Empatía en estudiantes de medicina de la universidad del norte, Colombia. Comparación de dos grupos (2012 y 2015)

Indexación: Scopus.Introduction: Empathy is an important component of the doctor-patient relationship, so the provision of empathy training to medical students must be a permanent goal of MD programs. Objective: To determine whether the academic medical empathy training activities implemented at Universidad del Norte in 2013 resulted in significant changes in medical students enrolled in 2015 compared to those enrolled in 2012. Materials and methods: Cross-sectional study conducted on 934 medical students (426 men and 508 women) enrolled at Universidad del Norte in 2015 who were administered the Spanish version of the Jefferson Scale of Empathy. The comparison group consisted of 345 medical students (106 men and 239 women) enrolled in 2012 at the same university. An analysis of variance (ANOVA) was performed and differences between academic years and between genders were evaluated, as well as the interactions between these two factors. Results: Although, in general, there were no significant differences between both groups in the three dimensions that were evaluated (p>0.05), statistically significant differences were observed in questions 4, 17 and 20, which are part of the Perspective Taking dimen-sion, and in question 6, included in the Walking in Patient’s Shoes dimension (p<0.05), since scores medias were higher in the 2012 cohort. Conclusions: The empathy training activities implemented in the medical program did not produce significant changes. Therefore, it is necessary to assess and improve both the con-tents and the teaching-learning processes related to empathy training in the medical program offered at Universidad del Norte.https://revistas.unal.edu.co/index.php/revfacmed/article/view/7049

Obonuco San Isidro nueva variedad mejorada de arveja para la zona de reconversión del trigo en Nariño.

El artículo presenta todas las características de la variedad mejorada de arveja, se muestra el origen genético, el comportamiento agronómico, la descripción varietal, la preparación del suelo, la fertilización, el sistema, densidad y época de siembra y el manejo integrado del cultivo como malezas, plagas, enfermedades y cosecha y la conclusión

Catálogo de terremotos de América del Sur homogéneo en Mw para el periodo pre-1964

On the frame of The South America Risk Assessment (SARA) project, an earthquake catalogue was compiled for South America, in terms of the moment magnitude (Mw), with data from the Centro Regional de Sismología para América del Sur (CERESIS), recent national and international studies, and from the analysis conducted during the project. In particular, it is included the latest versions of catalogue CERESIS-91 prepared by CERESIS and published by the National Council of Science and Technology CONCYTEC of Peru, the determination of parameters by recent studies, including those proposed by the ISC-GEM catalogue, and where available, the national catalogues that meet the criteria of transparency required by the project. The results presented in this work correspond to the pre-1964 time window. The first phase of the study is the development of a critical inventory of all public studies related to earthquakes in South America. Studies for the same event have been associated with each other from the comparison of the time, of the epicentre coordinates and the size of the earthquake (magnitude or maximum seismic intensity). For each event, a set of parameters considered reliable has been preliminarily selected. The main problem of the catalogue is the need to express the values of magnitude in terms of moment magnitude (Mw). Currently, few studies on historical earthquakes provide this value for the study region. For many events, values in terms of Ms and mb are available; although for most cases, because of the time of occurrence of these events, the magnitude values were calculated from macroseismic data. For these earthquakes we have used empirical conversion relationships published in literature for Ms and mb to Mw. There are also events for which only a value of maximum intensity (Imax or Io) is available. For these events, regional relationships Imax to Mw have been determined, using the most reliable and recent data of Mw and Imax values. In a second phase, for some events that have a sufficient number of macroseismic data, the source parameters have (including location, Mw and uncertainties) been determined using the method of Bakun and Wentworth (1997), regionally calibrated, based on what already has been obtained for Ecuador, Venezuela in literature and Colombia in the present project. In this way, the magnitude Mw was evaluated for 2564 earthquakes in South America. The lower threshold is defined in Mw = 5 for the Andean region. For Brazil, a lower threshold was not applied.Published6T. Studi di pericolosità sismica e da maremotoN/A or not JC

Obonuco Andina nueva variedad mejorada de arveja para la zona de economía campesina del sur de Nariño.

El artículo presenta todas las características de la variedad mejorada de arveja, se muestra el origen genético, el comportamiento agronómico, los atributos culinarios, las cualidades de mercadeo, la descripción varietal, el manejo agronómico como la preparación del suelo, la fertilización, el sistema, densidad y época de siembra y el manejo de malezas, plagas y enfermedades y las conclusiones.Obonuco Andina, variedad mejorada de arveja para el sistema de economía campesina de Nariñ

Hazardous faults of South America; compilation and overview

The heterogeneous South American geology has coined a wide variety of neotectonic settings where crustal seismogenic sources do occur. This fact has led to different approaches for mapping and inventory neotectonic structures. The South American Risk Assessment project promoted the discussion and update under uniform standards of the available information on neotectonic deformation, for its application in regional Probabilistic Seismic Hazard Assessments. As a result, 1533 hazardous faults have been inventoried onshore South America, 497 of them qualifying to feed the engine model driving probabilistic maps. Main hazardous structures are concentrated throughout the eastern boundary of the Northern Andean Sliver and along the foreland-facing Andean Thrust Front. Space geodesy and seismicity illuminate the seismogenic significance of these deformation belts, although few neotectonic surveys have been conducted to date in the latter region. The characteristics of the main structures or deformation zones are here outlined according to their filiation to neotectonic domains, which are dependant on the geologic, seismotectonic, or morphotectonic settings in Andean and extra-Andean regions. The knowledge accrued on the hazardous faults in South America here compiled, reinforces the fact that some of these structures constitute significant hazard sources for many urban areas and critical facilities and should be incorporated in seismic hazard assessments. However, the available fault data are insufficient in many cases or carry significant epistemic uncertainties for fault source characterization. This contribution aims to summarize the present knowledge on the South American hazardous faults as well as the main challenges for successful fault data incorporation into seismic hazard models

Ten simple rules for making training materials FAIR

Author summary: Everything we do today is becoming more and more reliant on the use of computers. The field of biology is no exception; but most biologists receive little or no formal preparation for the increasingly computational aspects of their discipline. In consequence, informal training courses are often needed to plug the gaps; and the demand for such training is growing worldwide. To meet this demand, some training programs are being expanded, and new ones are being developed. Key to both scenarios is the creation of new course materials. Rather than starting from scratch, however, it’s sometimes possible to repurpose materials that already exist. Yet finding suitable materials online can be difficult: They’re often widely scattered across the internet or hidden in their home institutions, with no systematic way to find them. This is a common problem for all digital objects. The scientific community has attempted to address this issue by developing a set of rules (which have been called the Findable, Accessible, Interoperable and Reusable [FAIR] principles) to make such objects more findable and reusable. Here, we show how to apply these rules to help make training materials easier to find, (re)use, and adapt, for the benefit of all

HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers

Amplification and oncogenic mutations of ERBB2, the gene encoding the HER2 receptor tyrosine kinase, promote receptor hyperactivation and tumor growth. Here we demonstrate that HER2 ubiquitination and internalization, rather than its overexpression, are key mechanisms underlying endocytosis and consequent efficacy of the anti-HER2 antibody-drug conjugates (ADCs) ado-trastuzumab emtansine (T-DM1) and trastuzumab deruxtecan (T-DXd) in lung cancer cell lines and patient-derived xenograft models. These data translated into a 51% response rate in a clinical trial of T-DM1 in 49 patients with ERBB2/HER2-amplified or mutant lung cancers. We show that co-treatment with irreversible pan-HER inhibitors enhances receptor ubiquitination and consequent ADC internalization and efficacy. We also demonstrate that ADC switching to T-DXd, which harbors a different cytotoxic payload, achieves durable responses in a patient with lung cancer and corresponding xenograft model developing resistance to T-DM1. Our findings may help guide future clinical trials and expand the field of ADC as cancer therapy

High Expression Levels of Total IGF-1R and Sensitivity of NSCLC Cells In Vitro to an Anti-IGF-1R Antibody (R1507)

© 2009 Gong et al