PREVALENCIA DE ALTERACIONES NUTRICIONALES EN PACIENTES CON SÍNDROME DE OVARIO POLIQUÍSTICO QUE ASISTEN AL HOSPITAL SANTA INÉS EN EL PERIODO ENERO – DICIEMBRE 2021

Antecedentes: El síndrome de ovario poliquístico (SOP) es el trastorno endocrino metabólico más frecuente en mujeres en edad fértil, con una prevalencia de hasta el 10% en América Latina, que afecta la calidad de vida de la mujer y se asocia con patologías metabólicas y cardiovasculares graves, aumento de la subfertilidad y embarazos anómalos. (1,2) Objetivo: Describir la prevalencia de alteraciones nutricionales en mujeres con SOP que asisten al Hospital Santa Inés en el periodo enero – diciembre 2021, por el servicio de Ginecología y Obstetricia de la Dra. María Isabel Sigüenza. Metodología: El estudio se fundamenta en un enfoque de tipo cuantitativo descriptivo con diseño no experimental y de corte transversal, se utilizará el muestreo no probabilístico. Para esta investigación, se tomará en consideración el total del universo poblacional de análisis. Para el análisis y tabulación de datos se utilizará el programa SPSS 26. Resultados: La prevalencia de alteraciones nutricionales de mujeres con SOP es de 60,1%. La mayoría de las mujeres que asistió al servicio gineco-obstétrico se encuentran en el grupo de edad de 25-29 años. Existe una correlación significativa media entre la edad y la presencia de alteraciones nutricionales del grupo estudiado. Conclusiones: La prevalencia de alteraciones nutricionales afecta de manera negativa a la fisiopatología del SOP y las principales alteraciones tienen una correlación con las variables edad, peso, talla e IMC, se observa que existe una prevalencia del 60,1% de sobrepeso y obesidad dentro de la muestra.Background: Polycystic ovarian syndrome (PCOS) is the most frequent metabolic endocrine disorder in women of childbearing age, with a prevalence of up to 10% in Latin America, which affects the quality of life of women and is associated with metabolic pathologies. and serious cardiovascular diseases, increased subfertility and abnormal pregnancies. (1,2) Objective: To describe the prevalence of nutritional alterations in women with PCOS who attend the Santa Inés Hospital in the period January - December 2021, by the Gynecology and Obstetrics service of Dr. María Isabel Sigüenza. Methodology: The study is based on a descriptive quantitative approach with a non-experimental and cross-sectional design, non-probabilistic sampling will be used. For this research, the total population universe of analysis will be taken into consideration. For the analysis and tabulation of data, the SPSS 26 program will be used. Results: The prevalence of nutritional disorders in women with PCOS is 60.1%. Most of the women who attended the gynecological-obstetric service are in the age group of 25-29 years. There is a significant mean correlation between age and the presence of nutritional alterations in the studied group. Conclusions: The prevalence of nutritional alterations negatively affects the pathophysiology of PCOS and the main alterations have a correlation with the variables age, weight, height and BMI, it is observed that there is a prevalence of 60.1% of overweight and obesity within of the sample.0000-0003-0986-686

Black carbon in the Southern Andean snowpack

The Andean snowpack is an important source of water for many communities. As other snow-covered regions around the world, the Andes are sensitive to black carbon (BC) deposition from fossil fuel and biomass combustion. BC darkens the snow surface, reduces the albedo, and accelerates melting. Here, we report on measurements of the BC content conducted by using the meltwater filtration (MF) technique in snow samples collected across a transect of more than 2500 km from the mid-latitude Andes to the southern tip of South America. Addressing some of the key knowledge gaps regarding the effects of the BC deposition on the Andean snow, we identified BC-impacted areas, assessed the BC-related albedo reduction, and estimated the resulting snow losses. We found that BC concentrations in our samples generally ranged from 2 to 15 ng g-1, except for the nearly BC-free Patagonian Icefields and for the BC-impacted sites nearby Santiago (a metropolis of 6 million inhabitants). We estimate that the seasonal snowpack shrinking attributable to the BC deposition ranges from 4 mm water equivalent (w.e.) at relatively clean sites in Patagonia to 241 mm w.e. at heavily impacted sites close to Santiago. © 2022 The Author(s). Published by IOP Publishing Ltd

Black carbon in the Southern Andean snowpack

The Andean snowpack is an important source of water for many communities. As other snow-covered regions around the world, the Andes are sensitive to black carbon (BC) deposition from fossil fuel and biomass combustion. BC darkens the snow surface, reduces the albedo, and accelerates melting. Here, we report on measurements of the BC content conducted by using the meltwater filtration (MF) technique in snow samples collected across a transect of more than 2500 km from the mid-latitude Andes to the southern tip of South America. Addressing some of the key knowledge gaps regarding the effects of the BC deposition on the Andean snow, we identified BC-impacted areas, assessed the BC-related albedo reduction, and estimated the resulting snow losses. We found that BC concentrations in our samples generally ranged from 2 to 15 ng g-1, except for the nearly BC-free Patagonian Icefields and for the BC-impacted sites nearby Santiago (a metropolis of 6 million inhabitants). We estimate that the seasonal snowpack shrinking attributable to the BC deposition ranges from 4 mm water equivalent (w.e.) at relatively clean sites in Patagonia to 241 mm w.e. at heavily impacted sites close to Santiago. © 2022 The Author(s). Published by IOP Publishing Ltd

Black carbon footprint of human presence in Antarctica

Black carbon (BC) from fossil fuel and biomass combustion darkens the snow and makes it melt sooner. The BC footprint of research activities and tourism in Antarctica has likely increased as human presence in the continent has surged in recent decades. Here, we report on measurements of the BC concentration in snow samples from 28 sites across a transect of about 2,000 km from the northern tip of Antarctica (62°S) to the southern Ellsworth Mountains (79°S). Our surveys show that BC content in snow surrounding research facilities and popular shore tourist-landing sites is considerably above background levels measured elsewhere in the continent. The resulting radiative forcing is accelerating snow melting and shrinking the snowpack on BC-impacted areas on the Antarctic Peninsula and associated archipelagos by up to 23 mm water equivalent (w.e.) every summer

Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase

Black carbon footprint of human presence in Antarctica

Black carbon (BC) from fossil fuel and biomass combustion darkens the snow and makes it melt sooner. The BC footprint of research activities and tourism in Antarctica has likely increased as human presence in the continent has surged in recent decades. Here, we report on measurements of the BC concentration in snow samples from 28 sites across a transect of about 2,000 km from the northern tip of Antarctica (62°S) to the southern Ellsworth Mountains (79°S). Our surveys show that BC content in snow surrounding research facilities and popular shore tourist-landing sites is considerably above background levels measured elsewhere in the continent. The resulting radiative forcing is accelerating snow melting and shrinking the snowpack on BC-impacted areas on the Antarctic Peninsula and associated archipelagos by up to 23 mm water equivalent (w.e.) every summer

Safety of 6000 intravitreal dexamethasone implants

Purpose To evaluate the real-life safety profile of intravitreal dexamethasone implant injection for various retinal conditions. Methods Retrospective multicenter analysis of intravitreal dexamethasone implant injections (700 mu g) due to various retinal conditions including central retinal venous occlusion (1861 injections), diabetic macular oedema (3104 injections), post-surgical cystoid macular oedema (305 injections) and uveitis (381 injections). The eyes were evaluated mainly for the occurrence of adverse events such as glaucoma, cataract, retinal detachment and endophthalmitis along during the follow-up period. Results A total of 6015 injections in 2736 eyes of 1441 patients (mean age of 65.7 +/- 12.9 years) were in total analysed over an average period of 18 months (range 6 months to 102 months). A total of 576 eyes (32.5% of the phakic eyes) developed cataract requiring surgical intervention. However, visually insignificant cataract progression was observed in another 259 phakic eyes (14.6%) which did not require surgical removal. A total of 727 eyes (26.5%) experienced an intraocular pressure (IOP) rise of >25 mm Hg, with 155 eyes (5.67%) having a prior history of glaucoma and 572 eyes (20.9%) having new onset IOP rise. Overall, more than 90% of eyes with IOP rise were managed medically, and 0.5% eyes required filtering surgery. Endophthalmitis (0.07%), retinal detachment (0.03%) and vitreous haemorrhage (0.03%) were rare. There was no significant change in visual acuity (p=0.87) and central macular thickness (p=0.12) at the last follow-up. Conclusion This is the largest real-life study assessing the safety of intravitreal dexamethasone implant injections in various retinal conditions. Cataract progression and intraocular pressure rise are the most common side effects, but are often rather easily manageable

Riociguat treatment in patients with pulmonary arterial hypertension: Final safety data from the EXPERT registry

International audienc

Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

International audienc