2,870 research outputs found
Electrolytic separation of crystals of transition-metal oxides
Versatile flux system grows large, well-formed, stoichiometric single crystals of mixed oxides of the transition-metal elements. These crystals have important uses in the microwave field, and applications as lasers and masers in communications
Using microsimulation feedback for trip adaptation for realistic traffic in Dallas
This paper presents a day-to-day re-routing relaxation approach for traffic
simulations. Starting from an initial planset for the routes, the route-based
microsimulation is executed. The result of the microsimulation is fed into a
re-router, which re-routes a certain percentage of all trips. This approach
makes the traffic patterns in the microsimulation much more reasonable.
Further, it is shown that the method described in this paper can lead to strong
oscillations in the solutions.Comment: Accepted by International Journal of Modern Physics C. Complete
postscript version including figures in
http://www-transims.tsasa.lanl.gov/research_team/papers
Congestion behavior and tolls in a bottleneck model with stochastic capacity
In this paper we investigate a bottleneck model in which the capacity of the bottleneck is assumed stochastic and follows a uniform distribution. The commuters’ departure time choice is assumed to follow the user equilibrium principle according to mean trip cost. The analytical solution of the proposed model is derived. Both the analytical and numerical results show that the capacity variability would indeed change the commuters’ travel behavior by increasing the mean trip cost and lengthening the peak period. We then design congestion pricing schemes within the framework of the new stochastic bottleneck model, for both a time-varying toll and a single-step coarse toll, and prove that the proposed piecewise time-varying toll can effectively cut down, and even eliminate, the queues behind the bottleneck. We also find that the single-step coarse toll could either advance or postpone the earliest departure time. Furthermore, the numerical results show that the proposed pricing schemes can indeed improve the efficiency of the stochastic bottleneck through decreasing the system’s total travel cost
The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn's disease
Background and Aims: Recent data suggest that polymorphisms in the organic cation transporter (OCTN) genes OCTN1 (SLC22A4) and OCTN2 (SLC22A5) represent disease-causing mutations within the IBD5 locus (chromosome 5q31). We investigated associations with disease susceptibility, phenotype, and evidence for epistasis with CARD15 in 679 patients with Crohn’s disease (CD) or ulcerative colitis (UC).
Methods: A total of 374 patients with CD, 305 patients with UC, and 294 healthy controls (HCs) were studied. Genotyping for single nucleotide polymorphisms IGR2096, IGR2198, and IGR2230, OCTN1 variant (SLC22A4 1672C→T), and OCTN2 variant (SLC22A5 −207G→C) was performed using the TaqMan system.
Results: The IBD5 OCTN1 and OCTN2 polymorphisms were in strong linkage disequilibrium (D′, >0.959). IGR2198 variant allele frequency (49.1% vs 40.8%; P = .0046) and homozygosity (21% vs 14.8%; P = .044) were associated with CD versus HCs. Variant allelic frequency of OCTN1 (53.6% vs 43%; P = .0008) and OCTN2 (56.1% vs 48.4%; P = .0092) polymorphisms and homozygosity for the OCTN1/2-TC haplotype (28.4% vs 16%; P = .0042) were associated with CD versus HCs. IGR2198 homozygosity and TC homozygosity were associated with stricturing/penetrating disease at follow-up (P = .011 and P = .011, respectively) and disease progression (P = .038 and P = .049, respectively) on univariate analysis and with need for surgery on multivariate analysis (P = .016 and P = .004, respectively). In the absence of the IBD5 risk haplotype, no association of OCTN1/2 variants with CD was detected. No associations were seen with UC.
Conclusions: The IBD5 locus influences susceptibility, progression, and need for surgery in CD. However, the contribution of OCTN1/2 variants is not independent of the IBD5 haplotype; a causative role for these genes remains plausible but is not yet proven. Further genetic, functional, and expression data are now required. </p
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