Immunodominant Antigens of Leishmania chagasi Associated with Protection against Human Visceral Leishmaniasis

One of the most striking features of infection by Leishmania chagasi is that infection leads to a spectrum of clinical outcomes ranging from asymptomatic infection to active disease. The existence of asymptomatic infected people has served as an incentive to believe that an effective vaccine is possible, but unfortunately no successful immunological characterization of such cases was obtained. Patients recovered from visceral leishmaniasis show a similar immunological profile to asymptomatic infected individuals and both exhibit a strong cell-mediated immune response against Leishmania antigens and are resistant to disease. Since the past decade several approaches were undertaken to try to shed light on the immunological profile associated with such “resistance” to infections, notwithstanding antigenic recognition profile associated to resistance to infection was not successfully explored. In the present manuscript we describe a specific IgG recognizing pattern associated with resistant individuals (asymptomatic infected people and recovery patients to visceral leishmaniasis). These data highlight the possibility of using specific proteins in serological tests for the identification of asymptomatic infected individuals

Os inquéritos domiciliares e o Sistema Nacional de Informações em Saúde The household surveys and the National Health Information System

Neste artigo apresenta-se um breve histórico dos inquéritos domiciliares em saúde de abrangência nacional, que foram desenvolvidos no Brasil ao longo dos últimos 20 anos. Discutem-se alguns problemas metodológicos importantes envolvidos na concepção e no desenho amostral dos inquéritos de base populacional e faz-se uma breve revisão dos aspectos contemplados pelos suplementos de saúde da Pesquisa Nacional por Amostra de Domicílios (PNAD), que foram a campo em 1981, 1986, 1998 e 2003. Tendo em vista o compromisso já assumido pelo Ministério da Saúde e pelo IBGE quanto à inclusão de um novo suplemento na PNAD de 2008, abre-se um debate sobre as vantagens e as limitações da PNAD como instrumento capaz de gerar dados de base populacional sobre morbidade, acesso e utilização de serviços de saúde. Finalmente destaca-se a necessidade de formulação de política para a geração de informações a partir de inquéritos de base populacional e sua incorporação ao Sistema Nacional de Informações em Saúde. Os inquéritos devem ser realizados periodicamente e os recursos financeiros para sua realização garantidos.<br>In this article the authors present a brief review of the household health surveys developed in Brazil in the last 20 years. Some important methodological problems related to their conception and sample design are discussed, and a brief review of the National Household Survey Health supplements conducted in 1981, 1986, 1998 and 2003 is presented. Given the already established agreement between the Ministry of Health and the Brazilian Institute of Geography and Statistics as to inclusion of a Health supplement in the 2008 National Household Survey, the authors propose a debate on the advantages and limitations of this instrument for the collection of data on morbidity, access to and utilization of health services. Finally, the authors stress the need for a policy towards generation of population-based information and its incorporation in the National Health Information System. Surveys must be periodically conducted and their financing must be guaranteed