Sustainable Development, Ecological Complexity, and Environmental Values

Sustainable Development, Ecological Complexity, and Environmental Values contributes to expanding the idea of sustainability by integrating different thematic issues related to sustainable development in its threefold consideration (economic, social, and environmental) with regard to the case of the Basque Country. On the global scale, changes have clearly accelerated; ecological and social sustainability are two facets of the same changing reality. First, social sustainability depends on ecological sustainability. If we continue degrading nature's capacity to produce the ecosystems' services (water filtration, climate stabilization, etc) and resources (food, materials), both individuals and nations will be affected by growing pressures and increasing conflicts, as well as by threats to public health and personal safety. Second, ecological sustainability depends on social sustainability, a socially unjust and unfair system wiht an ever-increasing population that is not able to have its needs met will necessarily lead to environmental collapse. In addition, human behavior and the social dynamic often lie at the heart of social and ecological problems. It must be, therefore, assumed that there will not be sustainable development if sustainable societies do not first exist. A sustainable society has the challenge of developing human capital. In this book, these global questions are treated as they relate to specific place and context, the Basque Country and its modern institutions.This book was published with generous financial support from the Basque Government.Introduction—Ignacio Ayestarán and Miren Onaindia ? 1. An Evaluation of Ecosystem Services as a Base for the Sustainable Management of a Region by Miren Onaindia and Gloria Rodríguez-Loinaz ? 2. An Evaluation of Millennium Ecosystems from the Basque Country by Igone Palacios, Izaskun Casada-Arzuaga, Iosu Madariaga, and Xabier Arana ? 3. Climate Change: Activities of the EOLO Group at the University of the Basque Country by Agustín Ezcurra, Jon Sáenz, and Gabriel Ibarra-Berastegi ? 4. The Environmental Value of the Karstic Landscape of the Urdaibai Biosphere Reserve: The Asnarre Promontory (Bizkaia) by Arantza Aranburu, Laura Damas-Mollá, Patxi García-Garmilla, Iñaki Yusta, M. Arriolabengoa, Peru Iridoy, and Eneko Iriarte ? 5. Recent Environmental Transformation of the Bilbao Estuary: Natural and Anthropogenic Processes by Alejandro Cearreta, Maria Jesús Irabien, and Eduardo Leorri ? 6. The Landscape of the Autonomous Community of the Basque Country: The Evolution of Forest Systems by Lorena Peña and Ibone Amezaga ? 7. Critical Theories of Sustainable Development by Eguzki Urteaga ? 8. Bases for the Transition toward a Sustainable Economy by Roberto Bermejo, David Hoyos, and Eneko Garmendia ? 9. Environmental Values, the Epistemology of Complex Problems, and Postnormal Science in the Face of Global Change by Ignacio Ayestáran ? 10. Science, Gender, and Sustainable Development by Teresa Nuño Angós ? 11. Environmental Education as Training: A Case Study at the University of the Basque Country by Araitz Uskola Ibarluzea ? 12. Social Values and Sustainable Practices among Basque Inshore Fishermen by Pío Pérez Aldasoro ? 13. Sustainable Development and the Values of Well-Being and Globalization by Eduardo Rubio Ardanaz, Juan Antonio Rubio-Ardanaz, and Xiao Fang ? Index ? List of Contributor

Amplification of IGH/MYC fusion in clinically aggressive IGH/BCL2-positive germinal center B-cell lymphomas

Activation of an oncogene via its juxtaposition to the IGH locus by a chromosomal translocation or, less frequently, by genomic amplification is considered a major mechanism of B-cell lymphomagenesis. However, amplification of an IGH/oncogene fusion, coined a complicon, is a rare event in human cancers and has been associated with poor outcome and resistance to treatment. In this article are descriptions of two cases of germinal-center-derived B-cell lymphomas with IGH/BCL2 fusion that additionally displayed amplification of an IGH/MYC fusion. As shown by fluorescence in situ hybridization, the first case contained a IGH/MYC complicon in double minutes, whereas the second case showed a BCL2/IGH/MYC complicon on a der(8)t(8;14)t(14;18). Additional molecular cytogenetic and mutation analyses revealed that the first case also contained a chromosomal translocation affecting the BCL6 oncogene and a biallelic inactivation of TP53. The second case harbored a duplication of REL and acquired a translocation affecting IGL and a biallelic inactivation of TP53 during progression. Complicons affecting Igh/Myc have been reported previously in lymphomas of mouse models simultaneously deficient in Tp53 and in genes of the nonhomologous end-joining DNA repair pathway. To the best of our knowledge, this is the first time that IGH/MYC complicons have been reported in human lymphomas. Our findings imply that the two mechanisms resulting in MYC deregulation, that is, translocation and amplification, can occur simultaneously