The social consequences of industrial accidents : disabled mine workers in Lesotho

No abstract providedGR 201

MT-WAVE: Profiling multi-tier web applications

The web is evolving: what was once primarily used for sharing static content has now evolved into a platform for rich client-side applications. These applications do not run exclusively on the client; while the client is responsible for presentation and some processing, there is a significant amount of processing and persistence that happens server-side. This has advantages and disadvantages. The biggest advantage is that the user’s data is accessible from anywhere. It doesn’t matter which device you sign into a web application from, everything you’ve been working on is instantly accessible. The largest disadvantage is that large numbers of servers are required to support a growing user base; unlike traditional client applications, an organization making a web application needs to provision compute and storage resources for each expected user. This infrastructure is designed in tiers that are responsible for different aspects of the application, and these tiers may not even be run by the same organization. As these systems grow in complexity, it becomes progressively more challenging to identify and solve performance problems. While there are many measures of software system performance, web application users only care about response latency. This “fingertip-to-eyeball performance” is the only metric that users directly perceive: when a button is clicked in a web application, how long does it take for the desired action to complete? MT-WAVE is a system for solving fingertip-to-eyeball performance problems in web applications. The system is designed for doing multi-tier tracing: each piece of the application is instrumented, execution traces are collected, and the system merges these traces into a single coherent snapshot of system latency at every tier. To ensure that user-perceived latency is accurately captured, the tracing begins in the web browser. The application developer then uses the MT-WAVE Visualization System to explore the execution traces to first identify which system is causing the largest amount of latency, and then zooms in on the specific function calls in that tier to find optimization candidates. After fixing an identified problem, the system is used to verify that the changes had the intended effect. This optimization methodology and toolset is explained through a series of case studies that identify and solve performance problems in open-source and commercial applications. These case studies demonstrate both the utility of the MT-WAVE system and the unintuitive nature of system optimization

Non-Functional Parathyroid Adenoma Presenting as a Massive Cervical Hematoma: A Case Report

Parathyroid adenoma usually manifests with symptoms related to hypercalcemia, such as urinary stone and bone fracture. It may also present with asymptomatic hypercalcemia. However, spontaneous cervical hematoma may occur very rarely as a result of extracapsular hemorrhage of a cervical parathyroid adenoma causing acute painful cervical swelling, bruising, dyspnea, hoarseness and dysphagia. We report a 44-year-old woman who manifested as a spontaneous cervical hematoma without any clinical evidence of hyperparathyroidism

Deposition of fluorescent NIPAM-based nanoparticles on solid surfaces: quantitative analysis and the factors affecting it

Recently, responsive surfaces have attracted attention due to their potential applications. Reported research have studied the deposition of environmentally responsive particles on different surfaces, qualitatively tested their response to environmental conditions and studied their possible applications. In this work, novel fluorescent temperature-sensitive nanoparticles were synthesized using a surfactant free emulsion polymerization technique: poly(N-isopropylacrylamide-co-5% vinyl cinnamate) (p(NIPAM)5%VC). The new particles were characterized using dynamic light scattering and fluorescence spectroscopy. A novel sensitive method for the quantitative analysis of p(NIPAM) 5% VC using fluorescence spectroscopy was developed to determine the concentration of nanoparticle dispersions. This was further used to quantitatively determine the mass of nanoparticles deposited per unit area of glass pre-treated with acid, glass pre-treated with base, quartz, stainless steel, gold and teflon at 25 °C and 60 °C. Factors affecting the adsorption/desorption of the nanoparticles were studied, including the effect of substrate surface charge, surface roughness (using atomic force microscopy, AFM), hydrophilicity/hydrophobicity and the temperature at which the adsorption/desorption experiments were carried out. The results show that the effect of surface charge is the most significant, followed by that of surface roughness and temperature. Meanwhile, the influence of the hydrophobicity/hydrophilicity of the surface on the adsorption/desorption of nanoparticles appears to be far less significant than the previously mentioned factors

Assessment of pulmonary artery pressure by echocardiography—A comprehensive review

Pulmonary hypertension is a pathological haemodynamic condition defined as an increase in mean pulmonary arterial pressure ≥ 25mmHg at rest, assessed using gold standard investigation by right heart catheterisation. Pulmonary hypertension could be a complication of cardiac or pulmonary disease or a primary disorder of small pulmonary arteries. Elevated pulmonary pressure (PAP) is associated with increased mortality, irrespective of the aetiology. The gold standard for diagnosis is invasive right heart catheterisation, but this has its own inherent risks. In the past 30 years, immense technological improvements in echocardiography have increased its sensitivity for quantifying pulmonary artery pressure (PAP) and it is now recognised as a safe and readily available alternative to right heart catheterisation. In future, scores combining various echo techniques can approach the gold standard in terms of sensitivity and accuracy, thereby reducing the need for repeated invasive assessments in these patients