Comparative Estimation of Russia’s Regions Investment Potential on the Base of the Multivariate Statistical Analysis

The article introduces the algorithm of Russia’s regions investment potential estimation, developed by means of multivariate statistical methods, determines the factors, reflecting regions investment state. The integral indicator was developed on their basis, using statistical data. The article presents regions’ classification on the basis of the integral inde

Study of Precipitates in Oxide Dispersion-Strengthened Steels by SANS, TEM, and APT

In this work, the nanostructure of oxide dispersion-strengthened steels was studied by small-angle neutron scattering (SANS), transmission electron microscopy (TEM), and atom probe tomography (APT). The steels under study have different alloying systems differing in their contents of Cr, V, Ti, Al, and Zr. The methods of local analysis of TEM and APT revealed a significant number of nanosized oxide particles and clusters. Their sizes, number densities, and compositions were determined. A calculation of hardness from SANS data collected without an external magnetic field, or under a 1.1 T field, showed good agreement with the microhardness of the materials. The importance of taking into account two types of inclusions (oxides and clusters) and both nuclear and magnetic scattering was shown by the analysis of the scattering data. © 2024 by the authors

Cell-Population Dynamics in Diffuse Gliomas during Gliomagenesis and Its Impact on Patient Survival

Diffuse gliomas continue to be an important problem in neuro-oncology. To solve it, studies have considered the issues of molecular pathogenesis from the intratumoral heterogeneity point. Here, we carried out a comparative dynamic analysis of the different cell populations’ content in diffuse gliomas of different molecular profiles and grades, considering the cell populations’ functional properties and the relationship with patient survival, using flow cytometry, immunofluorescence, multiparametric fluorescent in situ hybridization, polymerase chain reaction, and cultural methods. It was shown that an increase in the IDH-mutant astrocytomas and oligodendrogliomas malignancy is accompanied by an increase in stem cells’ proportion and mesenchymal cell populations’ appearance arising from oligodendrocyte-progenitor-like cells with cell plasticity and cells’ hypoxia response programs’ activation. In glioblastomas, malignancy increase is accompanied by an increase in both stem and definitive cells with mesenchymal differentiation, while proneuronal glioma stem cells are the most likely the source of mesenchymal glioma stem cells, which, in hypoxic conditions, further give rise to mesenchymal-like cells. Clinical confirmation was a mesenchymal-like cell and mesenchymal glioma stem cell number, and the hypoxic and plastic molecular programs’ activation degree had a significant effect on relapse-free and overall survival. In general, we built a multi-vector model of diffuse gliomas’ pathogenetic tracing up to the practical plane

Cell-Population Dynamics in Diffuse Gliomas during Gliomagenesis and Its Impact on Patient Survival

Diffuse gliomas continue to be an important problem in neuro-oncology. To solve it, studies have considered the issues of molecular pathogenesis from the intratumoral heterogeneity point. Here, we carried out a comparative dynamic analysis of the different cell populations’ content in diffuse gliomas of different molecular profiles and grades, considering the cell populations’ functional properties and the relationship with patient survival, using flow cytometry, immunofluorescence, multiparametric fluorescent in situ hybridization, polymerase chain reaction, and cultural methods. It was shown that an increase in the IDH-mutant astrocytomas and oligodendrogliomas malignancy is accompanied by an increase in stem cells’ proportion and mesenchymal cell populations’ appearance arising from oligodendrocyte-progenitor-like cells with cell plasticity and cells’ hypoxia response programs’ activation. In glioblastomas, malignancy increase is accompanied by an increase in both stem and definitive cells with mesenchymal differentiation, while proneuronal glioma stem cells are the most likely the source of mesenchymal glioma stem cells, which, in hypoxic conditions, further give rise to mesenchymal-like cells. Clinical confirmation was a mesenchymal-like cell and mesenchymal glioma stem cell number, and the hypoxic and plastic molecular programs’ activation degree had a significant effect on relapse-free and overall survival. In general, we built a multi-vector model of diffuse gliomas’ pathogenetic tracing up to the practical plane

Antibodies to the Spike Protein Receptor-Binding Domain of SARS-CoV-2 at 4–13 Months after COVID-19

Identification of factors behind the level and duration of persistence of the SARS-CoV-2 antibodies in the blood is assumed to set the direction for studying humoral immunity mechanisms against COVID-19, optimizing the strategy for vaccine use, antibody-based drugs, and epidemiological control of COVID-19. Objective: This study aimed to study the relationship between clinical and demographic characteristics and the level of IgG antibodies to the RBD of SARS-CoV-2 spike protein after COVID-19 in the long term. Residents of the Altai Region of Western Siberia of Russia, Caucasians, aged from 27 to 93 years (median 53.0 years), who recovered from COVID-19 between May 2020 and February 2021 (n = 44) took part in this prospective observational study. The titer of IgG antibodies to the RBD of SARS-CoV-2 spike protein was measured repeatedly in the blood at 4–13 months from the beginning of the clinical manifestation of COVID-19 via the method of enzyme-linked immunosorbent assay. The antibody titer positively correlated with age (p = 0.013) and COVID-19 pneumonia (p = 0.002) at 20–40 and 20–24 weeks from the onset of COVID-19 symptoms, respectively. Age was positively associated with antibody titer regardless of history of COVID-19 pneumonia (beta regression coefficient p = 0.009). The antibody titer decreased in 15 (34.1%) patients, increased in 10 (22.7%) patients, and did not change in 19 (43.2%) patients from the baseline to 48–49 weeks from the onset of COVID-19 symptoms, with seropositivity persisting in all patients. Age and COVID-19 pneumonia are possibly associated with higher IgG antibodies to the spike protein RBD of SARS-CoV-2 following COVID-19 in the long term. Divergent trends of anti-RBD IgG levels in adults illustrate inter-individual differences at 4–13 months from the onset of COVID-19 symptoms

The Cutter-Loaders Works in Kansk-Achinsk Coal Mines for Kranlayn Use Modernization

Рассматривается возможность применения экскаваторов кранлайн на угольных разрезах Канско-Ачинского бассейна: «Березовский-1», «Бородинский», «Назаровский» и связанные с этим изменения элементов систем разработки.This article discusses the possibility of using kranlayn in Kansk-Achinsk coal mines «Berezovsky-1», «Borodino», «Nazarovo» and the related changes of design elements

The Cutter-Loaders Works in Kansk-Achinsk Coal Mines for Kranlayn Use Modernization

Рассматривается возможность применения экскаваторов кранлайн на угольных разрезах Канско-Ачинского бассейна: «Березовский-1», «Бородинский», «Назаровский» и связанные с этим изменения элементов систем разработки.This article discusses the possibility of using kranlayn in Kansk-Achinsk coal mines «Berezovsky-1», «Borodino», «Nazarovo» and the related changes of design elements

Nucleation and Growth of Magnetron-Sputtered Ag Nanoparticles as Witnessed by Time-Resolved Small Angle X-Ray Scattering

Kinetic aspects of the synthesis of Ag nanoparticles (NPs) by magnetron sputtering are studied by in situ and time-resolved small angle X-ray scat-tering (SAXS). Part of the NPs are found to become confined within a capture zone at 1–10 mm from the surface of the target and circumscribed by the plasma ring. Three regimes of the NP growth are identified: 1) early growth at which the average NP diameter rapidly increases to 90 nm; 2) cycling instabilities at which the SAXS signal periodically fluctuates either due to expelling of large NPs from the capture zone or due to the axial rotation of the NP cloud; and 3) steady-state synthesis at which stable synthesis of the NPs is achieved. The NP confinement within the capture zone is driven by the balance of forces, the electrostatic force being dominant. On reaching the critical size, large NPs acquire an excessive charge and become expelled from the capture zone via the electrostatic interactions. As a result, signifi-cant NP deposits are formed on the inner walls of the aggregation chamber as well as in the central area of the targe

Лингвистическая корректность и достоверность содержания русской версии модуля гастроинтестинальных симптомов опросника PedsQL™ для пациентов педиатрического профиля

Background. Health Related Quality of Life (HRQL) is a person’s perception of the effect of a disease on physical, social and psychological functioning and wealth. Questionnaires that help assess the HRQL can give a concept of child’s state, identify arcane issues and they are of great importance for a full understanding of how the state of health affects the child. Universal HRQL tools allow to compare results with general parameters, indicators with specific symptoms better reflect clinically significant moments. The most widespread in the Russian Federation was the general PedsQLTM 4.0 questionnaire, widely used in practice to assess HRQL in children with various pathologies. Objective.The aim of the study is to describe the analysis of linguistic accuracy and authenticity of the content of the Russian version of the module of gastrointestinal symptoms of the PedsQLTM questionnaire, measuring HRQL, in children with gastrointestinal disorders (GIDs).Materials and methods. The establishment of linguistic accuracy and authenticity of the content was carried out according to international standards. The process included forward translation, scientific assessment and coordination, reverse translation, verification of the reverse translation and interviews with 17 children aged 5–18 years with symptoms of GIDs and 20 parents of children with symptoms of GIDs aged 2–18 years.Results. The Russian version of PedsQLTM module of gastrointestinal symptoms (report from children 5-18 years old, report from parents for children 2–18 years old) was developed without significant difficulties. Eight questions required discussion after the forward translation, one change was made after the reverse translation, and three changes were made after the study of the symptom’s module by patients and parents.Conclusion. A conceptually equivalent version of the of PedsQLTM module of gastrointestinal symptoms in Russian has been developed for children aged 2–18 years. It allows to improve the assessment of HRQL in children with GIDs in the Russian Federation. To assess authenticity and reliability of the Russian version of the module, it’s recommended to conduct further research using a larger sampleОбоснование. Качество жизни, связанное со здоровьем (КЖСЗ) — это восприятие человеком влияния болезни на физическое, социальное и психологическое функционирование и благосостояние. Опросники, которые помогают оценивать КЖСЗ, могут дать представление о состоянии ребенка, выявить скрытые проблемы и имеют большое значение для полного понимания того, как влияет состояние здоровья на ребенка. Универсальные инструменты исследования КЖСЗ позволяют сравнивать результаты с общими параметрами, показатели со специфичными симптомами лучше отражают клинически значимые моменты. Наибольшую распространенность в Российской Федерации получил общий опросник PedsQL™ 4.0, широко используемый в практике для оценки КЖСЗ у детей с различной патологией.Цель исследования— описать анализ лингвистической корректности и достоверности содержания русской версии модуля гастроинтестинальных симптомов опросника PedsQL™, измеряющих КЖСЗ, у детей с расстройствами желудочно-кишечного тракта (ЖКТ).Материалы и методы. Установление лингвистической корректности и соответствия содержанию проводилось по международным стандартам. Процесс включал в себя прямой перевод, экспертную оценку и согласование, обратный перевод, проверку обратного перевода и интервью с 17 детьми в возрасте 5–18 лет с симптомами заболеваний ЖКТ и 20 родителями детей с симптомами заболеваний ЖКТ в возрасте 2–18 лет.Результаты. Русская версия модуля гастроинтестинальных симптомов PedsQL™ (отчет детей 5–18 лет, отчет родителей для детей 2–18 лет) была разработана без значимых трудностей. Восемь вопросов потребовали обсуждения после прямого перевода, после обратного перевода было внесено одно изменение, а после изучения модуля симптомов пациентами и родителями — три изменения.Заключение. Была разработана концептуально эквивалентная версия модуля симптомов PedsQL™ на русском языке для детей в возрасте 2–18 лет. Она позволяет улучшить оценку КЖСЗ у детей с расстройствами ЖКТ в Российской Федерации. Для оценки достоверности и надежности русскоязычной версии модуля рекомендуется проведение дальнейших исследований с использованием большей выборки