Impacts of alcohol consumption by mothers and fathers, parental monitoring, adolescent disclosure and novelty-seeking behaviour on the likelihood of alcohol use and inebriation among adolescents

The aim of this prospective cohort study was to examine how alcohol consumption by mothers and fathers, parental monitoring (knowledge, control, and solicitation), adolescent disclosure and novelty seeking were associated with the likelihood of alcohol use and inebriation among adolescents in three different age groups (13–14 years, 14–15 years, and 17 years). The results showed that alcohol consumption by parents is of significance for adolescent alcohol consumption (odds ratio mothers: 1.47 [1.17–1.84], odds ratio fathers 1.33 [1.08–1.65]) and inebriation, especially in the 17-year-old age group. The results showed that novelty seeking was a strong risk factor in all three age groups, while parental control and knowledge had no impact. This study shows that parental solicitation increased the odds at age 17 for alcohol consumption (2.64 [1.02–6.83]) and inebriation, while adolescent disclosure decreased the odds (0.18 [0.05–0.68]). In summary, the study shows that parents should be particularly attentive to adolescents with high novelty-seeking behaviour and that parental alcohol consumption influences adolescent alcohol habits.publishedVersio

Photostability of commercial sunscreens upon sun exposure and irradiation by ultraviolet lamps

BACKGROUND: Sunscreens are being widely used to reduce exposure to harmful ultraviolet (UV) radiation. The fact that some sunscreens are photounstable has been known for many years. Since the UV-absorbing ingredients of sunscreens may be photounstable, especially in the long wavelength region, it is of great interest to determine their degradation during exposure to UV radiation. Our aim was to investigate the photostability of seven commercial sunscreen products after natural UV exposure (UVnat) and artificial UV exposure (UVart). METHODS: Seven commercial sunscreens were studied with absorption spectroscopy. Sunscreen product, 0.5 mg/cm(2), was placed between plates of silica. The area under the curve (AUC) in the spectrum was calculated for UVA (320–400 nm), UVA1 (340–400 nm), UVA2 (320–340 nm) and UVB (290–320 nm) before (AUC(before)) and after (AUC(after)) UVart (980 kJ/m(2 )UVA and 12 kJ/m(2 )of UVB) and before and after UVnat. If theAUC Index (AUCI), defined as AUCI = AUC(after)/AUC(before), was > 0.80, the sunscreen was considered photostable. RESULTS: Three sunscreens were unstable after 90 min of UVnat; in the UVA range the AUCI was between 0.41 and 0.76. In the UVB range one of these sunscreens was unstable with an AUCI of 0.75 after 90 min. Three sunscreens were photostable after 120 min of UVnat; in the UVA range the AUCI was between 0.85 and 0.99 and in the UVB range between 0.92 and 1.0. One sunscreen showed in the UVA range an AUCI of 0.87 after UVnat but an AUCI of 0.72 after UVart. Five of the sunscreens were stable in the UVB region. CONCLUSION: The present study shows that several sunscreens are photounstable in the UVA range after UVnat and UVart. There is a need for a standardized method to measure photostability, and the photostability should be marked on the sunscreen product

Stroke genetics informs drug discovery and risk prediction across ancestries

Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries

GENTOOLS : How to integrate a gender and diversity perspective in innovation systems

Godkänd; 2016; 20160829 (andbra

Fluorescence demarcation of basal cell carcinoma controlled by histopathological mapping

The demand for fast and effective tools for diagnosis of skin cancer is increasing due to the escalating incidence of skin cancer in recent years. Fluorescence imaging has gained rising interest for detection and delineation of basal cell carcinoma (BCC), which is the most common type of skin cancer. By applying δ-5-aminolaevulinic acid (ALA) protoporphyrin IX (Pp IX) is accumulated in the tumour; hence, the Pp IX can be used as a fluorescent marker for tumours. More information may be obtained by combining the ALA induced fluorescence with fluorescence without externally applied fluorophore, so called autofluorescence. In this work we present a method for demarcation of BCC, using a non-expensive multispectral imaging set up assisted by image warping for image alignment. To calibrate the method, histopathological mapping has been carried out by excising the tumours with Mohs micrographic surgery. The Z-images, combining information of autofluorescence and ALA induced fluorescence, showed good agreement with the histopathological mapping of BCCs located on the face in 5 out of 12 patients and partial agreement in 7 patients. Since the face is an area where demarcation of tumours usually is considered difficult, this result shows a potential for the method as a pre-operative guiding tool for this type of skin lesions

Bispectral fluorescence imaging combined with texture analysis and linear discrimination for correlation with histopathologic extent of basal cell carcinoma

Fluorescence imaging has been shown to be a potential complement to visual inspection for demarcation of basal cell carcinoma (BCC), which is the most common type of skin cancer. Earlier studies have shown promising results when combining autofluorescence with protoporphyrin IX (Pp IX) fluorescence, induced by application of delta-5-aminolaevulinic acid (ALA). In this work, we have tried to further improve the ability of this technique to discriminate between areas of tumor and normal skin by implementing texture analysis and Fisher linear discrimination (FLD) on bispectral fluorescence data of BCCs located on the face. Classification maps of the lesions have been obtained from histopathologic mapping of the excised tumors. The contrast feature obtained from co-occurrence matrices was found to provide useful information, particularly for the ALA-induced Pp IX fluorescence data. Moreover, the neighborhood average features of both autofluorescence and Pp IX fluorescence were preferentially included in the analysis. The algorithm was trained by using a training set of images with good agreement with histopathology, which improved the discriminability of the validation set. In addition, cross validation of the training set showed good discriminability. Our results imply that FLD and texture analysis are preferential for correlation between bispectral fluorescence images and the histopathologic extension of the tumors