Epidémiologie de l’infection urinaire chez l’enfant au CHU-Campus de Lomé

Titre : Epidémiologie de l’infection urinaire chez l’enfant au CHU-Campus de Lomé.Objectif : Evaluer la prévalence et étudier l’épidémiologie des infections urinaires.Méthodologie : Il s’agit d’une étude prospective qui s’est déroulée du 1er janvier au 31décembre 2009, dans le service de pédiatrie du CHU-Campus de Lomé. Elle a concerné les enfants âgés de moins de 15 ans, reçus en consultation pour fièvre avec ou sans point d’appel sur l’arbre urinaire.Résultats : La prévalence de l’infection urinaire était de 9.67%. Nous avons noté une prédominance féminine avec un sex-ratio de 0.66. La fièvre était le premier motif de consultation (97,87%). L’Eschérichia Coli est le germe le plus fréquemment isolé (51.6 %).Conclusion : L’infection urinaire chez l’enfant est une pathologie fréquente et le germe le plus fréquemment en cause est l’Escherichia Coli.Mots clés : Infection urinaire, enfant, prévalence, sensibilité des germes.English AbstractTitle. Epidemiology of urinary infection in children at the Campus teaching hospital in LomeObjective of the study. The study aims at analyzing the prevalence and epidemiology of urinary infection.Methodology. It is a retrospective study concerning children under 15 years old examined at the pediatrics department of Campus teaching hospital from January 1 to December 30, 2009 for clinical signs related to urinary infection.Results. The prevalence of urinary infection was 9.67%. Females predominated and the sexratio was 0.66. Fever was the first cause of consultation (97. 87%), Escherichia coli was the main germ isolated (51.6 %).Conclusion. Urinary infection in children is a frequent disease, it is often caused by Escherichia coli.Key words. Urinary infection, children, prevalence, germ sensitivity

Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates

Erratum in Publisher Correction: Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates. Szenker-Ravi E, Ott T, Khatoo M, Moreau de Bellaing A, Goh WX, Chong YL, Beckers A, Kannesan D, Louvel G, Anujan P, Ravi V, Bonnard C, Moutton S, Schoen P, Fradin M, Colin E, Megarbane A, Daou L, Chehab G, Di Filippo S, Rooryck C, Deleuze JF, Boland A, Arribard N, Eker R, Tohari S, Ng AY, Rio M, Lim CT, Eisenhaber B, Eisenhaber F, Venkatesh B, Amiel J, Crollius HR, Gordon CT, Gossler A, Roy S, Attie-Bitach T, Blum M, Bouvagnet P, Reversade B.Nat Genet. 2022 Jun;54(6):906. doi: 10.1038/s41588-022-01053-8.PMID: 35304595 No abstract available.International audienceThe vertebrate left-right axis is specified during embryogenesis by a transient organ: the left-right organizer (LRO). Species including fish, amphibians, rodents and humans deploy motile cilia in the LRO to break bilateral symmetry, while reptiles, birds, even-toed mammals and cetaceans are believed to have LROs without motile cilia. We searched for genes whose loss during vertebrate evolution follows this pattern and identified five genes encoding extracellular proteins, including a putative protease with hitherto unknown functions that we named ciliated left-right organizer metallopeptide (CIROP). Here, we show that CIROP is specifically expressed in ciliated LROs. In zebrafish and Xenopus, CIROP is required solely on the left side, downstream of the leftward flow, but upstream of DAND5, the first asymmetrically expressed gene. We further ascertained 21 human patients with loss-of-function CIROP mutations presenting with recessive situs anomalies. Our findings posit the existence of an ancestral genetic module that has twice disappeared during vertebrate evolution but remains essential for distinguishing left from right in humans