Razina tjelesne pripremljenosti mladih odraslih osoba s intelektualnim poteškoćama i bez njih

Intellectual disability (ID) and living in residential home settings may be a disadvantage for an active lifestyle and healthy aging. The purpose of this study was to determine physical fitness levels of women with mild intellectual disabilities (n=31; mean age 22.22±3.11 years), clients of residential homes, and to compare them to the levels of their control peers (n=31; 23.16±3.12 years of age). First, cardiovascular disease risk factors (CVD) of the participants were determined based on the information from residential home doctor, participants’ health reports, and blood samples. Health-related physical fitness parameters (balance, cardiorespiratory endurance, muscular endurance, and flexibility) were measured, and body composition and anaerobic power were assessed. The significant differences were found between the groups (p<.05) in body mass index, muscular endurance, maximum walking distance, peak VO2, balance, flexibility, and power. The results of the study indicated that the fitness levels of women with ID were lower than those of their control peers. Women with ID should be encouraged to participate in physical activity programs to improve their physical fitness.Intelektualne poteškoće i život u domu mogu nepovoljno utjecati na aktivan životni stil i zdravo starenje. Cilj ovog istraživanja bio je utvrditi razinu tjelesne pripremljenosti žena s lakšim intelektualnim poteškoćama (n=31; prosječna dob 22,22 ± 3,11 godina), korisnika domova za nemoćne te ih usporediti s vrijednostima njihovih vršnjakinja u kontrolnoj skupini (n=31; dob 23,16 ± 3,12 godina). Na temelju podataka dobivenih od liječnika iz domova te zdravstvenih izvješća sudionika i analiza uzoraka krvi, najprije su određeni rizični faktori za razvoj karidiovaskularnih bolesti. Izmjereni su parametri zdravstvenog fitnesa (ravnoteža, kardiorespiratorna izdržljivost, mišićna izdržljivosti i fleksibilnost) te su procijenjeni sastav tijela i anaerobna izdržljivost. Dobivene su značajne razlike između skupina (p<=0,05) u indeksu tjelesne mase, mišićnoj izdržljivost, maksimalnoj prehodanoj udaljenosti, vršnom VO2, ravnoteži, fleksibilnosti i snazi. Rezultati istraživanja pokazuju da je razina tjelesne pripremljenosti žena s intelektualnim poteškoćama bila niža od razine dobivene u kontrolnoj skupini njihovih vršnjakinja. Žene s intelektualnim poteškoćama trebalo bi poticati da sudjeluju u programima tjelesne aktivnosti kako bi poboljšale svoju fizičku pripremljenost

Characterization of greater middle eastern genetic variation for enhanced disease gene discovery

The Greater Middle East (GME) has been a central hub of human migration and population admixture. The tradition of consanguinity, variably practiced in the Persian Gulf region, North Africa, and Central Asia1-3, has resulted in an elevated burden of recessive disease4. Here we generated a whole-exome GME variome from 1,111 unrelated subjects. We detected substantial diversity and admixture in continental and subregional populations, corresponding to several ancient founder populations with little evidence of bottlenecks. Measured consanguinity rates were an order of magnitude above those in other sampled populations, and the GME population exhibited an increased burden of runs of homozygosity (ROHs) but showed no evidence for reduced burden of deleterious variation due to classically theorized ‘genetic purging’. Applying this database to unsolved recessive conditions in the GME population reduced the number of potential disease-causing variants by four- to sevenfold. These results show variegated genetic architecture in GME populations and support future human genetic discoveries in Mendelian and population genetics

Prospective English Language Teachers' Views On Literature In Their Teacher Education Curriculum And Its Potential Value

Foreign language teachers use literary texts in their classrooms for their potential practical uses among which the existence of their enriched lexis is the leading one. Still, much research is needed to map and develop literature teaching in foreign language classrooms in Turkey. In this study, views of prospective English language teachers on literature and its place in their teacher education curriculum are studied. Eighty-four second and third year prospective teachers of English participated in this study. A five point Likert-type scale including 24 questions was developed and the reliability of the scale was found to be .962, pointing at the scale's high internal reliability. The findings indicated that 78% of the prospective teachers have positive feelings about literature courses in their teacher education programs. In terms of the genres, although accepting the novel and short story as important genres, majority of them do not think that poetry is an important genre that can be used in EFL classrooms. Although most of the participants believe that literature courses help learning about the target culture while developing students' lexis, in terms of language skills, they do not fully agree that speaking can be developed by means of literature.WoSScopu

Effect of Coronatine on Antioxidant Enzyme Response of Chickpea Roots to Combination of PEG-Induced Osmotic Stress and Heat Stress

WOS: 000314295600007Abiotic stresses, such as high temperature and drought, are major limiting factors of crop production and growth. Coronatine (COR), a structural and functional analog of jasmonates, is suggested to have a role in abiotic stress tolerance. The aim of our study was to examine whether pretreatment with COR enhances the tolerance of chickpea (Cicer arietinum L. cv ICC 4958) roots to PEG-induced osmotic stress, heat stress, and their combination. Therefore, seedlings raised hydroponically in a growth chamber for 15 days were pretreated with or without COR at 0.01 mu M for 24 h and then exposed to 6 % PEG 6000-induced osmotic stress or heat (starting at 35 A degrees C and then gradually increased 1 A degrees C every 15 min and kept at 44 A degrees C for 1 h) stress for 3 days. After different treatment periods, the changes in relative growth rate (RGR); malondialdehyde (MDA), proline (Pro), and hydrogen peroxide (H2O2) contents; and the activities of antioxidant enzymes/isoenzymes in roots of chickpea seedlings with or without 0.01 mu M COR application were studied. RGR in roots was increased by COR application. Under all stress conditions, H2O2, MDA, and Pro levels increased sharply, but pretreatment with COR significantly reduced them. Moreover, COR increased the activities of H2O2 scavenger enzymes such as catalase (CAT) under heat stress, ascorbate peroxidase (POX) under PEG stress, and CAT and POX under combined stresses. Therefore, COR might alleviate adverse effects of PEG stress and heat stress and combined stresses on roots of chickpea by reduction of H2O2 production, enhancing or keeping the existent activity of antioxidant enzymes, thereby preventing membrane peroxidation.Ege University Research FoundationEge University [2009-FEN-014]This work was supported by Ege University Research Foundation (2009-FEN-014). The authors thank Dr. Carol Bender of Oklahoma State University for kindly providing pure coronatine and Prof. Dr. Cengiz Toker of Akdeniz University for providing Cicer arietinum ICC 4958 seeds

MDR1 C3435T POLYMORPHISM: A PRELIMINARY STUDY ON ITS RELATIONSHIP WITH THE RISK OF COLORECTAL CANCER

Objective: Colorectal carcinoma (CRC) is the third most frequent cancer in the world and a heterogenious disease which aroze from one or a combination of different genetic mechanisms. The multiple drug resistance-1 (MDR1) gene which encodes P-glycoprotein (P-gp) plays a part in the bioavailability of drugs and cell toxicity. In the current study, we aimed to investigate the possible relation between the MDR1 gene C3435T polymorphism and CRC risk in the Turkish population

Whole mitochondrial genome analysis of a family with NARP/MILS caused by m.8993T > C mutation in the MT-ATP6 gene

Mutations in mitochondrial DNA (mtDNA) encoded nucleotide 8993 can cause NARP syndrome (neuropathy, ataxia, and retinitis pigmentosa) or MILS (maternally inherited Leigh syndrome). The rare T8993C mutation in the MT-ATP6 gene is generally considered to be clinically milder, but there is marked clinical heterogeneity ranging from asymptomatic carriers to fatal infantile Leigh syndrome. Clinical heterogeneity has mostly been attributed to mtDNA heteroplasmy, but environmental, autosomal, tissue-specific factors, nuclear modifier genes, and mtDNA variations may also modulate disease expression. Here, we report the results of whole mitochondrial genome analysis of a family with m.8993T>C mutation in the MT-ATP6 gene and associated with NARP/MILS, and discuss the familial inheritance, effects of variation in combinations and heteroplasmy levels on the clinical findings. The whole mitochondrial genome was sequenced with similar to 182x average depth of coverage per sample with next-generation sequencing technology. Thus, all heteroplasmic (>%10) and homoplasmic variations were determined (except for 727C insertion) and classified according to the associations with mitochondrial diseases. (C) 2012 Elsevier Inc. All rights reserved

Epidemia of Tularemia in Central Anatolia

Simsek, Hulya/0000-0001-8636-9033; Celebi, Bekir/0000-0002-4545-5573; GAZYAGCI, SERKAL/0000-0002-0043-6942WOS: 000281052900003Tularemia is a zoonotic disease caused by Francisella tularensis which can be transmitted to humans by tick bites contaminated water handling infected materials and inhalation. The different clinical types are ulceroglandular, glandular, oropharyngeal, oculoglandular, typhoidal and pneumonic tularemia. Streptomycin and tetracycline are commonly used to treat this infection. In this study approched other patients after the suspected tularemia patient attended to Kirikkale University, Faculty of Medicine with the servical mass complaint at January 2010. To find the reservoir for tularemia, laboratory research was carried on the mice. suspected to be infected with Francisella tularensis in the town of infection

Exercise Capacity, Peripheral Muscle Strength, and Inactivity in Diabetic Patients With Heart Failure

Aim: Studies investigating the effects of type II diabetes mellitus on exercise capacity, peripheral muscle strength, and physical activity level in patients with heart failure are limited. This study aimed to compare maximal exercise capacity, peripheral muscle strength, and physical activity level in patients with heart failure with and without diabetes mellitus