Ependimoma bulbomedular: abordaje y tecnica quirúrgica. A propósito de un caso

Las lesiones ocupantes de espacio de la unión bulbomedular son un conjunto de tumores que implican cierta complejidad. Aunque son un grupo pequeno de lesiones, han sido bien definidas a lo largo de la historia. En este manuscrito se presenta el caso de una paciente con un ependimoma en dicha localización. El caso muestra la importancia de un equipo quirúrgico experto en la materia con amplio conocimiento del abordaje óptimo y las técnicas correctas para el buen desarrollo de la intervención. Durante la redacción de este manuscrito se resaltaron los aspectos más importantes que rodean a la intervención quirúrgica desde el punto de vista anestésico, de monitorización neurofisiológica y del abordaje y la técnica llevada a cabo por los neurocirujanos.Space-occupying lesions of the bulbomedullary junction are a group of tumors involving some complexity. Although they are a small group of lesions, they have been well defined throughout history. In this manuscript we present the case of a patient with an ependymoma in that location. The case shows the importance of an expert surgical team with extensive knowledge of the optimal approach and the correct techniques for the successful performance of the intervention. During the writing of this manuscript, the most important aspects surrounding the surgical intervention were highlighted from the point of view of anesthesia, neurophysiological monitoring and the approach and technique carried out by the neurosurgeons

Occurrence and identification of microplastics along a beach in the Biosphere Reserve of Lanzarote

This work studied the accumulation of plastic debris in a remote beach located in La Graciosa island (Chinijo archipelago, Canary Islands). Microplastics were sampled in the 1&#-5&;8239#mm mesh opening range. An average plastic density of 36.3 g/m2 was obtained with a large variability along the 90 m of the beach (from 8.5 g/m2 to 103.4 g/m2). Microplastic particles preferentially accumulated in the part of the beach protected by rocks. A total number of 9149 plastic particles were collected, recorded and measured, 87% of which corresponded to fragments. Clear colours and microscopic evidence of weathering corresponded to aged plastics wind-driven by the surface Canary Current. The chemical composition of plastics particles corresponded to PE (63%), PP (32%) and PS (3%). Higher PE/PP ratios were recorded in the more protected parts of the beach, suggesting preferential accumulation of more aged fragments

Graphene oxide and reduced derivates, as powder or film scaffolds, differentially promote dopaminergic neuron differentiation and survival.

Emerging scaffold structures made of carbon nanomaterials, such as graphene oxide (GO) have shown efficient bioconjugation with common biomolecules. Previous studies described that GO promotes the differentiation of neural stem cells and may be useful for neural regeneration. In this study, we examined the capacity of GO, full reduced (FRGO), and partially reduced (PRGO) powder and film to support survival, proliferation, differentiation, maturation, and bioenergetic function of a dopaminergic (DA) cell line derived from the mouse substantia nigra (SN4741). Our results show that the morphology of the film and the species of graphene (GO, PRGO, or FRGO) influences the behavior and function of these neurons. In general, we found better biocompatibility of the film species than that of the powder. Analysis of cell viability and cytotoxicity showed good cell survival, a lack of cell death in all GO forms and its derivatives, a decreased proliferation, and increased differentiation over time. Neuronal maturation of SN4741 in all GO forms, and its derivatives were assessed by increased protein levels of tyrosine hydroxylase (TH), dopamine transporter (DAT), the glutamate inward rectifying potassium channel 2 (GIRK2), and of synaptic proteins, such as synaptobrevin and synaptophysin

Brain Oxygen Perfusion and Oxidative Stress Biomarkers in Fetuses with Congenital Heart Disease-A Retrospective, Case-Control Pilot Study.

Fetuses with congenital heart disease (CHD) have circulatory changes that may lead to predictable blood flow disturbances that may affect normal brain development. Hypoxemia and hypoperfusion may alter the redox balance leading to oxidative stress (OS), that can be assessed measuring stable end-products. OS biomarkers (OSB) were measured in amniotic fluid in fetuses with (n = 41) and without CHD (n = 44) and analyzed according to aortic flow, expected cyanosis after birth, and a CHD classification derived from this. Birth head circumference (HC) was used as a neurodevelopment biomarker. CHD fetuses had higher levels of ortho-Tyrosine (o-Tyr) than controls (p = 0.0003). There were no differences in o-Tyr levels considering aortic flow obstruction (p = 0.617). Fetuses with expected extreme cyanosis presented the highest levels of o-Tyr (p = 0.003). Among groups of CHD, fetuses without aortic obstruction and extreme cyanosis had the highest levels of o-Tyr (p = 0.005). CHD patients had lower HC than controls (p = 0.023), without correlation with OSB. Patients with HC < 10th percentile, presented high levels of o-Tyr (p = 0.024). Fetuses with CHD showed increased OSB and lower HC when compared to controls, especially those with expected extreme cyanosis. Our results suggest that increased levels of OSB are more influenced by the effect of low oxygenation than by aortic flow obstruction. Future studies with larger sample size are needed to further investigate the role of OSB as an early predictor of neurodevelopmental problems in CHD survivors

Desarrollo de un sistema interactivo para el estudio de la órbita y su contenido: anatomía macroscópica

En este proyecto se ha desarrollado un sistema interactivo para mejorar el proceso de enseñanza-aprendizaje en la docencia de la anatomía macroscópica de la órbita y su contenido por medio de preparaciones anatómicas. Se pretende facilitar el aprendizaje de forma autónoma en español e inglés y, la autoevaluación sobre los conocimientos adquiridos.Unidad Docente de Anatomía y EmbriologíaFac. de Óptica y OptometríaFALSEsubmitte

Factores pronósticos en gliomas astrocitarios malignos supratentoriales del adulto

Reducción altaUniv. de Granada, Departamento de Anatomía Patológica e Historia de la Ciencia. Leída 08-07-8

Cencini, Amadeo, ¿Ha cambiado algo en la Iglesia después de los escándalos sexuales?. Análisis y propuestas para la formación.

Es recensión de: Cencini, Amadeo, ¿Ha cambiado algo en la Iglesia después de los escándalos sexuales? Análisis y propuestas para la formación, Salamanca 2022

Rivi, Prospero, Con tutto il cuore e con tutta l’anima. Una via francescana alla contemplazione, Edizione Prziuncula, Assisi 2018, 153 pp., 21x15 cms.

Es recensión de Rivi, Prospero, Con tutto il cuore e con tutta l’anima. Una via francescana alla contemplazione, Edizione Prziuncula, Assisi 2018, 153 pp., 21x15 cms