A comparative study of dyslipidaemia in men and woman with androgenic alopecia

Several studies have analyzed the relationship between androgenetic alopecia and cardiovascular disease (mainly heart disease). However few studies have analyzed lipid values in men and women separately. This case-control study included 300 patients consecutively admitted to an outpatient clinic, 150 with early onset androgenetic alopecia (80 males and 70 females) and 150 controls (80 males and 70 females) with other skin diseases. Female patients with androgenic alopecia showed significant higher triglycerides values (123.8 vs 89.43 mg/dl, p = 0.006), total cholesterol values (196.1 vs 182.3 mg/dl, p = 0.014), LDL-C values (114.1 vs 98.8 mg/dl, p = 0.0006) and lower HDL-C values (56.8 vs 67.7 mg/dl, p <0.0001) versus controls respectively. Men with androgenic alopecia showed significant higher triglycerides values (159.7 vs 128.7 mg/dl, p = 0.04) total cholesterol values (198.3 vs 181.4 mg/dl, p = 0.006) and LDL-C values (124.3 vs 106.2, p = 0.0013) versus non-alopecic men. A higher prevalence of dyslipidemia in women and men with androgenic alopecia has been found. The elevated lipid values in these patients may contribute, alongside other mechanisms, to the development of cardiovascular disease in patient with androgenic alopecia.YesVarios estudios han analizado la relación entre la alopecia androgenética y las enfermedades cardiovasculares (especialmente las cardiopatías). Sin embargo pocos estudios han analizado los valores de lípidos en hombres y mujeres por separado. Este caso-control de estudio incluyó a 300 pacientes consecutivos ingresados ​​en una clínica para pacientes ambulatorios, 150 con la aparición temprana alopecia androgenética (80 hombres y mujeres 70) y 150 controles (80 hombres y mujeres 70) con enfermedades de la piel. Mujeres con alopecia androgénica mostraron significativamente más altos valores de triglicéridos (123,8 vs 89,43 mg / dl, p = 0,006), valores de colesterol total (196,1 vs 182,3 mg / dl, p = 0,014), los valores de LDL-C (114,1 vs 98,8 mg / dl , p = 0,0006) y más baja los valores de HDL-C (56,8 vs 67,7 mg / dl, p <0,0001) en comparación con los controles, respectivamente. Los hombres con alopecia androgénica mostraron significativamente más altos valores de triglicéridos (159,7 vs 128,7 mg / dl, p = 0,04) el colesterol total valores (198,3 vs 181,4 mg / dl, p = 0,006) y LDL-C los valores (124,3 vs 106,2, p = 0,0013) en comparación con alopecia hombres . Una mayor prevalencia de la dislipidemia en las mujeres y los hombres con alopecia androgénica se ha encontrado. Los valores elevados de lípidos en estos pacientes puede contribuir, junto con otros mecanismos, para el desarrollo de enfermedad cardiovascular en pacientes con alopecia androgénic

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

Diagnóstico y proyección de vivienda del Municipio de Villanueva (Bolívar) hasta el año 2004

Tesis (Ingeniero Civil).-- Universidad de Cartagena. Facultad de Ciencias E Ingeniería. Programa de Ingeniería Civil, 1999.El presente estudio tiene por objeto analizar y evaluar las condiciones actuales de vivienda del municipio de Villanueva (Bolivar) para realizar un diagnostico, y con base a este proyectar el desarrollo de la vivienda para el año 2004

Calcium enhances polyhydroxyalkanoate production and promotes selective growth of the polyhydroxyalkanoate-storing biomass in municipal activated sludge

Activated sludge from municipal wastewater treatment processes can be used directly for the production of biodegradable polyesters from the family of polyhydroxyalkanoates (PHAs). However, municipal activated sludge typically cannot accumulate PHAs to very high levels and often low yields of polymer produced on substrate are observed. In the present work, it was found that the presence of calcium promotes selective growth and enrichment of the PHA-storing biomass fraction and significantly improved both PHA contents and yields. Calcium addition resulted in PHA contents of 0.60 +/- 0.03 gPHA/gVSS and average PHA yields on substrate of 0.49 +/- 0.03 gCODPHA/gCODHAc compared to 0.35 +/- 0.01 gPHA/gVSS and 0.19 +/- 0.01 gCODPHA/gCODHAc without calcium addition. After 48 h, three times more PHA was produced compared to control experiments without calcium addition. Higher PHA content and selective biomass production is proposed to be a consequence of calcium dependent increased levels of passive acetate uptake. Such more efficient substrate uptake could be related to a formation of calcium acetate complexes. Findings lead to bioprocess methods to stimulate a short-term selective growth of PHA-storing microorganisms and this enables improvements to the techno-economic feasibility for municipal waste activated sludge to become a generic resource for industrial scale PHA production

Skin Cancer Prevalence in Outdoor Workers of Ski Resorts

Background. Snow reflectivity and altitude increase the exposure of ski resort workers to solar ultraviolet radiation. The aim was to assess the presence of skin cancer in ski resorts workers and compare it with other groups of outdoor workers reviewing published studies. Methods. An observational cross-sectional prospective study was conducted in the three largest ski resorts in Spain: Baqueira Beret, Lleida; Formigal, Huesca and Sierra Nevada, Granada. All outdoor workers including ski instructors were invited to participate in the study. The participants completed a validated questionnaire about sun exposure and underwent a skin examination. Results. 219 workers were included in the study (80% male; mean age 43.8 (SD 11.31) years). Actinic keratosis (AK) but no other skin cancers were detected in 32 participants (14.62%). Those with AK worked in the Southernmost ski resort, were more likely to have light colour hair, and were older and with higher photoaging grade than those without them. Conclusion. Compared to other studies, outdoor workers on ski resorts show a higher prevalence of AK than general population but a lower prevalence than other groups of outdoor workers

Monitoring ecological change during rapid socio-economic and political transitions: Colombian ecosystems in the post-conflict era

After more than 50-years of armed conflict, Colombia is now transitioning to a more stable social and political climate due to a series of peace agreements between the government and different armed groups. Consequences of these socio-economic and political changes on ecosystems are largely uncertain, but there is growing concern about derived increases in environmental degradation. Here, we review the capacity of Colombia to monitor the state of its ecosystems and their rate of change over time. We found several important programs currently set in place by different institutions as well as by independent groups of scientists that address different aspects of environmental monitoring. However, most of the current initiatives could be improved in terms of data coverage, quality and access, and could be better articulated among each other. We propose a set of activities that would increase the capacity of Colombia to monitor its ecosystems, provide useful information to policy makers, and facilitate scientific research. These include: 1) the establishment of a national center for ecological synthesis that focuses on analyzing existing information; 2) the establishment of an ecological observatory system that collects new information, integrates remote sensing products, and produces near real-time products on key ecological variables; and 3) the creation of new platforms for dialog and action within existing scientific and policy groups. © 2017 The Author

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele