Bulk composition of the Kaba meteorite by ICP OES and ICP MS

The Tenth Symposium on Polar Science/Poster presentations: [OA] Antarctic meteorites, Wed. 4 Dec. / Entrance Hall (1st floor), National Institute of Polar Researc

Avaliação do método prático para dimensionamento de estoques (MPDE) no contexto de melhorias na gestão de estoques em uma Empresa de médio porte do setor / Method practical for stocks sizing (MPSS) of assessment in the context of improvements in management stocks on a company average size of timber industry

A proposta deste estudo é verificar a desempenho da metodologia prática de dimensionamento de estoques (MPDE). A MPDE foi desenvolvida visando definir as decisões necessárias para obter o desempenho logístico considerando o cenário em que a empresa alvo está inserida. Tudo isso para oferecer melhorias na decisão de quanto estoque manter na empresa além de ações para diminuir o risco de ruptura de estoque. Este trabalho foi aplicado em uma empresa de médio porte do setor madeireiro no estado do Pará. O estudo de caso fará um diagnóstico da situação anterior à implantação do MPDE e posteriormente comparar e identificar as melhorias e também as ineficiências do método na empresa em questão. Para a realização do estudo optou-se por uma pesquisa tanto qualitativa quanto quantitativa, através de entrevistas com gestores responsáveis pela empresa e também indicadores quantitativos de estoque. Como finalidade, pretende-se diagnosticar as reais mudanças que ocorreram na empresa estudada e como essas mudanças contribuíram ou não para a melhoria da eficácia dos estoques do estudo de caso. 

Introduction #6

Ce sixième numéro de GLAD! est un numéro varia qui présente une grande cohérence thématique : dans la rubrique « Recherches », les articles explorent des formes de résistance artistique et culturelle féministe et/ou queer, dans différents contextes (Amérique du Nord, Amérique Latine, Europe, Afrique) et par le biais de divers moyens d’expression (cinéma, littérature, arts plastiques). La rubrique « Créations », qui propose trois œuvres littéraires originales jouant de façon féministe et subversive avec et sur la langue, fait écho de très belle façon à ces articles scientifiques. La rubrique « Actualités » s’enrichit de plusieurs recensions et résumés de thèse qui attestent de la variété et du dynamisme des études francophones en genre et langage, et la rubrique « Chronique » met en évidence la dimension politique de ces études en discutant la question du changement de prénom.This sixth issue of GLAD! is a varia issue with a strong topical coherence: in the "Research" section, the articles explore forms of feminist and queer artistic and cultural resistance in different contexts (North America, Latin America, Europe, Africa) involving various means of expression (cinema, literature, visual arts). The "Creations" section, which provides two original literary works, playing in a feminist and subversive way with and about the language, echoes these scientific articles in a beautiful way. The "News" section is enriched with several reviews and thesis summaries that illustrate the variety and dynamism of French gender and language studies, and the "Chronicle" section highlights the political dimension of these studies by discussing the issue of the practice of changing first names

Asymmetric Total Synthesis of (+)‐Merobatzelladine B

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91220/1/ange_201201001_sm_miscellaneous_information.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/91220/2/4204_ftp.pd

Health related quality of life outcomes following surgery and/or radiation for patients with potentially unstable spinal metastases.

Currently there is no prospective pain and health related quality of life (HRQOL) data of patients with potentially unstable spinal metastases who were treated with surgery ± radiation or radiation alone.An international prospective cohort multicenter study of patients with potentially unstable spinal metastases, defined by a SINS score 7 to 12, treated with surgery ± radiation or radiotherapy alone was conducted. HRQOL was evaluated with the numeric rating scale (NRS) pain score, the SOSGOQ2.0, the SF-36, and the EQ-5D at baseline and 6, 12, 26, and 52 weeks after treatment.A total of 136 patients were treated with surgery ± radiotherapy and 84 with radiotherapy alone. At baseline, surgically treated patients were more likely to have mechanical pain, a lytic lesion, a greater median Spinal Instability Neoplastic score, vertebral compression fracture, lower performance status, HRQOL, and pain scores. From baseline to 12 weeks post-treatment, surgically treated patients experienced a 3.0-point decrease in NRS pain score (95% CI -4.1 to -1.9, p.001), and a 12.7-point increase in SOSGOQ2.0 score (95% CI 6.3-19.1, p.001). Patients treated with radiotherapy alone experienced a 1.4-point decrease in the NRS pain score (95% CI -2.9 to 0.0, p=.046) and a 6.2-point increase in SOSGOQ2.0 score (95% CI -2.0 to 14.5, p=.331). Beyond 12 weeks, significant improvements in pain and HRQOL metrics were maintained up to 52-weeks follow-up in the surgical cohort, as compared with no significant changes in the radiotherapy alone cohort.Patients treated with surgery demonstrated clinically and statistically significant improvements in pain and HRQOL up to 1-year postsurgery. Treatment with radiotherapy alone resulted in improved pain scores, but these were not sustained beyond 3 months and HRQOL outcomes demonstrated nonsignificant changes over time. Within the SINS potentially unstable group, distinct clinical profiles were observed in patients treated with surgery or radiotherapy alone

A Scalable Approach to Modeling on Accelerated Neuromorphic Hardware.

Neuromorphic systems open up opportunities to enlarge the explorative space for computational research. However, it is often challenging to unite efficiency and usability. This work presents the software aspects of this endeavor for the BrainScaleS-2 system, a hybrid accelerated neuromorphic hardware architecture based on physical modeling. We introduce key aspects of the BrainScaleS-2 Operating System: experiment workflow, API layering, software design, and platform operation. We present use cases to discuss and derive requirements for the software and showcase the implementation. The focus lies on novel system and software features such as multi-compartmental neurons, fast re-configuration for hardware-in-the-loop training, applications for the embedded processors, the non-spiking operation mode, interactive platform access, and sustainable hardware/software co-development. Finally, we discuss further developments in terms of hardware scale-up, system usability, and efficiency

Distribution and quantitative estimates of variant Creutzfeldt Jakob Diseases prions in the tissues of clinical and asymptomatic patients

In the United-Kingdom, ≈1 of 2,000 persons could be infected with variant Creutzfeldt-Jakob disease (vCJD). Therefore, risk of transmission of vCJD by medical procedures remains a major concern for public health authorities. In this study, we used in vitro amplification of prions by protein misfolding cyclic amplification (PMCA) to estimate distribution and level of the vCJD agent in 21 tissues from 4 patients who died of clinical vCJD and from 1 asymptomatic person with vCJD. PMCA identified major levels of vCJD prions in a range of tissues, including liver, salivary gland, kidney, lung, and bone marrow. Bioassays confirmed that the quantitative estimate of levels of vCJD prion accumulation provided by PMCA are indicative of vCJD infectivity levels in tissues. Findings provide critical data for the design of measures to minimize risk for iatrogenic transmission of vCJD

Combinations of motor measures more strongly predict adverse health outcomes in old age: the rush memory and aging project, a community-based cohort study

<p>Abstract</p> <p>Objective</p> <p>Motor impairment in old age is a growing public-health concern, and several different constructs have been used to identify motor impairments in older people. We tested the hypothesis that combinations of motor constructs more strongly predict adverse health outcomes in older people.</p> <p>Methods</p> <p>In total, 949 people without dementia, history of stroke or Parkinson's disease, who were participating in the Rush Memory and Aging Project (a longitudinal community-based cohort study), underwent assessment at study entry. From this, three constructs were derived: 1) physical frailty based on grip strength, timed walk, body mass index and fatigue; 2) Parkinsonian Signs Score based on the modified motor section of the Unified Parkinson's Disease Rating Scale; and 3) a motor construct, based on nine strength measures and nine motor performances. Disability and cognitive status were assessed annually. A series of Cox proportional-hazards models, controlling for age, sex and education, were used to examine the association of each of these three constructs alone and in various combinations with death, disability and Alzheimer's disease (AD).</p> <p>Results</p> <p>All three constructs were related (mean <it>r </it>= 0.50, all <it>P </it>< 0.001), and when considered individually in separate proportional-hazards models, were associated with risk of death, incident disability and AD. However, when considered together, combinations of these constructs more strongly predicted adverse health outcomes.</p> <p>Conclusions</p> <p>Physical frailty, parkinsonian signs score and global motor score are related constructs that capture different aspects of motor function. Assessments using several motor constructs may more accurately identify people at the highest risk of adverse health consequences in old age.</p