Uji Aktivitas Antioksidan Dari Ekstrak Bekatul Padi Ketan Merah Dan Hitam (Oryza Sativa L. Var. Glutinosa) Dan Formulasinya Dalam Sediaan Krim

Rice bran is a by-product of rice milling process that contain bioactive compounds such as tocopherol, tocotrienol, and oryzanol. This study aimed to test the antioxidant activity of the extract of red and black glutinous rice bran (Oryza sativa L. var. glutinosa) and then formulatethem into cream. Testing of antioxidant activity using DPPH (2,2-diphenyl-1-pikrihidrazil). The IC50 of the extract of red and black glutinous rice bran are 31.7525 and 434.7525 ppm, respectively. Subsequently, extract of red and black glutinous rice bran is formulated into type o/w cream with concentration of 2.5%. The results of evaluation of physical cream consist of organoleptic, homogeneity, pH, stability to temperature changes, power test spread, test of power washed and test of irritation. The results showed that the cream of both red (FI) and black (FII) glutinous rice bran extract meet the physical properties requirements and do not irritate during the 8 weeks of storage. The result of antioxidant activity test showed that inhibition percentage of FI and FII are 95.0974 and 92.3569% in the first week, and 89.9576 and 86.9537% in the eighth week, respectively. Key words: extract of rice bran, glutinous rice bran red, glutinous rice bran black, antioxidant, cream

Formulasi Losion Antioksidan Ekstrak Buah Stroberi (Fragaria Ananassa)

Penelitian tentang formulasi losion antioksidan dari ekstrak buah stroberi (Fragaria ananassa) dengan konsentrasi 0,5; 1; dan 2% telah dilakukan. Aktivitas antioksidan losion ditentukan dengan menghitung nilai IC50. Aktivitas antioksidan losion pada konsentrasi 0,5; 1; dan 2% dinilai sebagai antioksidan yang sangat kuat, dengan nilai IC50 berturut-turut 0,47 ppm; 0,82 ppm; dan 1,53 ppm. Evaluasi formula losion antioksidan meliputi organoleptis, homogenitas, stabilitas, dan pH. Hasil penelitian menunjukkan bahwa sediaan losion tidak berubah dan stabil selama 8 minggu penyimpanan

Corn cutworm control 1985

"This guide recommends management practices and insecticides for reduction of injury caused by the various cutworms attacking corn in Missouri. It also discusses the life cycles of the more common species which feed at and below ground and those species which are primarily above ground foliage feeders."--First page.Gene Munson, Armon J. Keaster, Richard N. Story and Judy A. Grundler (Department of Entomology, College of Agriculture)Revised 2/85/5

Corn cutworm control for 1983

"This guide recommends management practices and insecticides for reduction of injury caused by the various cutworms attacking com in Missouri. It also discusses the life cycles of the more common species which feed at and below ground and those species which are primarily above ground foliage feeders."--First page.George W. Thomas, Armon J. Keasler, Richard N. Story and Judy A. Grundler (Department of Entomology, College of Agriculture)Revised 2/83/8

Synoptic-scale to mesoscale atmospheric circulation connects fluvial and coastal gravel conveyors and directional deposition of coastal landforms in the Dead Sea basin

Streams convey coarse-clastic sediments towards coasts, where interactions with deltaic and coastal processes determine their resultant sedimentology and geomorphology. Extracting hydroclimatic signals from such environments is a desired goal, and therefore studies commonly rely on interpreting available paleoclimatic proxy data, but the direct linking of depositional and geomorphic processes with the hydroclimate remains obscure. This is a consequence of the challenge of linking processes that are often studied separately and span across large spatial and temporal scales, including synoptic-scale hydroclimatic forcing, streamflows, water body hydrodynamics, fluvial and coastal sediment transport, and sedimentation. Here, we explore this chain of connected processes in the unique setting of the Dead Sea basin, where present-day hydroclimatology is closely tied with geomorphic evolution and sediment transport of streams and coasts that rapidly respond to lake-level fall. We use a 5-year (2018–2022) rich dataset of (i) high-resolution synoptic-scale circulation patterns, (ii) continuous wind-wave and rain–flood records, and (iii) storm-scale fluvial and coastal sediment transport of “smart” and marked boulders. We show the significance of Mediterranean cyclones in the concurrent activation of fluvial (floods) and coastal (wind waves) sediment conveyors. These synoptic-scale patterns drive the westerlies necessary for (i) delivering the moisture across the Judean desert, which is transformed into floods, and at the same time, (ii) the coeval, topographically funneled winds that turn into surface southerlies (&gt;10 m s−1) along the Dead Sea rift valley. During winter, these mesoscale southerlies generate 10–30 high-amplitude, northward-propagating storm waves, with &lt;4 m wave heights. Such waves transport cobbles for hundreds of meters alongshore, northward and away from the supplying channel mouths. Four to nine times per winter the rainfall generated by these atmospheric patterns is capable of generating floods that reach the stream mouths, delivering poorly sorted, coarse gravel. This usually occurs during the decay of the associated storm waves. This gravel is dispersed alongshore by waves during subsequent storms. As storm waves dominate and are &gt;5 times more frequent than flash floods, coarse-clastic beach berms and fan deltas are deposited preferentially north of the delivering channel mouths. This asymmetric depositional architecture, controlled by the regional hydroclimatology, is identified for both the modern and late Pleistocene coast and delta environments, implying that the dominance of present-day Mediterranean cyclones also persisted in the region during the late Pleistocene when Lake Lisan occupied the basin.</p

Laser Printing of Multilayered Alternately Conducting and Insulating Microstructures

Production of multilayered microstructures composed of conducting and insulating materials is of great interest as they can be utilized as microelectronic components. Current proposed fabrication methods of these microstructures include top-down and bottom-up methods, each having their own set of drawbacks. Laser-based methods were shown to pattern various materials with micron/sub-micron resolution; however, multilayered structures demonstrating conducting/insulating/conducting properties were not yet realized. Here, we demonstrate laser printing of multilayered microstructures consisting of conducting platinum and insulating silicon oxide layers by a combination of thermally driven reactions with microbubble-assisted printing. PtCl2 dissolved in N-methyl-2-pyrrolidone (NMP) was used as a precursor to form conducting Pt layers, while tetraethyl orthosilicate dissolved in NMP formed insulating silicon oxide layers identified by Raman spectroscopy. We demonstrate control over the height of the insulating layer between ∼50 and 250 nm by varying the laser power and number of iterations. The resistivity of the silicon oxide layer at 0.5 V was 1.5 × 1011 ωm. Other materials that we studied were found to be porous and prone to cracking, rendering them irrelevant as insulators. Finally, we show how microfluidics can enhance multilayered laser microprinting by quickly switching between precursors. The concepts presented here could provide new opportunities for simple fabrication of multilayered microelectronic devices

Identifying barriers to patient acceptance of active surveillance: content analysis of online patient communications.

OBJECTIVES: Qualitative research aimed at identifying patient acceptance of active surveillance (AS) has been identified as a public health research priority. The primary objective of this study was to determine if analysis of a large-sample of anonymous internet conversations (ICs) could be utilized to identify unmet public needs regarding AS. METHODS: English-language ICs regarding prostate cancer (PC) treatment with AS from 2002-12 were identified using a novel internet search methodology. Web spiders were developed to mine, aggregate, and analyze content from the world-wide-web for ICs centered on AS. Collection of ICs was not restricted to any specific geographic region of origin. NLP was used to evaluate content and perform a sentiment analysis. Conversations were scored as positive, negative, or neutral. A sentiment index (SI) was subsequently calculated according to the following formula to compare temporal trends in public sentiment towards AS: [(# Positive IC/#Total IC)-(#Negative IC/#Total IC) x 100]. RESULTS: A total of 464 ICs were identified. Sentiment increased from -13 to +2 over the study period. The increase sentiment has been driven by increased patient emphasis on quality-of-life factors and endorsement of AS by national medical organizations. Unmet needs identified in these ICs include: a gap between quantitative data regarding long-term outcomes with AS vs. conventional treatments, desire for treatment information from an unbiased specialist, and absence of public role models managed with AS. CONCLUSIONS: This study demonstrates the potential utility of online patient communications to provide insight into patient preferences and decision-making. Based on our findings, we recommend that multidisciplinary clinics consider including an unbiased specialist to present treatment options and that future decision tools for AS include quantitative data regarding outcomes after AS

A selective eradication of human nonhereditary breast cancer cells by phenanthridine-derived polyADP-ribose polymerase inhibitors

INTRODUCTION: PARP-1 (polyADP-ribose polymerase-1) is known to be activated in response to DNA damage, and activated PARP-1 promotes DNA repair. However, a recently disclosed alternative mechanism of PARP-1 activation by phosphorylated externally regulated kinase (ERK) implicates PARP-1 in a vast number of signal-transduction networks in the cell. Here, PARP-1 activation was examined for its possible effects on cell proliferation in both normal and malignant cells. METHODS: In vitro (cell cultures) and in vivo (xenotransplants) experiments were performed. RESULTS: Phenanthridine-derived PARP inhibitors interfered with cell proliferation by causing G2/M arrest in both normal (human epithelial cells MCF10A and mouse embryonic fibroblasts) and human breast cancer cells MCF-7 and MDA231. However, whereas the normal cells were only transiently arrested, G2/M arrest in the malignant breast cancer cells was permanent and was accompanied by a massive cell death. In accordance, treatment with a phenanthridine-derived PARP inhibitor prevented the development of MCF-7 and MDA231 xenotransplants in female nude mice. Quiescent cells (neurons and cardiomyocytes) are not impaired by these PARP inhibitors. CONCLUSIONS: These results outline a new therapeutic approach for a selective eradication of abundant nonhereditary human breast cancers

Barriers and facilitators of access to psychological services for indigenous populations: A scoping review and thematic analysis

Background: The extent to which behavior-analytic interventions are offered to Indigenous populations across CANZUS in accessible and culturally appropriate ways is unknown. We conducted a scoping review with a thematic analysis of the extant literature to find: (1) what are the barriers and facilitators for providing effective and equitable delivery of psychological services (with a behavioral component) to Indigenous populations; and (2) what tools and practices exist for an effective and equitable service delivery. Methods: We systematically reviewed Medline, CINAHL, PubMed, PsycInfo, Web of science, Ovid and INNZ databases between 1990 and 2020. For the scoping review, we adhered to the JBI methodological approach (2015) and the PRISMA strategy for the identification, selection, and appraisal of the reviewed articles. A total of 1265 unique articles met the criteria for the screening by title; 238 by abstract; 57 were included for full text assessment; and 37 were included in the final analysis. Results: Three themes were revealed to account for the barriers and facilitators of culturally friendly practices: (1) connecting practices are about interactions shaping the relationship between service provider and service client; (2) innovative practices test new approaches and innovations that could facilitate access to psychological services and overcome barriers, and (3) reflective practices are about critically examining the processes and actions undertaken toward effective cultural adaptation of services. Conclusions: Our analysis suggests that the level of success in bringing together services and the recipients of treatment (connection), showing flexibility and persistence in finding solutions (innovation) and examining the role of our behaviors in reaching our goals (reflection) is determined by the providers' action in the aforementioned three dimensions of practice

Oral rehydration versus intravenous therapy for treating dehydration due to gastroenteritis in children: a meta-analysis of randomised controlled trials

BACKGROUND: Despite treatment recommendations from various organizations, oral rehydration therapy (ORT) continues to be underused, particularly by physicians in high-income countries. We conducted a systematic review of randomised controlled trials (RCTs) to compare ORT and intravenous therapy (IVT) for the treatment of dehydration secondary to acute gastroenteritis in children. METHODS: RCTs were identified through MEDLINE, EMBASE, CENTRAL, authors and references of included trials, pharmaceutical companies, and relevant organizations. Screening and inclusion were performed independently by two reviewers in order to identify randomised or quasi-randomised controlled trials comparing ORT and IVT in children with acute diarrhea and dehydration. Two reviewers independently assessed study quality using the Jadad scale and allocation concealment. Data were extracted by one reviewer and checked by a second. The primary outcome measure was failure of rehydration. We analyzed data using standard meta-analytic techniques. RESULTS: The quality of the 14 included trials ranged from 0 to 3 (Jadad score); allocation concealment was unclear in all but one study. Using a random effects model, there was no significant difference in treatment failures (risk difference [RD] 3%; 95% confidence intervals [CI]: 0, 6). The Mantel-Haenzsel fixed effects model gave a significant difference between treatment groups (RD 4%; 95% CI: 2, 5) favoring IVT. Based on the four studies that reported deaths, there were six in the IVT groups and two in ORT. There were no significant differences in total fluid intake at six and 24 hours, weight gain, duration of diarrhea, or hypo/hypernatremia. Length of stay was significantly shorter for the ORT group (weighted mean difference [WMD] -1.2 days; 95% CI: -2.4,-0.02). Phlebitis occurred significantly more often with IVT (number needed to treat [NNT] 33; 95% CI: 25,100); paralytic ileus occurred more often with ORT (NNT 33; 95% CI: 20,100). These results may not be generalizable to children with persistent vomiting. CONCLUSION: There were no clinically important differences between ORT and IVT in terms of efficacy and safety. For every 25 children (95% CI: 20, 50) treated with ORT, one would fail and require IVT. The results support existing practice guidelines recommending ORT as the first course of treatment in appropriate children with dehydration secondary to gastroenteritis