12 research outputs found
Association Between Interstitial Lung Abnormalities and All-Cause Mortality.
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This article is open access.Interstitial lung abnormalities have been associated with lower 6-minute walk distance, diffusion capacity for carbon monoxide, and total lung capacity. However, to our knowledge, an association with mortality has not been previously investigated.To investigate whether interstitial lung abnormalities are associated with increased mortality.Prospective cohort studies of 2633 participants from the FHS (Framingham Heart Study; computed tomographic [CT] scans obtained September 2008-March 2011), 5320 from the AGES-Reykjavik Study (Age Gene/Environment Susceptibility; recruited January 2002-February 2006), 2068 from the COPDGene Study (Chronic Obstructive Pulmonary Disease; recruited November 2007-April 2010), and 1670 from ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints; between December 2005-December 2006).Interstitial lung abnormality status as determined by chest CT evaluation.All-cause mortality over an approximate 3- to 9-year median follow-up time. Cause-of-death information was also examined in the AGES-Reykjavik cohort.Interstitial lung abnormalities were present in 177 (7%) of the 2633 participants from FHS, 378 (7%) of 5320 from AGES-Reykjavik, 156 (8%) of 2068 from COPDGene, and in 157 (9%) of 1670 from ECLIPSE. Over median follow-up times of approximately 3 to 9 years, there were more deaths (and a greater absolute rate of mortality) among participants with interstitial lung abnormalities when compared with those who did not have interstitial lung abnormalities in the following cohorts: 7% vs 1% in FHS (6% difference [95% CI, 2% to 10%]), 56% vs 33% in AGES-Reykjavik (23% difference [95% CI, 18% to 28%]), and 11% vs 5% in ECLIPSE (6% difference [95% CI, 1% to 11%]). After adjustment for covariates, interstitial lung abnormalities were associated with a higher risk of death in the FHS (hazard ratio [HR], 2.7 [95% CI, 1.1 to 6.5]; Pâ=â.03), AGES-Reykjavik (HR, 1.3 [95% CI, 1.2 to 1.4]; Pâ<â.001), COPDGene (HR, 1.8 [95% CI, 1.1 to 2.8]; Pâ=â.01), and ECLIPSE (HR, 1.4 [95% CI, 1.1 to 2.0]; Pâ=â.02) cohorts. In the AGES-Reykjavik cohort, the higher rate of mortality could be explained by a higher rate of death due to respiratory disease, specifically pulmonary fibrosis.In 4 separate research cohorts, interstitial lung abnormalities were associated with a greater risk of all-cause mortality. The clinical implications of this association require further investigation.National Institutes of Health (NIH)
T32 HL007633
Icelandic Research Fund
141513-051
Landspitali Scientific Fund
A-2015-030
National Cancer Institute grant
1K23CA157631
NIH
K08 HL097029
R01 HL113264
R21 HL119902
K25 HL104085
R01 HL116931
R01 HL116473
K01 HL118714
R01 HL089897
R01 HL089856
N01-AG-1-2100
HHSN27120120022C
P01 HL105339
P01 HL114501
R01 HL107246
R01 HL122464
R01 HL111024
National Heart, Lung, and Blood Institute's Framingham Heart Study contract
N01-HC-2519.5
GlaxoSmithKline
NCT00292552
5C0104960
National Institute on Aging (NIA) grant
27120120022C
NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association)
Althingi (the Icelandic Parliament)
NIA
27120120022
Bienestar psicológico, asertividad y rendimiento académico en estudiantes universitarios sanmarquinos
In this investigation the relations between the psychological well-being are examined, the assertiveness and the academic yield in the students of representative Faculties of the diverse areas of study of the University of San Marcos. For it, the Scale of Psychological Wellbeing of Ryff (that measures positive relations, autonomy, dominion of the surroundings, personal growth and intention in the life), the Inventory of Asertividad de Rathus and the academic yield were used. The study is of corelational descriptive type, with a circumstantial nonprobabilĂstica sampling of the studied population to. The data were process with statistical package SPSS (Statistical for Package the Social Sciencies), making a correlation analysis and getting to be that yes significant correlation exists, p < 0.05, between the study variables, accepting the raised general hypothesis. In addition one was that significant relation between the psychological well-being and the assertiveness exists, as much in men as in the women. Of equal way in all the faculties the relation is significant between the variables in study, except in the faculty of industrial engineering the relation between assertiveness and academic yield did not turn out to be significantEn esta investigaciĂłn se examinan las relaciones entre el bienestar psicolĂłgico, la asertividad y el rendimiento acadĂ©mico en los estudiantes de Facultades representativas de las diversas ĂĄreas de estudio de la Universidad de San Marcos. Para ello, se utilizĂł la Escala de Bienestar PsicolĂłgico de Ryff (que mide relaciones positivas, autonomĂa, dominio del entorno, crecimiento personal y propĂłsito en la vida), el Inventario de Asertividad de Rathus y el rendimiento acadĂ©mico. El estudio es de tipo descriptivo-correlacional, con un muestreo no probabilĂstico circunstancial de la poblaciĂłn a estudiada. Los datos fueron procesados con el paquete estadĂstico SPSS (Statistical Package for the Social Sciencies), realizando un anĂĄlisis de correlaciĂłn y llegando a encontrarse que sĂ existe correlaciĂłn significativa, p<0.05, entre las variables de estudio, aceptando la hipĂłtesis general planteada. AdemĂĄs, se encontrĂł que existe relaciĂłn significativa entre el bienestar psicolĂłgico y la asertividad, tanto en varones como en las mujeres. De igual manera, en todas las facultades la relaciĂłn es significativa entre las variables en estudio, excepto en la Facultad de IngenierĂa Industrial donde la relaciĂłn entre asertividad y rendimiento acadĂ©mico no resultĂł ser significativa
Bienestar psicológico, asertividad y rendimiento académico en estudiantes universitarios sanmarquinos
Development and Progression of Interstitial Lung Abnormalities in the Framingham Heart Study
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A comparison of visual and quantitative methods to identify interstitial lung abnormalities
Background: Evidence suggests that individuals with interstitial lung abnormalities (ILA) on a chest computed tomogram (CT) may have an increased risk to develop a clinically significant interstitial lung disease (ILD). Although methods used to identify individuals with ILA on chest CT have included both automated quantitative and qualitative visual inspection methods, there has been not direct comparison between these two methods. To investigate this relationship, we created lung density metrics and compared these to visual assessments of ILA. Methods: To provide a comparison between ILA detection methods based on visual assessment we generated measures of high attenuation areas (HAAs, defined by attenuation values between â600 and â250 Hounsfield Units) in >4500 participants from both the COPDGene and Framingham Heart studies (FHS). Linear and logistic regressions were used for analyses. Results: Increased measures of HAAs (in â„10 % of the lung) were significantly associated with ILA defined by visual inspection in both cohorts (P < 0.0001); however, the positive predictive values were not very high (19 % in COPDGene and 13 % in the FHS). In COPDGene, the association between HAAs and ILA defined by visual assessment were modified by the percentage of emphysema and body mass index. Although increased HAAs were associated with reductions in total lung capacity in both cohorts, there was no evidence for an association between measurement of HAAs and MUC5B promoter genotype in the FHS. Conclusion: Our findings demonstrate that increased measures of lung density may be helpful in determining the severity of lung volume reduction, but alone, are not strongly predictive of ILA defined by visual assessment. Moreover, HAAs were not associated with MUC5B promoter genotype
The MUC5B promoter polymorphism is associated with specific interstitial lung abnormality subtypes
To access publisher's full text version of this article click on the hyperlink belowThe MUC5B promoter polymorphism (rs35705950) has been associated with interstitial lung abnormalities (ILA) in white participants from the general population; whether these findings are replicated and influenced by the ILA subtype is not known. We evaluated the associations between the MUC5B genotype and ILA in cohorts with extensive imaging characterisation. We performed ILA phenotyping and MUC5B promoter genotyping in 5308 and 9292 participants from the AGES-Reykjavik and COPDGene cohorts, respectively. We found that ILA was present in 7% of participants from the AGES-Reykjavik, 8% of non-Hispanic white participants from COPDGene and 7% of African-American participants from COPDGene. Although the MUC5B genotype was strongly associated (after correction for multiple testing) with ILA (OR 2.1, 95% CI 1.82.4, p=1x10-26), there was evidence of significant heterogeneity between cohorts (I-2=81%). When narrowed to specific radiologic subtypes, (e.g. subpleural ILA), the MUC5B genotype remained strongly associated (OR 2.6, 95% CI 2.2-3.1, p=1x10-30) with minimal heterogeneity (I-2=0%). Although there was no evidence that the MUC5B genotype influenced survival, there was evidence that MUC5B genotype improved risk prediction for possible usual interstitial pneumonia (UIP) or a UIP pattern in non-Hispanic white populations. The MUC5B promoter polymorphism is strongly associated with ILA and specific radiologic subtypes of ILA, with varying degrees of heterogeneity in the underlying populations.NIH
Icelandic Research Fund and Landspitali Scientific Fund
Veterans Administratio
The MUC5B promoter polymorphism is associated with specific interstitial lung abnormality subtypes
To access publisher's full text version of this article click on the hyperlink belowThe MUC5B promoter polymorphism (rs35705950) has been associated with interstitial lung abnormalities (ILA) in white participants from the general population; whether these findings are replicated and influenced by the ILA subtype is not known. We evaluated the associations between the MUC5B genotype and ILA in cohorts with extensive imaging characterisation. We performed ILA phenotyping and MUC5B promoter genotyping in 5308 and 9292 participants from the AGES-Reykjavik and COPDGene cohorts, respectively. We found that ILA was present in 7% of participants from the AGES-Reykjavik, 8% of non-Hispanic white participants from COPDGene and 7% of African-American participants from COPDGene. Although the MUC5B genotype was strongly associated (after correction for multiple testing) with ILA (OR 2.1, 95% CI 1.82.4, p=1x10-26), there was evidence of significant heterogeneity between cohorts (I-2=81%). When narrowed to specific radiologic subtypes, (e.g. subpleural ILA), the MUC5B genotype remained strongly associated (OR 2.6, 95% CI 2.2-3.1, p=1x10-30) with minimal heterogeneity (I-2=0%). Although there was no evidence that the MUC5B genotype influenced survival, there was evidence that MUC5B genotype improved risk prediction for possible usual interstitial pneumonia (UIP) or a UIP pattern in non-Hispanic white populations. The MUC5B promoter polymorphism is strongly associated with ILA and specific radiologic subtypes of ILA, with varying degrees of heterogeneity in the underlying populations.NIH
Icelandic Research Fund and Landspitali Scientific Fund
Veterans Administratio
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Association Between Interstitial Lung Abnormalities and All-Cause Mortality.
ImportanceInterstitial lung abnormalities have been associated with lower 6-minute walk distance, diffusion capacity for carbon monoxide, and total lung capacity. However, to our knowledge, an association with mortality has not been previously investigated.ObjectiveTo investigate whether interstitial lung abnormalities are associated with increased mortality.Design, setting, and populationProspective cohort studies of 2633 participants from the FHS (Framingham Heart Study; computed tomographic [CT] scans obtained September 2008-March 2011), 5320 from the AGES-Reykjavik Study (Age Gene/Environment Susceptibility; recruited January 2002-February 2006), 2068 from the COPDGene Study (Chronic Obstructive Pulmonary Disease; recruited November 2007-April 2010), and 1670 from ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints; between December 2005-December 2006).ExposuresInterstitial lung abnormality status as determined by chest CT evaluation.Main outcomes and measuresAll-cause mortality over an approximate 3- to 9-year median follow-up time. Cause-of-death information was also examined in the AGES-Reykjavik cohort.ResultsInterstitial lung abnormalities were present in 177 (7%) of the 2633 participants from FHS, 378 (7%) of 5320 from AGES-Reykjavik, 156 (8%) of 2068 from COPDGene, and in 157 (9%) of 1670 from ECLIPSE. Over median follow-up times of approximately 3 to 9 years, there were more deaths (and a greater absolute rate of mortality) among participants with interstitial lung abnormalities when compared with those who did not have interstitial lung abnormalities in the following cohorts: 7% vs 1% in FHS (6% difference [95% CI, 2% to 10%]), 56% vs 33% in AGES-Reykjavik (23% difference [95% CI, 18% to 28%]), and 11% vs 5% in ECLIPSE (6% difference [95% CI, 1% to 11%]). After adjustment for covariates, interstitial lung abnormalities were associated with a higher risk of death in the FHS (hazard ratio [HR], 2.7 [95% CI, 1.1 to 6.5]; Pâ=â.03), AGES-Reykjavik (HR, 1.3 [95% CI, 1.2 to 1.4]; Pâ<â.001), COPDGene (HR, 1.8 [95% CI, 1.1 to 2.8]; Pâ=â.01), and ECLIPSE (HR, 1.4 [95% CI, 1.1 to 2.0]; Pâ=â.02) cohorts. In the AGES-Reykjavik cohort, the higher rate of mortality could be explained by a higher rate of death due to respiratory disease, specifically pulmonary fibrosis.Conclusions and relevanceIn 4 separate research cohorts, interstitial lung abnormalities were associated with a greater risk of all-cause mortality. The clinical implications of this association require further investigation