sPlotOpen – An environmentally balanced, open-access, global dataset of vegetation plots

Assessing biodiversity status and trends in plant communities is critical for understanding, quantifying and predicting the effects of global change on ecosystems. Vegetation plots record the occurrence or abundance of all plant species co-occurring within delimited local areas. This allows species absences to be inferred, information seldom provided by existing global plant datasets. Although many vegetation plots have been recorded, most are not available to the global research community. A recent initiative, called ?sPlot?, compiled the first global vegetation plot database, and continues to grow and curate it. The sPlot database, however, is extremely unbalanced spatially and environmentally, and is not open-access. Here, we address both these issues by (a) resampling the vegetation plots using several environmental variables as sampling strata and (b) securing permission from data holders of 105 local-to-regional datasets to openly release data. We thus present sPlotOpen, the largest open-access dataset of vegetation plots ever released. sPlotOpen can be used to explore global diversity at the plant community level, as ground truth data in remote sensing applications, or as a baseline for biodiversity monitoring. Main types of variable contained: Vegetation plots (n = 95,104) recording cover or abundance of naturally co-occurring vascular plant species within delimited areas. sPlotOpen contains three partially overlapping resampled datasets (c. 50,000 plots each), to be used as replicates in global analyses. Besides geographical location, date, plot size, biome, elevation, slope, aspect, vegetation type, naturalness, coverage of various vegetation layers, and source dataset, plot-level data also include community-weighted means and variances of 18 plant functional traits from the TRY Plant Trait Database. Spatial location and grain: Global, 0.01?40,000 m². Time period and grain: 1888-2015, recording dates. Major taxa and level of measurement: 42,677 vascular plant taxa, plot-level records.Fil: Sabatini, Francesco Maria. Martin-universität Halle-wittenberg; Alemania. German Centre For Integrative Biodiversity Research (idiv) Halle-jena-leipzig; AlemaniaFil: Lenoir, Jonathan. Université de Picardie Jules Verne; FranciaFil: Hattab, Tarek. Université de Montpellier; FranciaFil: Arnst, Elise Aimee. Manaaki Whenua - Landcare Research; Nueva ZelandaFil: Chytrý, Milan. Masaryk University; República ChecaFil: Giorgis, Melisa Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Vanselow, Kim André. University of Erlangen-Nuremberg; AlemaniaFil: Vásquez Martínez, Rodolfo. Jardín Botánico de Missouri Oxapampa; PerúFil: Vassilev, Kiril. Bulgarian Academy of Sciences; BulgariaFil: Vélez-Martin, Eduardo. ILEX Consultoria Científica; BrasilFil: Venanzoni, Roberto. University of Perugia; ItaliaFil: Vibrans, Alexander Christian. Universidade Regional de Blumenau; BrasilFil: Violle, Cyrille. Paul Valéry Montpellier University; FranciaFil: Virtanen, Risto. German Centre for Integrative Biodiversity Research; AlemaniaFil: von Wehrden, Henrik. Leuphana University of Lüneburg; AlemaniaFil: Wagner, Viktoria. University of Alberta; CanadáFil: Walker, Donald A.. University of Alaska; Estados UnidosFil: Waller, Donald M.. University of Wisconsin-Madison; Estados UnidosFil: Wang, Hua-Feng. Hainan University; ChinaFil: Wesche, Karsten. Senckenberg Museum of Natural History Görlitz; Alemania. Technische Universität Dresden; AlemaniaFil: Whitfeld, Timothy J. S.. University of Minnesota; Estados UnidosFil: Willner, Wolfgang. University of Vienna; AustriaFil: Wiser, Susan K.. Manaaki Whenua. Landcare Research; Nueva ZelandaFil: Wohlgemuth, Thomas. Swiss Federal Institute for Forest, Snow and Landscape Research; SuizaFil: Yamalov, Sergey. Russian Academy of Sciences; RusiaFil: Zobel, Martin. University of Tartu; EstoniaFil: Bruelheide, Helge. German Centre for Integrative Biodiversity Research; Alemani

Gene-enhanced tissue engineering for dental hard tissue regeneration: (2) dentin-pulp and periodontal regeneration

Potential applications for gene-based tissue engineering therapies in the oral and maxillofacial complex include the delivery of growth factors for periodontal regeneration, pulp capping/dentin regeneration, and bone grafting of large osseous defects in dental and craniofacial reconstruction. Part 1 reviewed the principals of gene-enhanced tissue engineering and the techniques of introducing DNA into cells. This manuscript will review recent advances in gene-based therapies for dental hard tissue regeneration, specifically as it pertains to dentin regeneration/pulp capping and periodontal regeneration

Harnstoff, Kreatinin, Harnstoff- und Kreatinin-Clearance: Untersuchungen an 25 gesunden Probanden über ein Jahr

Peer Reviewe

Gold-Catalyzed Domino Aminocyclization/1,3-Sulfonyl Migration of N‑Substituted <i>N</i>‑Sulfonyl-aminobut-3-yn-2-ols to 1‑Substituted 3‑Sulfonyl‑1<i>H</i>‑pyrroles

A method to prepare 1-substituted 3-sulfonyl-1<i>H</i>-pyrroles efficiently that relies on the gold­(I)-catalyzed cycloisomerization of N-substituted<i> N</i>-sulfonyl-aminobut-3-yn-2-ols is described. The method was shown to be applicable to a broad range of 1,7-enyne alcohols containing electron-withdrawing, electron-donating, and sterically demanding substrate combinations. The mechanism is suggested to involve activation of the propargylic alcohol by the Au­(I) catalyst, which causes the intramolecular nucleophilic addition of the sulfonamide unit to the alkyne moiety. The resulting nitrogen-containing heterocyclic intermediate undergoes dehydration and deaurative 1,3-sulfonyl migration, a process that remains rare in gold catalysis, to give the aromatic nitrogen-containing product

Some interrelationships between a community work and training program and selected indices of family functioning

This was an exploratory study of some of the relationships between a Community Work and Training Program and the family functioning of certain participants in that program. The CWT projects studied were those operated by the Public Welfare Departments of Clackamas and Marion Counties, Oregon during the three –year span between January 1, 1965 and December 31, 1967. Participants\u27 names were randomly selected from the records of the two welfare offices and the respondents interviewed during the summer of 1968. A questionnaire was developed which consisted of twenty primarily open-ended questions and this was administered to a total of sixty couples. The questions focused on changes in parental, child, financial, marital and social functioning which occurred during the time the husband participated in the work training project. To identify these changes a list was drawn up of fourteen indices of family functioning and these indices were later categorized under two general headings, external and internal to the family. The basic hypothesis was that the CWT Program contributed to positive family functioning. This was expanded into a guiding hypothesis which stated that family functioning is improved through participation in the CWT Program and that this improvement is associated with the program, work itself and the social work services provided by the welfare departments. To determine the validity of these hypotheses a number of null hypotheses were then advanced and tested. The findings of the study were as follows. Internal family functioning was improved during participation on CWT and this improvement affected the total family unit. External functioning, however, deteriorated and this was attributed to the reduced income resulting from the families’ dependence for support upon Public Welfare. The improved internal functioning was associated with the social work services provided and with the work itself. This improvement was evident despite the reported failure of the program to meet the two most important expectations of the participants, namely material benefits and vocational training. The most important limitations noted in the research were two. The first was the lapse of time which occurred between the interviews and the period when many of the participants actually worked on the program. Inevitably, such lapse of time had some effect on respondents’ recall. Second in importance in considering the possible application of the findings was the fact that some 15.58% of the respondents from Marion County were Spanish-Americans. This minority group would conceivably not be representative of another area. Among the program’s negative features mentioned by participants was the lack of choice available in job assignment and the inadequate compensation for performance on the job. Despite these, however, the overall conclusion reached by the research group was that participants in the CWT projects saw the program as beneficial in helping to maintain family life

Bisbiguanide analogs induce mitochondrial stress to inhibit lung cancer cell invasion

Summary: Targeting cancer metabolism to limit cellular energy and metabolite production is an attractive therapeutic approach. Here, we developed analogs of the bisbiguanide, alexidine, to target lung cancer cell metabolism and assess a structure-activity relationship (SAR). The SAR led to the identification of two analogs, AX-4 and AX-7, that limit cell growth via G1/G0 cell-cycle arrest and are tolerated in vivo with favorable pharmacokinetics. Mechanistic evaluation revealed that AX-4 and AX-7 induce potent mitochondrial defects; mitochondrial cristae were deformed and the mitochondrial membrane potential was depolarized. Additionally, cell metabolism was rewired, as indicated by reduced oxygen consumption and mitochondrial ATP production, with an increase in extracellular lactate. Importantly, AX-4 and AX-7 impacted overall cell behavior, as these compounds reduced collective cell invasion. Taken together, our study establishes a class of bisbiguanides as effective mitochondria and cell invasion disrupters, and proposes bisbiguanides as promising approaches to limiting cancer metastasis

Polynomial Chaos and Collocation Methods and Their Range of Applicability

International audienceIn this chapter the different polynomial chaos and stochastic collocation methodologies used within the UMRIDA project are compared. Guidelines for their use and applicability are formulated