63 research outputs found
Multi-Omic Analysis of Stroke Recurrence in African Americans from the Vitamin Intervention for Stroke Prevention (VISP) Clinical Trial
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 04/03/2021
- Field of study
DNA methylation analyses identify an intronic ZDHHC6 locus associated with time to recurrent stroke in the Vitamin Intervention for Stroke Prevention (VISP) clinical trial
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2021
- Field of study
Aberrant DNA methylation profiles have been implicated in numerous cardiovascular diseases; however, few studies have investigated how these epigenetic modifications contribute to stroke recurrence. The aim of this study was to identify methylation loci associated with the time to recurrent cerebro- and cardiovascular events in individuals of European and African descent. DNA methylation profiles were generated for 180 individuals from the Vitamin Intervention for Stroke Prevention clinical trial using Illumina HumanMethylation 450K BeadChip microarrays, resulting in beta values for 470,871 autosomal CpG sites. Ethnicity-stratified survival analyses were performed using Cox Proportional Hazards regression models for associations between each methylation locus and the time to recurrent stroke or composite vascular event. Results were validated in the Vall d'Hebron University Hospital cohort from Barcelona, Spain. Network analyses of the methylation loci were generated using weighted gene coexpression network analysis. Primary analysis identified four significant loci, cg04059318, ch.2.81927627R, cg03584380, and cg24875416, associated with time to recurrent stroke. Secondary analysis identified three loci, cg00076998, cg16758041, and cg02365967, associated with time to composite vascular endpoint. Locus cg03584380, which is located in an intron of ZDHHC6, was replicated in the Vall d'Hebron University Hospital cohort. The results from this study implicate the degree of methylation at cg03584380 is associated with the time of recurrence for stroke or composite vascular events across two ethnically diverse groups. Furthermore, modules of loci were associated with clinical traits and blood biomarkers including previous number of strokes, prothrombin fragments 1 + 2, thrombomodulin, thrombin-antithrombin complex, triglyceride levels, and tissue plasminogen activator. Ultimately, these loci could serve as potential epigenetic biomarkers that could identify at-risk individuals in recurrence-prone populations.Supported through Academic Library Services’ PLOS Institutional Account Progra
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
- Author
- Aase Handberg
- Abhijna R Ballal
- Abhimanyu Thakur
- Abuelreich Sarah
- Achille Anselmo
- Adam L Maddox
- Adityas Purnianto
- Adrian E Morelli
- Adrian L Harris
- Adriana F Paes Leme
- Adriana T Larregina
- Afrodité Németh
- Afsareen Bano
- Agnieszka Razim
- Agustin Enciso-Martinez
- Ahmed Ge Ibrahim
- Ahmed Somaida
- Aija Linē
- Ainhoa Alberro
- Ajay P Singh
- Akbar L Marzan
- Akhil Srivastava
- Akira Yokoi
- Al Charest
- Alain R Brisson
- Alan J Zimmerman
- Albano Cáceres-Verschae
- Aled Clayton
- Aleksandra Inic-Kanada
- Aleksei Tikhonov
- Alena Ivanova
- Alessandra Ciullo
- Alessandro Gori
- Alessio Noghero
- Alex J Rai
- Alexander Otahal
- Alexander R Ivanov
- Alexis G Murillo Carrasco
- Alice Gualerzi
- Alicia Galinsoga
- Alicia Llorente
- Aliosha I Figueroa-Valdés
- Alireza Fazeli
- Alissa M Weaver
- Alok Raghav
- Alvaro Compañ-Bertomeu
- Amanda Khoo
- Amanda Salviano-Silva
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- Amankeldi A Salybekov
- Amélie Nadeau
- Amin Zakeri
- Amirmohammad Nasiri Kenari
- Amit K Srivastava
- Amy A Baxter
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- Anaïs Bécot
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- Andras G Miklosi
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- Andrea Galisova
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- Andreina Schoeberlein
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- Andrew Devitt
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- Sheila Spada
- Shekari Faezeh
- Sherif A Ibrahim
- Shikha Rani
- Shilpa Buch
- Shin-Ichi Kano
- Shirley Potter
- Shivakumar K Reddy
- Shuai Chen
- Siew Ling Ong
- Sigrun Lange
- Silvia Picciolini
- Silvia Sánchez Martín
- Silvio Kau-Strebinger
- Simon J Powis
- Simon Swift
- Simona Taverna
- Simonides I van de Wakker
- Siyu Chen
- Sneha Raju
- Soazig Le Lay
- Sofija Glamočlija
- Solange Landreville
- Somchai Chutipongtanate
- Sonal Sukreet
- Soo Kim
- Sophie Cavallero
- Sophie Rome
- Soren Jacobsen
- Ssang-Goo Cho
- Stanley M Lemon
- Stanley S Stylli
- Stefan Schneider
- Stefania Raimondo
- Stefano Forte
- Steffi Bosch
- Stella Kourembanas
- Stephanie F Rutter
- Stephanie Jung
- Stephanie M Bollard
- Stephen Lenzini
- Stephen Redenti
- Steven J Biller
- Steven M Jay
- Stuart Hunt
- Subbaya Subramanian
- Subhadip Ghatak
- Sujan K Mondal
- Sujata Mohanty
- Sukhbir Kaur
- Suman Dutta
- Sun Young Lee
- Suresh Mathivanan
- Surya Shrivastava
- Susann Allelein
- Susanne Gabrielsson
- Susanne Krasemann
- Susmita Sahoo
- Suvendra N Bhattacharyya
- Sveva Bollini
- Swasti Tiwari
- Swift Simon
- Sylwia Bobis-Wozowicz
- Syrine Arif
- Tae Ryong Lee
- Taeyoung Kang
- Takahiro Ochiya
- Takanori Eguchi
- Tamás Beke-Somfai
- Tamás Visnovitz
- Tania Limongi
- Tania Martins-Marques
- Tanina Arab
- Tara Thompson-Felix
- Taral R Lunavat
- Tatiane De Rossi
- Tatu Rojalin
- Tecla Marangon
- Teena Kjb Gamage
- Ter‐Ovanesyan Dmitry
- Thabiso E Motaung
- Thanh Kha Phan
- Theresa L Whiteside
- Théry Clotilde
- Thibaud Dauphin
- Thomas Kislinger
- Thomas Michael Shiju
- Thupten Tsering
- Tiana F Koukoulis
- Tijana Jovanovic-Talisman
- Timothea Konstantinou
- Timothy V Domashevich
- Tine Hiorth Schøyen
- Tobias Tertel
- Tom Ap Driedonks
- Tom G Keulers
- Tommaso Neri
- Tomofumi Yamamoto
- Tong Wang
- Torrecilhas Ana C.
- Tosar Juan P.
- Trude Aspelin
- Tsuneya Ikezu
- Ursula S Sandau
- Useckaite Zivile
- Uta Erdbrügger
- Valentina R Minciacchi
- Valentina Zappulli
- Valeria Barreca
- Valle Francesco
- van der Pol Edwin
- van Herwijnen Martijn J. C.
- Varga Zoltan
- Vasiliki Mahairaki
- Vasiliy S Chernyshev
- Vatsal Deliwala
- Veer Bala Gupta
- Vendula Pospichalova
- Vengala Rao Yenuganti
- Venkatesh Kumar Chetty
- Vera A Tang
- Vera Mugoni
- Vera Tscherrig
- Verity J Ford
- Verline Justilien
- Veronica Huber
- Veronika Kralj-Iglic
- Veronika Stoka
- Victor Bodart-Santos
- Vijaya Sunkara
- Vikramsingh Gujar
- Viktoria Szeifert
- Viktoria Weber
- Vincent Hyenne
- Vincent Yeung
- Vincenza Dolo
- Violaine Moreau
- Vito G D'Agostino
- Vivek Kumar Gupta
- Vladimir Bokun
- Vroniqa Ku'ulei-Lyn Faustino
- Vytautas Žėkas
- Wai-Leng Lee
- Wanessa F Altei
- Wauben Marca H. M.
- Wehman Ann M.
- Wei Duan
- Wei Guo
- Wei Seong Toh
- Welsh Joshua A.
- Wen-Wei Chang
- Wilfrid Boireau
- Wilfried W Bazié
- Willem Stoorvogel
- Williams Sarah
- Witwer Kenneth W.
- Wolfgang Holnthoner
- Wyatt N Vreeland
- Xabier Osteikoetxea
- Xandra O Breakefield
- Xavier Loyer
- Xiaomei Yan
- Xiaoqin Wang
- Xinhua Lei
- Xinlei Li
- Xiuming Liang
- Yagmur Yildizhan
- Yang You
- Yasuo Inoshima
- Yi Wen
- Yinghong Zhou
- Yingtang Gao
- Yiyao Huang
- Yoel Sadovsky
- Yohan Kim
- Yong Song Gho
- Yongkang Yang
- Yonis Bare
- Yoon-Kyoung Cho
- Yoshinobu Takakura
- Young-Gyun Park
- Yu Fujita
- Yu Xiao
- Yuki Yamamoto
- Yumi Kumagai
- Yunjie Wu
- Yunxi Chen
- Yusuke Yamamoto
- Yusuke Yoshioka
- Yvan Courageux
- Yvonne Couch
- Zach Troyer
- Zendrini Andrea
- Zheng Lei
- Zheng Zhao
- Zijlstra Andries
- Zimmerman Alan J.
- Zivile Useckaite
- Zoltan Varga
- Zoltán Varga
- Zoltán Wiener
- Zucai Suo
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly
Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission
- Author
- Abrams Simon
- Adeniji Kayode
- Agranoff Daniel
- Agwuh Ken
- Ahmed Katie A
- Ail Dhiraj
- Aldera Erin L
- Alegria Ana
- Alex Beatrice
- Angus Brian
- Armstrong Jane A
- Ashish Abdul
- Ashworth Milton
- Asiimwe Innocent G
- Atkinson Dougal
- Bach Benjamin
- Baillie J Kenneth
- Baillie J Kenneth
- Bakshi Siddharth
- Barclay Wendy S
- Bari Shahedal
- Barlow Gavin
- Barlow Samantha L
- Barnass Stella
- Barrett Nicholas
- Bassford Christopher
- Basude Sneha
- Baxter David
- Beadsworth Michael
- Bernatoniene Jolanta
- Berridge John
- Best Nicola
- Bogaert Debby
- Booth Laura
- Bothma Pieter
- Brennan Benjamin
- Brittain-long Robin
- Bullock Katie
- Bulteel Naomi
- Burden Tom
- Burtenshaw Andrew
- Carlucci Nicola
- Carson Gail
- Caruth Vikki
- Cass Emily
- Catterall Benjamin W A
- Chadwick David
- Chadwick David
- Chambler Duncan
- Chand Meera
- Chee Nigel
- Child Jenny
- Chukkambotla Srikanth
- Clark Jordan J
- Clark Tom
- Clarke Emily A
- Clohisey Sara
- Cole Sarah
- Cole Sarah
- Collini Paul
- Connor Marie
- Cooke Graham S
- Cooper Louise
- Cosgrove Catherine
- Cox Helen
- Cupitt Jason
- Cutino-moguel Maria-teresa
- Dalton Jo
- Dark Paul
- Davis Christopher
- Dawson Chris
- De Silva Thushan
- De Silva Thushan
- Dervisevic Samir
- Dincarslan Oslem
- Doce Carracedo Alejandra
- Docherty Annemarie B
- Docherty Annemarie B
- Donnison Phil
- Donohue Chloe
- Douthwaite Sam
- Drake Thomas M
- Drake Thomas M
- Dunn Chris
- Dunning Jake
- Durand Ingrid
- Dushianthan Ahilanadan
- Dyer Philip
- Dyer Tristan
- Elliott Angela
- Eunice Zhang J
- Evans Anthony
- Evans Cariad
- Eziefula Chi
- Fairfield Cameron J
- Fairfield Cameron J
- Fegan Christopher
- Filipe Ana Da Silva
- Finch Lorna
- Finn Adam
- Fisher Lewis W S
- Flaherty Lisa
- Fletcher Tom
- Foster Terry
- Fullerton Duncan
- Gamble Carrol
- Garcia-dorival Isabel
- Garg Atul
- Garg Sanjeev
- Garg Sanjeev
- Girvan Michelle
- Gkrania-klotsas Effrossyni
- Godden Jo
- Goldsmith Arthur
- Graham Clive
- Green Christopher A
- Greenhalf William
- Greenhalf William
- Griffiths Fiona
- Gunning Philip
- Gupta Rishi K
- Halpin Sophie
- Hardwick Hayley
- Hardwick Hayley E
- Hardy Elaine
- Harrison Ewen M
- Harrison Ewen M
- Harrison Janet
- Hartley Catherine
- Hartshorn Stuart
- Harvey Daniel
- Havalda Peter
- Hawcutt Daniel B
- Hendry Ross
- Hiscox Julian A
- Ho Antonia
- Ho Antonia Ying Wai
- Hobrok Maria
- Hodgson Luke
- Holmes Anthony
- Horby Peter W
- Hormis Anil
- Ijaz Samreen
- Jackson Clare
- Jacobs Michael
- Jain Susan
- Jennings Paul
- Jensen Rebecca L
- Jones Christopher B
- Jones Trevor R
- Kaliappan Agilan
- Kasipandian Vidya
- Keating Seán
- Kegg Stephen
- Kelsey Michael
- Kendall Jason
- Kerrison Caroline
- Kerslake Ian
- Khandaker Shadia
- Khoo Saye
- King Katharine
- Kiy Robyn T
- Klenerman Paul
- Knight Stephen R
- Koch Oliver
- Koduri Gouri
- Koshy George
- Koukorava Chrysa
- Laha Shondipon
- Laird Steven
- Lake Annette
- Lant Suzannah
- Larkin Susan
- Latawiec Diane
- Lavelle-langham Lara
- Law Andrew
- Law Andrew
- Leeming Gary
- Lefteri Daniella
- Leiner Tamas
- Lett Lauren
- Lillie Patrick
- Lim Wei Shen
- Limb James
- Linnett Vanessa
- Little Jeff
- Livoti Lucia A
- Lyons Ruth
- Lyttle Mark
- Maclean Alan
- Macmahon Michael
- Macnaughton Emily
- Mancini Maria
- Mankregod Ravish
- Marsh Laura
- Massey Hannah
- Masson Huw
- Matovu Elijah
- Matthew Ridley P
- Maziere Nicole
- Mccafferty Sarah
- Mccullough Katherine
- Mcdonald Sara
- Mcdonald Sarah
- Mcevoy Laurence
- Mcewen Ruth
- Mclauchlan John
- Mclean Kenneth A
- Meda Manjula
- Mentzer Alexander J
- Merson Laura
- Metelmann Soeren
- Meynert Alison M
- Miah Nahida S
- Middleton Joanna
- Mills Gary
- Minton Jane
- Mirfenderesky Mariyam
- Mitchell Joyce
- Mohandas Kavya
- Mok Quen
- Moon James
- Moore Elinoor
- Moore Shona C
- Moore Shona C
- Moore Shona C
- Morgan Patrick
- Morrice Kirstie
- Morris Craig
- Mortimore Katherine
- Moses Samuel
- Mpenge Mbiye
- Mulla Rohinton
- Murphy Derek
- Murphy Ellen G
- Murphy Lee
- Murphy Michael
- Nagarajan Thapas
- Nagel Megan
- Nelson Mark
- Norman Lisa
- Noursadeghi Mahdad
- Oosthuyzen Wilna
- Oosthuyzen Wilna
- Openshaw Peter J M
- Openshaw Peter J M
- Ostermann Marlies
- Otahal Igor
- O’shea Matthew K
- Pais Mark
- Palmarini Massimo
- Panchatsharam Selva
- Papakonstantinou Danai
- Papineni Padmasayee
- Paraiso Hassan
- Patel Brij
- Pattison Natalie
- Paxton William A
- Penrice-randal Rebekah
- Pepperell Justin
- Peters Mark
- Phull Mandeep
- Pilgrim Jack
- Pintus Stefania
- Pius Riinu
- Pollakis Georgios
- Pooni Jagtur Singh
- Post Frank
- Price David
- Price Nicholas
- Prince Tessa
- Prout Rachel
- Rae Nikolas
- Rambaut Andrew
- Relph Katharine A
- Reschreiter Henrik
- Reynolds Tim
- Reynolds Will
- Richardson Neil
- Roberts Devender
- Roberts Mark
- Roberts Stephanie
- Robertson David L
- Roger Thompson A A
- Rose Alistair
- Rousseau Guy
- Russell Clark D
- Russell Clark D
- Ryan Brendan
- Sales Debby
- Saluja Taranprit
- Sancho-shimizu Vanessa
- Saviciute Egle
- Scott Janet T
- Scott-brown James
- Semple Malcolm G
- Semple Malcolm G
- Shah Aarti
- Shankar-hari Manu
- Shanmuga Prad
- Sharma Anil
- Shaw Catherine A
- Shaw Victoria
- Shaw Victoria E
- Shawcross Anna
- Shears Rebecca K
- Sigfrid Louise
- Siggins Matthew K
- Sizer Jeremy
- Small Benjamin
- Smith Richard
- Snelson Catherine
- Solomon Tom
- Spittle Nick
- Sriskandan Shiranee
- Staines Nikki
- Stambach Tom
- Stewart Richard
- Stuart David
- Subramaniam Krishanthi S
- Subudhi Pradeep
- Summers Charlotte
- Szakmany Tamas
- Szemiel Agnieska
- Taggart Aislynn
- Tanianis-hughes Jolanta
- Tatham Kate
- Tedder Richard S
- Thomas Jo
- Thomas Jordan
- Thompson Chris
- Thompson Robert
- Thomson Emma C
- Thwaites Ryan S
- Thwaites Ryan S
- Tridente Ascanio
- Trochu Erwan
- Tupper-carey Darell
- Turtle Lance
- Turtle Lance C W
- Twagira Mary
- Ustianowski Andrew
- Vallotton Nick
- Van Tonder Libby
- Vincent-smith Lisa
- Visuvanathan Shico
- Vuylsteke Alan
- Waddy Sam
- Wake Rachel
- Walden Andrew
- Welters Ingeborg
- Wham Murray
- Whitehouse Tony
- Whittaker Paul
- Whittington Ashley
- Wijesinghe Meme
- Wilcock Eve
- Williams Martin
- Wilson Lawrence
- Winchester Stephen
- Wiselka Martin
- Wolverson Adam
- Wootton Daniel G
- Workman Andrew
- Wrobel Nicola
- Yates Bryan
- Young Peter
- Zambon Maria
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/04/2022
- Field of study
Abstract Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory and Emerging Infections Consortium World Health Organization Clinical Characterisation Protocol UK study). Although procalcitonin was higher in bacterial coinfection, this was neither clinically significant (median [IQR], 0.33 [0.11–1.70] ng/mL vs 0.24 [0.10–0.90] ng/mL) nor diagnostically useful (area under the receiver operating characteristic curve, 0.56 [95% confidence interval, .51–.60]).</jats:p
Implementation of corticosteroids in treating COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK:prospective observational cohort study
- Author
- Adeniji Kayode
- Agranoff Daniel
- Agwuh Ken
- Ahmed Katie A
- Ail Dhiraj
- Aldera Erin L
- Alegria Ana
- Alex Beatrice
- Allen Sam
- Andrikopoulos Petros
- Angus Brian
- Armstrong Jane A
- Ashish Abdul
- Ashworth Milton
- Asiimwe Innocent G
- Atkinson Dougal
- Bach Benjamin
- Baillie J Kenneth
- Baillie J Kenneth
- Bakshi Siddharth
- Barclay Wendy S
- Bari Shahedal
- Barlow Gavin
- Barlow Samantha L
- Barnass Stella
- Barrett Nicholas
- Bassford Christopher
- Basude Sneha
- Baxter David
- Beadsworth Michael
- Bernatoniene Jolanta
- Berridge John
- Berry Colin
- Best Nicola
- Bogaert Debby
- Booth Laura
- Bothma Pieter
- Brennan Benjamin
- Brittain-Long Robin
- Bullock Katie
- Bulteel Naomi
- Burden Tom
- Burtenshaw Andrew
- Carlucci Nicola
- Carson Gail
- Caruth Vikki
- Cass Emily
- Catterall Benjamin WA
- Chadwick David
- Chadwick David
- Chambler Duncan
- Chand Meera
- Chechi Kanta
- Chee Nigel
- Child Jenny
- Chukkambotla Srikanth
- Clark Jordan J
- Clark Richard
- Clark Tom
- Clarke Emily A
- Clohisey Sara
- Cole Sarah
- Collini Paul
- Connor Marie
- Cooke Graham S
- Cooper Louise
- Cosgrove Catherine
- Coutts Audrey
- Cox Helen
- Cupitt Jason
- Cutino-Moguel Maria-Teresa
- da Silva Filipe Ana
- Dalton Jo
- Dark Paul
- Davis Christopher
- Dawson Chris
- de Silva Thushan
- Dervisevic Samir
- Dincarslan Oslem
- Doce Carracedo Alejandra
- Docherty Annemarie B
- Docherty Annemarie B
- Donegan Cara
- Donegan Cara
- Donelly Lorna
- Donnison Phil
- Donohue Chloe
- dos Santos Correia Gon alo
- Douthwaite Sam
- Drake Thomas M
- Drake Thomas M
- Drummond Andrew
- Dumas Marc-Emmanuel
- Dunn Chris
- Dunning Jake
- Dunning Jake
- DuRand Ingrid
- Dushianthan Ahilanadan
- Dyer Philip
- Dyer Tristan
- Elliott Angela
- Evans Anthony
- Evans Cariad
- Eziefula Chi
- Fairfield Cameron J
- Fairfield Cameron J
- Fawkes Angie
- Fegan Chrisopher
- Finch Lorna
- Finn Adam
- Fisher Lewis WS
- Flaherty Lisa
- Fletcher Tom
- Foster Terry
- Fullerton Duncan
- Gamble Carrol
- Garcia-Dorival Isabel
- Garg Atul
- Garg Sanjeev
- Garg Sanjeev
- Gilchrist Tammy
- Girvan Michelle
- Girvan Michelle
- Gkrania-Klotsas Effrossyni
- Godden Jo
- Goldsmith Arthur
- Graham Clive
- Green Christopher A
- Greenhalf William
- Griffin Julian
- Griffiths Fiona
- Gunning Philip
- Gupta Rishi K
- Hafezi Katarzyna
- Halpin Sophie
- Hardwick Hayley
- Hardwick Hayley E
- Hardy Elaine
- Harrison Ewen M
- Harrison Ewen M
- Harrison Janet
- Hartley Catherine
- Hartshorn Stuart
- Harvey Daniel
- Havalda Peter
- Hawcutt Daniel B
- Hendry Ross
- Hiscox Julian A
- Ho Antonia
- Ho Antonia YW
- Hobrok Maria
- Hodgson Luke
- Holmes Anthony
- Horby Peter W
- Hormis Anil
- Ijaz Samreen
- Jackson Clare
- Jacobs Michael
- Jain Susan
- Jennings Paul
- Jensen Rebecca L
- Jones Christopher B
- Jones Trevor R
- Kaliappan Agilan
- Kasipandian Vidya
- Keating Seán
- Kegg Stephen
- Kelsey Michael
- Kendall Jason
- Kerrison Caroline
- Kerslake Ian
- Khandaker Shadia
- Khoo Say
- King Katharine
- Kiy Robyn T
- Klenerman Paul
- Knight Stephen R
- Koch Oliver
- Koduri Gouri
- Koshy George
- Koukorava Chrysa
- Laha Shondipon
- Laird Steven
- Lake Annette
- Lant Suzannah
- Larkin Susan
- Latawiec Diane
- Lavelle-Langham Lara
- Law Andrew
- Law Andrew
- Lee James
- Leeming Gary
- Leeming Gary
- Lefteri Daniella
- Leiner Tamas
- Lett Lauren
- Lewis Matthew
- Liggi Sonia
- Lillie Patrick
- Lim Wei Shen
- Limb James
- Linnett Vanessa
- Little Jeff
- Livoti Lucia A
- Lyttle Mark
- MacGillivray Louise
- Maclean Alan
- MacMahon Michael
- MacNaughton Emily
- Mancini Maria
- Mankregod Ravish
- Marsh Laura
- Maslen Lynn
- Massey Hannah
- Masson Huw
- Matovu Elijah
- Maziere Nicole
- McCafferty Sarah
- McCullough Katherine
- McDonald Sarah
- McDonald Sarah E
- McEvoy Laurence
- McEwen Ruth
- McLauchlan John
- Mclean Kenneth A
- Meda Manjula
- Mentzer Alexander J
- Merson Laura
- Metelmann Soeren
- Meynert Alison M
- Miah Nahida S
- Middleton Joanna
- Mills Gary
- Minton Jane
- Mirfenderesky Mariyam
- Mitchell Joyce
- Mohandas Kavya
- Mok Quen
- Moon James
- Moonesinghe S Ramani
- Moore Elinoor
- Moore Shona C
- Moore Shona C
- Morgan Patrick
- Morrice Kirstie
- Morris Craig
- Mortimore Katherine
- Moses Samuel
- Mpenge Mbiye
- Mulholland Rachel H
- Mulla Rohinton
- Murphy Derek
- Murphy Ellen G
- Murphy Lee
- Murphy Michael
- Nagarajan Thapas
- Nagel Megan
- Nelson Mark
- Nguyen-Van-Tam Jonathan S
- Norman Lisa
- Norris Lillian
- Noursadeghi Mahdad
- Närhi Fiina
- O'Shea Matthew K
- Olanipekun Michael
- Oosthuyzen Wilna
- Openshaw Peter JM
- Openshaw Peter JM
- Osagie Anthonia
- Ostermann Marlies
- Otahal Igor
- Pais Mark
- Palmarini Massimo
- Palmieri Carlo
- Palmieri Carlo
- Panchatsharam Selva
- Papakonstantinou Danai
- Papineni Padmasayee
- Paraiso Hassan
- Patel Brij
- Pattison Natalie
- Paxton William A
- Penrice-Randal Rebekah
- Pepperell Justin
- Peters Mark
- Phull Mandeep
- Pilgrim Jack
- Pintus Stefania
- Pius Riinu
- Pius Riinu
- Planche Tim
- Plotkin Daniel
- Pollakis Georgios
- Post Frank
- Price David
- Price Nicholas
- Prince Tessa
- Prout Rachel
- Rae Nikolas
- Rambaut Andrew
- Reschreiter Henrik
- Reynolds Tim
- Reynolds Will
- Richardson Neil
- Ridley P Matthew
- Roberts Devender
- Roberts Mark
- Roberts Stephanie
- Robertson David L
- Rose Alistair
- Rousseau Guy
- Ruge Bobby
- Russell Clark D
- Russell Clark D
- Ryan Brendan
- Sales Debby
- Saluja Taranprit
- Sancho-Shimizu Vanessa
- Sands Caroline
- Sarah Sarah
- Saviciute Egle
- Schmid Matthias
- Scott Janet T
- Scott-Brown James
- Semple Malcolm G
- Semple Malcolm G
- Shah Aarti
- Shankar-Hari Manu
- Shanmuga Prad
- Sharma Anil
- Shaw Catherine A
- Shaw Catherine A
- Shaw Victoria
- Shaw Victoria E
- Shawcross Anna
- Shears Rebecca K
- Shenkin Susan D
- Sigfrid Louise
- Singh Pooni Jagtur
- Sizer Jeremy
- Small Benjamin
- Smith Richard
- Snelson Catherine
- Solomon Tom
- Spencer Rebecca G
- Spencer Rebecca G
- Spittle Nick
- Sriskandan Shiranee
- Staines Nikki
- Stambach Tom
- Stewart Richard
- Stuart David
- Subramaniam Krishanthi S
- Subudhi Pradeep
- Summers Charlotte
- Swann Olivia V
- Szakmany Tamas
- Szemiel Agnieska
- Taggart Aislynn
- Takats Zoltan
- Takis Panteleimon
- Tanianis-Hughes Jolanta
- Tatham Kate
- Tedder Richard S
- Thomas Jo
- Thomas Jordan
- Thompson AA Roger
- Thompson Chris
- Thompson Robert
- Thomson Emma C
- Thwaites Ryan S
- Tridente Ascanio
- Trochu Erwan
- Tupper-Carey Darell
- Turtle Lance
- Turtle Lance CW
- Twagira Mary
- Vallotton Nick
- van Tonder Libby
- Vancheeswaran Rama
- Vincent-Smith Lisa
- Visuvanathan Shico
- Vuylsteke Alan
- Waddy Sam
- Wake Rachel
- Walden Andrew
- Welters Ingeborg
- Wham Murray
- Whitehouse Tony
- Whittaker Paul
- Whittington Ashley
- Wijesinghe Meme
- Wilcock Eve
- Williams Martin
- Wilson Lawrence
- Winchester Stephen
- Wiselka Martin
- Wolverson Adam
- Wootton Daniel G
- Workman Andrew
- Wrobel Nicola
- Yates Bryan
- Young Peter
- Zambon Maria
- Zhang J Eunice
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
BACKGROUND: Dexamethasone was the first intervention proven to reduce mortality in patients with COVID-19 being treated in hospital. We aimed to evaluate the adoption of corticosteroids in the treatment of COVID-19 in the UK after the RECOVERY trial publication on June 16, 2020, and to identify discrepancies in care. METHODS: We did an audit of clinical implementation of corticosteroids in a prospective, observational, cohort study in 237 UK acute care hospitals between March 16, 2020, and April 14, 2021, restricted to patients aged 18 years or older with proven or high likelihood of COVID-19, who received supplementary oxygen. The primary outcome was administration of dexamethasone, prednisolone, hydrocortisone, or methylprednisolone. This study is registered with ISRCTN, ISRCTN66726260. FINDINGS: Between June 17, 2020, and April 14, 2021, 47 795 (75·2%) of 63 525 of patients on supplementary oxygen received corticosteroids, higher among patients requiring critical care than in those who received ward care (11 185 [86·6%] of 12 909 vs 36 415 [72·4%] of 50 278). Patients 50 years or older were significantly less likely to receive corticosteroids than those younger than 50 years (adjusted odds ratio 0·79 [95% CI 0·70–0·89], p=0·0001, for 70–79 years; 0·52 [0·46–0·58], p80 years), independent of patient demographics and illness severity. 84 (54·2%) of 155 pregnant women received corticosteroids. Rates of corticosteroid administration increased from 27·5% in the week before June 16, 2020, to 75–80% in January, 2021. INTERPRETATION: Implementation of corticosteroids into clinical practice in the UK for patients with COVID-19 has been successful, but not universal. Patients older than 70 years, independent of illness severity, chronic neurological disease, and dementia, were less likely to receive corticosteroids than those who were younger, as were pregnant women. This could reflect appropriate clinical decision making, but the possibility of inequitable access to life-saving care should be considered. FUNDING: UK National Institute for Health Research and UK Medical Research Council
Finishing the euchromatic sequence of the human genome
- Author
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- Sutherland Grant R.
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- Wright Rita A.
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- Xuan Yali
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- Yakub Syed
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- Zeng Yixin
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- Zhang Guohua
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- Zhang Haiqing
- Zhang Haiqing
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- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
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- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Robust estimation of bacterial cell count from optical density
- Author
- Aarnio Tiu
- Aaron Leow Chung Yong
- Abbas Anser
- Abduraimova Aiganym
- Abraham Doris
- Acar Beliz Leyla
- Acosta Joaquin
- Adler Nina
- Adulyanukosol Natthawut
- Agena Ejouan
- Agena Ethan
- Aggarwal Priya
- Aguirre Adriana Lizeth Rubio
- Ahlgren Christopher
- Ahuja Janvi
- Aizik Dror
- Akbary Mina
- Akinfenwa Akinwumi
- Akingbesote Ngozi D.
- Akova Umut
- Aldo Ferdinan
- Alexopoulos Ioannis
- Allen Lucy
- Alonso Alejandro
- Altarawneh Dina
- Alvarado Andres Benjamin Sanchez
- Ambre Sanika
- Ameziane Annissa
- Amheine Khadija
- Amin Ihya Fakhrurizal
- Amir Sayeda Sakina
- Amstel Chiel van
- An Yongyan
- Anand Nithishwer Mouroug
- Ananthakrishnan Sathvik
- Anderson Karl
- Angel Sagi
- Annem Vidhya
- Anson Chung Tsun Ho
- Anwar Mariam
- Appel Alana
- Araya Lucas
- Armstrong Alexander
- Arora Neha
- Arora Vasu
- Arruda Beck
- Ashwin F Amal Jude
- Astapenka Artur
- Astles Ben
- Astorino Gabe
- Aubry Celine
- Avileli Rebecca
- Azad Mahnaz Sabeta
- Babar Rehmat
- Babu Priyanka
- Badalli Turan
- Badash Lior
- Baichman-Kass Amichai
- Baldwin Geoff S.
- Baltensperger Oliver Andreas
- Bao Guanke
- Bao Minyue
- Baronaite Ugne
- Barrat Leon Michael
- Barrington Seth
- Barshap Alon
- Bartzoka Natalia
- Basu Anubhav
- Basulto Cynthia
- Bath Scott
- Battina Rohith
- Bauersachs Daniel
- Beal Jacob
- Beale Renee
- Beard Eleanor
- Beck Selina
- Becker Evan
- Benavides Samantha Ayde Pena
- Bennis Nicole
- Bete Anna
- Bhatt Darshak
- Bhowmick Shilpa
- Bian Weixin
- Bijman Eline Yafele
- Bindt Felix
- Blas Karla Soto
- Bo Tang
- Boada Yadira
- Boer Meine
- Bohner Ariel
- Borovko Irina
- Bott Amie
- Bouwmeester Susan
- Bowman Kyle
- Boxem Mike
- Boxuan Cheng
- Boyce Kira
- Boyer Jess
- Brasas Valentas
- Brewer Mathew
- Briand William
- Brink Matilda
- Browne Emily
- Buckley-Taylor Russell
- Budhan Stephanie
- Buller Lisa
- Burckhardt Nele
- Burgland Zachary
- Burns Frank
- Burridge Matt
- Burud Hanna Nedreberg
- Buson Felipe Xavier
- Butterfield Tom
- Byagathvalli Gaurav
- Byatt Gabriel
- Byun Sumin
- Caballero Amalia
- Cai Fu
- Cai Niangui
- Caldwell Sarah
- Camacho Yazmin
- Camille Monteil
- Campbell Robert
- Cao Qinhao
- Cao Yixin
- Cao Yuze
- Carrillo Leo
- Carter Jonah
- Casas Alexis
- Castillo Nora Esther Torres
- Castillo Sandra
- Cave John
- Chai Ruochen
- Chamiec-Case Elizabeth
- Chan Janice
- Chan Yuan-Yao
- Chandramouli Priyanka
- Chang Annabel
- Chang Catherine
- Chang Kevin
- Chang Thomas
- Chang Ting-Chen
- Chang Yu-Ci
- Chapman Tyler
- Chater Dounia
- Chau Anthony
- Chavez Benjamin
- Chavez Francisco
- Chehade Ibrahim
- Chen Carmen
- Chen Chih-Chiang
- Chen Ching-Wei
- Chen Janice
- Chen Junhong
- Chen Junyang
- Chen Junyu
- Chen Pei-Hong
- Chen Ryan
- Chen Weixuan
- Chen Yan
- Chen Yi-Cian
- Chen Yifei
- Chen Zhuoyang
- Cheng Cheng
- Cheng Haolun
- Cheng Hsuan
- Cheng Yu-Hong
- Cheng Yu-Hsuan
- Chenxi Liang
- Cherupalla Arjun
- Chi Jordi
- Chi Shumei
- Chiang Jason
- Chiang Woody
- Ching Lai Tsz
- Ching Lam Kai
- Ching Law Hiu
- Ching Luk Hau
- Chinnathambi Sathivel
- Cho Sungwoo
- Choi Lee Sze
- Choi Youngeun
- Chou Ryan
- Chou Ryan
- Chu Wai Yan
- Chua Yah Tse Sabrina
- Chuang Yi-Chien
- Chulkova Nadezhda
- Chun Cheung Man
- Chun Emily
- Chun Ng Tsz
- Cifuentes Rodrigo Hernandez
- Clapper Jude
- Clapper Jude
- Clark Brittany
- Clemente Borja Sanchez
- Clerc Valerian
- Clodomir Christina
- Coates Ryan
- Cohen Katherine
- Colant Noelle
- Coleman Sarah
- Colgan Cian
- Cone Eli
- Corre Christophe
- Costa Ben
- Cott Rachel Van
- Craw Darilyn
- Crispim Larissa de Souza
- Crone Michael Andrew
- Crooijmans Marjolein
- Crosby Laurel Constanti
- Crowley Peter
- Cruz Frida
- Cubukcu Hande
- Culfogienis Dylan
- Czekster Clarissa
- Dai Leijie
- Dalangin Rochelin
- Daniel Benjamin
- Daniels Lea
- Das Neves Laura
- Das Diptatanu
- Davis Christina
- De Silva Nimaya
- Deb Shalini S.
- Deepak Kumar S.
- Deibel Emilie
- Dejoie Julianne
- Dejoux Alice
- DeKloe Jackson
- Del Toro Mariano
- Delalez Nicolas
- Delgadillo Sabrina
- Delhomme Jean
- Demchuk Aubrey
- Deng Nian Ruei
- Deng Rui
- Denter Jennifer
- Deshmukh-Reeves Ed
- Despres Philippe C.
- Devi Velvizhi
- Dhaliwal Gurpreet
- Diaz Fernanda
- Ding Shizhi
- Ding Yiming
- Ding Zhipeng
- Dingyue Tang
- Dirven Yvette
- Dissmann Jil-Sophie
- Do Stephanie
- Dogra Arushi
- Dominguez Viana Isabel Perez
- Dong Dongyang
- Dong Haitao
- Dong Jason
- Dong Shan
- Dong Shan
- Dong Shan
- Dong Shangzhi
- Dong Shangzhi
- Doyle David
- Doyle Shannon
- Dube Alexandre
- Dubuc Emilien
- Dunstan Izzy
- Dusseaux Theodore A.
- Dvorkin Steve
- Edelmayer Marco
- Ehrenworth Amy
- Eidloth Franziska
- Eijkens Bruno
- Eilers Keno
- El Moubayed Yorgo
- Elcin Evrim
- Elias Noel
- Elikan Max
- Ellermeier Craig
- Elliott Hannah
- Elsa Yeung Hoi Lam
- Emilov Kristian
- Espinoza Diego
- Evans Rhys
- Faidh Mohammed
- Falgenhauer Elisabeth
- Fan Catherine
- Fang Chengzhu
- Fang Choco
- Fang Xiangyi
- Farhi Einan
- Farias Sebastian
- Farny Natalie
- Farny Natalie G.
- Farrell Jennifer
- Fassler Jan
- Faurdal David
- Faustova Ilona
- Feng Xinhua
- Fernandez Cesar Ibrahym Rodriguez
- Fierro Daniela Olono
- Figueroa Ana Cristina
- Figueroa Jose Arnulfo Juarez
- Fikry Clara
- Filzen Rachael
- Fischer Matthew
- Fitzgerald Kevin
- Fitzgerald Liza
- Flores Vinicius
- Foda Asmaa
- Fong Yuhui Deborah
- Forman Victor
- Frank Stefanie
- Frankel Eva
- Freire Paulo J. C.
- Friedman Yonatan
- Frohlich Lisa
- Fu Wenhan
- Fu Yousi
- Fuentes Ernie
- Fulton Leah
- Fung Ip Ning
- Fung Yam Shing
- Gabrielli Jacopo
- Gahagan Maddison
- Gaitt Tobias
- Gaizauskaite Aukse
- Gallegos Isabella
- Gamoneda Diego
- Gandhi Rishi
- Gao Cecily
- Garavito Paula
- Garcia Chrismar
- Garcia David
- Garrido Delia
- Garulli Elisa
- Gaspar Camila
- Gaudi Alex
- Ge Gao
- Ge Yubin
- George Stephan
- Gerard Antoine
- Gershater Markus
- Ghosh Souvik
- Giannopoulos Alexandros Dimitriou
- Giannoula Yvoni
- Gilman Daniel Barber James
- Glockner Eleanor
- Goenka Anushya
- Goetz Marley
- Gogineni Namrata
- Gokul [NO FIRST NAME IN SCOPUS]
- Gonzalo Gonzalo Saiz
- Goodson Michael
- Gopaul Deshmukh
- Gou Yanchen
- Govers Jolijn
- Graaf Floor de
- Grace Tsui Shing Yan
- Graves Daniel
- Grazulyte Inga
- Greenwald Matthew
- Gu Jiajun
- Gu Yiheng
- Gu Yining
- Guadagnino Brett
- Guenther James
- Guerassimoff Lea
- Guo Jintao
- Gupta Shreya
- Guptil Chris
- Guseva Anna
- Ha Jacqueline
- Haddock-Angelli Traci
- Haight Travis
- Hale Mitch
- Hamady Carla
- Han Wang
- Han Weitang
- Handal Paola
- Hanrong Zhu
- Hansen Cecilie
- Hao Junyao
- Hao Mei
- Hao Zhengguo
- Haoran Xu
- Haralsvik Anne Kristin
- Hariyani Imtiyaz
- Hartley Zach
- Hassan Sondoss
- Hau Sion
- He Fa
- He Hanker
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- He Karen
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- He Menglan
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- He Yuna
- He Zhien
- Healy Liam
- Heath Emily
- Heger Theresa
- Hei Chan Yick
- Heijningen Franca van
- Heintze Maxime
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- Heng Heng
- Heng Mary
- Henras Anthony
- Herbert Heydy
- Hernandez Ivan Martin
- Hernandez Laura Armero
- Herrmann Max
- Heux Stephanie
- Hewitt Amy
- Hiesinger Marlene
- Hill Kurt
- Hin Chan Lok
- Hin Wong Chung
- Hin Yu Man
- Ho Anthony
- Ho Ng Sze
- Ho Tim
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- Hofer Sebastian
- Holman Olivor
- Holmedal Ingebjorg
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- Horz Philip
- Hoskan Mehmet Ali
- Hosseini Reza
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- Houmani Moustafa
- Hsiao Chia-Yi
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- Hsu Chia-Wei
- Hsu Yi-Hsuan
- Hu Miao
- Hu Shi
- Hu Vivian
- Hu Wenyue
- Hu Xinyi
- Hu Yunyun
- Hu Zhaoqing
- Hu Zhiyuan
- Huang Fangliang
- Huang Jiaxi
- Huang Morris
- Huang Ray
- Huang William
- Huang Yansong
- Huang Yaohua
- Huang Yilin
- Huang Yinpin
- Huanying He
- HuaYue Zhang
- Huerta Ana Laura Torres
- Humphreys Christopher
- Hung Chia
- Husnatter Kai
- Huuki Liz
- Huynh Juilanne
- Hwang Michael
- Ibrahim Ahmed
- Ikagawa Yuichiro
- Ikhsan Muhammad
- Ikwuagwu Bon
- Imgold Markus
- Inanc Tugba
- Inckemann Rene
- Isaac Ashley
- Isaacs Farren
- Isogai Tatsuki
- Iwuogo Amanda
- Iyer Aditya
- Iyer Tvarita Shivakumar
- Izzati Nurul
- Jacq Annick
- Jain Rishabh
- Jain Shubham
- Jainarayanan Ashwin Kumar
- Jakutis Gabrielius
- Jaoui Samuel
- Japranata Valdi Ven
- Jaramillo Alfonso
- Jasiunas Simas
- Jasti Naveen
- Jay Leung Chung Yin
- Jayaraman Guhan
- Jayaraman Srimathi
- Jenakendran Jenaagan
- Jensen Joen Haahr
- Jesse Hayley
- Jha Aryaman
- Ji Peicheng
- Jiacheng Wu
- Jiahe Zhang
- Jiamiao Liu
- Jian Liu
- Jiang Nannan
- Jiang Zhenyu
- Jianzhao Yang
- Jiaqi Hu
- Jiaqi Xiao
- Jimenez Carlene
- Jin Kaifeng
- Jingjing Zhao
- Jinyu Zhu
- Jo Kyuhee
- Joe Lam Kai Ching
- Johnson Elizabeth
- Johnson Michael
- Jones Ari
- Jones Cara
- Jones Ethan
- Jones Megan
- Jones Melissa
- Jongkees Seino
- Jonsson Martin
- Jude Marcia Smiti
- Jung Younji
- Juskaite Ieva
- Justice Isaac
- Kabbara Ismat
- Kadimi Sricharan
- Kailash B.P.
- Kalinowski Jorn
- Kalinowski Jorn
- Kalson Pranshu
- Kamble Yash Laxman
- Kanata Eleni
- Kanaya Toshihiro
- Kang Han
- Kang Xu
- Kang Ziqi
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- Kantor Nicole
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- Karpus Laurynas
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- Karumanchi Pranathi
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- Katopodi Xanthi Leda
- Kawasaki Yusuke
- Kayihan Ceyhun
- Keating Collin
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- Kittur M. Sagar
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- leelahakorn Nattawut
- Leeuw Monique de
- Lefevre Marine
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- Liu Jingang
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- Zepeng Xu
- Zerva Anastasia
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- Zhang Yunqian
- Zhang Zixuan
- Zhao Nannan
- Zhao Peng
- Zhao Tianyan
- Zhao Wenxue
- Zhao Yihang
- Zhaoting Li
- Zhecheng Huang
- Zheng Daniel
- Zheng Jiyang
- Zhiwei Song
- Zhong Yanling
- Zhou Hanmi
- Zhou Jiajie
- Zhou Jianan
- Zhou Rui
- Zhou Shuyao
- Zhou Xuanhao
- Zhou Yanjun
- Zhou Yi
- Zhou Yinchi
- Zhou Yineng
- Zhou Yuezhang
- Zhou Yuxin
- Zhou Zhiyu
- Zhu Chushu
- Zhu Ke
- Zhu Xueqian
- Zi Lihan
- Zilinskaite Nemira
- Zimmermann Andreas
- Zimmermann Jennifer
- Zirong Zeng
- Ziwei Zhou
- Ziyi Zhao
- Zorrilla Francisco
- Zou Jiahua
- Zukauskaite Kristina
- Zulueta Patricia
- Zvirblyte Justina
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data
Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia Nervosa
- Author
- Abramovic Lucija
- Adams Hieab HH
- Adan Roger
- Agartz Ingrid
- Alfredsson Lars
- Alhusaini Saud
- Almasy Laura
- Ames David
- Andersson Micael
- Ando Tetsuya
- Andreassen Ole
- Andreassen Ole A
- Anttila Verneri
- Arepalli Sampath
- Arias-Vasquez Alejandro
- Aribisala Benjamin S
- Armstrong Nicola J
- Aschauer Harald
- Ashbrook David G
- Assareh Amelia A
- Athanasiu Lavinia
- Baker Jessica
- Barrett Jeffrey
- Bastin Mark E
- Batury V-L
- Becker James T
- Bencko Vladimir
- Bergen Andrew
- Bernard Manon
- Berrettini Wade
- Birgegard Andreas
- Bis Joshua C
- Blangero John
- Bohlken Marc M
- Boks Marco P
- Boni Claudette
- Boomsma Dorret I
- Bralten Janita
- Brandt Harry
- Breen Gerome
- Brodaty Henry
- Brouwer Rachel M
- Brown Andrew A
- Brunner Han G
- Buckner Randy L
- Buitelaar Jan K
- Bulayeva Kazima B
- Bulik CM
- Bulik Cynthia M
- Bulik-Sullivan Brendan
- Burghardt Roland
- Cahn Wiepke
- Calhoun Vince D
- Cannon Dara M
- Carlberg Laura
- Carless Melanie A
- Cassina Matteo
- Cavalleri Gianpiero L
- Chakravarty M Mallar
- Chauhan Ganesh
- Chen Qiang
- Cheung J
- Ching Christopher RK
- Cichon Carolyn Cesta Sven
- Cichon Sven
- Clementi Maurizio
- Cohen-Woods Sarah
- Coleman Joni
- Cone Roger
- Cookson Mark R
- Corvin Aiden
- Courtet Philippe
- Crawford Steven
- Crespo-Facorro Benedicto
- Crow Scott
- Crowley Jim
- Cuellar-Partida Gabriel
- Curran Joanne E
- Czisch Michael
- Dale Anders M
- Danner Unna
- Davies Gareth E
- Davis Oliver
- de Geus Eco JC
- de Zubicaray Greig I
- de Zwaan Martina
- Deary Ian J
- Dedoussis George
- Degortes Daniela
- Delanty Norman
- Den Braber Anouk
- Depondt Chantal
- DeSocio Janiece
- Desrivieres Sylvane
- Dick Danielle
- Dikeos Dimitris
- Dillman Allissa
- Dina Christian
- Ding Bo
- Djurovic Srdjan
- Dmitrzak-Weglarz Monika
- Docampo Elisa
- Donohoe Gary
- Drevets Wayne C
- Duggirala Ravi
- Duncan Laramie
- Dyer Thomas D
- Ebling Maritza
- Egberts Karin
- Ehrlich Stefan
- Ehrlich Stefan
- Ehrlich Stefan
- Erk Susanne
- Escaramis Georgia
- Esko Tonu
- Espeseth Thomas
- Espeseth Thomas
- Estivill Xavier
- Favaro Angela
- Fedko Iryna O
- Fernandez Guillen
- Fernandez-Aranda Fernando
- Ferrucci Luigi
- Fichter Manfred
- Finan Chris
- Fischer Krista
- Fischl Bruce
- Fisher Simon E
- Floyd James
- Focker Manuel
- Foretova Lenka
- Foroud Tatiana M
- Forzan Monica
- Fox Caroline
- Fox Peter T
- Francks Clyde
- Franke Barbara
- Franklin Christopher
- Fukunaga Masaki
- Gallinger Valerie Gaborieau Steven
- Gambaro Giovanni
- Gaspar Helena
- Gibbs J Raphael
- Giddaluru Sudheer
- Giegling Ina
- Glahn David C
- Goldman Aaron L
- Goldstein Jackie
- Gollub Randy L
- Gonidakis Fragiskos
- Goring Harald HH
- Gorwood Philip
- Grabe Hans J
- Gratacos Monica
- Green Robert C
- Greve Douglas
- Grimm Oliver
- Grp ENIGMA Genetics Working
- Gruber Oliver
- Guadalupe Tulio
- Gudnason Vilmundur
- Guelfi Sebastian
- Guillaume Sebastien
- Guo Yiran
- Hager Reinmar
- Hakobjan Marina MH
- Hakonarson Hakon
- Halmi Katherine
- Hansell Narelle K
- Hardy John
- Harrison Rebecca
- Hartberg Cecilie B
- Hartman Catharina A
- Hashimoto Ryota
- Hass Johanna
- Hatzikotoulas Konstantinos
- Haukvik Unn K
- Hauser Joanna
- Hebebrand Johannes
- Hegenscheid Katrin
- Heinz Andreas
- Heister Angelien JGAM
- Helder Sietske
- Hendriks Judith
- Herms Stefan
- Hernandez Dena G
- Hernandez Maria C Valdes
- Herpertz-Dahlmann Beate
- Herzog Wolfgang
- Heslenfeld Dirk J
- Hibar D
- Hibar Derrek P
- Hilliard Christopher
- Hinney Anke
- Ho Beng-Choon
- Hoekstra Pieter J
- Hoffmann Wolfgang
- Hohn David
- Holmes Avram J
- Holsboer Florian
- Homuth Georg
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- Hosten Norbert
- Hottenga Jouke-Jan
- Huckins Laura
- Hudson James
- Huemer Julia
- Ikeda Masashi
- Ikram M Arfan
- Imgart Hartmut
- Inoko Hidetoshi
- Jahanshad N
- Jahanshad Neda
- Jamain Sigrid Jall Stephane
- Janout Vladimir
- Janowitz Deborah
- Jenkinson Mark
- Jia Tianye
- Jimenez-Murcia Susana
- Johnson Craig
- Johnson Robert
- Jonsson Erik G
- Jordan Jenny
- Jr Jack Clifford R
- Jr Kent Jack W
- Julia Antonio
- Jureus Anders
- Kahn Rene S
- Kalsi Gursharan
- Kaminska Debora
- Kanai Ryota
- Kaplan Allan
- Kaprio Jaakko
- Karhunen Leila
- Karwautz Andreas
- Kas Martien
- Kasperaviciute Dalia
- Kaye Walter
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- Kennedy James
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- Kiezebrink Kirsty
- Kim Sungeun
- Kim Youl-Ri
- Klareskog Lars
- Klein Marieke
- Kloszewska Iwona
- Klump Kelly
- Knudsen Gun Peggy
- Kochunov Peter
- Koeleman Bobby
- Koubek Doris
- Kraemer Bernd
- Kwok John B
- La Via Maria
- Landen Mikael
- Launer Lenore J
- Lawrie Stephen M
- Le Hellard Stephanie
- Le Hellard Stephanie
- Leboyer Marion
- Lee Phil H
- Levitan Robert
- Li Dong
- Lichtenstein Paul
- Liewald David CM
- Lilenfeld Lisa
- Lissowska Jolanta
- Liu Xinmin
- Longo Dan L
- Longstreth WT
- Loohuis Loes M Olde
- Lopez Lorna M
- Lovestone Simon
- Lu Lu
- Luciano Michelle
- Lundervold Astri
- Luting Xue
- Macare Christine
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- Mannik Katrin
- Marsal Sara
- Martin Nicholas
- Martin Nicholas G
- Matarin Mar
- Mather Karen A
- Mattay Venkata S
- Mattheisen Manuel
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- Mazoyer Bernard
- McDevitt Sara
- McDonald Colm
- McGuffin Peter
- McIntosh Andrew M
- Mckay David R
- McMahon Francis J
- McMahon Katie L
- Mecocci Patrizia
- Medland Sarah E
- Meisenzahl Eva
- Melle Ingrid
- Merl Elisabeth
- Metspalu Andres
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- Meyer-Lindenberg Andreas
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- Mitchell James
- Mitchell Karen
- Mohnke Sebastian
- Monteleone Alessio Maria
- Monteleone Palmiero
- Montgomery Grant
- Montgomery Grant W
- Morris Derek W
- Mortensen Preben
- Mostert Jeanette C
- Mueller Timo
- Mueller-Myhsok Bertram
- Muhleisen Thomas W
- Munn-Chernoff Melissa
- Naber Marlies AM
- Nacmias Benedetta
- Nalls Michael A
- Nauck Matthias
- Navratilova Marie
- Needham Margaret
- Nho Kwangsik
- Nichols Thomas E
- Nilsson Ida
- Nilsson Lars G
- Norring Claes
- Nothen Markus M
- Ntalla Ioanna
- Nugent Allison C
- Nyberg Lars
- Nyquist Paul
- O'Toole Julie
- Ohi Kazutaka
- Olvera Rene L
- Ophoff Roel
- Ophoff Roel A
- Palotie Aarno
- Pandolfo Massimo
- Pantel Jacques
- Papezova Hana
- Papmeyer Martina
- Paus Tomas
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- Perez-Iglesias Rocio
- Perica Vesna Boraska
- PGC-ED
- Pike G Bruce
- Pinto Richard Parker Dalila
- Pol Hilleke E Hulshoff
- Potkin Steven G
- Putz Benno
- Rabionet Raquel
- Raevuori Anu
- Rajewski Andrzej
- Ramasamy Adaikalavan
- Ramoz Nicolas
- Rayner N William
- Reichborn-Kjennerud Ted
- Reinvang Ivar
- Renteria Miguel E
- Reppermund Simone
- Ricca Valdo
- Rietschel Marcella
- Ripatti Samuli
- Ripke Stephan
- Risacher Shannon L
- Ritschel Franziska
- Roberts Marion
- Roffman Joshua L
- Roiz-Santianez Roberto
- Romanczuk-Seiferth Nina
- Rose Emma J
- Rosen Glenn D
- Rotondo Alessandro
- Rujescu Dan
- Rujescu Dan
- Rybakowski Filip
- Ryten Mina
- Sachdev Perminder S
- Salami Alireza
- Samann Philipp G
- Santonastaso Paolo
- Satizabal Claudia L
- Saykin Andrew J
- Scherag Andre
- Scherer Stephen
- Schmaal Lianne
- Schmidt Helena
- Schmidt Reinhold
- Schmidt Ulrike
- Schnell Knut
- Schofield Peter R
- Schork Andrew J
- Schork Nicholas
- Schosser Alexandra
- Schumann Gunter
- Scott Laura
- Seiler Stephan
- Seitz J
- Seitz Jochen
- Seshadri Sudha
- Shen Li
- Shin Jean
- Simmons Andrew
- Singleton Andrew
- Sisodiya Sanjay M
- Slachtova Lenka
- Sladek Robert
- Slagboom P Eline
- Slof-Op't Landt Margarita
- Slopien Agnieszka
- Smith Colin
- Smith Tosha
- Smoller Jordan W
- Soininen Hilkka
- Soranzo Nicole
- Sorbi Sandro
- Southam Lorraine
- Sprooten Emma
- Steen Vidar
- Steen Vidar M
- Stein Jason L
- Strengman Eric
- Strike Lachlan T
- Strober Michael
- Sussmann Jessika E
- Szatkiewicz Jin
- Szeszenia-Dabrowska Neonila
- Tachmazidou Ioanna
- Tenconi Elena
- Teumer Alexander
- Thalamuthu Anbupalam
- Thompson Paul M
- Thompson PM
- Thornton Laura
- Toga Arthur W
- Toro Roberto
- Tortorella Alfonso
- Tozzi Federica
- Trabzuni Daniah
- Traynor Bryan J
- Treasure Janet
- Troncoso Juan
- Tschop Matthias
- Tsitsika Artemis
- Turner Jessica A
- Tziouvas Konstantinos
- van Bokhoven Hans
- van der Brug Marcel
- van der Lee Sven J
- van der Marel Saskia SL
- van der Wee Nic JA
- van Donkelaar Marjolein MJ
- van Duijn Cornelia M
- van Eijk Kristel R
- van Elburg Annemarie
- van Furth Eric
- van Haren Neeltje EM
- van Hulzen Kimm JE
- van Tol Marie-Jose
- van't Ent Dennis
- Veltman Dick J
- Vinke Louis N
- Volzke Henry
- Wade Tracey
- Wagner Gudrun
- Walter Henrik
- Walters Raymond
- Walters Raymond K
- Walton E
- Walton Esther
- Walton Esther
- Wardlaw Joanna M
- Wassink Thomas H
- Watson Hunna
- Weale Michael E
- Weinberger Daniel R
- Weiner Michael W
- Wen Wei
- Westlye Lars T
- Westman Eric
- Whelan Christopher D
- White Tonya
- Wichmann H-Erich
- Widen Elisabeth
- Williams Robert W
- Winkler Anderson M
- Wittfeld Katharina
- Woldehawariat Girma
- Wolf Christiane
- Woodside D Blake
- Wright Margaret J
- Yanek Lisa R
- Yanovski Jack
- Yao Shuyang
- Yilmaz Z
- Yilmaz Zeynep
- Zerwas Stephanie
- Zielke Ronald H
- Zipfel Stephan
- Zonderman Alan B
- Zwiers Marcel P
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/07/2019
- Field of study
A prenylated dsRNA sensor protects against severe COVID-19
- Author
- Adeniji Kayode
- Agranoff Daniel
- Agwuh Ken
- Ahmed Katie A.
- Ail Dhiraj
- Aldera Erin L.
- Alegria Ana
- Alex Beatrice
- Allan Jay
- Allen Sam
- Andrikopoulos Petros
- Angus Brian
- Armstrong Jane A.
- Ashish Abdul
- Ashworth Milton
- Asiimwe Innocent G.
- Atkinson Dougal
- Bach Benjamin
- Baillie J. Kenneth
- Baillie J. Kenneth
- Bakshi Siddharth
- Barclay Wendy S.
- Bari Shahedal
- Barlow Gavin
- Barlow Samantha L.
- Barnass Stella
- Barrett Nicholas
- Bassford Christopher
- Basude Sneha
- Baxter David
- Beadsworth Michael
- Bernatoniene Jolanta
- Berridge John
- Berry Colin
- Best Nicola
- Bogaert Debby
- Booth Laura
- Bothma Pieter
- Brennan Benjamin
- Brittain-Long Robin
- Bullock Katie
- Bulteel Naomi
- Burden Tom
- Burtenshaw Andrew
- Cameron-Ruiz Natalia
- Carlucci Nicola
- Carracedo Alejandra Doce
- Carson Gail
- Caruth Vikki
- Cass Emily
- Castello Alfredo
- Catterall Benjamin W. A.
- Chadwick David
- Chadwick David
- Chambler Duncan
- Chand Meera
- Chechi Kanta
- Chee Nigel
- Child Jenny
- Chukkambotla Srikanth
- Clark Jordan J.
- Clark Tom
- Clarke Emily A.
- Clohisey Sara
- Clohisey Sara
- Cole Sarah
- Cole Sarah
- Collini Paul
- Connor Marie
- Cooke Graham S.
- Cooper Louise
- Cosgrove Catherine
- Cox Helen
- Crozier Thomas W. M.
- Cupitt Jason
- Cutino-Moguel Maria-Teresa
- Da Silva Filho Joao Luiz
- da Silva Filipe Ana
- Dalton Jo
- Dark Paul
- Davies Emma L.
- Davis Christopher
- Davis Ilan
- Dawson Chris
- de Lima Ferreira Luiz Carlos
- de Silva Thushan
- Dervisevic Samir
- Dincarslan Oslem
- Docherty Annemarie B.
- Donegan Cara
- Donnison Phil
- Donohue Chloe
- dos Santos Correia Gonçalo
- Douthwaite Sam
- Drake Thomas M.
- Drummond Andrew
- Dumas Marc-Emmanuel
- Dunn Chris
- Dunning Jake
- DuRand Ingrid
- Dushianthan Ahilanadan
- Dyer Philip
- Dyer Tristan
- Elliott Angela
- Evans Anthony
- Evans Cariad
- Eziefula Chi
- Fairfield Cameron J.
- Fawkes Angie
- Fegan Chrisopher
- Finch Lorna
- Finn Adam
- Fisher Lewis W. S.
- Flaherty Lisa
- Fletcher Tom
- Foster Terry
- Freire Santana Monique
- Fullerton Duncan
- Gamble Carrol
- Garcia-Dorival Isabel
- Garg Atul
- Garg Sanjeev
- Girvan Michelle
- Gkrania-Klotsas Effrossyni
- Godden Jo
- Goldsmith Arthur
- Graham Clive
- Green Christopher A.
- Greenhalf William
- Greenhalf William
- Greenwood Edward J. D.
- Griffin Julian L.
- Griffiths Fiona
- Grimes Graeme
- Gu Quan
- Gunning Philip
- Gupta Rishi K.
- Halpin Sophie
- Hardwick Hayley
- Hardy Elaine
- Harrison Ewen M.
- Harrison Janet
- Hartley Catherine
- Hartshorn Stuart
- Harvey Daniel
- Havalda Peter
- Hawcutt Daniel B.
- Hendry Ross
- Herder Vanessa
- Ho Antonia
- Ho Antonia Ying Wai
- Hobrok Maria
- Hodgson Luke
- Holmes Anthony
- Horby Peter W.
- Hormis Anil
- Hughes Joseph
- Ijaz Samreen
- Iselin Louisa
- Jackson Clare
- Jacobs Michael
- Jain Susan
- Jarmson Innes
- Jarrett Ruth F.
- Jennings Paul
- Jensen Rebecca L.
- Jones Christopher B.
- Jones Trevor R.
- Kaliappan Agilan
- Kasipandian Vidya
- Keating Seán
- Kegg Stephen
- Kelsey Michael
- Kendall Jason
- Kerrison Caroline
- Kerslake Ian
- Khandaker Shadia
- Khoo Saye
- King Katharine
- Kiy Robyn T.
- Klenerman Paul
- Knight Stephen R.
- Koch Oliver
- Koduri Gouri
- Koshy George
- Koukorava Chrysa
- Kuchi Srikeerthana
- Laha Shondipon
- Laird Steven
- Lake Annette
- Lant Suzannah
- Larkin Susan
- Latawiec Diane
- Lavelle-Langham Lara
- Law Andrew
- Law Andrew
- Lee James
- Lee Jeffrey Y.
- Leeming Gary
- Lefteri Daniella
- Lehner Paul J.
- Leiner Tamas
- Lett Lauren
- Lewis Matthew R.
- Liggi Sonia
- Lillie Patrick
- Lim Wei Shen
- Limb James
- Linnett Vanessa
- Little Jeff
- Livoti Lucia A.
- Loney Colin
- Lytras Spyros
- Lyttle Mark
- MacLean Alan
- MacMahon Michael
- MacNaughton Emily
- Mancini Maria
- Mankregod Ravish
- Marsh Laura
- Marti Matthias
- Maslen Lynn
- Massey Hannah
- Masson Huw
- Matovu Elijah
- Maziere Nicole
- McCafferty Sarah
- McCullough Katherine
- McDonald Sarah
- McDonald Sarah E.
- McEvoy Laurence
- McEwen Ruth
- McLauchlan John
- Mclean Kenneth A.
- Meda Manjula
- Mentzer Alexander J.
- Merson Laura
- Metelmann Soeren
- Meynert Alison
- Meynert Alison M.
- Miah Nahida S.
- Middleton Joanna
- Mills Gary
- Minton Jane
- Mirfenderesky Mariyam
- Mitchell Joyce
- Mohandas Kavya
- Mok Quen
- Moon James
- Moore Elinoor
- Moore Shona C.
- Moore Shona C.
- Morgan Patrick
- Morrice Kirstie
- Morris Craig
- Mortimore Katherine
- Moses Samuel
- Mpenge Mbiye
- Mulla Rohinton
- Murphy Derek
- Murphy Ellen G.
- Murphy Lee
- Murphy Lee
- Murphy Michael
- Nagarajan Thapas
- Nagel Megan
- Nelson Mark
- Noerenberg Marko
- Norman Lisa
- Norris Lillian
- Noursadeghi Mahdad
- O?Shea Matthew K.
- Olanipekun Michael
- Oosthuyzen Wilna
- Openshaw Peter J. M.
- Openshaw Peter J. M.
- Osagie Anthonia
- Ostermann Marlies
- Otahal Igor
- Pais Mark
- Palmalux Natasha
- Palmarini Massimo
- Palmarini Massimo
- Palmieri Carlo
- Palmieri Carlo
- Panchatsharam Selva
- Papakonstantinou Danai
- Papineni Padmasayee
- Paraiso Hassan
- Patel Brij
- Pattison Natalie
- Paxton William A.
- Penrice-Randal Rebekah
- Pepperell Justin
- Peters Mark
- Phull Mandeep
- Pilgrim Jack
- Pinto Rute M.
- Pintus Stefania
- Pius Riinu
- Planche Tim
- Plotkin Daniel
- Pollakis Georgios
- Post Frank
- Price David
- Price Nicholas
- Prince Tessa
- Prout Rachel
- Rae Nikolas
- Rambaut Andrew
- Reschreiter Henrik
- Reynolds Tim
- Reynolds Will
- Richardson Neil
- Ridley P. Matthew
- Rihn Suzannah J.
- Roberts Devender
- Roberts Mark
- Roberts Stephanie
- Robertson David L.
- Robertson David L.
- Rose Alistair
- Rousseau Guy
- Ruge Bobby
- Russell Clark D.
- Ryan Brendan
- Sales Debby
- Saluja Taranprit
- Sancho-Shimizu Vanessa
- Sands Caroline J.
- Saviciute Egle
- Schmid Matthias L.
- Scott Janet T.
- Scott-Brown James
- Semple Malcolm G.
- Semple Malcolm G.
- Shah Aarti
- Shankar-Hari Manu
- Shanmuga Prad
- Sharma Anil
- Shaw Catherine A.
- Shaw Victoria
- Shaw Victoria E.
- Shawcross Anna
- Shears Rebecca K.
- Sigfrid Louise
- Singh Pooni Jagtur
- Sizer Jeremy
- Small Benjamin
- Smith Richard
- Snelson Catherine
- Solomon Tom
- Spencer Rebecca G.
- Spittle Nick
- Sriskandan Shiranee
- Staines Nikki
- Stambach Tom
- Stanton Richard J.
- Stewart Douglas G.
- Stewart Richard
- Stuart David
- Subramaniam Krishanthi S.
- Subudhi Pradeep
- Sugrue Elena
- Summers Charlotte
- Swann Olivia V.
- Swingler Simon
- Szakmany Tamas
- Szemiel Agnieska
- Taggart Aislynn
- Takats Zoltan
- Takis Panteleimon
- Tanianis-Hughes Jolanta
- Tatham Kate
- Tedder Richard S.
- Thomas Jo
- Thomas Jordan
- Thompson A. A. Roger
- Thompson Chris
- Thompson Robert
- Thomson Emma C.
- Thwaites Ryan S.
- Tridente Ascanio
- Trindade Maranhão Costa Fabio
- Trochu Erwan
- Tupper-Carey Darell
- Turnbull Matthew L.
- Turtle Lance C. W.
- Twagira Mary
- Vallotton Nick
- van Tonder Libby
- Vancheeswaran Rama
- Varjak Margus
- Vincent-Smith Lisa
- Visuvanathan Shico
- Vuylsteke Alan
- Waddy Sam
- Wake Rachel
- Walden Andrew
- Wang Bo
- Wang Eddie C. Y.
- Welters Ingeborg
- Wham Murray
- Whitehouse Tony
- Whittaker Paul
- Whittington Ashley
- Wickenhagen Arthur
- Wijesinghe Meme
- Wilcock Eve
- Williams Martin
- Wilson Lawrence
- Wilson Sam J.
- Winchester Stephen
- Wiselka Martin
- Wolverson Adam
- Wootton Daniel G.
- Workman Andrew
- Wrobel Nicola
- Yates Bryan
- Young Peter
- Zambon Maria
- Zhang J. Eunice
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 29/10/2021
- Field of study
Inherited genetic factors can influence the severity of COVID-19, but the molecular explanation underpinning a genetic association is often unclear. Intracellular antiviral defenses can inhibit the replication of viruses and reduce disease severity. To better understand the antiviral defenses relevant to COVID-19, we used interferon-stimulated gene (ISG) expression screening to reveal that OAS1, through RNase L, potently inhibits SARS-CoV-2. We show that a common splice-acceptor SNP (Rs10774671) governs whether people express prenylated OAS1 isoforms that are membrane-associated and sense specific regions of SARS-CoV-2 RNAs, or only express cytosolic, nonprenylated OAS1 that does not efficiently detect SARS-CoV-2. Importantly, in hospitalized patients, expression of prenylated OAS1 was associated with protection from severe COVID-19, suggesting this antiviral defense is a major component of a protective antiviral response
Viral coinfections in hospitalized coronavirus disease 2019 patients recruited to the international severe acute respiratory and emerging infections consortium WHO clinical characterisation protocol UK study
- Author
- Adeniji Kayode
- Agranoff Daniel
- Agwuh Ken
- Ahmed Katie A.
- Ail Dhiraj
- Aldera Erin L.
- Alegria Ana
- Allen Sam
- Angus Brian
- Armstrong Jane A.
- Ashish Abdul
- Ashworth Milton
- Asiimwe Innocent G.
- Atkinson Dougal
- Baillie J. Kenneth
- Baillie J. Kenneth
- Bakshi Siddharth
- Barclay Wendy S.
- Bari Shahedal
- Barlow Gavin
- Barlow Samantha L.
- Barnass Stella
- Barrett Nicholas
- Bassford Christopher
- Basude Sneha
- Baxter David
- Beadsworth Michael
- Bernatoniene Jolanta
- Berridge John
- Berry Colin
- Best Nicola
- Bogaert Debby
- Booth Laura
- Bothma Pieter
- Brennan Benjamin
- Brittain-Long Robin
- Bullock Katie
- Bulteel Naomi
- Burden Tom
- Burtenshaw Andrew
- Carlucci Nicola
- Carracedo Alejandra Doce
- Caruth Vikki
- Cass Emily
- Catterall Benjamin W. A.
- Chadwick David
- Chadwick David
- Chambler Duncan
- Chand Meera
- Chechi Kanta
- Chee Nigel
- Child Jenny
- Chukkambotla Srikanth
- Clark Jordan J.
- Clark Richard
- Clark Tom
- Clarke Emily A.
- Clohisey Sara
- Cole Sarah
- Cole Sarah
- Collini Paul
- Connor Marie
- Cooke Graham S.
- Cooper Louise
- Cosgrove Catherine
- Coutts Audrey
- Cox Helen
- Cupitt Jason
- Cutino-Moguel Maria-Teresa
- Dalton Jo
- Dark Paul
- Davis Chris
- Davis Christopher
- Dawson Chris
- de Silva Thushan
- Dervisevic Samir
- Dincarslan Oslem
- Docherty Annemarie B.
- Donegan Cara
- Donnelly Lorna
- Donnison Phil
- Donohue Chloe
- dos Santos Correia Gonçalo
- Douthwaite Sam
- Drake Thomas M.
- Drummond Andrew
- Dumas Marc-Emmanuel
- Dunn Chris
- Dunning Jake
- DuRand Ingrid
- Dushianthan Ahilanadan
- Dyer Philip
- Dyer Tristan
- Elliott Angela
- Evans Anthony
- Evans Cariad
- Eziefula Chi
- Fairfield Cameron J.
- Fawkes Angie
- Fegan Chrisopher
- Filipe Ana da Silva
- Finch Lorna
- Finn Adam
- Fisher Lewis W. S.
- Flaherty Lisa
- Fletcher Tom
- Foster Terry
- Fullerton Duncan
- Gamble Carrol
- Garcia-Dorival Isabel
- Garg Atul
- Garg Sanjeev
- Garg Sanjeev
- Gilchrist Tammy
- Girvan Michelle
- Gkrania-Klotsas Effrossyni
- Godden Jo
- Goldsmith Arthur
- Graham Clive
- Grammatikopoulos Tassos
- Green Christoper A.
- Greenhalf William
- Griffin Julian L.
- Griffiths Fiona
- Gunning Philip
- Gunson Rory
- Gupta Rishi K.
- Hafezi Katarzyna
- Halpin Sophie
- Hardwick Hayley
- Hardwick Hayley E.
- Hardy Elaine
- Harrison Ewen M.
- Harrison Janet
- Hartley Catherine
- Hartshorn Stuart
- Harvey Daniel
- Havalda Peter
- Hawcutt Daniel B.
- Hendry Ross
- Hiscox Julian A.
- Ho Antonia
- Ho Antonia Ying Wai
- Hobrok Maria
- Hodgson Luke
- Holden Karl
- Holmes Anthony
- Horby Peter W.
- Hormis Anil
- Howard Joanne
- Ijaz Samreen
- Jackson Clare
- Jacobs Michael
- Jain Susan
- Jennings Paul
- Jensen Rebecca L.
- Jones Christopher B.
- Jones Trevor R.
- Kaliappan Agilan
- Kasipandian Vidya
- Keating Seán
- Kegg Stephen
- Kelsey Michael
- Kendall Jason
- Kerrison Caroline
- Kerslake Ian
- Khandaker Shadia
- Khoo Saye
- King Katharine
- Kiy Robyn T.
- Klenerman Paul
- Knight Stephen R.
- Knight Susan
- Koch Oliver
- Koduri Gouri
- Koshy George
- Koukorava Chrysa
- Laha Shondipon
- Lahnsteiner Eva
- Laird Steven
- Lake Annette
- Lant Suzannah
- Larkin Susan
- Latawiec Diane
- Lavelle-Langham Lara
- Law Andrew
- Law Andrew
- Lee James
- Leeming Gary
- Lefteri Daniella
- Leiner Tamas
- Lett Lauren
- Lewis Matthew R.
- Liggi Sonia
- Lillie Patrick
- Lim Wei Shen
- Limb James
- Linnett Vanessa
- Little Jeff
- Livoti Lucia A.
- Lyttle Mark
- MacGillivray Louise
- Maclean Alan
- MacLean Alasdair
- MacMahon Michael
- MacNaughton Emily
- Mancini Maria
- Mankregod Ravish
- Marsh Laura
- Maslen Lynn
- Massey Hannah
- Masson Huw
- Matovu Elijah
- Maziere Nicole
- McCafferty Sarah
- McCullough Katherine
- McDonald Sarah
- McDonald Sarah E.
- McDonald Sarah E.
- McEvoy Laurence
- McEwen Ruth
- McLauchlan John
- Mclean Kenneth A.
- Meda Manjula
- Mentzer Alexander J.
- Merson Laura
- Metelmann Soeren
- Meynert Alison M.
- Miah Nahida S.
- Middleton Joanna
- Mills Gary
- Minton Jane
- Mirfenderesky Mariyam
- Mitchell Joyce
- Mohandas Kavya
- Mok Quen
- Moon James
- Moore Elinoor
- Moore Shona C.
- Moore Shona C.
- Morgan Patrick
- Morrice Kirstie
- Morris Craig
- Mortimore Katherine
- Moses Samuel
- Mpenge Mbiye
- Mulla Rohinton
- Murphy Derek
- Murphy Ellen G.
- Murphy Lee
- Murphy Michael
- Nagarajan Thapas
- Nagel Megan
- Nelson Mark
- Norman Lisa
- Norris Lillian
- Norris Lucy
- Noursadeghi Mahdad
- O'Shea Matthew K.
- Olanipekun Michael
- Oosthuyzen Wilna
- Oosthuyzen Wilna
- Openshaw Peter J. M.
- Openshaw Peter J. M.
- Osagie Anthonia
- Ostermann Marlies
- Otahal Igor
- Pais Mark
- Palmarini Massimo
- Palmieri Carlo
- Palmieri Carlo
- Panchatsharam Selva
- Papakonstantinou Danai
- Papineni Padmasayee
- Paraiso Hassan
- Pascall David
- Patel Brij
- Pattison Natalie
- Paxton William A.
- Penrice-Randal Rebekah
- Pepperell Justin
- Peters Mark
- Phull Mandeep
- Pilgrim Jack
- Pintus Stefania
- Pius Riinu
- Planche Tim
- Plotkin Daniel
- Pollakis Georgios
- Pooni Jagtur Singh
- Post Frank
- Price David
- Price Nicholas
- Prince Tessa
- Prout Rachel
- Rae Nikolas
- Rambaut Andrew
- Reschreiter Henrik
- Reynolds Tim
- Reynolds Will
- Richardson Neil
- Ridley P Matthew
- Roberts Devender
- Roberts Mark
- Roberts Stephanie
- Robertson David L.
- Rose Alistair
- Rousseau Guy
- Ruge Bobby
- Russell Clark D.
- Ryan Brendan
- Sales Debby
- Saluja Taranprit
- Sancho-Shimizu Vanessa
- Sands Caroline J.
- Saviciute Egle
- Schmid Matthias L.
- Scott Janet T.
- Scott-Brown James
- Semple Malcolm G.
- Semple Malcolm G.
- Shah Aarti
- Shankar-Hari Manu
- Shanmuga Prad
- Sharma Anil
- Shaw Catherine A.
- Shaw Victoria
- Shaw Victoria E.
- Shawcross Anna
- Shears Rebecca K.
- Sigfrid Louise
- Sizer Jeremy
- Small Benjamin
- Smith Richard
- Snelson Catherine
- Solomon Tom
- Spencer Rebecca G.
- Spittle Nick
- Sriskandan Shiranee
- Staines Nikki
- Stambach Tom
- Stewart Richard
- Stuart David
- Subramaniam Krishanthi S.
- Subudhi Pradeep
- Summers Charlotte
- Swann Olivia V.
- Szakmany Tamas
- Szemiel Agnieska
- Taggart Aislynn
- Tait Sarah
- Takats Zoltan
- Takis Panteleimon
- Tanianis-Hughes Jolanta
- Tatham Kate
- Tedder Richard S.
- Thomas Jo
- Thomas Jordan
- Thompson A. A. Roger
- Thompson Chris
- Thompson Robert
- Thomson Emma C.
- Thwaites Ryan S.
- Tonder Libby van
- Tridente Ascanio
- Trochu Erwan
- Tupper-Carey Darell
- Turtle Lance C.W.
- Twagira Mary
- Vallotton Nick
- Vancheeswaran Rama
- Vincent-Smith Lisa
- Vink Elen
- Visuvanathan Shico
- Vuylsteke Alan
- Waddy Sam
- Wake Rachel
- Walden Andrew
- Welters Ingeborg
- Wham Murray
- Whitehouse Tony
- Whittaker Paul
- Whittington Ashley
- Wijesinghe Meme
- Wilcock Eve
- Williams Martin
- Wilson Lawrence
- Winchester Stephen
- Wiselka Martin
- Wolverson Adam
- Wootton Daniel G.
- Workman Andrew
- Wrobel Nicola
- Yates Bryan
- Young Peter
- Zambon Maria
- Zhang J. Eunice
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 30/11/2022
- Field of study
Background
We conducted this study to assess the prevalence of viral coinfection in a well characterized cohort of hospitalized coronavirus disease 2019 (COVID-19) patients and to investigate the impact of coinfection on disease severity.
Methods
Multiplex real-time polymerase chain reaction testing for endemic respiratory viruses was performed on upper respiratory tract samples from 1002 patients with COVID-19, aged <1 year to 102 years old, recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK study. Comprehensive demographic, clinical, and outcome data were collected prospectively up to 28 days post discharge.
Results
A coinfecting virus was detected in 20 (2.0%) participants. Multivariable analysis revealed no significant risk factors for coinfection, although this may be due to rarity of coinfection. Likewise, ordinal logistic regression analysis did not demonstrate a significant association between coinfection and increased disease severity.
Conclusions
Viral coinfection was rare among hospitalized COVID-19 patients in the United Kingdom during the first 18 months of the pandemic. With unbiased prospective sampling, we found no evidence of an association between viral coinfection and disease severity. Public health interventions disrupted normal seasonal transmission of respiratory viruses; relaxation of these measures mean it will be important to monitor the prevalence and impact of respiratory viral coinfections going forward
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