Video-Tape and Other Media in F. L. Teacher Training

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The radio source B 1834+620: A double-double radio galaxy with interesting properties

We present a study of the peculiar radio galaxy B 1834+620. It is characterised by the presence of a 420-kpc large edge-brightened radio source which is situated within, and well aligned with, a larger (1.66 Mpc) radio source. Both sources apparently originate in the same host galaxy, which has a R_s-magnitude of 19.7 and a redshift of 0.5194, as determined from the strong emission-lines in the spectrum. We have determined the rotation measures towards this source, as well as the radio spectral energy distribution of its components. The radio spectrum of the large outer source is steeper than that of the smaller inner source. The radio core has a spectrum that peaks at a frequency of a few GHz. The rotation measures towards the four main components are quite similar, within $\sim\!2$ rad m$^{-2}$ of 58 rad m$^{-2}$. They are probably largely galactic in origin. We have used the presence of a bright hotspot in the northern outer lobe to constrain the advance velocity of the inner radio lobes to the range between 0.19c and 0.29c, depending on the orientation of the source. This corresponds to an age of this structure in the range between 2.6 and 5.8 Myr. We estimate a density of the ambient medium of the inner lobes of \la 1.6 \times 10^{-30} gr\,cm$^{-3}$ (particle density \la 8 \times 10^{-7} cm$^{-3}$). A low ambient density is further supported by the discrepancy between the large optical emission-line luminosity of the host galaxy and the relatively low radio power of the inner lobes.Comment: Accepted for publication in MNRA

Introduction to the special issue on Ophthalmic Genetics: Vision in 2020

In this special issue of the American Journal of Medical Genetics, Part C, we explore the ever‐expanding field of Ophthalmic Genetics. The eye is unique among organs for its accessibility to physical examination, permitting exploration of every tissue by slit lamp microscopy, ophthalmoscopy, and imaging including color and autofluorescent photography, ultrasound, optical coherence tomography (OCT), electrophysiology, and adaptive optics confocal and scanning laser ophthalmoscopy. This accessibility permits a variety of surgical and nonsurgical treatments, including the first FDA‐approved gene therapy, voretigene neparvovec‐rzyl for RPE65‐associated Leber Congenital Amaurosis. In this issue, we sought to provide a survey highlighting how heritable ophthalmic disorders are recognizable and accessible to clinical geneticists as well as ophthalmologists

Component leasing on the World Wide Web

MMM is an infrastructure for managing the deployment and use of distributed application services on the WWW. MMM propagates a paradigm that enables the leasing of software components, as opposed to the classical software licensing model Applications reside and execute on the software provider's platforms, but are managed through the MMM infrastructure. Users interact with the application services through a standard Internet browser not requiring any additional software. The MMM user interface offers users a virtual file space, application service composition functions: execution support, and visualization features. The MMM implementation is based on standard Web technologies, such as HTML, XML, and MetaHTML, distributed object computing frameworks, such as CORBA, and database technology, such as ODBC. In this paper we give a technical account of the MMM architecture and discuss its primary features

Wannier-function approach to spin excitations in solids

We present a computational scheme to study spin excitations in magnetic materials from first principles. The central quantity is the transverse spin susceptibility, from which the complete excitation spectrum, including single-particle spin-flip Stoner excitations and collective spin-wave modes, can be obtained. The susceptibility is derived from many-body perturbation theory and includes dynamic correlation through a summation over ladder diagrams that describe the coupling of electrons and holes with opposite spins. In contrast to earlier studies, we do not use a model potential with adjustable parameters for the electron-hole interaction but employ the random-phase approximation. To reduce the numerical cost for the calculation of the four-point scattering matrix we perform a projection onto maximally localized Wannier functions, which allows us to truncate the matrix efficiently by exploiting the short spatial range of electronic correlation in the partially filled d or f orbitals. Our implementation is based on the FLAPW method. Starting from a ground-state calculation within the LSDA, we first analyze the matrix elements of the screened Coulomb potential in the Wannier basis for the 3d transition-metal series. In particular, we discuss the differences between a constrained nonmagnetic and a proper spin-polarized treatment for the ferromagnets Fe, Co, and Ni. The spectrum of single-particle and collective spin excitations in fcc Ni is then studied in detail. The calculated spin-wave dispersion is in good overall agreement with experimental data and contains both an acoustic and an optical branch for intermediate wave vectors along the [100] direction. In addition, we find evidence for a similar double-peak structure in the spectral function along the [111] direction.Comment: 16 pages, 11 figures, 5 table

Impact of high-energy tails on granular gas properties

The velocity distribution function of granular gases in the homogeneous cooling state as well as some heated granular gases decays for large velocities as $f\propto\exp(- {\rm const.} v)$. That is, its high-energy tail is overpopulated as compared with the Maxwell distribution. At the present time, there is no theory to describe the influence of the tail on the kinetic characteristics of granular gases. We develop an approach to quantify the overpopulated tail and analyze its impact on granular gas properties, in particular on the cooling coefficient. We observe and explain anomalously slow relaxation of the velocity distribution function to its steady state.Comment: 5 pages, 5 figure

Optimizing Higher-Order Lagrangian Perturbation Theory for Standard CDM and BSI models

We investigate the performance of Lagrangian perturbation theory up to the second order for two scenarios of cosmological large-scale structure formation, SCDM (standard cold dark matter) and BSI (broken scale invariance). The latter model we study as a representative of COBE-normalized CDM models which fit the small-scale power of galaxy surveys. In this context we optimize the performance of the Lagrangian perturbation schemes by smoothing the small-scale fluctuations in the initial data. The results of the so obtained Lagrangian mappings are computed for a set of COBE-normalized SCDM and BSI initial data of different sizes and at different times. We compare these results against those obtained with a numerical PM-code. We find an excellent performance of the optimized Lagrangian schemes down to scales close to the correlation length. This is explained by the counterintuitive fact that nonlinearities in the model can produce more small-scale power, if initially such power is removed. The optimization scheme can be expressed in a way which is independent of the type of fluctuation spectrum and of the size of the simulations.Comment: 19 pages uuencoded compressed postscript file (including 7 figures). Figure 8 (greyscale and color postcript files) are available by anonymous ftp from ftp://ibm-3.mpa-garching.mpg.de/pub/aow . See the directory with this preprint numbe

A rare canonical splice-site variant in VPS13B causes attenuated Cohen syndrome

Background: To describe a patient with a history of obesity, retinal dystrophy, type II diabetes, and mild cognitive impairment; found to harbour biallelic splice-site variants in VPS13B. // Materials & methods: A complete ophthalmic evaluation was performed at Moorfields Eye Hospital (London, United Kingdom), consisting of measurement of best-corrected visual acuity (BCVA), slit lamp and dilated fundus evaluation, colour, autofluorescence and near-infrared retinal imaging, spectral domain-optical coherence tomography, and electroretinogram (ERG). Whole-genome sequencing was performed as part of the UK’s 100,000 Genomes Project. // Results: A 26-year-old Pakistani man with normal appearance, stature, and head size presented with decreased BCVA and severely constricted visual fields to our Ophthalmic Genetics clinic. He had a history of obesity, type II diabetes, and mild cognitive impairment. His evaluation showed retina-wide, severe photoreceptor dysfunction in both eyes, with undetectable scotopic and photopic ERG waveforms. Genomic analysis identified a homozygous rare splice donor variant in the VPS13B gene (c.5024+2T>C) that was demonstrated to lead to skipping of the in-frame exon 31 (p.Gln1607_Ser1675delinsHis). // Conclusions: Exon 31 skipping in VPS13B may lead to a hypomorphic change, with partial gene function and an incomplete, mild Cohen syndrome-like phenotype