10 research outputs found
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
- Acampora M
- Accini Mendoza Jl
- Aceto L
- Acevedo B
- Acevedo L
- Acheatel R
- Actis Mv
- Adams M
- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
- Agosta Gf
- Aguilar M
- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
- Akatova E
- Akrap B
- Al Joundi T
- Al-Khalili F
- Albisu J
- Alcalde Jm
- Alcide P
- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
- Andersen K
- Andor M
- Angelova I
- Angiolillo D
- Anita S
- Anker Sd
- Antalik L
- Antonicelli R
- Aparicio Cv
- Apel T
- Apostolovic S
- Ara M
- Aragorn L
- Arango Jl
- Araujo Fonseca M
- Ardissino D
- Arenas Leon Jl
- Arevalo S
- Argiolas G
- Arif I
- Armas E
- Aron G
- Arora S
- Asafu-Adjaye N
- Ashcom T
- Ashford M
- Ashino K
- Asim Oktay Ao
- Assarsson E
- Ata B
- Ather N
- Atieh M
- Aull L
- Avalos V
- Avdonina N
- Awasthi Ak
- Axthelm C
- Ayala M
- Ayasse D
- Ayasse M
- Azizad M
- Azize Gm
- B Becker
- Baar M
- Babu R
- Backer T
- Badea C
- Baden M
- Baehl S
- Baek C
- Baeumer A
- Bagi Es
- Bai A
- Bailey K
- Bailey S
- Bair S
- Baker A
- Baker C
- Bakhai A
- Bakker H
- Baksi A
- Baldin Mg
- Bali Hk
- Ballantyne C
- Ballmajo M
- Balode A
- Balukova E
- Bang Sa
- Banker D
- Banker K
- Baquero A
- Barbarash Ol
- Barbato E
- Barbosa E
- Barnett S
- Baron S
- Barreto M
- Barroso A
- Barroso W
- Bartkowiak A
- Bartosh L
- Bartuseviciene S
- Bashir K
- Baszak J
- Bata Ir
- Bayram E
- Beall K
- Beaudry M
- Beauregard La
- Beckett L
- Belejchak P
- Belle Isle J
- Belohlavek J
- Bendelow T
- Bender D
- Benedetti G
- Benjamin S
- Benton J
- Berdoff R
- Berger V
- Bergeron P
- Bergholtz T
- Bergler-Klein J
- Berk M
- Berli Ma
- Bernstein M
- Berra Fc
- Berti S
- Berulfsen A
- Bevilacqua Mt
- Bhadade S
- Bilazarian S
- Bilodeau N
- Binder A
- Binns Y
- Birdane A
- Bisne V
- Bitzer V
- Blagdon M
- Blahey M
- Blankenberg S
- Blazsek Z
- Bloch S
- Blom Kb
- Bluemel J
- Blumberg C
- Blumenthal R
- Bocanera M
- Bodanese L
- Boffetti P
- Bohra P
- Bohula E
- Boivin Mc
- Bolduc H
- Boley K
- Bolognesi Mg
- Bolsmann C
- Boman K
- Bonner J
- Borrayo Na
- Boström På
- Botelho R
- Botta C
- Boudreaux R
- Boulanger K
- Bourgeois S
- Bouvy C
- Bowen L
- Boyarkin M
- Bradley A
- Brady L
- Bramlet D
- Brath H
- Braun P
- Bredlau C
- Brickman T
- Briggs S
- Briké C
- Brodmann M
- Brons S
- Brousalis L
- Brouwer M
- Brown C
- Brown N
- Brown S
- Buchannan C
- Budaj A
- Budassi N
- Budkova J
- Bugan V
- Buhlman S
- Bulashova O
- Bunschoten P
- Burke W
- Burley T
- Burova N
- Burris H
- Burton C
- Burton J
- Burton M
- Burtt D
- Busak L
- Busic N
- Byars W
- Bøen Rh
- C Clavier-Firmin
- C Conradie
- C Contzen
- C Cotes
- C Covert
- C Cuneo
- Caballero-Valiente B
- Cabau Jr
- Calabrese A
- Campanale Eg
- Candusso R
- Cantor W
- CANTOS Trial Group. Krum H
- Capova L
- Carabajal T
- Carr K
- Carrillo J
- Caruso G
- Casala J
- Caso P
- Casoinic F
- Castillo J
- Castillo T
- Cech V
- Cei L
- Cendali G
- Cepinskiene L
- Cerda L
- Cermak O
- Chachalis G
- Chaggar S
- Chambers J
- Chamblee T
- Chang K
- Chang Kc
- Chang Wh
- Charlier F
- Charmarthi B
- Chattin W
- Chauhan D
- Chauhan H
- Chaussé I
- Chavada J
- Chaverra I
- Chaware G
- Chee L
- Chella S
- Chen Cp
- Chen J
- Chen Mh
- Chen Y
- Chen Yc
- Chen Zc
- Cheng Jj
- Cheng S
- Cheng Sm
- Cherlin R
- Cheung D
- Chhabra A
- Chintala P
- Chiodi L
- Choi Aj
- Chou S
- Chouinard G
- Christensen L
- Christenson S
- Chung A
- Churina S
- Cifkova R
- Ciglenecki N
- Cioffi A
- Cislowski D
- Cleveland T
- Clocotan M
- Cmrecnjak J
- Colfer H
- Colhoun H
- Collier D
- Collins R
- Coloma G
- Colquhoun D
- Colvin T
- Coman S
- Commerford P
- Commerford P
- Conrado Y
- Cools F
- Cornel Jh
- Corona V
- Coronel J
- Cosgrove N
- Cosgrove S
- Cosmi F
- Costa Amorim R
- Coufalova Z
- Covell W
- Cox B
- Cox R
- Craig W
- Crandall L
- Crawford G
- Crea F
- Crepps K
- Crocamo A
- Cromer M
- Cruz H
- Cruz H
- Cruz M
- Csala L
- Cucher F
- Cuentas I
- Cuervo A
- Curiac D
- Cymerman K
- Cyprian R
- Czerski T
- D'Amours Dg
- D Dash
- D Dattani
- D Denham
- D Desai
- D Desalle
- D Digangi
- D Dunn
- Da Costa F
- Da Silva A
- Da Silva D Jr
- Da Silva O Jr
- Dahlen G
- Dalseg Am
- Damron M
- Danik J
- Davalos C
- Dave B
- Dave K
- Davidsson K
- Davies M
- Davies N
- Davis B
- Davis M
- Dawkins-Hughes S
- Dawood Sy
- Dayer M
- De Boer P
- De Caterina R
- De Jong C
- De Knijf K
- De Krumbach L
- De Los Milagros Had M
- De Los Rios M
- De Rosa S
- De Vos A
- De Wolf L
- Dean J
- Debnam S
- Decsi K
- Decsi Kl
- Dedek V
- Dedkova S
- Defosse C
- Degennaro N
- Dehning M
- Dela Llana A
- Delfonso F
- Delforge M
- Delgadillo T
- Dellasa M
- Dellborg M
- Dellorso M
- Demidova M
- Den Hartog F
- Denecke C
- Dengler T
- Dermitzakis A
- Deslongchamps F
- Dessalvi Cc
- Destro M
- Dettmer M
- Devasia T
- Deweerdt N
- Dhanak R
- Dhawan M
- Di Biase M
- Diago M
- Diaz M
- Dicken T
- Dickstein K
- Diederich C
- Diederich M
- Diehl R
- Diller P
- Dimattia M
- Dimitrov G
- Diodati J
- Dobariya H
- Dobilas V
- Dodds G
- Doesborg L
- Doggett J
- Dognini Gp
- Doi M
- Dokupilova A
- Dommerholt R
- Donahue K
- Donath M
- Donaubauer T
- Dong X
- Dormidontova G
- Dorogova I
- Dos Santos A
- Dos Santos F
- Dos Santos P
- Doughty A
- Doughty L
- Dovgalevskiy Y
- Dovgolis S
- Dragutksy B
- Dreese M
- Drost I
- Drouin K
- Duchesne L
- Duckert A
- Duda N
- Dudarev M
- Dudhatra N
- Duff J
- Duhan S
- Dunhurst F
- Dussan Ma
- Dutka C
- Dwenger E
- Dzupina A
- Dékány Jn
- E Eleuteri
- E Englmann
- Earl J
- East C
- Eaton C
- Eaves W
- Ebeling K
- Ebrahim I
- Eccleston D
- Echeverria L
- Eder F
- Edgerton L
- Edillo C
- Edwards J
- Edwards T
- Eichinger G
- Einhorn D
- Eki Y
- El Hachem M
- El Hafi S
- Ellenbroek D
- Ellis M
- Emil B
- Endo T
- Engelen W
- Erhard M
- Erickson B
- Ervin W
- Eskridge L
- Espinosa V
- Everett Bm
- F Fedele
- F Fonseca
- F Fucci
- Facello A
- Facello M
- Faghih M
- Fail P
- Falcon D
- Fang C
- Fang Cy
- Farias E
- Fattal P
- Fawson A
- Feitosa G
- Felario Junior Ga
- Felix L
- Feng Y
- Feng Z
- Ferdinand K
- Ferkl R
- Fernandez Aa
- Ferrari V
- Ferrario M
- Ferraz R
- Ferreira Dos Santos T
- Ferreira-Jardim A
- Fien E
- Filardi Pp
- Filho P
- Fintel D
- Firek C
- Fischer Sm
- Fisher J
- Fitilev S
- Fitz-Patrick D
- Fitzpatrick L
- Flaksa I
- Flather M
- Flezar M
- Fliesser-Goerzer E
- Flores E
- Flores E
- Flores Gs
- Flores H
- Floro T
- Foerster A
- Folkeringa Rj
- Fonseca A
- Fontaine S
- Forgon T
- Forgosh L
- Forker A
- Forster T
- Foster M
- Foucauld J
- Fowler V
- Fox B
- Franco M
- Francoeur L
- Frandsen B
- Frandsen B
- Frankenstein L
- Fratczak M
- Freitas E
- French J
- Frivold G
- Fruchter G
- Fu G
- Fucak E
- Fuchs R
- Fucili A
- Fukuike C
- Fullerton D
- Fulop P
- Fulop T
- Fulwani M
- Furch G
- Furuseth B
- G Gacioch
- G Gosselin
- Gabito A
- Gabor M
- Gabriel J
- Gabrielli D
- Gaeb-Strasas B
- Gamba C
- Ganau A
- Gapon L
- Garas S
- Garcia Duran R
- Garcia Pinna J
- Garcia Rinaldi R
- Garcia F
- Garcia N
- Garcia-Fragoso V
- Garcia-Portela M
- Garner K
- Gazizianova V
- Gelb R
- Genest J
- Genova D
- George F
- Germann H
- Gersh B
- Gervais B
- Ghali J
- Ghondale N
- Ghosh N
- Ghosh S
- Giese C
- Gilbert J
- Gilley J
- Gits F
- Glancy R
- Glenny J
- Glover J
- Glynn Rj
- Godoy Sanchez M
- Goette A
- Goff R
- Goffinet C
- Gohel P
- Goldberg N
- Gomez Sanchez J
- Gonsorcik J
- Gonzales D
- Gonzales V
- Gonzalez E
- Gordeev I
- Gorges R
- Gospodinov K
- Gotcheva N
- Goudev A
- Gould R
- Govindaraj D
- Goyal B
- Goyal S
- Grabeau R
- Grable M
- Graham J
- Graham Ja
- Graif J
- Gralow J
- Gravellone M
- Gravenhorst-Muenter U
- Green E
- Greener R
- Greenway F
- Grieshaber V
- Griffin S
- Grigaraviciene I
- Grigorova V
- Gros C
- Grosse A
- Grover A
- Grundtvig M
- Gudipati Rvc
- Guerrero A
- Guillinta P
- Gundala Ak
- Gupta A
- Gupta A
- Gupta M
- Gupta V
- Gutmann J
- Guzman I
- Guzman P
- Gwyn M
- Gyorgyova E
- H Haldane
- H Hansen
- H Haught
- H Hill
- Haase F
- Haege R
- Haenel T
- Hage F
- Hageman T
- Hagemann D
- Hagenow A
- Hagiwara Y
- Haidar A
- Haider K
- Hakas J
- Haldis T
- Hall C
- Hall L
- Hall S
- Halliwell Tc
- Halpern S
- Hamer Bjb
- Hamud-Socoro A
- Han B
- Han S
- Hanak P
- Hanefeld M
- Hangyal T
- Hansson A
- Hanustiakova A
- Hao Y
- Hardas S
- Hardee L
- Harrell W
- Harrington A
- Harris B
- Hartleib M
- Hartwell J
- Hasan F
- Hasbani E
- Hasegawa K
- Hattler B
- Haughton G
- Haynes E
- Haywood A
- He Y
- He Z
- Heaney L
- Hecht J
- Heeren G
- Hegedus V
- Heider J
- Heisters J
- Henley L
- Hennig D
- Henriksson A
- Hermans K
- Hernandez E
- Hernandez I
- Hernandez M
- Hernández N
- Herrman Jp
- Herzog W
- Hess E
- Hettwer Magedanz E
- Hickey L
- Hiden C
- Hielscher S
- Higuchi T
- Higuchi Y
- Hilkert R
- Hilton T
- Himpel-Boenninghoff A
- Hinderaker P
- Hioki M
- Hirayama A
- Hiroma J
- Ho Cj
- Hodnett P
- Hoffman M
- Hofsoey K
- Hogan C
- Hollanders G
- Holmes Z
- Holoubek D
- Holscher A
- Hominal M
- Homza M
- Hong T
- Hong T
- Hoogslag Pam
- Horackova K
- Horak A
- Hornig M
- Horvat P
- Hosokawa S
- Hotchkiss D
- Houra M
- Hristova K
- Hsieh Ic
- Huang A
- Huang P
- Huang Ph
- Humbert J
- Hurtig U
- Hutchens E
- Huynh T
- Hwang Jj
- Hwang Jj
- Hyun K
- Härstedt N
- Høivik Ho
- I Ilic
- I Ivanov
- Iachini K
- Iannopollo G
- Ibarra J
- Ibarra M
- Ibañez J
- Iby M
- Ichisawa M
- Igbokidi O
- Iijima T
- Ilahi T
- Ilic S
- Ilsley M
- Imbrognio M
- Imre Bs
- Inada T
- Inagaki M
- Indolfi C
- Infusino F
- Invitti C
- Ipp E
- Isaza D
- Istratoaie O
- Istvan Kp
- Iteld B
- Ito K
- Ivan P
- Iveta H
- Izmozherova N
- J Jiang
- J Johnson
- J Johnston
- J Jose
- Jacques G
- Jafri A
- Jafry B
- Jagtap P
- Jaguszewska G
- Jain A
- Jansen M
- Jardula M
- Jayasinghe R
- Jefferson D
- Jenkins R
- Jensen Ed
- Jeric M
- Jerzewski A
- Jeserich M
- Jia Z
- Jiang T
- Jiang X
- Jimenez D
- Jirvankar P
- Johansen Bb
- Johansen E
- Johansson K
- Johnson E
- Jones S
- Jonsson Je
- Joosten C
- Joshi U
- Julien Ve
- JuliĂŁo K
- Jure D
- Jure H
- Jutrisa N
- K Kaigawa
- K Katahira
- K Kiroglu
- K Kordic
- K Kostov
- Kabakchieva Vm
- Kaczmarek N
- Kafarakis P
- Kaiserova L
- Kajihara S
- Kala P
- Kaldara E
- Kalina A
- Kalkman C
- Kam J
- Kamensky G
- Kamiya H
- Kamiya J
- Kan G
- Kaneno Y
- Kanitz S
- Kapp I
- Kara Yd
- Karakai H
- Karel I
- Karpuram M
- Karsai Xz
- Kastelein Jjp
- Kataoka M
- Katona A
- Katova T
- Kaur H
- Kawahara M
- Kawai M
- Kawasaki T
- Kawka-Urbanek T
- Kazanskay E
- Ke Y
- Keba E
- Keenan S
- Kelehan S
- Kellnerova I
- Kelly R
- Kelt T
- Kendall T
- Kereiakes D
- Khan A
- Khan M
- Khan R
- Khan S
- Khariouzov A
- Khirmanov V
- Khromtsova O
- Kick J
- Kiefer R
- Kietselaer B
- Kim B
- Kim Ks
- Kim M
- Kimmel M
- King A
- King T
- Kirkland S
- Kiss Rg
- Kissel S
- Kitchens D
- Klamm M
- Klein C
- Klein P
- Klemsdal To
- Kleve R
- Klugherz B
- Knight J
- Knutsson A
- Koba M
- Kobalava Z
- Kodem Dr
- Koeitti P
- Koenig W
- Kojima E
- Kok M
- Koldas N
- Koleckar P
- Kolikova V
- Kolleroy C
- Kolokathis F
- Komati S
- Komura Y
- Kondagunta V
- Konradi A
- Kooiman E
- Kopaczewski J
- Kopczyńska M
- Korban E
- Koren M
- Kormann A
- Korte M
- Korth-Wiemann B
- Kose V
- Kosmacheva E
- Kostakou P
- Kostis J
- Kotek L
- Kouz Sm
- Kovacic D
- Kovacs A
- Kozak M
- Kozlova S
- Krapivsky A
- Kreckova M
- Kreutter F
- Krupciakova B
- Krupicka J
- Kuenzler J
- Kulibaba E
- Kulkarni L
- Kullal P
- Kultursay H
- Kumar Ks
- Kumbla M
- Kuntzsch A
- Kuo Jy
- Kuramochi T
- Kuruma T
- Kusnick B
- Kuzin A
- Kyo E
- L Levinson
- L Lim
- L Link
- L Liu
- Laane E
- Labovitz R
- Lachance P
- Lai Wt
- Lail J
- Lainscak M
- Lake J
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- Lamance J
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- Landers B
- Landolfi A
- Landzberg J
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- Lazov P
- Ledger G
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- Leggewie S
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- Leimbach W
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- Lembo G
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- Lennard M
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- Levine D
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- Liberato Nl
- Libov I
- Lierse T
- Ligueros M
- Lillo J
- Lima F
- Limaye Ap
- Lin T
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- Lindner C
- Liniado G
- Lino E
- Lipchenko A
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- Liviu C
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- Lohkare M
- Lok Dja
- Long C
- Longaker R
- Lopes R
- Lopez P
- Lorch G
- Lorenc Z
- Lorenzatti A
- Lousberg A
- Lozhkina N
- Lu Z
- Luciardi H
- Lucksinger G
- Luecke-Uzar M
- Luedemann J
- Lukac J
- Lundqvist M
- Lupkovics G
- Luquez H
- Luz Serrano H
- Lv Y
- Lynd S
- Lysek R
- Lönnberg I
- M Malek
- M Mallagray
- M Mandati
- M Mandviwala
- M Marsters
- M Mays
- M Mcdonald
- M Medvegy
- M Meinrich
- M Mikus
- M Milanova
- M Moustafa
- Ma C
- Ma G
- Maboyi S
- Macdonald J
- Macfadyen Jg
- Machova V
- Madder R
- Maehara G
- Maffei L
- Magness K
- Maheshwari A
- Maheux K
- Maia L
- Majercak I
- Majul C
- Makedonska Jj
- Makhe B
- Makotoko E
- Malchikova S
- Maletz L
- Malhotra S
- Malhotra V
- Malik J
- Mancikova I
- Mandic L
- Manenti E
- Manfreda S
- Manga P
- Mani Ck
- Mani H
- Manne S
- Manning B
- Mannucci E
- Manolis A
- Manolis Aj
- Manov E
- Mantas I
- Manuel J
- Manukov D
- Manukov I
- Manyari D
- Manzur F
- Marcela Wenetz Lm
- Marchelletta N
- Marchi Al
- Marcinkeviciene J
- Marcun R
- Marengo Garcia De Carvalho L
- Marinaro S
- Marino P
- Mariottoni B
- Maron B
- Marschke T
- Marshall L
- Martin E
- Martin L
- Martinez E
- Martinez J
- Maruzzo S
- Marziali A
- Masarikova L
- Massaccesi R
- Mathew A
- Matyasek I
- Mauersberger K
- Maus O
- Mavromatis K
- Maximov D
- Mayer T
- Maynard R
- Mays B
- Mazutavicius R
- Mbulaiteye A
- Mcalister R
- Mccoy C
- Mccrary D Jr
- Mccullough-O'Brien H
- Mcgill J
- Mcgrew F
- Mcintosh C
- Mckenzie A
- Mckenzie C
- Mckibbin A
- Mclaurin B
- Mclellan Ba
- Mcmahon G
- Mcneil D
- Mcneill R
- Mcpherson C
- Medina F
- Megalou A
- Mehrle A
- Mehta A
- Mehta S
- Meijlis P
- Meissner A
- Mejia I
- Melbie K
- Mellberg L
- Melliza T
- Mendoza N
- Mendoza Y
- Mercuro G
- Merkely B
- Messina T
- Mestdagh I
- Meyer R
- Michalaros Y
- Michalska A
- Michaud N
- Michel K
- Mickel C
- Micko K
- Mihaly N
- Mikdadi G
- Mikusova T
- Milicic D
- Militaru C
- Miliuniene R
- Milkas A
- Miller A
- Miller C
- Miller G
- Miller R
- Miller W
- Minescu B
- Minocha G
- Mitchell J
- Mittal A
- Miyamoto T
- Moats Djr
- Modi R
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- Yoshimoto E
- Yossen M
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- Younis L
- Youssef G
- Yuan Z
- Yunoki C
- Yupanqui H
- Z Zhai
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- Zhou H
- Zidova M
- Zielinski M
- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Detection of the third heart sound using a tailored wavelet approach: Method verification
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Vitrectomy for Diabetic Macular Edema
- Author
- A Gandorfer
- A Sakamoto
- A Yanyali
- CM Lee
- CM Yang
- D Kent
- ECL Heij
- ETDRS Research Group
- F Kuhn
- FL Ferris 3rd
- FP Nasrallah
- G Effenterre Van
- H Funatsu
- H Hoerauf
- H Lewis
- H Takagi
- J Ahn
- J Sebag
- JF Arevalo
- JI Patel
- JK Chhablani
- JW Harbour
- K Kumagai
- KL Hartley
- M Kakinoki
- M Stefaniotou
- MS Figueroa
- N Bhagat
- N Tachi
- P Massin
- PM Beer
- QD Nguyen
- R Klein
- SD Pendergast
- SE Moss
- T Ikeda
- T Otani
- T Otani
- T Otani
- T Yamamoto
- T Yamamoto
- T Yamamoto
- Y Mochizuki
- Y Seko
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Clinical Evaluation of 64-Slice CT Assessment of Global Left Ventricular Function Using Automated Cardiac Phase Selection
- Author
- Arevalo F Sakamoto T
- Braunwald E Sonnenblick E, Ross J
- de Feyter PJ van Eenige MJ, Dighto
- Hundt W Siebert K, Wintersperger B
- Jacob Geleijns
- Juergens KU Fischbach R
- Koch K Oellig F, Oberholzer K, Ben
- Lu B Mao SS, Zhuang N, Bakhsheshi
- Lucia J.M. Kroft
- Opie LH
- Orakzai SH Orakzai RH, Nasir K, Bu
- Ota T Hein I, Okumura M, Anno H, K
- Raman SV Shah M, McCarthy B, Garci
- Raoul M.S. Joemai
- Sugeng L Mor-Avi V, Weinert L, Nie
- Suzuki S Furui S, Kaminaga T, Yama
- Tavel ME
- Taylor GJ Humphries JO, Mellits ED
- White HD Norris RM, Brown MA, Bran
- Wouter J.H. Veldkamp
- Publication venue
- 'Japanese Circulation Society'
- Publication date
- 01/01/2007
- Field of study
Plasticity in the olfactory bulb of the maternal mouse is prevented by gestational stress
- Author
- A Haim
- A Saghatelyan
- A Veyrac
- AJ Koleske
- AM Sanchez
- AS Fleming
- B Leuner
- B Leuner
- B Leuner
- B Leuner
- C Dickinson
- C Rochefort
- C Rochefort
- C Romero-Grimaldi
- CE Feierstein
- CH Kinsley
- CM Larsen
- CS Woolley
- DA Slattery
- EB Bloss
- EJ Fraser
- F Lazarini
- F Lazarini
- FA Champagne
- FV Smith
- GK Mak
- GK Mak
- H Kopel
- H Shoji
- ID Neumann
- JD Gatewood
- JL Pawluski
- JL Pawluski
- JL Pawluski
- JP Guilloux
- JW Smith
- KM Kendrick
- L Belnoue
- L Belnoue
- LR Meek
- LS Own
- M Alonso
- M Brus
- M Darnaudery
- M Numan
- M Pallotto
- M Pardon
- M Sakamoto
- M Sakamoto
- MA Arevalo
- MC Ostermeyer
- MM Moreno
- MR Farrell
- N Mandairon
- P Taupin
- PJ Brunton
- R Corona
- R Gandelman
- R Gandelman
- RE Brown
- RF Seegal
- RH Porter
- RS Bridges
- S Baker
- S Brummelte
- S Shams
- S Sultan
- S Yoshihara
- SL Ferri
- SM O’Mahony
- SV Puram
- T Shingo
- V Breton-Provencher
- V Lemaire
- W Wang
- WP Smotherman
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Diabetic Retinopathy
- Author
- A Castellarin
- A Kakehashi
- A Miki
- BC Joondeph
- CM Yang
- CM Yang
- CM Yang
- CN Koutsandrea
- D Thomas
- DA Laidlaw
- DF Williams
- DH Steel
- Diabetic Retinopathy rsVitrectomy Study Group
- Diabetic Retinopathy Vitrectomy Study Group
- DP Han
- E Chen
- E Juan de Jr
- Early Treatment Diabetic Retinopathy Study Research Group
- EC Heij La
- EC Heij La
- F Genovesi-Ebert
- F Kuhn
- FI Tolentino
- FT Micelli
- GC Brown
- GW Abrams
- GW Blankenship
- H Ahmadieh
- H Ghoraba
- H Helbig
- H Helbig
- H Lewis
- H Lewis
- H Sawa
- H Takagi
- HW Flynn Jr
- I Karel
- J Oldendoerp
- JB Carter
- JF Arevalo
- JF West
- JH Park
- JJ Scuderi
- JO Mason III
- JS Rinkoff
- JW Harbour
- K Heimann
- K Kadonosono
- L Laatikainen
- L Tong
- LS Morse
- M Gonvers
- M Wand
- MA Novak
- MS Mandelcorn
- MW Ulbig
- N Barzideh
- N Tachi
- N Wilson-Holt
- NM Holekamp
- P Kroll
- P Summanen
- PE Liggett
- PY Ramulu
- RG Michels
- RL Steinmetz
- RP Singh
- RT Oyakawa
- RV Pearson
- S Celebi
- SD Pendergast
- SD Pendergast
- SD Schwatz
- SR Gollamudi
- SR Virata
- T Ikeda
- T Ikeda
- T Otani
- T Sakamoto
- T Sakuraba
- T Yamamoto
- TA Rice
- TA Rice
- TG Chu
- The Diabetic Retinopathy Study Research Group
- The Diabetic Retinopathy Study Research Group
- The Diabetic Retinopathy Vitrectomy Study Research Group
- The Diabetic Retinopathy Vitrectomy Study Research Group
- TM Aaberg
- VS Hershberger
- Y Imamura
- Y Sato
- YH Huang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Estetrol and the brain
- Author
- A Abot
- A Jayaraman
- A Okereafor
- A Quesada
- A Stola
- A Trotter
- AA Hagen
- ACOG
- AD Ramirez
- AJ Khalaj
- AU Zaidi
- B Fleiss
- BJ Deroo
- C Aguirre
- C Gerosa
- C Gibson
- CA Mazzucco
- CB Wade
- CC Aguirre
- CF Holinka
- CM Revankar
- CM Robertson
- CS Ennen
- CY Kuan
- D Stein
- DA Edwards
- DB Dubal
- DM Herrington
- DN Krause
- DT Solum
- DW Brann
- E Tskitishvili
- E Tskitishvili
- E Tskitishvili
- EG Warmerdam
- EH Pettus
- EM Graham
- ER Rosario
- F Acconcia
- F Delaunay
- F Domoki
- F Labombarda
- GR Gordon
- GV Johnson
- H Bartosik-Psujek
- H Sakamoto
- H Xu
- H Xu
- HB Sarnat
- HJTC Coeling Bennink
- HJTC Coelingh Bennink
- HS Lee
- IA Schiering
- J Bryce
- J Kuhn
- J Nilsen
- J Nilsen
- J Nilsen
- J Nilsen
- J Nilsen
- J Nilsen
- J Nilsen
- J Qiu
- J Yao
- JA O’Keefe
- JA Park
- JC Carroll
- JF Arnal
- JJ Cho
- JJ Haigh
- JQ Zhang
- K Grossman
- K Jin
- K Shiota
- KK Koh
- KM Dhandapani
- L Lorenz
- L Prokai
- LJ Currie
- LM Garcia-Segura
- M Ankarcrona
- M Douglas-Escobar
- M Gonzalez
- M Levitz
- M Nomura
- M Rothermundt
- M Singh
- M Singh
- M Thoresen
- M Thoresen
- M Thoresen
- M Visser
- M Zonta
- MA Arevalo
- MM McCarty
- MS Knaap Van der
- N Badawi
- N Badawi
- NJ Alkayed
- O Olah
- OO Ogunshola
- P Dan
- P Kaur
- P Mannella
- P Pacher
- P Rosa La
- PD Gluckman
- PJ Shughrue
- PJ Shughrue
- PM Wise
- PS Quadros
- QG Zhang
- R Li
- RA Alyea
- RC Pierson
- RD Brinton
- RD Brinton
- RD Brinton
- RD Spence
- RE Oakey
- RL Roof
- RL Roof
- RL Roof
- RS Kenchappa
- RW Irwin
- S Barouk
- S He
- S Hirano
- S Raab
- S Samantaray
- S Shankaran
- S Shankaran
- S Suzuki
- S Suzuki
- S Zanelli
- SA Gardiner
- SA Hart
- SJ Mulligan
- SK Mani
- SM Gold
- SM Gold
- SR Hammes
- SW Mitra
- T Funakoshi
- T Hajszan
- T Hoehn
- V Jahagirdar
- VW Henderson
- X Li
- Y Goodman
- Y Zhu
- YC Chang
- Z Ireland
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/05/2019
- Field of study
peer reviewedEstrogens play an important role not only in reproductive system but in the central nervous system as well. Major events of ontogenesis occur earlier in pregnancy are connected to the formation of estrogen receptors and expression of estrogens leading to the normal physiological development of the central nervous system, though development of brain by itself is a complex process and lasts during the whole pregnancy. Estetrol (E4) is a recently described natural estrogen with four hydroxyl-groups that is synthesized exclusively during pregnancy by the human fetal liver. Its role in the central nerovus system is not fully understood. Our studies showed for the first time and proved impressive antioxidative effects of E4 in vitro and proved its tremendous neuroprotective, promyelinating, neurogenic and cerebro-angiogenic properties in vivo. E4 dicreases brain damage markers (S100B and GFAP) in blood assuming that E4 attenuates neonatal hypoxic-ischemic encephalopathy in vivo. We have also shown that the combined use of E4 with other steroids do not have any priority over the signle use of E4. E4’s antioxidative actions mostly depend on ERα and ERβ, whereas neurogenesis and possibly promyelinating activities might be realized through ERβ. Taken together our studies suggest importance of E4 treatment possibly not only in neonates but in adults with different neurological diseases like that that opening new directions for the use of E4 in clinical practice in neurological diseases
Observatory science with eXTP
- Author
- A C Fabian
- A Cumming
- A Cumming
- A Cumming
- A De Rosa
- A De Rosa
- A Deibel
- A Franchini
- A G Markowitz
- A Goldstein
- A Heger
- A J Levan
- A J Levan
- A L Piro
- A L Watts
- A L Watts
- A L Watts
- A M Archibald
- A M Hillas
- A M Soderberg
- A Marinucci
- A Markowitz
- A Markowitz
- A Markowitz
- A O Benz
- A P Marscher
- A Papitto
- A Patruno
- A R Bell
- A R King
- A Rane
- A Rowlinson
- A Rowlinson
- A Santangelo
- A Segura
- A Spitkovsky
- A Tchekhovskoy
- Agata Różańska
- Alberto Pellizzoni
- Alessandra De Rosa
- Alessandro Riggio
- Alexander A. Lutovinov
- Alexander Heger
- Altan Baykal
- Andrea Sanna
- Andrea Santangelo
- Andrea Vacchi
- Andrew Cumming
- Andrzej A. Zdziarski
- Andy Shearer
- Angelo F. Gambino
- Anna Bilous
- Anna L. Watts
- Antonia Rowlinson
- Antonino D’Aì
- Antonios Manousakis
- B A Zauderer
- B A Zauderer
- B D Metzger
- B D Metzger
- B D Metzger
- B De Marco
- B Gendre
- B Haskell
- B Haskell
- B M Peterson
- B P Abbott
- B P Abbott
- B P Abbott
- B P Abbott
- B P Abbott
- B P Abbott
- B P Abbott
- B P Abbott
- B P Abbott
- B P Abbott
- B P Abbott
- B P Abbott
- B Warner
- B Warner
- B Zhang
- B Zhang
- B Zhang
- B Zhang
- Balman
- Ben W. Stappers
- Biswajit Paul
- Bruce Gendre
- C C Cheung
- C G Bassa
- C H Lee
- C J Hailey
- C J Saxton
- C Knigge
- C Kouveliotou
- C M Urry
- C Motch
- C O Heinke
- C R D’Angelo
- C Wang
- Chanda Prescod-Weinstein
- ChiChuan Jin
- Christian Gouiffès
- Christian Motch
- Craig O. Heinke
- D Altamirano
- D Bhattacharya
- D Caprioli
- D Eichler
- D Fertig
- D Giannios
- D Grupe
- D J Patnaude
- D J Walton
- D K Galloway
- D L Band
- D L Coppejans
- D Lazzati
- D Lin
- D M Siegel
- D M Siegel
- D N Burrows
- D N Burrows
- D R Ballantyne
- D R Ballantyne
- D R Ballantyne
- D R Lorimer
- D Sanyal
- David R. Ballantyne
- Denys Malyshev
- Devaky Kunneriath
- Diego Altamirano
- Diego F. Torres
- Diego Götz
- Domitilla de Martino
- Duncan K. Galloway
- E A Helder
- E Berger
- E Bozzo
- E Bozzo
- E Bozzo
- E Costa
- E F Keane
- E G Kording
- E Kording
- E Kuulkers
- E Kuulkers
- E M Reynoso
- E M Rossi
- E Nardini
- E Petroff
- E Petroff
- E Rivers
- E S Phinney
- Edward F. Brown
- Edward M. Cackett
- Ehud Behar
- Elena M. Rossi
- Eleonora Torresi
- Elisa Costantini
- Emanuele Nardini
- Emanuele Perinati
- Emrah Kalemci
- En-Wei Liang
- Enrico Bozzo
- F D’Ammando
- F Fraschetti
- F FĂĽrst
- F FĂĽrst
- F Haardt
- F K Liu
- F K Liu
- F M Rieger
- F Ozel
- F Peng
- F Shankar
- F Ă–zel
- F.-K. Thielemann
- FangJun Lu
- Federico Fraschetti
- Feng Yuan
- Filippo D’Ammando
- Francesco Longo
- Francesco Tombesi
- Frank Chambers
- G B Field
- G C Brown
- G C Perola
- G Ghisellini
- G Ghisellini
- G Huang
- G J Schwarz
- G Knevitt
- G L Israel
- G L Israel
- G Lodato
- G Miniutti
- G Nelemans
- G Risaliti
- G Torricelli-Ciamponi
- G Wiktorowicz
- G Yang
- G Zhang
- Gang Li
- George Younes
- Gerry Doyle
- Giovanni Miniutti
- Giulia Stratta
- Gloria Sala
- H Gao
- H He
- H Klus
- H L Chen
- H Ritter
- H Schatz
- H Schatz
- Hendrik Schatz
- I Donnarumma
- I Donnarumma
- I E Papadakis
- I M McHardy
- I M McHardy
- I Maurer
- Ian McHardy
- Immacolata Donnarumma
- Ingo Kreykenbohm
- Iossif E. Papadakis
- Iván Agudo
- J A Nousek
- J Aleksic
- J Ballet
- J Casanova
- J Chenevez
- J Chiang
- J Giacalone
- J Guo
- J I Katz
- J J E Kajava
- J J M in ’t Zand
- J J M in ’t Zand
- J J M in ’t Zand
- J J M in’tZand
- J J M in’tZand
- J Jose
- J José
- J L Fisker
- J L Sokoloski
- J Luo
- J O Sundqvist
- J P Leahy
- J P Osborne
- J Puls
- J S Bloom
- J S Heyl
- J S Heyl
- J S Hong
- J Stevens
- J U Ness
- J van Paradijs
- J van Paradijs
- J W Armstrong
- J Wilms
- Jacco Vink
- Jean J. M. in ’t Zand
- Jean-Luc Atteia
- Jelle S. Kaastra
- Jeroen Homan
- Jerome Rodriguez
- Jian-Min Wang
- JinLu Qu
- Jir̆à Svoboda
- Joern Wilms
- Jonathan Granot
- Joonas Nättilä
- Jordi José
- JoĂŁo Braga
- Julian P. Osborne
- Julien Malzac
- JunFeng Wang
- JĂ©rĂ´me Chenevez
- K A Postnov
- K C Gendreau
- K D Alexander
- K D French
- K Hayasaki
- K Hryniewicz
- K Ioka
- K J H Phillips
- K Jahoda
- K Koyama
- K Koyama
- K Perez
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- Kazushi Iwasawa
- L A Antonelli
- L Amati
- L Bildsten
- L Bildsten
- L E Strubbe
- L Foschini
- L G Spitler
- L Izzo
- L Keek
- L Keek
- L Keek
- L Keek
- L Keek
- L Kreidberg
- L M van Haaften
- L Piro
- L Wyrzykowski
- Laurens Keek
- Liang Chen
- LiJing Shao
- Long Ji
- Lorenzo Amati
- Luca Izzo
- Luca Zampieri
- Luciano Burderi
- Lucien Kuiper
- Luigi Pacciani
- M Ackermann
- M Bachetti
- M C Begelman
- M Chakraborty
- M Coriat
- M Falanga
- M G Blasi
- M GĂĽdel
- M J Rees
- M L Ahnen
- M Linares
- M Lyutikov
- M M Basko
- M Molina
- M Paolillo
- M R Drout
- M R Metzger
- M Revnivtsev
- M S E Roberts
- M S Fulbright
- M Sako
- M Salvato
- M Sanfrutos
- M Y Fujimoto
- M Zamfir
- M. Coleman Miller
- M. Cristina Baglio
- Manuel GĂĽdel
- Manuel Linares
- Marco Feroci
- Margarita Hernanz
- Maria Chernyakova
- Mariano MĂ©ndez
- Massimiliano De Pasquale
- Maurizio Falanga
- Maurizio Paolillo
- Mauro Orlandini
- Melania Del Santo
- Michael Zingale
- Miguel A. PĂ©rez Torres
- MingYu Ge
- Missagh Mehdipour
- N Degenaar
- N Degenaar
- N Gehrels
- N Gehrels
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- N N Weinberg
- N R Tanvir
- Nathalie Degenaar
- Nevin N. Weinberg
- Niccolò Bucciantini
- Nils A. Andersson
- Nobuyuki Kawai
- O GonzaĂlez-MartĂn
- O Kargaltsev
- O S Salafia
- Oleg Kargaltsev
- P Arevalo
- P Blasi
- P D Lasky
- P Giommi
- P Grandi
- P J Wheatley
- P Meszaros
- P Meszaros
- P T Boyd
- P T O’Brien
- P Uttley
- Pablo Reig
- Pablo RodrĂguez-Gil
- Paola Grandi
- Patrizia Romano
- Paul T. O’Brien
- Pere Blay
- Peter A. Jenke
- Peter G. Jonker
- Peter J. Wheatley
- Piergiorgio Casella
- Ping Zhou
- Poshak Gandhi
- Q Chu
- R C Carrington
- R Chornock
- R Ciolfi
- R Cornelisse
- R Cornelisse
- R Cornelisse
- R D Blandford
- R di Stefano
- R G Berkhout
- R H Cyburt
- R Jager
- R K Wallace
- R L Cooper
- R Maiolino
- R Margutti
- R Martone
- R Nakamura
- R Narayan
- R Nordon
- R P Kudritzki
- R Perna
- R S Warwick
- R Sari
- R Urquhart
- R Walter
- Ramandeep Gill
- Riccardo Campana
- Riccardo Ciolfi
- Robert D. Ferdman
- Roberto P. Mignani
- Romana Mikusincova
- Rosario Iaria
- Ruben Salvaterra
- Rudy Wijnands
- S A Rappaport
- S A Rappaport
- S B Cenko
- S Balman
- S Bhattacharyya
- S Bhattacharyya
- S Bhattacharyya
- S Bianchi
- S Bogdanov
- S Campana
- S E Woosley
- S Gezari
- S Gezari
- S Horiuchi
- S Kang
- S Komossa
- S Komossa
- S Komossa
- S Komossa
- S Mahmoodifar
- S MartĂnez-NĂşnez
- S N Zhang
- S P Reynolds
- S P Reynolds
- S P Reynolds
- S Rosswog
- S S Bogdanov
- S S Tsygankov
- S Sahiner
- S Schanne
- S van Velzen
- S van Velzen
- S Velzen
- S Yang
- Sara Turriziani
- Sergio Campana
- ShanShan Weng
- ShaoLin Xiong
- Shu Zhang
- Shuang-Nan Zhang
- Shuo Zhang
- Silvia Zane
- Simin Mahmoodifar
- Stan E. Woosley
- Stefanie Komossa
- Stefano Bianchi
- Stefano Vercellone
- Stephen A. Drake
- Steven N. Shore
- Stéphane Paltani
- Stéphane Schanne
- Sudip Bhattacharyya
- Søren Brandt
- T E Strohmayer
- T E Strohmayer
- T E Strohmayer
- T E Strohmayer
- T E Woods
- T Enoto
- T G Wang
- T Inoue
- T J Galama
- T J Moriya
- T Kallman
- T M Tauris
- T M Tauris
- T M Tauris
- T M Tauris
- T Piran
- T Piran
- T Sakamoto
- T Sakamoto
- T Yaqoob
- Takanori Sakamoto
- Thomas J. Maccarone
- Thomas M. Tauris
- Tiziana Di Salvo
- Tod E. Strohmayer
- Tomaso Belloni
- Torsten Neubert
- Tuomas Savolainen
- Tuomo Salmi
- Tyrone E. Woods
- U Lee
- Uria Peretz
- V Allevato
- V Doroshenko
- V Grinberg
- V Grinberg
- V Grinberg
- V Tatischeff
- Valerio D’Elia
- Valery F. Suleimanov
- Victor Doroshenko
- W Fong
- W Fong
- W H G Lewin
- W Yu
- W Zhang
- WenFei Yu
- X Gong
- Xiang-Dong Li
- Xiao Zhang
- XiLong Fan
- XueFeng Wu
- Y Cavecchi
- Y Cavecchi
- Y Cavecchi
- Y Liu
- Y Uchiyama
- Y Uchiyama
- Y X Wu
- Yang Chen
- Yu-Peng Chen
- YunPeng Men
- YuPeng Xu
- Yuri Cavecchi
- Z G Dai
- Zhen Yan
- Zi-Gao Dai
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Proteomics dedicated to biofilmology: What have we learned from a decade of research?
- Author
- A Banerjee
- A Collet
- A Derouiche
- A Dharmaprakash
- A Khemiri
- A Khemiri
- A Khemiri
- A Koerdt
- A Magalhaes
- A Resch
- A Ritter
- A Sakamoto
- A Siroy
- A Staes
- AG Pereira-Medrano
- AJ Park
- AR Morris
- Arbia Khemiri
- AU Khan
- B Hao
- B Sampathkumar
- B Steyn
- BD Hoyle
- C Arevalo-Ferro
- C Arevalo-Ferro
- C Besanceney-Webler
- C Guegan
- C Lassek
- C Mace
- C Park
- C Rathsam
- C Solano
- C Varela
- C Wagner
- CA Kolmeder
- CF Batzilla
- CG Kumar
- CG Pierce
- CJ Seneviratne
- CM Rodrigues
- CR Arciola
- CS Ang
- D Akuzov
- D McDougald
- D Monroe
- D Ribet
- D Romero
- D Seyer
- D Srivastava
- D Vallenet
- DB Schlisselberg
- DF Rodrigues
- DG Davies
- DH Meyer
- DM Deng
- DO Serra
- DW Jackson
- E Altindis
- E Calvo
- EA Zottola
- EK Hall
- F Abram
- F Perrot
- F Tremoulet
- G Gicquel
- G Posch
- G Sun
- GA Junter
- GJ Veenstra
- H Asakura
- H Benamara
- H Malen
- H Mikkelsen
- H Mikkelsen
- H Mikkelsen
- H Mikkelsen
- H Yonezawa
- H Yonezawa
- HB Wang
- HT Taff
- I Benz
- I Schmidt
- J Babauta
- J Chandra
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- J Li
- J Mukherjee
- J Nesper
- J Pandhal
- J Roth
- J Schlegelova
- JC Biffinger
- JC Boucher
- JC Boucher
- JC Nickel
- JC Provenzano
- JH Merritt
- JH Shin
- JL Brooks
- JM Fletcher
- JM Gilmore
- JP Pearson
- JQ Gerlach
- JR Chambers
- JS Webb
- JW Costerton
- JW Costerton
- K McNeill
- K Otto
- K Sauer
- K Sauer
- K Sauer
- K Vriendt De
- KA Neilson
- KF Jarrell
- KF Kong
- KJ Martin
- KP Katuri
- L Benard
- L Coquet
- L Dussart
- L Muszkieta
- L Xu
- LE Hancock
- LS Thompson
- M Allegrucci
- M Burmolle
- M Kalmokoff
- M Kishi
- M Marceau
- M Martinez-Gomariz
- M McNamara
- M Morikawa
- M Otto
- M Toyofuku
- M Vera
- M Whiteley
- M Yamaguchi
- MA Schembri
- MC Oosthuizen
- MC Oosthuizen
- ME Clark
- ME Davey
- ME Zegans
- MI Sarro
- MP Jennings
- MR Chapman
- MR Thompson
- MS Saldias
- N Grantcharova
- N Hansmeier
- N Solis
- N Solis
- NE Scott
- NJ Phillips
- OE Petrova
- OE Petrova
- OE Petrova
- P Lindblad
- P Stoodley
- Pascal Cosette
- PG Hitchen
- PG Hitchen
- PJ Vaysse
- PJ Vaysse
- PK Mukherjee
- PN Danese
- PR Secor
- QY Yin
- R Orme
- RA Brady
- RC Barry
- RJ Ram
- S Jager
- S Kalathil
- S Kjelleberg
- S Marti
- S Planchon
- S Planchon
- S Renier
- S Shibata
- S Stelzer
- S Sugimoto
- S Vilain
- S Vilain
- S Vilain
- S Wiese
- SB Guttenplan
- SE Ong
- SJ Bauman
- SL Chua
- SM Hinsa
- SP Gygi
- SR Schooling
- SS Park
- SS Yoon
- ST Chellappa
- ST Rutherford
- SW Singer
- T Guina
- T Iwase
- T Zimaro
- TC Chao
- Thierry Jouenne
- TK Gallaher
- TK Pham
- TR Neu
- TT Huynh
- U Romling
- V Carvalhais
- V Schaar
- V Vadyvaloo
- V Zijnge
- VS Iyer
- WL Wu
- WM Dunne Jr
- Y Cao
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- Z Zainal-Abidin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Antiinflammatory therapy with canakinumab for atherosclerotic disease
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- Abaci F.
- Abbate A.
- Abdullakutty J.
- Abhaichand R.
- Abhyankar A.
- Abib E.Jr.
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- Abrantes J.
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- Acevedo B.
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- Acheatel R.
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- Adjic N.C.
- Affaki G.S.
- Agafina A.
- Agarwal D.K.
- Aggarwal R.K.
- Agosta G.F.
- Aguilar M.
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- Ahmad I.
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- Ahn Y.
- Aish B.
- Aiub F.
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- Ajax K.
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- Akai Y.
- Akatova E.
- Akrap B.
- Akyea-Djamson A.
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- Al-Khalili F.
- Alan A.
- Albisu J.
- Alcalde J.M.
- Alcide P.
- Alfieri A.
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- Alllison D.C.
- Almaliky T.
- Alvarisqueta A.
- Amerena J.
- Amos A.
- Anadiotis A.
- Andersen K.
- Andor M.
- Angelova I.
- Angiolillo D.
- Anita S.
- Anker S.D.
- Anneveldt A.
- Antalik L.
- Antolick A.
- Antonicelli R.
- Aparicio C.V.
- Apel T.
- Apostolovic S.
- Ara M.
- Aragorn L.
- Arango J.L.
- Araujo Fonseca M.
- Ardissino D.
- Arenas Leon JL.
- Arevalo S.
- Argiolas G.
- Arif I.
- Armas E.
- Aron G.
- Arora S.
- Arthur A.
- Asafu-Adjaye N.
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- Ashford M.
- Ashino K.
- Asim Oktay AO.
- Aslam A.
- Assarsson E.
- Ata B.
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- Atieh M.
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- Avdonina N.
- Awasthi A.K.
- Axthelm C.
- Ayala M.
- Ayasse D.
- Ayasse M.
- Azizad M.
- Azize G.M.
- Baar M.
- Babu R.
- Backer T.
- Badea C.
- Baden M.
- Baehl S.
- Baek C.
- Baeumer A.
- Bagi E.S.
- Bai A.
- Bailey K.
- Bailey S.
- Bair S.
- Baker A.
- Baker C.
- Bakhai A.
- Bakker H.
- Baksi A.
- Baldin M.G.
- Bali H.K.
- Ballantyne C.
- Ballmajo M.
- Balode A.
- Balukova E.
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- Publication venue
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- Publication date
- Field of study
BACKGROUND: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. METHODS: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P=0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P=0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P=0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P=0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P=0.31). CONCLUSIONS: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. Copyright © 2017 Massachusetts Medical Society