67 research outputs found
Reliability of Longitudinal Brain Volume Loss Measurements between 2 Sites in Patients with Multiple Sclerosis: Comparison of 7 Quantification Techniques
Brain perfusion in dementia with Lewy bodies and Alzheimer’s disease: an arterial spin labeling MRI study on prodromal and mild dementia stages
The first Ru(II) bipyridyl-capped cyclodextrin: Evidence of electron- transfer through the cavity
Glycosidic Bond Expanded Cyclic Oligosaccharides: Synthesis and HostGuest Binding Property of a Cyclic Pentasaccharide
Self-assembled monolayers of a-cyclodextrin derivatives on gold and their host-guest behaviour
Docobalt cluster functionalized 2,2':6',2"-terpyridine ligands and their ruthenium(II) complexes
A series of 2.2`:6`.2``-terpyridine (tpy) ligands functionalized in the 4`-position with alkyne substituents has been prepared and characterized. Treatment of these ligands with [RuCl3(tpy)] yields complexes with pendant alkyne groups which then readily react with Co-2(CO)(8) to give novel compounds containing both cluster and classical coordination motifs. The new compounds are characterized by mass spectrometric and spectroscopic methods, and the single crystal structure of [Ru(tpy)(4`-HC=CCH(2)Otpy)][PF6](2) is reported. (C) 2001 Elsevier Science B.V. All rights reserved
Aza-capped cyclodextrins for intra-cavity metal complexation
International audienceAza-capped, methylated cyclodextrins (CDs) were obtained in high yields by reacting the soft nitrogen nucleophile 2-nitrobenzenesulfonamide with either A, B-dimesylated CDs in basic media or their diol analogues under Mitsunobu reaction conditions followed by deprotection with thiophenol. A methyl pyridine substituent was grafted on the N atom of these secondary amines. When built on an alpha-CD scaffold, the resulting tertiary amine no longer undergoes nitrogen inversion at room temperature and behaves as a confining ligand, opening the way to intra-cavity metal complexation and promoting the formation of supramolecular helices
Supplementary Material for: Functional Disconnectivity during Inter-Task Resting State in Dementia with Lewy Bodies
<b><i>Aims:</i></b> Limited research has been done on the functional connectivity in visuoperceptual regions in dementia with Lewy bodies (DLB) patients. This study aimed to investigate the functional connectivity differences between a task condition and an inter-task resting state condition within a visuoperceptual paradigm, in DLB patients compared with Alzheimer disease (AD) patients and healthy elderly control subjects. <b><i>Methods:</i></b> Twenty-six DLB, 29 AD, and 22 healthy subjects underwent a detailed clinical and neuropsychological examination along with a functional MRI during the different conditions of a visuoperceptual paradigm. Functional images were analyzed using group-level spatial independent component analysis and seed-based connectivity analyses. <b><i>Results:</i></b> While the DLB patients scored well and did not differ from the control and AD groups in terms of functional activity and connectivity during the task conditions, they showed decreased functional connectivity in visuoperceptual regions during the resting state condition, along with a temporal impairment of the default-mode network activity. Functional connectivity disturbances were also found within two attentional-executive networks and between these networks and visuoperceptual regions. <b><i>Conclusion:</i></b> We found a specific functional profile in the switching between task and resting state conditions in DLB patients. This result could help better characterize functional impairments in DLB and their contribution to several core symptoms of this pathology such as visual hallucinations and cognitive fluctuations
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