Brote de toxiinfeccion alimentaria de probable etiologia virica por virus Norwalk

ResumenEn mayo de 1989 se produjo un brote de toxiinfección alimentaria (TIA) en el colegio público de Adzaneta, Castellón. Se realizó un estudio para describirlo, averiguar sus causas y adoptar las medidas de control adecuadas. Afectó a 16 niños y 2 profesores (tasa de ataque: 28,57 %). Se cumplieron los criterios clínicos y epidemiológicos para considerar al virus Norwalk como agente responsable. Probablemente su origen estuvo en un manipulador enfermo. En heces de éste y de un caso se visualizaron (ME) estructuras redondas de tamaño similar al virus Norwalk. En España el número de brotes de TIA sin agente causal conocido ha aumentado en los últimos años. Quizá este microorganismo sea responsable de una parte de estos brotes en los que, por diversos motivos, no se llega a identificar su agente causal.SummaryIn May 1989, a foodborne outbreak of acute gastroenteritis was Identified in a state school in Adzaneta, Castellón. A dtudy was undertaken to describe it, investigate its causes, and recommend adequate control measures. Sixteen children and 2 teachers were affected (attack rate: 28.57 %). Kaplan and cols clinical and epidemiological criteria for Norwalk-like virus as the responsable agent were present. The probable origin of the outbreak was a foodhandler who was already ill beforehand. The examination of stools of the foodhandler and a patient showed small round structures similar to the Norwalk virus. In Spain, the number of foodborne outbreaks without known causal agent has steadily increased in recent years. It may be that this microorganism is responsible for some of these outbreaks in which, for several reasons, the causal agent cannot be Identified

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Holocene alluvial sequence in the Val de Zaragoza (Los Monegros) in the palaeoenvironmental context of the Ebro Basin (NE Spain)

Flat-bottomed valleys formed by Holocene fills are the most characteristic landforms in the center of the Ebro basin. This paper analyzes, within a regional framework, a small fluvial basin located in the north of the Alcubierre Range. Three Holocene morphosedimentary units (H1-H3) and a sub-functional level (H4) are identified. These units are representative of the regional geomorphological evolutionary process in the Ebro basin. New chronological insights on climate and landscape management are provided by a study of the Bastarás weir, a construction made for water flow management during the Little Ice Age (LIA). The integration of Val de Zaragoza radiocarbon datings into the regional framework enables the authors to identify the main formation stages, as well as the influence of climatic and human factors on its evolution. The intensification of human pressure in the territory is reflected in a progressive increase in sediment accumulation rates in the valleys, peaking during Roman times and the Little Ice Age.Los valles de fondo plano formados por rellenos holocenos constituyen los paisajes más característicos del sector central de la cuenca del Ebro. En este trabajo se analiza una pequeña cuenca fluvial localizada en el norte de la Sierra de Alcubierre, en la que se han identificado tres unidades morfosedimentarias holocenas (H1-H3) y un nivel subfuncional (H4), que son representativos de la evolución geomorfológica regional de la Cuenca del Ebro. Uno de los aspectos más relevantes del valle lo constituye el azud de Bastarás, construcción realizada durante la Pequeña Edad del Hielo para el aprovechamiento del agua, que aporta nuevos datos cronológicos sobre dicha época y acerca de la gestión del territorio. La integración de las dataciones radiocarbónicas obtenidas en la Val de Zaragoza en un marco regional ha permitido precisar las principales etapas de formación de los valles de fondo plano, así como la importancia de los factores climáticos y humanos en su evolución. La intensificación de la presión humana sobre el territorio queda reflejada en un progresivo aumento en las tasas de acumulación de sedimentos en los valles, alcanzando sus picos máximos en Época Romana y en la Pequeña Edad del Hielo