Principios psicológicos para la educación de los niños autistas en el ocio y tiempo libre.

Sin resume

Sex Hormone-Related Functions in Regenerating Male Rat Liver

Sex hormone receptors were quantitated in normal male rat liver and in regenerating liver at several different times after partial (70%) hepatectomy. Both estrogen and androgen receptor content were altered dramatically by partial hepatectomy. Total hepatic content and nuclear retention of estrogen receptors increased, with the zenith evident 2 days after partial hepatectomy, corresponding to the zenith of mitotic index. Serum estradiol increased after 1 day, and reached a maximum at 3 days after surgery. In contrast, total and nuclear androgen receptor content demonstrated a massive decline at 1, 2, and 3 days after resection. Serum testosterone displayed a parallel decline. In addition, hepatic content of two androgen-responsive proteins was reduced to 15% and 13% of normal values during this period. The activity of these various proteins during regeneration of male rat liver is comparable to that observed in the liver of normal female rats. Taken together, these results indicate that partial hepatectomy induces a feminization of certain sexually dimorphic aspects of liver function in male rats. Furthermore, these data provide evidence that estrogens, but not androgens, may have an important role in the process of liver regeneration. © 1986, American Gastroenterological Association. All rights reserved

Assessing the competitiveness of Matera and the Basilicata Region (Italy) ahead of the 2019 European Capital of Culture

Cities/regions are increasingly using events to aid social/economic development. The European Capital of Culture promotes urban management and economic production using culture to drive social legacies, job creation and civic repositioning. This paper aims to understand how Matera and Basilicata’s residents perceive destination competitiveness ahead of the 2019 European Capital of Culture. This paper adapts the Integrated Model of Destination Competitiveness and suggests a new determinant to understand resident perceptions. This paper contributes a new determinant to consider in competitiveness research: social conditions to improve local wellbeing. Two hundred respondents identify strengths/weaknesses of each competitiveness determinant. The results presented in this study display sample mean values and standard deviations for each indicator, as well as Wilcoxon test statistic (z). Competitive indicators are those showing means above 4.0. Descriptive and inferential analyses using SPSS 17 show strengths/weaknesses comparing Matera (city) and Basilicata (region) with similarities and differences outlined to consider both urban and regional perspectives and differences. For the data analysis, Wilcoxon paired signed rank test displays differences in the competitiveness factors between Matera and Basilicata. Wilcoxon (a nonparametric alternative to paired sample t-test) was performed since the data distribution was left skewed and Kolmogorov–Smirnov statistic indicates violation of normality assumption. Results show the majority of inherited, created and supporting resources are competitive, as well as image and social conditions; however, management and organisation needs improvement. It is essential that European Capital of Culture hosts have long-term competitive strategies in place to strengthen urban and regional capacity when delivering diverse cultural programmes, at present, and into the future. This study offers insight before the 2019 European Capital of Culture to inform planners and policymakers ahead of the event and offers consideration and discussion of social impacts and the need to gain such insight in competitiveness research going forward

Food consumption analysis in Spanish elderly based upon the Mini Nutritional Assessment Test

Background/Aims: Aged people are an increasing population group worldwide, and nutritional impairments may contribute to additional health problems. The characterization of food consumption of elderly people is a good approach to implementing adequate nutritional policies in order to improve their nutritional status. The aim of this study was to describe and analyze specific aspects of food intake based upon the Mini Nutritional Assessment (MNA) test in a representative country sample. Methods: The survey consisted of a cross-sectional study assessing the nutritional status of 22,007 Spanish people aged 65 years or older using the MNA test. These data, including dietary information, were obtained by health professionals specifically trained to carry out the questionnaire. A multiple regression analysis was used to evaluate the contributing impact of the diet-related MNA questions on the total MNA score. Results: Differences in the food choices between men and women were found, but not in the mode of feeding. Obese and non-obese individuals, categorized by a body mass index (BMI) more or less than 30, showed similar intake patterns of protein-rich foods, but differences in fruits, vegetables and fluids. On the other hand, undernourished and non-undernourished subjects, according to the MNA criteria, revealed different food consumption. Loss of appetite and mode of feeding were the items with the highest influence the MNA total score. Conclusions: While age, gender and BMI considered together are responsible for 11.3% of the total MNA score, dietary-related items can predict the 62.4% of the total MNA classification in the overall elderly Spanish population

Circadian rhythm of hepatic cytosolic and nuclear estrogen and androgen receptors

Mammalian liver is a sex steroid-responsive tissue. The effects of these hormones presumably are mediated by hepatic estrogen receptors (ER) and androgen receptors (AR). Serum levels of sex hormones display circadian rhythms. Further, estrogens and androgens are commonly administered; administration of these agents is associated frequently with liver disease. Therefore, we investigated whether the cytosolic and nuclear sex steroid receptors also display a similar circadian rhythm, and whether variations occurred in the distribution of receptors between cytosolic and nuclear compartments. Animals were killed every 4 h from midnight till the following midnight; cytosolic and nuclear levels of both ER and AR were measured. Cytosolic ER reached a maximum level at 4 am, and a minimum at 8 pm and midnight of both days. Nuclear ER was highest at 8 am and lowest at 4 pm and 8 pm, a pattern which parallels variations in serum estradiol levels. Cytosolic AR was highest at 8 pm and lowest at midnight and 4 am. Nuclear AR was highest at 4 am and lowest at 4 pm and 8 pm. The highest level of nuclear AR does not correspond to the maximum serum testosterone level, which occurred at 4 pm. The total hepatic content of both ER and AR was not constant over the 24-h period, but varied considerably with time of day. These studies suggest that both ER and AR show a distinct circadian rhythm in subcellular compartmentalization, and that total hepatic content of ER and AR varies significantly during a 24-h period. © 1986

Disaggregated Optical Network Orchestration based on the Physical Layer Digital Twin

The architecture and functionality of an open and disaggregated optical network is presented, focusing on the orchestration of the physical layer digital twin and the optical network controller, implemented on an experimental multi-vendor triangular-topology setup

Experimental Demonstration of Partially Disaggregated Optical Network Control Using the Physical Layer Digital Twin

Optical communications and networking are fast becoming the solution to support ever-increasing data traffic across all segments of the network, expanding from core/metro networks to 5G/6G front-hauling. Therefore, optical networks need to evolve towards an efficient exploitation of the infrastructure by overcoming the closed and aggregated paradigm, to enable apparatus sharing together with the slicing and separation of the optical data plane from the optical control. In addition to the advantages in terms of efficiency and cost reduction, this evolution will increase network reliability, also allowing for a fine trade-off between robustness and maximum capacity exploitation. In this work, an optical network architecture is presented based on the physical layer digital twin of the optical transport used within a multi-layer hierarchical control operated by an intent-based network operating system. An experimental proof of concept is performed on a three-node network including up to 1000 km optical transmission, open re-configurable optical add & drop multiplexers (ROADMs) and whitebox transponders hosting pluggable multirate transceivers. The proposed solution is based on GNPy as the optical physical layer digital twin and ONOS as intent-based network operating system. The reliability of the optical control decoupled by the data plane functioning is experimentally demonstrated exploiting GNPy as open lightpath computation engine and software optical amplifier models derived from the component characterization. Besides the lightpath deployment exploiting the modulation format evaluation given a generic traffic request, the architecture reliability is tested mimicking the use case of an automatic failure recovery from a fiber cut

Impact of global and subjective mini nutritional assessment (MNA) questions on the evaluation of the nutritional status: The role of gender and age

Undernutrition is a quite common condition in the elderly, often identified using the mini nutritional assessment (MNA) test. The aim of this research was to study the independent value of the global and the subjective MNA questions to predict the undernutrition according to the full MNA score, and to analyze the influence of gender and age on such items. A total of 22,007 Spanish people 65 years of age or older were evaluated using the MNA test. These data were obtained by trained community pharmacists by using receiver Operating Characteristic (ROC) curves. About 4.3% of the studied population were classified as undernourished according to the full MNA test. The subjective subscore (two questions) presented better predictive value than the global one (six questions). Indeed, 99.5% of subjects detected as well nourished using the MNA test were also correctly classified using the two subjective questions. In the present study, it was identified that the two subjective MNA questions can be an efficient tool for a quick screening to rule out non undernourished subjects