COMPARATIVE ANALYSIS OF PHYSICAL AND CHEMICAL PRORERTIES OF OILS FROM VARIOUS DEPOSITS

This article cites the results of a research of fundamental physico-chemical parameters of oil from Kashagan and Martishi. The main physicochemical characteristics of oil are given, including the pour point, kinematic viscosity, fractional composition, the content of mechanical impurities, salts and sulfur in oil from the Kashagan and Martishi fields. On the basis of the conducted research, it was concluded that the oil of both fields is in accordance with the main state-of-the-art physical and chemical indicators. A comparative analysis of the properties of oil from two fields was carried out. Comparison of the content of oil salts from two fields showed that the content of salts in oil from the Martyshi field exceeds this indicator in the Kashagan field, but also corresponds to GOST

Investigation of the effect of depressor additives on the rheological properties of oil

The article is devoted to the study of physico-chemical properties of oil fields Uzen, Kenkiyak, Martyshi and study the effect of depressor additives on the rheological properties of oil fields Uzen. The main analyses of oil were carried out, including the content of paraffins, viscosity, pour point. Depressor additives of brands were used during the research MR-1055/980, Deprop 4125, WX 161. It is established that the effect of depressor additives on oil has a positive effect on their physical and chemical characteristics

Experimental, Clinical and Morphological Analysis of H-Ras Oncoproteins for Locally Advanced Breast Cancer

BACKGROUND: Activated forms of Ras are enhanced in both breast cancer as well as the cell lines with EGFR and HER2 expression. Therefore, H-Ras could be activated in breast tumours in the absence of direct mutational activation of Ras itself and could contribute to 20-50% of the cases. Expression inhibition, signal transduction interruption from H-Ras to the nucleus could become a promising therapeutic target. AIM: The aim of this study was to investigate the clinical and morphological criteria of locally advanced breast cancer and the expression of H-Ras oncoprotein in patients who have been subjected to different regimens of farnesyltransferase inhibitor. METHODS: H-Ras status was assessed by immunohistochemistry (IHC). RESULTS: An association between the expressions of H-Ras and Her2/neu (p = 0.001) as well as the tumour proliferation index Ki-67 (p = 0.001) in patients with breast cancer was established. Analysis of the relationship between H-Ras expression showed a relatively strong association with progression-free survival both before the treatment (V = 0.47; p = 0.001) and after the treatment (V = 0.45; p = 0.001). These results may indicate the clinical applicability of H-Ras as a prognostic factor or serve as a therapeutic target for breast cancer treatment. CONCLUSION: These results could indicate the potential clinical application of H-Ras as a prognostic factor or a therapeutic target for breast cancer treatment

Automated echocardiographic detection of heart failure with preserved ejection fraction using artificial intelligence

Background: Detection of heart failure with preserved ejection fraction (HFpEF) involves integration of multiple imaging and clinical features which are often discordant or indeterminate. Objectives: We applied artificial intelligence (AI) to analyze a single apical four-chamber (A4C) transthoracic echocardiogram videoclip to detect HFpEF. Methods: A three-dimensional convolutional neural network was developed and trained on A4C videoclips to classify patients with HFpEF (diagnosis of HF, EF≥50%, and echocardiographic evidence of increased filling pressure; cases) versus without HFpEF (EF≥50%, no diagnosis of HF, normal filling pressure; controls). Model outputs were classified as HFpEF, no HFpEF, or non-diagnostic (high uncertainty). Performance was assessed in an independent multi-site dataset and compared to previously validated clinical scores. Results: Training and validation included 2971 cases and 3785 controls (validation holdout, 16.8% patients), and demonstrated excellent discrimination (AUROC:0.97 [95%CI:0.96-0.97] and 0.95 [0.93-0.96] in training and validation, respectively). In independent testing (646 cases, 638 controls), 94 (7.3%) were non-diagnostic; sensitivity (87.8%; 84.5-90.9%) and specificity (81.9%; 78.2-85.6%) were maintained in clinically relevant subgroups, with high repeatability and reproducibility. Of 701 and 776 indeterminate outputs from the HFA-PEFF and H2FPEF scores, the AI HFpEF model correctly reclassified 73.5 and 73.6%, respectively. During follow-up (median [IQR]:2.3 [0.5-5.6] years), 444 (34.6%) patients died; mortality was higher in patients classified as HFpEF by AI (hazard ratio [95%CI]:1.9 [1.5-2.4]). Conclusion: An AI HFpEF model based on a single, routinely acquired echocardiographic video demonstrated excellent discrimination of patients with versus without HFpEF, more often than clinical scores, and identified patients with higher mortality

Stress echo 2020: The international stress echo study in ischemic and non-ischemic heart disease

Abstract Background Stress echocardiography (SE) has an established role in evidence-based guidelines, but recently its breadth and variety of applications have extended well beyond coronary artery disease (CAD). We lack a prospective research study of SE applications, in and beyond CAD, also considering a variety of signs in addition to regional wall motion abnormalities. Methods In a prospective, multicenter, international, observational study design, > 100 certified high-volume SE labs (initially from Italy, Brazil, Hungary, and Serbia) will be networked with an organized system of clinical, laboratory and imaging data collection at the time of physical or pharmacological SE, with structured follow-up information. The study is endorsed by the Italian Society of Cardiovascular Echography and organized in 10 subprojects focusing on: contractile reserve for prediction of cardiac resynchronization or medical therapy response; stress B-lines in heart failure; hypertrophic cardiomyopathy; heart failure with preserved ejection fraction; mitral regurgitation after either transcatheter or surgical aortic valve replacement; outdoor SE in extreme physiology; right ventricular contractile reserve in repaired Tetralogy of Fallot; suspected or initial pulmonary arterial hypertension; coronary flow velocity, left ventricular elastance reserve and B-lines in known or suspected CAD; identification of subclinical familial ..

The Control of Population Tumor Cells via Compensatory Effect

Abstract: Mathematical models and simulation studies are powerful tools to investigate dynamic properties of complex systems. Complex models with constant parameters often approach a steady state. In this research, we present an overview of mathematical approaches applied to the description of control population tumor cells. We are researching the influence of D-factor on tumor cells population. We called it compensatory effect. There is Vaccination as biological analogue of the compensator effect. D-factor is presented as catastrophe theory’s fold form. Further, numeric results of model experiments are showing that this approach is positive efficient

The Control of Population Tumor Cells via Compensatory Effect

Mathematical models and simulation studies are powerful tools to investigate dynamic properties of complex systems. Complex models with constant parameters often approach a steady state. In this research, we present an overview of mathematical approaches applied to the description of control population tumor cells. We are researching the influence of D-factor on tumor cells population. We called it compensatory effect. There is Vaccination as biological analogue of the compensator effect. D-factor is presented as catastrophe theory’s fold form. Further, numeric results of model experiments are showing that this approach is positive efficient

DECREASED HEART RATE VARIABILITY IN SICKLE CELL ANEMIA AS EFFECT OF PULMONARY ARTERIAL HYPERTENSION

WOS: 000474853700006PubMed: 31002038Decreased heart rate variability (HRV) is associated with increased mortality risk in various diseases. The objective of this investigation: to study HRV in patients with sickle cell anemia (SCA) and to assess the effect of pulmonary arterial hypertension (PAH) on HRV in these patients. Materials and methods. HRV registration and Doppler echocardiographic assessment of systolic pulmonary arterial pressure (PAP) was carried out in 61 stable patients with SCA and 24 healthy subjects. Results. Low frequency power (LFP) and high frequency power (HFP) were decreased in SCA patients compared to healthy subjects. Among SCA patients, PAH patients had lower LFP and HFP than patients without PAH. In SCA patients, systolic PAP showed significant negative correlation with LFP and HFP. Conclusion. HRV is significantly decreased in SCA patients, especially in those with PAH. HRV may be particularly useful in early detection of PAH patients who may have worse prognosis and higher mortality risk

Interaction of Pinostrobin Oxime and Leukomizin with reactive oxygen species in model systems

Free radical processes are a common universal mechanism of cellular damage in the pulmonary and cardiovascular diseases, diseases of the pancreas and liver, atherosclerosis, cataracts, etc. In this work, we investigated the interaction of the pinostrobin oxime and leucomisine with active forms of oxygen. The study of the interaction of the pinostrobin oxime and leucomisine with a stable radical 2,2-diphenyl-1-picrylhydrazyl, superoxide anion radical, hydroxyl radical, and the effects on stimulated prooxidants (hydrogen peroxide) lipid peroxidation in post-nuclear fraction of liver. As comparison drugs used substances with known antioxidant and antiradical activity - butylated hydroxytoluene, quercetin, and mannitol. The experiments showed that pinostrobin oxime and leucomisine exhibit moderate antiradical activity against the studied free radicals