Faktor-Faktor Kritis Dalam Sistem Manajemen Mutu (SMM) Untuk Optimasi Profitabilitas Dan Daya Saing Perusahaan Jasa Konstruksi Di Indonesia

. In the middle of the emulation business competitiveness demand by selling quality development, financial company services is of course not escape in execution and development of product quality and service to the customer. Total Quality Management System (TQM) have been proved as the best technique of quality management which have applicated. Empirical study have concluded that application of TQM can give effect which is impact and result significantly to business. Along desire of industry so that all developer (subcontractors) have certificate, and possibility that this matter is prerequisite of new tender to public service company, The message by industry is very clear, do the company adopt ISO 9001:2000 and become competitive or disregarding it and become its own risk. But that way, at the opposite of successfulness the number of state and company which adopting Quality Management System, there is elementary question, how far company which have strained after follow that International standard, that is true succeed to improve its company performance. This research prove empirically and statistic correlation applying of competitiveness and profitability with Critical Success Factors (CSF) of Quality Management System

Gene Delivery Therapeutics in the Treatment of Periodontitis and Peri-Implantitis : A State of the Art Review

Background: Periodontal disease is a chronic inflammatory condition that affects supporting tissues around teeth, resulting in periodontal tissue breakdown. If left untreated, periodontal disease could have serious consequences; this condition is in fact considered as the primary cause of tooth loss. Being highly prevalent among adults, periodontal disease treatment is receiving increased attention from researchers and clinicians. When this condition occurs around dental implants, the disease is termed peri-implantitis. Periodontal regeneration aims at restoring the destroyed attachment apparatus, in order to improve tooth stability and thus reduce disease progression and subsequent periodontal tissue breakdown. Although many biomaterials have been developed to promote periodontal regeneration, they still have their own set of disadvantages. As a result, regenerative medicine has been employed in the periodontal field, not only to overcome the drawbacks of the conventional biomaterials but also to ensure more predictable regenerative outcomes with minimal complications. Regenerative medicine is considered a part of the research field called tissue engineering/regenerative medicine (TE/RM), a translational field combining cell therapy, biomaterial, biomedical engineering and genetics all with the aim to replace and restore tissues or organs to their normal function using in vitro models for in vivo regeneration. In a tissue, cells are responding to different micro-environmental cues and signaling molecules, these biological factors influence cell differentiation, migration and cell responses. A central part of TE/RM therapy is introducing drugs, genetic materials or proteins to induce specific cellular responses in the cells at the site of tissue repair in order to enhance and improve tissue regeneration. In this review, we present the state of art of gene therapy in the applications of periodontal tissue and peri-implant regeneration. Purpose: We aim herein to review the currently available methods for gene therapy, which include the utilization of viral/non-viral vectors and how they might serve as therapeutic potentials in regenerative medicine for periodontal and peri-implant tissues

A Systems Approach and Notional Response Model for Preserving the Health System during the COVID-19 Pandemic

During any pandemic, it has long been known that local jurisdictions would need to be self-sufficient with little or no outside assistance, particularly from the federal government. While all eyes have been on California, New York, and Massachusetts, the capacities of health systems in other states have yet to be put to the test. If there are subsequent waves of COVID-19 and other jurisdictions see significant increases in disease spread, the systems used to respond will become critical.Using a review and synthesis approach, this article explores our collective experience and knowledge as it pertains to use of alternate care sites for dealing with the patient surge created by a disease outbreak. Probing the concept of alternate care site (ACS) systems reveals various types of alternate care sites that may be employed during an outbreak. The historical value of ACS models used during outbreak response are discussed. This culminates in the development of a notional response model and list of actions that should be taken by all jurisdictions as we prepare for additional waves of disease

The ALMaQUEST survey – III. Scatter in the resolved star-forming main sequence is primarily due to variations in star formation efficiency

Using a sample of 11,478 spaxels in 34 galaxies with molecular gas, star formation and stellar maps taken from the ALMA-MaNGA QUEnching and STar formation (ALMaQUEST) survey, we investigate the parameters that correlate with variations in star formation rates on kpc scales. We use a combination of correlation statistics and an artificial neural network to quantify the parameters that drive both the absolute star formation rate surface density (Sigma_SFR), as well as its scatter around the resolved star forming main sequence (Delta Sigma_SFR). We find that Sigma_SFR is primarily regulated by molecular gas surface density (Sigma_H2) with a secondary dependence on stellar mass surface density (Sigma_*), as expected from an `extended Kennicutt-Schmidt relation'. However, Delta Sigma_SFR is driven primarily by changes in star formation efficiency (SFE), with variations in gas fraction playing a secondary role. Taken together, our results demonstrate that whilst the absolute rate of star formation is primarily set by the amount of molecular gas, the variation of star formation rate above and below the resolved star forming main sequence (on kpc scales) is primarily due to changes in SFE

What shapes a galaxy? - Unraveling the role of mass, environment and star formation in forming galactic structure

We investigate the dependence of galaxy structure on a variety of galactic and environmental parameters for ~500,000 galaxies at z<0.2, taken from the Sloan Digital Sky Survey data release 7 (SDSS-DR7). We utilise bulge-to-total stellar mass ratio, (B/T)_*, as the primary indicator of galactic structure, which circumvents issues of morphological dependence on waveband. We rank galaxy and environmental parameters in terms of how predictive they are of galaxy structure, using an artificial neural network approach. We find that distance from the star forming main sequence (Delta_SFR), followed by stellar mass (M_*), are the most closely connected parameters to (B/T)_*, and are significantly more predictive of galaxy structure than global star formation rate (SFR), or any environmental metric considered (for both central and satellite galaxies). Additionally, we make a detailed comparison to the Illustris hydrodynamical simulation and the LGalaxies semi-analytic model. In both simulations, we find a significant lack of bulge-dominated galaxies at a fixed stellar mass, compared to the SDSS. This result highlights a potentially serious problem in contemporary models of galaxy evolution.Comment: Accepted to MNRAS. 31 pages, 15 figure

The black hole mass metallicity relation and insights into galaxy quenching

One of the most important questions in astrophysics is what causes galaxies to stop forming stars. Previous studies have shown a tight link between quiescence and black hole mass. Other studies have revealed that quiescence is also associated with 'starvation', the halting of gas inflows, which results in the remaining gas being used up rapidly by star formation and in rapid chemical enrichment. In this work we find the final missing link between these two findings. Using a large sample of galaxies, we uncover the intrinsic dependencies of the stellar metallicity on galaxy properties. In the case of the star-forming galaxies, the stellar metallicity is driven by stellar mass. However, for passive galaxies the stellar metallicity is primarily driven by the black hole mass, as traced by velocity dispersion. This result finally reveals the connection between previous studies, where the integrated effect of black hole feedback prevents gas inflows, starving the galaxy, which is seen by the rapid increase in the stellar metallicity, leading to the galaxy becoming passive.Comment: 20 pages, 6 figures, submitted to Nature Astronom

The influence of defined ante-mortem stressors on the early post-mortem biochemical processes in the abdominal muscle of the Norway lobster, Nephrops norvegicus (Linnaeus, 1758)

The effects of four different ante-mortem stressors (exercise, emersion, starvation and a patent infection with the parasite Hematodinium sp.) on post-mortem processes have been investigated in the abdominal muscle of Norway lobster Nephrops norvegicus by measuring changes in the pH, the levels of glycogen, l-lactate, arginine phosphate, ATP, ADP, AMP, IMP, HxR, Hx and the adenylate energy charge (AEC) over a time course of 24 h with samples being taken at 0, 3, 6, 12 and 24 h. The acute stresses of intense exercise and 2 h emersion resulted in a premature onset of anaerobic glycolysis, leading both to an enhanced glycogen depletion rate and an early accumulation of l-lactate. The chronic stressors, starvation and parasite infection, resulted in a complete ante-mortem depletion of muscle glycogen and consequently the failure of post-mortem glycolytic fermentation. Post-mortem pH and ATP inter-conversion were significantly altered in chronically stressed animals. Ante-mortem, a rapid, almost complete depletion of arginine phosphate was observed in all stress groups. The AEC was altered significantly by all stresses, indicating a strong energy demand. The findings suggest that ante-mortem stressors strongly influence the post-mortem biochemical processes. The laboratory-based results are compared to 'field' data and effects on post-harvest product quality are discussed

The ALMaQUEST Survey - II. What drives central starbursts at z ∼ 0?

Starburst galaxies have elevated star formation rates (SFRs) for their stellar mass. In Ellison et al., we used integral field unit maps of SFR surface density (ΣSFR) and stellar mass surface density (Σ⋆) to show that starburst galaxies in the local universe are driven by SFRs that are preferentially boosted in their central regions. Here, we present molecular gas maps obtained with the Atacama Large Millimeter Array (ALMA) observatory for 12 central starburst galaxies at z ∼ 0 drawn from the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey. The ALMA and MaNGA data are well matched in spatial resolution, such that the ALMA maps of molecular gas surface density (⁠ΣH2⁠) can be directly compared with MaNGA maps at kpc-scale resolution. The combination of ΣH2⁠, Σ⋆ and ΣSFR at the same resolution allow us to investigate whether central starbursts are driven primarily by enhancements in star formation efficiency (SFE) or by increased gas fractions. By computing offsets from the resolved Kennicutt-Schmidt relation (⁠ΣH2 versus ΣSFR) and the molecular gas main sequence (Σ⋆ versus ΣH2⁠), we conclude that the primary driver of the central starburst is an elevated SFE. We also show that the enhancement in ΣSFR is accompanied by a dilution in O/H, consistent with a triggering that is induced by metal poor gas inflow. These observational signatures are found in both undisturbed (9/12 galaxies in our sample) and recently merged galaxies, indicating that both interactions and secular mechanisms contribute to central starbursts

The ALMaQUEST Survey: V. The non-universality of kpc-scale star formation relations and the factors that drive them

Using a sample of ~15,000 kpc-scale star-forming spaxels in 28 galaxies drawn from the ALMA-MaNGA QUEnching and STar formation (ALMaQUEST) survey, we investigate the galaxy-to-galaxy variation of the `resolved' Schmidt-Kennicutt relation (rSK; Sigma_H2 - Sigma_SFR), the `resolved' star forming main sequence (rSFMS; Sigma_* - Sigma_SFR) and the `resolved' molecular gas main sequence (rMGMS; Sigma_* - Sigma_H2). The rSK relation, rSFMS and rMGMS all show significant galaxy-to-galaxy variation in both shape and normalization, indicating that none of these relations is universal between galaxies. The rSFMS shows the largest galaxy-to-galaxy variation and the rMGMS the least. By defining an `offset' from the average relations, we compute a Delta_rSK, Delta_rSFMS, Delta_rMGMS for each galaxy, to investigate correlations with global properties. We find the following correlations with at least 2 sigma significance: the rSK is lower (i.e. lower star formation efficiency) in galaxies with higher M_*, larger Sersic index and lower specific SFR (sSFR); the rSFMS is lower (i.e. lower sSFR) in galaxies with higher M_* and larger Sersic index; the rMGMS is lower (i.e. lower gas fraction) in galaxies with lower sSFR. In the ensemble of all 15,000 data points, the rSK relation and rMGMS show equally tight scatters and strong correlation coefficients, compared with a larger scatter and weaker correlation in the rSFMS. Moreover, whilst there is no correlation between Delta_rSK and Delta_rMGMS in the sample, the offset of a galaxy's rSFMS does correlate with both of the other two offsets. Our results therefore indicate that the rSK and rMGMS are independent relations, whereas the rSFMS is a result of their combination.Comment: MNRAS, in pres