[N,N'-Bis(salisiliden)-1,3-propandiaminato]nikel(II) Kompleksinin Sentezi ve DNA Etkisinin İncelenmesi

Özet: Bu çalışmada, bis(salisiliden)-1,3-diaminopropan (H2L) Schiff bazı ile nikel(II) klorür hekzahidrat'ın etanoldeki reaksiyonundan [N,N'-bis(salisiliden)-1,3-propandiaminato]nikel(II) (NiL) kompleksi sentezlendi. Sentezlenen NiL kompleksinin pBR322 plazmid DNA ile etkileşimi ultraviyole absorpsiyon spektroskopisi (UV), dönüşümlü voltametri (CV) ve agaroz jel elektroforez ile incelendi. NiL kompleksinin DNA varlığında absorpsiyon spektrumunun hiperkromik etki gösterdiği ve kaydedilen dönüşümlü voltamogramında pik akımının azaldığı bulundu. NiL kompleksinin indirgeyici maddeler olmadan plazmid DNA'yı etkilediği agaroz jel elektroforez ile gösterildi. Ayrıca NiL kompleksinin Hyperchem® programıyla hesaplanan en düşük enerjili yapısının geometrisi, DNA'nın kısmi interkalasyon ve elektrostatik bağlama modlarıyla ilişkilendirilebilir bir sonuç vermektedir. Anahtar kelimeler: Nikel(II) kompleks, plazmid DNA yarılması, kısmi interkalasyon, elektrostatik etkileşim Synthesis and Investigation of DNA Effect of [N,N'-bis (salicylidene)-1,3-propanediaminato]nickel(II) Complex Abstract: In this study, N,N'-bis(salicylidene)-1,3-propanediaminato]nickel(II) (NiL) complex was synthesized from reaction of bis(salicylidene)-1,3-propanediamine (H2L) with nickel(II) chloride hexahydrate in ethanolic medium. The interaction of synthesized NiL complex with pBR322 plasmid DNA was investigated by ultraviolet absorption spectroscopy (UV), cyclic voltammetry (CV) and agarose jel electrophoresis. It was found that the absorption spectrum of NiL complex in the presence of plasmid DNA showed hyperchromism and its peak current was significantly decreased at recorded voltammogram. Effect of NiL complex on DNA in the absence of reductant agents showed by ajarose jel electrophoresis. Moreover, the geometry of the lowest-energy structure of NiL complex calculated by Hyperchem® program gave a good result to be associated with partial intercalation and electrostatic binding modes of the DNA. Key words: Ni(II) complex, plasmid DNA cleavage, partial intercalation, electrostatic interactio

Interaction of nonsteroidal anti-inflammatory drug naproxen sodium with DNA by electrochemical and spectroscopic methods

Naproxen sodium (NAPS), the sodium salt of (S)-6-methoxy-a-methyl-2-naphtalenacetic acid (Figure 1) is a non-steroidal anti inflammatory drug, which is used in the treatment of severe pain and inflammation. Naproxen blocks the enzyme that makes prostaglandins (cyclooxygenase)

Cd(II)-coordination polymers with isophthalic acid bearing a hydroxyphenylazo group and substituted bis(imidazole) linkers

Four Cd(II) coordination polymers, formulated as {(H(2)betib)(2)[Cd(mu-Hpdia)(2)]center dot H2O center dot MeOH center dot dmf}, (1), {[Cd(mu-Hpdia)(mu-dipib)]center dot dmf}(n) (2), [Cd(mu-Hpdia)(H2O)(2)(mu-betix)(0.5)](n) (3) and [Cd(mu(3)-Hpdia)(MeOH) (mu-bipix)(0.5)](n) (4) (Hpdia: 5-(4-hydroxyphenylazo)isophthalate, betib or bipib: 1,4-bis(2-x-imidazol-1-yl)butane, betix or bipix: 1,4-bis((2-x-imidazol-1-yl)methyl)benzene where x = ethyl- or isopropyl-) were synthesized under the same solvothermal conditions with 5-(4-hydroxyphenylazo)isophthalic acid and flexible or semi-flexible substituted bis(imidazole) linkers, and characterized by elemental analysis, IR spectroscopy, single crystal X-ray diffraction and thermal analysis methods. X-ray analysis results demonstrated that compounds 1-4 displayed 1D, 2D and 3D structures. In 1, the flexible betib ligand was protonated and the 2D structure formed by Hpdia was extended by hydrogen bonding to a 3D supramolecular network with the rtw topology. The hydrogen-bonded structure of 2 displayed a two-fold 3D -> 3D interpenetrated supramolecular network with the tcj/hc topology. Compounds 3 and 4, synthesized using semi-flexible bis(imidazol) ligands, exhibited 1D and 3D frameworks, respectively. The thermal, optical and photoluminescence properties of the compounds were also investigated. (C) 2020 Elsevier Ltd. All rights reserved.Scientific Research Fund of Eskisehir Osmangazi UniversityEskisehir Osmangazi University [201819D20]This work was supported by the Scientific Research Fund of Eskisehir Osmangazi University (Project No. 201819D20).WOS:0005282670000092-s2.0-8508169777

The structures and properties of zinc(II) and cadmium(II) coordination polymers based on semi-rigid phenylenediacetate and 1,4-bis(2-methylimidazol-1-ylmethyl)benzene linkers

A systematic investigation into the reactions of o- and p-phenylenediacetic acid with zinc(II) and cadmium(II) salts in the presence of the semi-rigid 1,4-bis(2-methylimidazol-1-ylmethyl)benzene (pbmeix) co-ligand is reported. Five new coordination polymers – [Zn(μ-opda)(μ-pbmeix)0.5]n 1, {[Zn(μ-ppda)(μ-pbmeix)]·H2O}n 2, {[Zn(μ-ppda)(μ-pbmeix)]∙0.5pbmeix·H2O}n 3, {[Cd(μ-opda)(μ-pbmeix)]·0.5DMF}n 4 and [Cd(μ-ppda)(μ-pbmeix)0.5]n 5 (o/ppda = 1,2-/1,4-phenylenediacetate) – have been prepared and structurally characterised. Compounds 1 and 5 were found to form three-dimensional coordination networks, 2 forms a two-dimensional structure whereas both 3 and 4 form one-dimensional nanotubular structures. Compounds 1 and 4 are opda complexes in which the dicarboxylate shows a tridentate coordination mode in 1 and a tetradentate coordination mode in 4. Compounds 2, 3 and 5 are ppda complexes in which the dicarboxylate adopts bidentate (2, 3) and hexadentate (5) coordination modes. The structure of 2 contains interpenetrated 2D frameworks and is a polycatenane with ppda linkers from one framework passing through Zn2(μ-pbmeix)2 rings from a neighbouring framework. The thermal stability of complexes 1–4 and luminescence properties of complexes 1 and 4 are also reported.</p

The structures and properties of zinc(II) and cadmium(II) coordination polymers based on semi-rigid phenylenediacetate and 1,4-bis(2-methylimidazol-1-ylmethyl)benzene linkers

A systematic investigation into the reactions of o- and p-phenylenediacetic acid with zinc(II) and cadmium(II) salts in the presence of the semi-rigid 1,4-bis(2-methylimidazol-1-ylmethyl)benzene (pbmeix) co-ligand is reported. Five new coordination polymers – [Zn(μ-opda)(μ-pbmeix)0.5]n 1, {[Zn(μ-ppda)(μ-pbmeix)]·H2O}n 2, {[Zn(μ-ppda)(μ-pbmeix)]∙0.5pbmeix·H2O}n 3, {[Cd(μ-opda)(μ-pbmeix)]·0.5DMF}n 4 and [Cd(μ-ppda)(μ-pbmeix)0.5]n 5 (o/ppda = 1,2-/1,4-phenylenediacetate) – have been prepared and structurally characterised. Compounds 1 and 5 were found to form three-dimensional coordination networks, 2 forms a two-dimensional structure whereas both 3 and 4 form one-dimensional nanotubular structures. Compounds 1 and 4 are opda complexes in which the dicarboxylate shows a tridentate coordination mode in 1 and a tetradentate coordination mode in 4. Compounds 2, 3 and 5 are ppda complexes in which the dicarboxylate adopts bidentate (2, 3) and hexadentate (5) coordination modes. The structure of 2 contains interpenetrated 2D frameworks and is a polycatenane with ppda linkers from one framework passing through Zn2(μ-pbmeix)2 rings from a neighbouring framework. The thermal stability of complexes 1–4 and luminescence properties of complexes 1 and 4 are also reported. © 2018 Elsevier Inc

Temperature-controlled formation of two Zn(II)-coordination polymers based on flexible o-phenylenediacetic acid and rigid 1,4-bis(imidazol-1-yl)benzene

Two new coordination polymers with the same components, namely {[}Zn(mu-opda)(mu-dib)(0.5)(dib)](n) (1) and {[}Zn(mu(3)-opda)(mu-dib)(0.5)] (2), were synthesized under different temperatures and characterized by elemental analyses, IR spectroscopy, powder and single X-ray diffractions. The X-ray results showed that complex 1, synthesized at 120 degrees C, was a 1D ladder-like coordination polymer. When the reaction temperature was increased from 120 to 170 degrees C, a 2D coordination polymer (complex 2) was obtained with the sql topology. The o-pda ligand displayed different coordination modes in 1 and 2. Moreover, thermal, photoluminescence and topological properties of the synthesized complexes were studied in detail. (C) 2015 Elsevier Ltd. All rights reserved