expression and nitric oxide production while increasing Akt and endothelial nitric oxide synthase phosphorylation. NaHS reduced JNK activity and p-P38/P38 activation, suggesting a decrease in endothelial cell activation without variation in ERK phosphorylation. PNU + NaHS increased mean arterial pressure when compared with NaHS or PNU alone, suggesting a dual effect of NaHS on vascular reactivity. CONCLUSION: NaHS when given before reperfusion protects against the effects of haemorrhage-induced I/R by acting primarily through a decrease in both proinflammatory cytokines and inducible nitric oxide synthase expression and an upregulation of the Akt/endothelial nitric oxide synthase pathway