518 research outputs found
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Immunoregulatory Potential of Exosomes Derived from Cancer Stem Cells.
Head and neck squamous cell carcinomas (HNSCCs) are malignancies that originate in the mucosal lining of the upper aerodigestive tract. Despite advances in therapeutic interventions, survival rates among HNSCC patients have remained static for years. Cancer stem cells (CSCs) are tumor-initiating cells that are highly resistant to treatment, and are hypothesized to contribute to a significant fraction of tumor recurrences. Consequently, further investigations of how CSCs mediate recurrence may provide insights into novel druggable targets. A key element of recurrence involves the tumor's ability to evade immunosurveillance. Recent published reports suggest that CSCs possess immunosuppressive properties, however, the underlying mechanism have yet to be fully elucidated. To date, most groups have focused on the role of CSC-derived secretory proteins, such as cytokines and growth factors. Here, we review the established immunoregulatory role of exosomes derived from mixed tumor cell populations, and propose further study of CSC-derived exosomes may be warranted. Such studies may yield novel insights into new druggable targets, or lay the foundation for future exosome-based diagnostics
Beta Irradiation of a Geometrically Metastable Superconducting Strip Detector with a Magnetic Flux Penetration Read-Out
Geometrical metastability, observed in superconducting type I tin flat
strips, has been previously proposed as a principle for particle detection. The
energy deposition of an incoming beta-particle induces the rupture of the
metastability and consequently the penetration of multiquantum flux tubes into
a superconducting tin strip. We present here the first absorption spectra from
two beta sources, which demonstrate the linearity and energy-resolution of
these detectors (presented at the 6th International Workshop on Low Temperature
Detectors for Dark Matter and Neutrinos (LTD-6), Interlaken, Switzerland, Sept.
1995)Comment: Compressed PostScript (filename.ps.Z), 8 pages, 2 figure
S-35 Beta Irradiation of a Tin Strip in a State of Superconducting Geometrical Metastability
We report the first energy loss spectrum obtained with a geometrically
metastable type I superconducting tin strip irradiated by the beta-emission of
S-35. (Nucl. Instr. Meth. A, in press)Comment: Compressed PostScript (filename.ps.Z), 9 pages, 2 figure
Elective Modernism and the Politics of (Bio) Ethical Expertise
In this essay I consider whether the political perspective of third wave science studies â âelective modernismâ â offers a suitable framework for understanding the policy-making contributions that (bio)ethical experts might make. The question arises as a consequence of the fact that I have taken inspiration from the third wave in order to develop an account of (bio)ethical expertise. I offer a prĂ©cis of this work and a brief summary of elective modernism before considering their relation. The view I set out suggests that elective modernism is a political philosophy and that although its use in relation to the use of scientific expertise in political and policy-making process has implications for the role of (bio)ethical expertise it does not, in the final analysis, provide an account that is appropriate for this latter form of specialist expertise. Nevertheless, it is an informative perspective, and one that can help us make sense of the political uses of (bio)ethical expertise
On POD analysis of PIV measurements applied to mixing in a stirred vessel with a shear thinning fluid
P.O.D. technique is applied to 2D P.I.V. data in the field of hydrodynamics in a mixing tank with a Rushton turbine and a shear thinning fluid. Classical eigen-value spectrum is presented and phase portrait of P.O.D. coefficients are plotted and analyzed in terms of trailing vortices. A spectrum of dissipation rate of kinetic energy is introduced and discussed. Length scales associated to each P.O.D. modes are proposed
Who are these youths? Language in the service of policy
In the 1990s policy relating to children and young people who offend developed as a result of the interplay of political imperatives and populist demands. The âresponsibilisationâ of young offenders and the âno excusesâ culture of youth justice have been âmarketedâ through a discourse which evidences linguistic changes. This article focuses on one particular area of policy change, that relating to the prosecutorial decision, to show how particular images of children were both reflected and constructed through a changing selection of words to describe the non-adult suspect and offender. In such minutiae of discourse can be found not only the signifiers of public attitudinal and policy change but also the means by which undesirable policy developments can be challenged
Crack-Like Processes Governing the Onset of Frictional Slip
We perform real-time measurements of the net contact area between two blocks
of like material at the onset of frictional slip. We show that the process of
interface detachment, which immediately precedes the inception of frictional
sliding, is governed by three different types of detachment fronts. These
crack-like detachment fronts differ by both their propagation velocities and by
the amount of net contact surface reduction caused by their passage. The most
rapid fronts propagate at intersonic velocities but generate a negligible
reduction in contact area across the interface. Sub-Rayleigh fronts are
crack-like modes which propagate at velocities up to the Rayleigh wave speed,
VR, and give rise to an approximate 10% reduction in net contact area. The most
efficient contact area reduction (~20%) is precipitated by the passage of slow
detachment fronts. These fronts propagate at anomalously slow velocities, which
are over an order of magnitude lower than VR yet orders of magnitude higher
than other characteristic velocity scales such as either slip or loading
velocities. Slow fronts are generated, in conjunction with intersonic fronts,
by the sudden arrest of sub-Rayleigh fronts. No overall sliding of the
interface occurs until either of the slower two fronts traverses the entire
interface, and motion at the leading edge of the interface is initiated. Slip
at the trailing edge of the interface accompanies the motion of both the slow
and sub-Rayleigh fronts. We might expect these modes to be important in both
fault nucleation and earthquake dynamics.Comment: 19 page, 5 figures, to appear in International Journal of Fractur
Dissipation of vibration in rough contact
The relationship which links the normal vibration occurring during the sliding of rough surfaces and the nominal contact area is investigated. Two regimes are found. In the first one, the vibrational level does not depend on the contact area, while in the second one, it is propor- tional to the contact area. A theoretical model is proposed. It is based on the assumption that the vibrational level results from a competition between two processes of vibration damping, the internal damping of the material and the contact damping occurring at the interface
Making drug harms: Punishments for drugs offenders who pose risks to children
Images of children are routinely used in discourses on drugs, offering a compelling rationale for adopting particular policy positions or legislative reforms. However, the importance of childhood to the constitution of drug harms, and the punishment and subjectification of drug users and offenders, have rarely been the subject of enquiry, whether within drug and alcohol studies, criminology or legal studies. Scholarship on criminal sentencing in England and Wales is also relatively sparse, and has been dominated by analyses of the âlegal-rationalâ logic of particular provisions or reforms. This paper, which relies on the premise that drugs and their effects are constituted through discourse, and are thus contingent, variable and unstable, identifies the âcollateral realitiesâ (Law, 2011) that are enacted during legislative and judicial attempts to stabilize the harms caused by drugs to children and communities
On the nature of surface roughness with application to contact mechanics, sealing, rubber friction and adhesion
Surface roughness has a huge impact on many important phenomena. The most
important property of rough surfaces is the surface roughness power spectrum
C(q). We present surface roughness power spectra of many surfaces of practical
importance, obtained from the surface height profile measured using optical
methods and the Atomic Force Microscope. We show how the power spectrum
determines the contact area between two solids. We also present applications to
sealing, rubber friction and adhesion for rough surfaces, where the power
spectrum enters as an important input.Comment: Topical review; 82 pages, 61 figures; Format: Latex (iopart). Some
figures are in Postscript Level
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