7 research outputs found
Discovering novel systemic biomarkers in photos of the external eye
- Author
- Publication venue
- Publication date
- 18/07/2022
- Field of study
External eye photos were recently shown to reveal signs of diabetic retinal
disease and elevated HbA1c. In this paper, we evaluate if external eye photos
contain information about additional systemic medical conditions. We developed
a deep learning system (DLS) that takes external eye photos as input and
predicts multiple systemic parameters, such as those related to the liver
(albumin, AST); kidney (eGFR estimated using the race-free 2021 CKD-EPI
creatinine equation, the urine ACR); bone & mineral (calcium); thyroid (TSH);
and blood count (Hgb, WBC, platelets). Development leveraged 151,237 images
from 49,015 patients with diabetes undergoing diabetic eye screening in 11
sites across Los Angeles county, CA. Evaluation focused on 9 pre-specified
systemic parameters and leveraged 3 validation sets (A, B, C) spanning 28,869
patients with and without diabetes undergoing eye screening in 3 independent
sites in Los Angeles County, CA, and the greater Atlanta area, GA. We compared
against baseline models incorporating available clinicodemographic variables
(e.g. age, sex, race/ethnicity, years with diabetes). Relative to the baseline,
the DLS achieved statistically significant superior performance at detecting
AST>36, calcium=300, and WBC<4 on
validation set A (a patient population similar to the development sets), where
the AUC of DLS exceeded that of the baseline by 5.2-19.4%. On validation sets B
and C, with substantial patient population differences compared to the
development sets, the DLS outperformed the baseline for ACR>=300 and Hgb<11 by
7.3-13.2%. Our findings provide further evidence that external eye photos
contain important biomarkers of systemic health spanning multiple organ
systems. Further work is needed to investigate whether and how these biomarkers
can be translated into clinical impact
Diagnosis of retinal detachments by a tele-ophthalmology screening program
- Author
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Deep Learning and Glaucoma Specialists
- Author
- Abigail E. Huang
- Anita Misra
- April Y. Maa
- Arielle Spitze
- Asaoka
- Ashish Bora
- Bernardes
- Bowd
- Chaum
- Chihara
- Chihara
- Christopher
- Christopher Semturs
- Clopper
- Dale R. Webster
- Derek J. Wu
- Felipe A. Medeiros
- Fingeret
- Greg S. Corrado
- Gulshan
- Hennis
- Herschler
- Hollands
- Jonas
- Jonas
- Jonathan Krause
- Krause
- Krippendorff
- Krizhevsky
- LeCun
- Lee
- Leite
- Li
- Lily Peng
- Liu
- Lopes
- Mardin
- Massey
- Mike Schaekermann
- Monica Gandhi
- Muhammad
- Naama Hammel
- Naho Kitade
- Newman-Casey PA
- Opitz
- Poon
- Prum
- Prum
- Quigley
- R. Carter Dunn
- Rory Sayres
- Rotchford
- Sayres
- Settles
- Shi
- Shibata
- Sonia Phene
- Susanna
- Sutton
- Szegedy
- Tatham
- Tham
- Thomas
- Tielsch
- Ting
- Varma
- Weinreb
- Weinreb
- Weinreb
- Yun Liu
- Zangwill
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Recommended from our members
Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study an international prospective cohort study
- Author
- Ababneh  Hazim
- Abad-Motos  Ane
- Abbas  Ferial Mohamed Ali
- Abbo  Olivier
- Abbott  Tom
- Abbott  Tom
- Abdelkabir  Mohammed
- Abdelkhalek  Mohamed
- Abdoun  Meriem
- Abdur-Rahman  Lukman
- Abdur-Rahman  Lukman
- Abebe  Metasebia
- Aboazamazem  Hajir
- Abou Chaar  Mohamad K.
- Abou Chaar  Mohamad K.
- Abouelnagah  Galal
- Abozied  Hesham
- Abu Salhiyeh  Ala A.
- Abu-Ismail  Luai
- Abu-Mehsen  Marah
- Abuawad  Carla
- Abukhalaf  Sadi A.
- Abuleil  Amro
- Ackermann  Travis
- Acquah  Daniel Kwesi
- Adam  Mohammed Elmujtba Adam Essa
- Adamina  Michel
- Adamina  Michel
- Ademuyiwa  Adesoji
- Adesanya  Opeoluwa
- Adisa  Adewale
- Adisa  Adewale
- Afolabi  Akinwale
- Agarwal  Arnav
- Agarwal  Gaurav
- Agarwal  Ketan
- Agastra  Ervis
- Agastra  Ervis
- Agbadebo  Mouhamed
- Agbonrofo  Peter
- Aguilera-Arevalo  Maria-Lorena
- Aguilera-Arevalo  Maria-Lorena
- Ahmad  Amer
- Ahmad  Siddique
- Ahmadi  Navid
- Ahmed  Waheed-Ul-Rahman
- Aigner  Felix
- Aiken  Taylor
- Akhavizadegan  Hamed
- Akhbari  Melika
- Akililu  Yemisirach Bizuneh
- Akinmade  Akinola
- Al Ameer  Ahmed
- Al Ameer  Ahmed
- Al Amri  Abdulrahman
- Al Balushi  Zainab
- Al Islam Ben Jouira  Rayet
- Al Maadany  Faraj
- Al-Manaseer  Balqees Mahmoud
- Al-Naggar  Hamza
- Al-Naggar  Hamza
- Al-Raimi  Ibrahim
- Al-Sabbagh  Yusra
- Al-Shehari  Mohammed
- Aladawi  Omar
- Alajalen  Amer
- Alalawi  Yousef
- AlAmeer  Ehab
- Alameer  Ehab
- Alansari  Arowa Hassan Abdulrahman
- Alawami  Mohammed
- Alawneh  Yazan
- Alayan  Mohammed
- Albared  Sara Maa
- Albertsmeier  Markus
- Albertsmeier  Markus
- Alderazi  Amer
- Aldlyami  Ehab
- Aldressi  Wafa
- Alecci  Anna
- Alexander  Philip
- AlFakhri  Abdullah
- Alharthi  Mohammed
- Alhassoun  Turki
- Alhefdhi  Amal
- Alkadeeki  Ghadah
- Alkaseek  Akram
- Alkhatib  Ahmad
- Allemand  Carola
- Almabayev  Ydyrys
- Almeida-Reis  Rui
- Almiqlash  Bushray
- Almoguera  Jorge
- Almugaddami  Ayman
- Almulhim  Abddulrahman Saleh
- Alnachoukati  Omar
- Alnahr  Hareth
- Alonso  JesĂșs AarĂłn MartĂnez
- Alonso  Manuel Diez
- Alonso  Nestor Fabian Pedraza
- Alqudah  Majdi Ali
- Alrayes  Bourhan
- Alsaadi  Hayder
- Alsaadi  Hayder
- Alser  Osaid
- Alshaar  Muhammad
- Alshahrani  Mushabab
- Alshareef  Khayriyah
- Alshehri  Ameen
- Alshryda  Sattar
- Alshryda  Sattar
- Alsibai  Sareyah
- Alsunna  Zaid
- Altaf  Humera Naz
- Althumairi  Azah
- Althumairi  Azah
- Althumairi  Azah
- Alvarado  Carlos Eduardo Otiniano
- Alyami  Mohammad
- Alzahrani  Abdulrahman
- Alzaidi  Turki M.
- Alzate  Juan Pablo
- Alzerwi  Nasser
- Amisi  Nicolas
- Amnaina  Mohamed
- Amor  MarĂa Sol Crespi
- André  Benoßt
- Angeles  Martina Aida
- Anwer  Mariyah
- Anyanwu  Lofty-John
- Aouabed  Nesrine
- Aqeelah  Ahmed
- Aqil  Sabra
- Arancibia  José Alfredo Calderón
- Arango  Maria Clara Mendoza
- Arbane  Gill
- Argus  Leah
- Arias  Claudia
- Arnalsteen  Laurent
- Arnaud  Alexis P.
- Arnaud  Alexis P.
- Asif  Muhammad
- Assefa  Melatework
- Atnafu  Bahru
- Aulerio  Giuliana D.
- Aurora Â
- Awad  Selmy
- Ayasra  Faris
- Ayasra  Faris
- Ayoub  Abdu
- Ayub  Bushra
- Ayub  Khurram
- Azevedo  José
- Azevedo  José
- Azevedo  Pedro
- Aziz  Aliya
- Azzam  Ahmed Y.
- Bacalbasa  Nicolae
- Badareesh  L.
- Badenes  Rafael
- Badiani  Sarit
- Baig  Mariam
- Bains  Lovenish
- Baiocchi  Glauco
- Baiocchi  Glauco
- Baiocchi  Glauco
- Bajaj  Ankur
- Balanta-Melo  Juliån
- Balasubramanya  Supriya
- Bali  Oussama
- Baliarsing  Lipika
- Ball  Alasdair
- Ballouhey  Quentin
- Ban  Vin Shen
- Bankhead-Kendall  Brittany
- Bankhead-Kendall  Brittany
- Barillas  Sabrina
- Barker  John
- Barros  Aldo Vieira
- Basnayake  Oshan
- Bastet  Joaquin
- Basu  Somprakas
- Bateman  Antony
- Bath  Michael
- Batista  Sylvia
- Bauset  Juan Carlos Catalå
- Bayo  Heura Llaquet
- BaĂa  Catarina
- Behzadi  Abdollah
- Bekele  Kebebe
- Bele  Uros
- Bele  Uros
- Bellver  Pedro Palazon
- Ben Amer  Anass
- Benallel  Nassim
- Benson  Ruth
- Berber  Norberto
- Bergeat  Damien
- Bergkvist  David JuliĂ
- Bernal-Sprekelsen  Juan Carlos
- Berndtson  Allison
- Bertrand  Marta
- Bescós  Coro
- Bezabih  Yoseph Solomon
- Bhanderi  Shivam
- Bhangu  Aneel
- Bhangu  Aneel
- Bhat  Dhananjaya
- Bhatti  Abu Bakar Hafeez
- Bhende  Vishal
- Bhutiani  Neal
- Bianco  AgustĂn
- Biccard  Bruce
- Blanco-Colino  Ruth
- Blanco-Colino  Ruth
- Blanco-Colino  Ruth
- Blasco  Laura Sånchez
- Boccalatte  Luis
- Boccalatte  Luis
- Boccalatte  Luis
- Boira  Mar Achalandabaso
- Boisson  Matthieu
- Bolatbekova  Raikhan
- Bolger  Jarlath
- Bollano  Enton
- Bonci  Eduard-Alexandru
- Bonci  Eduard-Alexandru
- Borda-Luque  Giuliano
- Boretto  Jorge G.
- Borges  Filipe Castro
- Bork  Ulrich
- Borowski  David W.
- Botero  Marcela Velez
- Bouaoud  Souad
- Bouche  Pierre-Alban
- Bouchenak  Kamel
- Boucher  Sophie
- Boudou  Rocio
- Bouhuwaish  Ahmad
- Brandariz  Rodrigo
- Branquinho  Rita
- Brar  Amanpreet
- Brar  Amanpreet
- Bravo  Ana Maria Minaya
- Bravo  Ana Maria Minaya
- Breen  Kerry
- Brennan  Caitlin
- Brien  Stephen O.
- Bright  Tim
- Brown  Wendy
- Brunaud  Laurent
- Brunner  Stefan M.
- Buarque  Igor Lima
- Bucyibaruta  Georges
- Bukhari  Syed Imran
- Buljubasich  Martin
- Burchakchi  Arturo
- Burgan  Dania
- Busnelli  Virginia Cano
- Buttaro  Martin
- Butyrskii  Aleksandr
- Bwala  Kefas
- Bywater  Edward P.
- C Â Ricci
- Caiado  André
- Caicedo  Lina
- Cal  Fernando Bonilla
- Callcut  Rachael
- Calvache  Albaro José Nieto
- Calvache  Jose Andres
- Calvache  Jose Andres
- Calvache  Jose Andres
- Calzaretta  Laura Gisela Alvarez
- Campana  Juan Pablo
- Campos  Heloisa Galvão do Amaral
- Capitaine  Daniel
- Cappeliez  Serge
- Cardoso  Paulo
- Carmichael  Heather
- Carminatti  Tomas
- Carrera  Jacqueline
- Carreras-Castañer  Anna
- Caruana  Edward
- Cereghini  Julian
- Cerovac  Anis
- Cerovac  Anis
- Chadi  Sami
- Chakrabortee  Sohini
- Chan  Matthew
- Chandrasinghe  Pramodh
- Chapatwala  Reema
- Charbonneau  Helene
- Charles  Shane
- Chaudhary  Muhammad Hamid
- Chaudhry  Daoud
- Chaudhry  Daoud
- Chaudhry  Navneet Kumar
- Chauhan  Govind Singh
- Chebaro  Alexandre
- Chew  Min Hoe
- Chin  Theresa
- Chinyowa  Simbarashe
- Chiuyari  Jose Rios
- Choong  Peter
- Chowdappa  Raghunandan Gorantlu
- Chowdhury  Sharfuddin
- Christensen  Peter
- Chuan  Alwin
- Chwat  Carina
- Chwat  Carina
- Clancy  Cillian
- Coimbra  Felipe José Fernandez
- Coleman  Julia
- Colmenares  Yahaira Tatiana Carpio
- Colås-Ruiz  Enrique
- Connelly  Tara
- Connor  Clare O.
- Coonar  Aman
- Corbett  Harriet
- Corella  Fernando
- Corripio-Sanchez  Ramon
- Costa  Luciana Cidade
- Costas-Chavarri  Ainhoa
- Costea  Radu
- Cotta  EstefanĂa
- Cox  Daniel
- Cox  Daniel
- Creavin  Ben
- Croattini  Roberto Sebastiån
- Croghan  Stefanie M.
- Crétolle  Célia
- Cukier  Moises
- Cukier  Moises
- Cullinane  Carolyn
- Cunha  Miguel F.
- Cunha  Miguel F.
- Dajti  Irida
- Dajti  Irida
- Dajti  Irida
- Daoud  Hassan
- Das  Rishi
- Davies-Jones  Gareth
- Davis  Niall
- Dawson  Amanda Caroline
- Dawson  Amanda Caroline
- Dawson  Brett E.
- Dbeis  Rachel
- De Andrés-Asenjo  Beatriz
- De Cortazar  Unai Garcia
- de Dieu  Haragirimana Jean
- de LeĂłn  Laura RomĂĄn GarcĂa
- De Simone  Belinda
- Dean  Benjamin
- Degefa  Eyueal
- Del Pilar Paucar Urbina  Arazzelly
- Delibegovic  Samir
- Delisau-Puig  Olga
- Dell  Angela
- Demetrashvili  Zaza
- Demetrashvili  Zaza
- Demetriades  Andreas K.
- Derilo  Habtamu
- Desai  Anant
- Deus  Ana Clåudia
- Dharap  Satish
- Dhondt  Bert
- Dhufera  Hailu
- Di Martino  Marcello
- Di Saverio  Salomone
- Di Vincenzo  Marcela
- Diaz-Couselo  Fernando
- Diehl  Thomas
- Dimofte  Mihail-Gabriel
- DiNome  Maggie
- Djahida  Bahraoui
- Doerner  Johannes
- Domenech  Julio
- Donlon  Noel
- Drake  Frederick
- Drake  Thomas
- Drasovean  Radu
- Duarte  Amalia Barrios
- Duarte  Carolina Lugo
- Dube  Surya Kumar
- Duchalais  Emilie
- Dudi-Venkata  Nagendra
- Duran  Irani
- Duric  Natalie
- Duro  Agustin
- Dwaga  Sumayya Essayah
- Dziakova  Jana
- Déserts  Marc Danguy des
- DĂaz-Feijoo  Berta
- Earley  Helen
- Eberbach  Helge
- Edwards  John
- Edwards  John
- Efetov  Sergey
- Efetov  Sergey
- Egoroff  Natasha
- Eiras  Miguel Angel Freiria
- Ekenze  Sebastian
- El Helw  Amin
- El Kafsi  JihÚne
- El-Boghdadly  Kariem
- El-Boghdadly  Kariem
- El-Hussuna  Alaa
- Elhadi  Muhammed
- Elhadi  Muhammed
- Elhajdawe  Fras
- Elliott  Brodie
- Ellojli  Ibrahim
- Elwahab  Sami Abd
- Emerson  Hannah
- Emile  Sameh
- Emile  Sameh
- Enjuto  Diego
- Escartin  Jorge
- Escudero  DamiĂĄn GarcĂa
- Escudero  Mario I.
- Eskander  Antoine
- Espin-Basany  Eloy
- Espino  Pablo Calvo
- Espinosa-Bravo  Martin
- Esquivel  Carlos
- Estruch  Nuria Montferrer
- Etchill  Eric
- Evans  Jonathan
- Evelyn  Nissi
- Ezanno  Anne-Cecile
- Fahadullah  Muhammad
- Fahmy  Mohamed
- Fakhradiyev  Ildar
- Fakhradiyev  Ildar
- Farfus  Anthony
- Farik  Shebani
- Farooq  Umer
- Faulkner  Gemma
- Faustin  Ntirenganya
- Fernandez  Juan Delgado
- Fernandez  Laura Gomez
- Fernandez  Maria Sol
- Fernåndez  Fåtima Sånchez
- Fernåndez-López  Antonio-José
- Ferrer  Antonio Perez
- Ferry  Jenny
- Figari  Marcelo
- Figueroa  Rodrigo
- Figueroa-Casanova  Rafael
- Filipce  Venko
- Filipescu  Daniela
- Fiore  Marco
- Fisseha  Tigist
- Flamey  Nicolas
- Fleming  Christina
- Flexman  Alana
- Fluegen  Georg
- Flumignan  Ronald
- Ford  Samuel
- Forero-Torres  Alexander
- Forneris  Agustin Albani
- Fotopoulou  Christina
- Fowler  Alexander
- Fraidenraij  Uriel
- Fredon  Fabien
- Fuentes  Marta Alcaraz
- Fuentes  Tyare
- Fujimoto  Yuki
- Futaba  Kaori
- Gagnier  Joel
- Gahwagi  Milad
- Gallegos  Diego
- Gallino  Esteban Sebastian
- Gallo  Gaetano
- Ganly  Ian
- Garcia  Manuel
- Garcia-Adamez  Jorge
- GarcĂa  Lucia Diego
- GarcĂa  Pablo MartĂn
- GarcĂa-Mansilla  AgustĂn Maria
- GarcĂa-Montoya  Oscar-JuliĂĄn
- Gaujoux  Sebastien
- Gauna  Guillermo Hernandez
- Gempt  Jens
- Georgiades  Fanourios
- Gerchunoff  José Ignacio
- Ghani  Muhammad Owais Abdul
- Ghazal  Ahmad
- Ghazwani  Salman
- Ghodke  Rahul
- Ghosh  Dhruva
- Ghosh  Dhruva
- Ghosh  Indranil
- Ghozy  Sherief
- Ghunaim  Mohammed
- Gialamas  Eleftherios
- Gialamas  Eleftherios
- Gigena  Cecilia
- Gil-Sala  Daniel
- Ginghina  Octav
- Giorgakis  Emmanouil
- Girard  Edouard
- Girard  Noémie
- Gishanthan  Shanthamoorthy
- Gjata  Arben
- Gjyli  Kostandin
- Glasbey  James C.
- Glasbey  James C.
- Glass  Nina
- Glowka  Tim R.
- Gohar  Muhammad
- Golet  Marta Roldón
- Gomes  Gustavo Mendonça AtaĂde
- Gomez  Jose Tomas Castell
- Gomez-Fernandez  Hugo
- Gomez-Rosado  Juan-Carlos
- Gonzalez  Diana Samantha
- Gonzalez  Marcos
- Gonzalez  Matias Ignacio
- Gonzalez  Santiago Valderrabano
- Gonzålez  Javier Serrano
- Gonzålez-Gimeno  Maria Jose
- Gonzålez-Suårez  Susana
- Goransky  Jeremias
- Gosain  Ankush
- Gourlay  Ralph
- Gousias  Konstantinos
- Gouvas  Nikolaos
- Gouvas  Nikolaos
- Grama  Florin
- Grassano  Bianca
- Greenhalgh  Michael
- Griffiths  Ewen
- Gronchi  Alessandro
- Groot  Gary
- Gross  Jefferson
- Guillen  Jose Ramon Oliver
- Gujjuri  Rohan R.
- Gujjuri  Rohan R.
- Gulla  Aiste
- Gunawansa  Nalaka
- Gupta  Anand
- Gupta  Rahul
- Gurumeta  Alfredo Abad
- Gut  Anna Eleonora
- Gómez  Mercedes Estaire
- Ha  Jeong
- Habumuremyi  Sosthene
- Hadzibegovic  Ana Danic
- Haidar  Hanan
- Haider  Fayza
- Haif  Assia
- Hailu  Samuel
- Hailu  Samuel
- Hakami  Ibrahim
- Hamad  Faten Reyad Bani
- Hamdun  Intisar Hisham Said
- Hameed  Zeeshan
- Hammed  Ali
- Hammond  John
- Haran  Cheyaanthan
- Hardie  John
- Harper  Luke
- Harrison  Ewen M.
- Harrison  Ewen M.
- Hashimoto  Daisuke
- Hassan  Ramy A.
- Hecker  Andreas
- Henein  Christin
- Heredia  Fernando
- Heriot  Alexander
- Hervieux  Erik
- Herzberg  Jonas
- Higuera  Felipe
- Hilmi  Ahmed
- Hirji  Sameer
- Hirschburger  Markus
- Hodgson  Russell
- Holc  Fernando
- Hollington  Paul
- Hollyman  Marianne
- Horch  Raymund E.
- Horisberger  Karoline
- Hossain  Kamral
- Huang  Abel
- Husain  Shatha
- Hutchinson  Peter
- Hyman  Gabriella Yael
- Höhn  Philipp
- Iascano  Fernando Martinez
- Ikele  Hilary
- Imanishimwe  Alphonsine
- Incorvia  Joseph
- Incorvia  Joseph
- Infante  Antonio Rodriguez
- Ingabire  Jc Allen
- Ionescu  Sebastian
- Isaac  Otolia
- Isik  Arda
- Isik  Arda
- Iskander  Othman
- Jain  Kavitha
- Jain  Ritu
- Jamal  Aiman
- Jamal  Mohammad
- James  Harelimana Grace
- Jauregui  Esteban Gabriel
- Javadpour  Mohsen
- Javed  Saad
- Javed  Saad
- Jaworska  Natalia
- Jayarajah  Umesh
- Jayarajah  Umesh
- Jeandel  Clement
- Jenkinson  Michael
- Jimaale  Elmi Ahmed Mohamed
- Jimenez  Raul
- Jimenez  Virginia
- Jiménez  Pablo Mijahil Avilés
- Jiménez  Pablo Mijahil Avilés
- Jin-Young  Jang
- Jira  Moa
- Jisry  Ghassan
- Jlassi  Haithem
- Johnson  David
- Jones  Conor S.
- Jonker  Pascal
- Jouffret  Lionel
- JĂșnior  Samuel Aguiar
- Kaafarani  Haytham
- Kaafarani  Haytham
- Kaafarani  Haytham
- Kabir  Syed Mohammad Umar
- Kabweru  Wilberforce M.
- Kache  Stephen
- Kacimi  Salah Eddine Oussama
- Kaidarova  Dilyara
- Kaiser  Julia Christina
- Kakeeto  Andrew
- Kaman  Lileswar
- Kamarajah  Sivesh K.
- Kamarajah  Sivesh K.
- Kamphues  Carsten
- Kandevani  Naser Yousefzadeh
- Kannan  Ravi
- Karout  Lina
- Karthigeyan  Madhivanan
- Kassir  Radwan
- Kauppila  Joonas H.
- Kauppila  Joonas H.
- Kaups-Fresno  Krista
- Kavalakat  Alfie
- Keatley  James M.
- Kembuan  Gabriele
- Keppler  Alexander M.
- Keppler  Lena
- Kerawala  Asad Ali
- Kerawala  Cyrus
- Kerpaci  Jola
- Khadidja  Kouidri
- Khalifa  Houda
- Khalil  Kareem S.
- Khamees  Almu'atasim
- Khan  Tabassum
- Khatri  Chetan
- Kherani  Safeena
- Khokhar  Muhammad Imran
- Khosravi  Mohammad
- Khosravi  Mohammad Hossein
- Kieser  David
- King  Jasmin
- Kirov  Mikhail
- Kiweewa  Ronald
- Klat  Jaroslav
- Knight  Stephen Richard
- Kochetkov  Viktor
- Koh  Cherry
- Koh  Frederick
- Koh  Frederick
- Kolias  Angelos
- Komen  Niels
- Konate  Ibrahima
- Konrads  Christian
- Kopetskyi  Slava
- Kopjar  Tomislav
- Kornblith  Lucy
- Kowalski  Luiz Paulo
- Koƥir  Jurij Aleƥ
- Koƥir  Jurij Aleƥ
- Kpangon  Cyrille
- Kronberger  Irmgard
- Kronberger  Irmgard Elisabeth
- Kroon  Hidde M.
- Kruijff  Schelto
- Kudsk-Iversen  SÞren
- Kulimbet  Mukhtar
- Kulkarni  Amruta
- Kumar  Aruna
- Kumar  Ashwani
- Kundra  Rakesh
- Kuroda  Naoto
- Kwan  Tsun Yu
- Königsrainer  Alfred
- la Medina  Antonio Ramos-De
- Laban  Simon
- Lakkis  Zaher
- Lakpriya  Sathya
- Lalmi  Ismahene
- LalĂn  Agustina Florencia Castro
- Lami  Mariam
- Landaluce-Olavarria  Aitor
- Larrañaga  Juan
- Latif  Haider
- Lau  Lorena Fuentes Rivera
- Laudani  Veronica
- Laudani  Veronica
- Laura  Saura GarcĂa
- Lavanya Kannaiyan  R.
- Lawal  Taiwo Akeem
- Lawani  Ismaïl
- Lawani  Ismaïl
- Lawday  Samuel
- Le Bian  Alban Zarzavadjian
- Lederhuber  Hans
- Lekuya  Hervé Monka
- Lekuya  Hervé Monka
- Lekuya  Hervé Monka
- Leung  Elaine
- LeventoÄlu  Sezai
- LeventoÄlu  Sezai
- Lewis-Lloyd  Christopher
- Lewis-Lloyd  Christopher
- Li  Elizabeth
- Li  Elizabeth
- Lidder  Surjit
- Lincango-Naranjo  Eddy
- Lincango-Naranjo  Eddy
- Lindert  Judith
- Linz  Valerie Catherine
- Litvin  Andrey
- Litvin  Andrey
- Liveris  Anna
- Liyo  Juan
- Llano  Lionel
- Lo  Terence
- Loaloa  Mohamed Reda
- Lobos  Pablo
- Lohsiriwat  Varut
- Losada  Manuel
- Lott  Natalie
- Lou  Wenhui
- Lowey  Megan
- Lozada  Jorge Centeno
- LoÌffler  Markus W.
- Lucchini  Sergio Martin
- Lucchini  Sergio Martin
- Lueckel  Stephanie
- Lugones  Ignacio
- Lule  Herman
- Lule  Herman
- Lule  Herman
- Luna  Joaquin
- Luzzi  Emilia
- López  Anna Sånchez
- López  Cristina Barrena
- Mabood  Waleed
- Macchiavello  Roberto
- MacKenzie  Shawn
- Madabhavi  Irappa
- Madkhali  Tariq
- Madrid  Constanza
- Mahakalkar  Chandrashekhar
- Maher  Mark
- Maimbo  Mayaba
- Maji  Suvendu
- Majid  Haroon Javaid
- Major  Piotr
- Major  Piotr
- Makdissi  Fabiana
- Makkai-Popa  Silviu Tiberiu
- Maldonado-Marcos  Eloy
- Maleki  Esmaeil Rezghi
- Malik  Muhammad Usman
- Mallén  Victoria Duque
- Manceau  Gilles
- Mann  Harvinder
- Mann  Harvinder
- Mansour  Ahmed
- Maricic  Maximiliano
- Mariño  Lucia Porteiro
- Marquez  Lucila
- Marson  Ella J.
- Martin  Janet
- Martin  Janet
- Martinez  Antonio Alberto
- Martinez  Eneida Diaz
- Martinez  Laura
- Martins  Paulo
- MartĂn  Maria Teresa FernĂĄndez
- MartĂn-LĂĄez  RubĂ©n
- MartĂnez  Daniel FernĂĄndez
- MartĂnez  MarĂa JosĂ©
- MartĂnez  Mireia Riba
- Marçal  André
- Mashbari  Hassan
- Mashhour  Mohamed
- Mashhour  Mohamed
- Mashhour  Mohamed
- Massoud  John George
- Mastroianni  Gustavo
- Mata-Suarez  Santiago Miguel
- Matai  Anil
- Mateo-Sierra  Olga
- Matovu  Paul
- Mayer  Horacio F.
- Mayol  Julio
- Mazingi  Dennis
- Mc Loughlin  Santiago
- McDonnell  Brendan
- McGuinness  Matthew James
- McIntosh  Nick
- McKay  Siobhan
- Mclean  Kenneth A.
- Mclean  Kenneth A.
- McNestry  Catherine
- Meara  John G.
- Meelad  Ayman
- Mege  Diane
- Megersa  Abebe
- Mehraj  Asif
- MejĂa  Dolores
- Melendez  Robinson Mas
- Melero  Alba Vazquez
- Melo  Miguel Rocha
- Mendes  Filipa
- Mendiola  Gian
- Mendoza  Efrain
- Mendoza  Veronica Alonso
- Mengesha  Mengistu G.
- Mengesha  Mengistu G.
- Mengesha  Mengistu Gebreyohanes
- Mentz  Ricardo Esteban
- Meola  Antonio
- Mercado  Pedro
- Mersich  Tamås
- Metallidis  Symeon
- MeÌvo Romaric Tobome  S.
- Michael  Antony Louis Rex
- Migliorelli  Federico
- Mihanovic  Jakov
- Mihanovic  Jakov
- Milan  Peiman Brouki
- Mills  Emily
- Mimica  Ximena
- Mironescu  Aurel
- Mishra  Tushar
- Misra  Sanjeev
- Misrai  Vincent
- Mittal  Rohin
- Mitul  Ashrarur Rahman
- Mlambo  Busisiwe
- Modabber  Ali
- Modolo  Maria Marta
- Modolo  Maria Marta
- Modolo  Maria Marta
- Modolo  Maria Marta
- Mohamed  Awadelkarim
- Mohammed  Alsnosy Abdullah Khalefa
- Mohammed  Diary
- Mohan  Helen
- Mohsen  Mustafa Abo
- Mohyieldin  Omar
- Moir  John
- Molitvin  Yegor
- Mondino  Jose
- Montal  Silvina
- Montenegro  Emileth
- Morales-Puebla  José Manuel
- Morris  Brian
- Morsy  Amr
- Mosley  Frances
- Moss  Jana-Lee
- Mostafa  Badr
- Motas  Natalia
- Moug  Susan
- Moya-Angeler  Joaquin
- Moyano  Pablo
- Mozafari  Masoud
- Mozel  Michelle
- Mozo  Ana Sånchez
- Msherghi  Ahmed
- Mubezi  Isaac
- Muheilan  Muheilan
- Munyaneza  Emmanuel
- Munyika  Akutu
- Muralidharan  Vijayaragavan
- Muriel  MarĂa Emilia
- Mushiwokufa  Willard
- Muthu  Sathish
- Naem  Antoine
- Nagar  Manoj
- Nakagawa  Suely
- Nappi  Francesco
- Naseem  Muhammad Yasir
- Nashidengo  Pueya Rashid
- Nashidengo  Pueya Rashid
- Naunheim  Matthew
- Nayen  Alejandra
- Ncogoza  Isaie
- Ndayishyigikiye  Marcel Didier
- Ndong  Abdourahmane
- Ndong  Abdourahmane
- Negoi  Ionut
- Negoi  Ionut
- Negussie  Abraham
- Nepogodiev  Dmitri
- Nepogodiev  Dmitri
- Nepogodiev  Dmitri
- Nessim  Carolyn
- Neto  Joao Pedreira Duprat
- Newman  Samuel
- Ng-Kamstra  Joshua
- Ngu  James
- Ngulube  Allan
- Niazi  Sami Ullah
- Nicholson  Kristina
- Nidaw  Melkamu
- Nikolaieva  Karine
- Niquen-Jimenez  Milagros
- Nitschke  Christine
- Nkembi  Armande Subayi
- Nogueiro  Jorge
- Noll  Florencia
- Noltes  Milou
- Noltes  Milou
- Norman  Lisa
- Norman  Lisa
- Nouh  Thamer
- Novysedlåk  René
- Novysedlåk  René
- Nowak  Kai
- Ntirenganya  Faustin
- Nunez  Jade
- Nurgozhin  Talgat
- Nuñez  Jorge
- Nuñez  Jorge
- Nwegbu  Chukwuemeka
- NĂșñez  Bernardo
- Odejinmi  Funlayo
- Odetto  Diego
- Ofori  Bernard
- Ojeda  Ximena Paola Vasquez
- Okereke  Chukwuma
- Okonkwo  Ijeoma
- Okunlola  Abiodun
- Olaogun  Julius
- Olaywah  Noor
- Oliva  Agustina Rene
- Oliveira  João
- Olivos  Maricarmen
- Olivos  Maricarmen
- Olori  Samson
- Olson  Kristofor A.
- Omar  Omar M.
- Omari  Rand Y.
- Oosterlinck  Wouter
- Ortiz  Maria Rosa
- Oscco  Regina Amparo Ugarte
- Osinaike  Babatunde
- Ots  Riinu
- Outani  Oumaima
- Outani  Oumaima
- Outani  Oumaima
- Pablo  Carmignani
- Pachajoa  Diana Alejandra Pantoja
- Pacheco  Glenda Marina Falcon
- Pacilli  Maurizio
- Padmore  Greg
- Palacios  Nelson Morales
- Pallardel  Jenner Betalleluz
- Panyko  Arpåd
- Paranjape  Charu
- Parmar  Chetan
- Passadore  Martin
- Pata  Francesco
- Patel  Akshay
- Patel  Rakesh
- Pawar  Pranay
- Peiper  Christian
- Pejkova  Sofija
- Pejkova  Sofija
- Pellino  Gianluca
- Perdomo  Valentina Gutiérrez
- Pereira  Rita Gonçalves
- Perez Rivera  Carlos J.
- Perez Rivera  Carlos J.
- Perez-Chrzanowska  Hanna
- Perinotti  Roberto
- Pfister  Karin
- Phadnis  Ashish
- Picciochi  Maria
- Picciochi  Maria
- Pigeolet  Manon
- Pilar Tormos PeÌrez  M.
- Pius  Riinu
- Plarre  Philipp
- Pockney  Peter
- Pockney  Peter
- Pockney  Peter
- Pockney  Peter
- Poggi  Catalina
- Police  Andrea
- Ponugoti  Nikhil
- Portilla  Ana LucĂa
- Portilla  Fabian Rojas
- Porumb  Vlad
- Powell  Simon
- Prada  Jorge
- Pramesh  C. S.
- Prat-Ortells  Jordi
- Prats  Milagros Carrasco
- Premoli  Eduardo Jorge
- Prieto  Mikel
- Puiggrós  Laura Cårdenas
- Putnis  Soni
- Pykhteev  Vadim
- Pérez  Beatriz Gómez
- Pérez-Bertólez  Sonia
- Qasem  Abdulrahman
- Qassem  Faisal
- Qassem  Mohamed
- Quante  Markus
- Quintana-Villamandos  Begoña
- Qureshi  Ahmad Uzair
- Qureshi  Ahmad Uzair
- R Â Casadei
- Ra'ed  Hazim
- Radenkovic  Dejan
- Raevskaya  Marianna
- Rahbari  Nuh
- Rahy-MartĂn  Aida Cristina
- Rai  Lajpat
- Rajan  Shiv
- Rajanbabu  Anupama
- Ramallo-SolĂs  Irene
- Rammohan  Ashwin
- Ramos  MarĂa Lourdes
- Ramos-Luengo  Adolfo
- Ranganath  N.
- Rasoaherinomenjanahary  Fanjandrainy
- Rassweiler-Seyfried  Marie-Claire
- Rattan  Rishi
- Rattanasirivilai  Pornjittra
- Raut  Monish
- Recinos  Gustavo
- Recinos  Gustavo
- Regalo  Guillermo
- Reim  Daniel
- Reinhard  Tobias
- Reinke  Caroline
- Reisenauer  Janani
- Ren  Dong-Lin
- Rennie  Sarah
- Rennie  Sarah
- Rice  Henry E.
- Rice  Henry E.
- Rida  Ahmed Hossam Eldin Fouad
- Rio  Javier
- Ripollés-Melchor  Javier
- Rissmann  Anke
- Roberts  Keith
- Rodas  Alejandra
- Rodriguez  Juliana
- Rodriguez-Abreu  Julia
- Rodriquez  Jennifer
- RodrĂguez-Tesouro  Ana
- Rogers  Luke
- Rokohl  Alexander Christopher
- Roman  Igor Alberdi San
- Romera  Susana Bella
- Ronellenfitsch  Ulrich
- Rosas  Patricio
- Roslani  April Camilla
- Roslani  April Camilla
- Roslani  April Camilla
- Rossi  Gustavo
- Rossi  Luciano
- Rosso  Andres
- Roth  Andreas
- Rubio-Palau  Josep
- Ruiz  Alitza Gutiérrez
- Ruiz-MarĂn  Miguel
- Russell  Crispin
- RutegÄrd  Martin
- Ruzgar  Nensi Melissa
- Ryan  Ăanna
- Saad  Mahmoud M.
- Saadi  Jose
- Sacdalan  Marie Dione
- Sacdalan  Marie Dione
- Sacras  Maria LuĂs
- Saenz  Dinimo Bolivar
- Safieddine  Najib
- Sagar  Jayesh
- Saier  Tim
- Salazar  Esteban Gonzalez
- Salazar  Ivana Ines Pedraza
- Sale  Danjuma
- Saleh  Ismail Ali
- Salem  Marwa
- Saliev  Timur
- Saliev  Timur
- Sallam  Asser
- Samadov  Elgun
- Samaka  Rehab
- Samison  Luc Hervé
- Sampaio-Alves  Mafalda
- Sancho-Muriel  Jorge
- Sandoval  Danilo Alfonso Arévalo
- Sandoval  Danilo Alfonso Arévalo
- Santos  IrÚne
- Santos  IrÚne
- Santos-Costa  Paulo
- Sanz-Gonzalez  Rosa
- Sarjanoja  Elise
- Sarwar  Muhammad Zeeshan
- Satoi  Sohei
- Satoi  Sohei
- Sauvain  Marc-Olivier
- Sayyed  Raza
- Scalabre  Aurélien
- Schache  Andrew
- Scher  Pablo
- Scherñuk  Jordån
- Schlager  Daniel
- Schmedding  Andrea
- Schnitzbauer  Andreas
- Schoneveld  Martijn
- Seegert  Sara
- Seeliger  Barbara
- Seguin-Givelet  Agathe
- Sekar  Arunkumar
- Serralheiro  Pedro
- Seyi-Olajide  Justina
- Seyi-Olajide  Justina
- Shah  Rakesh
- Shaikh  Shafaque
- Shanthanna  Harsha
- Sharma  Abhishek
- Sharma  Rahul Deo
- Sharma  Shilpa
- Shaw  Catherine
- Shaw  Catherine
- Shaw  Richard
- Shehata  Sameh
- Shehta  Ahmed
- Sherif  Ahmed Elshawadfy
- Shih  Emily
- Shrestha  Ashish Lal
- Shumbash  Kibruyisfaw
- Siamuchembu  Maphios
- Siddique  Haleema
- Sieira-Gil  Ramon
- Sigamoney  Kohila
- Sikakulya  Franck K.
- Silva  Camilo Ortiz
- Silva  Nelson
- Silva-Igua  Liliana
- Simoes  Joana Ff
- Simoes  Joana Ff
- Simoes  Joana Ff
- Sin  MÂȘPilar Canals
- Singh  Harvinder
- Singisetti  Kiran
- Sinnerton  Robert
- Sisay  Silamlak
- Slavchev  Mihail
- Slavchev  Mihail
- Slim  Karem
- Slullitel  Pablo
- Smart  Neil
- Soares  Ana
- Sodhai  Vivek
- Sole  Oriol Martin
- SolĂ©  MisericĂČrdia JordĂ
- Soni  Rajesh
- Sonksen  Julian
- Sooriyabandara  Charitha
- Soria  Vanesa Garcia
- Soto-Darias  Ivån
- Soualili  Zineddine
- Spelsberg  Fritz
- Squiers  John
- Srishankar  Selvaratnam
- St-Germain  Pascal
- Stadler  Josef
- Stang  MarĂa Verona
- Stavridis  Sotir
- Stavrou  Gregor A.
- Steinkamp  Pieter
- Steinkamp  Pieter
- Stephens  Matthew
- Stevens  Sean
- Stewart  Grant D.
- Stewart  Grant D.
- Stijns  Jasper
- Stoleriu  Mircea Gabriel
- Suarez  Marcelo Moreno
- Subbian  Anbukkani
- Suliaman  Taha
- Sultan  Rizwan
- Sultana  Asma
- Sumadi  Adnan
- Sund  Malin
- Surendran  Arthika
- Suroy  Atul
- Szakmany  Tamas
- Sånchez  Alberto Cabañero
- Sånchez  Iran Irani Durån
- SĂĄnchez-CabĂșs  Santiago
- Tabiri  Stephen
- Taboada  MarĂa Victoria
- Tachella  Sofia
- Tadesse  Anteneh
- Talat  Nabila
- Talib  Ahmar Iftikhar
- Talwar  Rishi
- Tamoos  Khalil
- Tampaki  Ekaterini Christina
- Tan  Lorwai
- Tariq  Aiman
- Tariq  Muhammad
- Tarrado  Xavier
- Taylor  Elliott H.
- Teague  Rebecca
- Teasdale  Ella
- Tefera  Teshome
- Tejero-Pintor  Francisco J.
- Tendeng  Jacques
- Teo  Nan Zun
- Teresa GavaldaÌ PelliceÌ Â M.
- Testelin  Sylvie
- Thakar  Sumit
- Thereska  Dariel
- Thereska  Dariel
- Thies  Cristina Ojeda
- Thyavihally  Yuvaraja
- Tirapegui  Sebastian
- Todorovic  Lazar
- Tojal  André
- Tolani  Musliu Adetola
- Toma  Elena Adelina
- Tornini  Alejandra
- Toro  Carlos Andres Marulanda
- Torres  Martha Luz
- Toscano  Marta Jimenez
- Totty  Joshua
- Townend  Philip
- Traeger  Luke
- Traverso  Rogelio
- Tripathi  Manjul
- Trout  Isobel M.
- Trujillo  Lina MarĂa
- Tsegaye  Bereket
- Tsoulfas  Georgios
- Tudela  Kiara
- Turinawe  Gaston
- Turner  Paul
- Turrado-Rodriguez  Victor
- Uffelmann  Constanza
- Ugarte-Sierra  Bakarne
- Usang  Usang
- Vaccaro  Carlos
- Vagni  Roberto
- Vaishnav  Dhaivat
- Valcarcel  Cristina Rey
- Valdez  Pedro
- Valerio  Ana Clara
- Vallam  Karthik Chandra
- Vallve-Bernal  Marc
- van Ramshorst  Gabrielle
- van Ramshorst  Gabrielle
- Vargas  Lara
- Varghese  Chris
- Varghese  Chris
- Varghese  Chris
- Varghese  Chris
- Vartanian  Jose Guilherme
- Vaughan-Shaw  Peter
- Vayoth  Sudheer Othiyil
- Vaysburg  Dennis
- Vaysse  Charlotte
- Velasco  Jorge Caño
- Velasquez  Enrique Jose Ruiz
- Venkatappa  Sunil Kumar
- Venn  Mary L.
- Verhaeghe  Romain
- Verhaeghe  Romain
- Vidal  Rafael Perez
- Vidya  Raghavan
- Vijayakumar Vijayakumar  M.
- Villanueva  Julio
- Vimalakanthan  Thanusan
- Vita  Diana Crego
- Vivancos  Patricia Caja
- Viveiros  Octavio
- Vives  Inmaculada
- Vives  Josep Maria Muñoz
- Vo  Uyen Giao
- von Pusch  Silke
- Vrapi  Enxhi
- Våzquez  Irene Ortega
- Wafi  Omar
- Wagner  Arthur
- Waissbluth  Sofia
- Waqar  Shahzad Hussain
- Watson  David
- Watson  Eleanor
- Watters  David
- Weeraddana  Prabuth Dulanjan
- Wells  Cameron
- Welter  Stefan
- Wettstein  Dåniel
- Wickramasinghe  Dakshitha
- Wickramasinghe  Dakshitha
- Wiegering  Armin
- Wijeysundera  Duminda
- Williams  Emmanuel
- Williams  Omolara
- Williams  Omolara
- Wilson  Michael
- Wolf  Sebastian
- Wolfer  Susanne
- Wong  Enoch
- Wright  Deborah
- Wright  Deborah
- Wright  Naomi
- Wuraola  Funmilola
- Wuraola  Funmilola
- Xaviour  Okedi Francis
- Xu  William
- Yadev  I.
- Yagoub  Ghozlan
- Yaqoob  Eesha
- Yaqoob  Hassan Nawaz
- Yasin  Seid Mohammed
- Yazbek  Guilherme
- Yebes  Alvaro
- Yeung  Justin
- Yip  Sebastian Shu
- Youssef  Mina
- Zabaleta  Jon
- Zahid  Imdad Ahmad
- Zanoni  Gerardo
- Zapardiel  Ignacio
- Zapata  Carlos Shiraishi
- Zarnescu  Narcis Octavian
- Zarour  Ahmad
- Zarour  Ahmad
- Zarour  Ahmad
- Zarratea  Celeste Soledad
- Zegarra  Sergio
- Zequi  Stenio C.
- Zezular  Damaris Idara Anabel
- Zhou  Xuanyu
- Zhussupov  Baurzhan
- Zijaj  Lorena
- Zimmelman  Natalie
- Zmora  Oded
- Zmora  Oded
- Zohra  Belabbes Fatima
- Publication venue
- HAL CCSD
- Publication date
- 01/11/2021
- Field of study
We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05â1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4â7 days or â„ 8 days of 1.25 (1.04â1.48), p = 0.015 and 1.31 (1.11â1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care. We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05â1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4â7 days or â„ 8 days of 1.25 (1.04â1.48), p = 0.015 and 1.31 (1.11â1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
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- Abadia M
- AbadâGurumeta A
- AbadâMotos A
- Abassy J
- Abate E
- Abbasov A
- Abbott D
- Abbott Tom EF
- Abdalla M
- Abdeldayem H
- Abdelkabir M
- Abdelkader Salama I
- Abdelkarim M
- Abdelsamed A
- Abdulfattah F
- Abdulwahed E
- AbdurâRahman LO
- Abel MK
- Abelevich A
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- Aboelkassem Ibrahim A
- Aboharp Hasan Z
- Abou Chaar MK
- Abreu da Silva A
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- Adam Essa Adam ME
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- Adamina Michel
- Adamina Michel
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- GraciaâRoche C
- Grainger C
- Grama F
- Grasset E
- Grasso M
- GrauâTalens EJ
- Grechenig M
- Grechi A
- Grecinos Gustavo
- Green L
- Green S
- Gregoric P
- Gribnev P
- Grieco C
- Griffiths Ewen A
- Griffiths Ewen A
- Griffiths O
- Grilo JV
- Grimley E
- Gronchi Alessandro
- Groot G
- Grossi U
- Grotenhuis BA
- Grove T
- GrubaÄ Ćœ
- Gruber R
- Gruendl Magdalena
- Guadagni S
- Guaglio M
- Guariglia CA
- Guerci C
- Guerra GR
- Guevara O
- GuevaraâMartĂnez J
- Guglielmetti L
- Guglielmi A
- Guidi G
- Guillamot Ruano P
- Gujjuri Rohan R
- Gultekin FA
- Gundara J
- Guner A
- Gupta A
- Gupta S
- Gutelkin Murat
- Gutierrez Samaniego M
- Gutiérrez Fernåndez AI
- Guven O
- GuĂ rdia N
- GĂłmez DĂaz CJ
- GĂłmez Sanz T
- GönĂŒllĂŒ E
- GĂŒler SA
- GĂŒreĆin A
- Hacım NA
- Hagger R
- Hainsworth A
- Haji A
- Hakami I
- Halkias C
- Halkias Constantine
- Hall J
- Hamdan KH
- Hamdy R
- Hammed A
- Hammed S
- Hammer C
- Hamza HM
- Hamzaoglu I
- Handa S
- Hanly A
- Hanna M
- Hanson A
- Haq A
- Haque PD
- Harald M
- Harbjerg JL
- Hardie CM
- Hardy NP
- Harries R
- Harris Benjamin
- Harris Benjamin
- Harris G
- Harrison Ewen M
- Hart C
- Hartveld L
- Hassan E
- Hawkin P
- Hawkins AT
- Hayati F
- Haynes AB
- Heer B
- Heinius G
- Helminen O
- Heneghan H
- Henriques P
- Henriques S
- Heras Aznar J
- Heritage Emily
- Herman A
- Hernandez Bartolome MA
- Hernandez Gutierrez J
- Hernandez P
- Hernandez R
- HernĂĄndezâGarcĂa M
- Herrera Mora DR
- Herrero Lopez M
- Herrod P
- Herzberg J
- Hill C
- Hirji S
- Hisham Intisar
- Hmedat A
- Ho D
- Ho MF
- Ho Michael
- Hoffmann PV
- Hogan A
- Hompes R
- Hon S
- Honarpisheh H
- Horn C
- Houlden C
- Hraishawi I
- Huhta H
- Humes D
- Humphreys L
- Hunt A
- Hunt L
- Hussain AH
- Hutchinson Peter
- Hutchinson Peter J
- Huynh KT
- Hwang Shelley
- I Sharara M
- Iannone I
- Ibrahim AF
- Ibrahim B
- Ibrahim S
- IbåñezâAguirre FJ
- IflazoÄlu N
- Ijichi TR
- Ikram H
- Illingworth B
- Impellizzeri H
- Inama M
- Incollingo P
- Inzunza M
- Ioannidis O
- Iordache N
- Iosifescu RV
- Ip M
- Ipponi P
- Isaac John
- Isik Arda
- Islam AA
- Ismail O
- Isolani SM
- Isoton JC
- Ivancevic N
- Iversen LH
- Izbicki J
- Izzo F
- Jackman J
- Jain A
- Jain D
- Jain M
- Jaloun H
- Jamal A
- James A
- Jang S
- Janik M
- Jayarajah U
- Jayasankar B
- Jayasilan J
- Jayasinghe JD
- Jeftic N
- Jelenkovic J
- Jenkinson Michael D
- Jenkinson Michael D
- Jenny HE
- Jeri S
- Jesudason MR
- Jeyaraj P
- Jeyarajan E
- Jezieniecki C
- Jha M
- Jia F
- Jimenez Higuera E
- Jimenez MiramĂłn J
- Jimenez Ramirez LJ
- Jimenez Toscano M
- Jimenez V
- Jiménez A
- Jobran F
- Jocson R
- Johnstone J
- Jones Conor S
- Jonescheit J
- Jonker Pascal
- Jordan P
- Jordan S
- Jouffret L
- Jover JM
- Jovine E
- JW Wilkin Richard
- JĂĄcome F
- JĂ€ger T
- Kaafarani H
- Kaafarani Haytham MA
- Kacem MJ
- Kakotkin V
- Kalayarasan R
- Kalfountzos C
- Kam da Silva Andrade A
- Kamal M
- Kamal N
- Kamalov A
- Kamarajah Sivesh K
- Kamarajah Sivesh K
- KamburoÄlu MB
- Kamel F
- Kamera BS
- Kamoka E
- Kamphues C
- Kanemitsu Y
- Kannummal Veetil S
- Kanthasamy S
- Kapoor S
- Kappenberger A
- Kara H
- Kara Y
- Karahasanoglu T
- Karaitianos IG
- Karamarkovic A
- Karandikar S
- Karim A
- Karimuddin A
- KarloviÄ D
- Kashif M
- Kasivisvanathan Veeru
- Kassir R
- Katory M
- Kattakayam A
- Katusic Z
- Kaul S
- Kauppila JH
- Kauppila JH
- Kaushal M
- Kavanagh D
- Kaya T
- Kayyal MY
- Kazachenko E
- Keatley James M
- Kebabçı E
- KecmanoviÄ D
- Keeler BD
- Keller Debby
- Keller Debby
- Kembuan G
- Kenic M
- Kennelly R
- Kent A
- Kerawala AA
- Khajuria A
- Khan A
- Khan AH
- Khan F
- Khan J
- Khan K
- Khan S
- Khan Tabassum
- Khatri Chetan
- Khaw Rachel A
- Khokhar MI
- Kiconco H
- Kilani AI
- Kilinc Tuncer G
- Killeen S
- Kim NJ
- Kirmizi Y
- Kjaer DW
- Klaristenfeld D
- Klatte Tobias
- Kleeff J
- Kler A
- Klimopoulos S
- Kloppers C
- KmeziÄ S
- Knezevic D
- Knight Andrew
- Knights E
- Knowles C
- Knowles J
- Kocatas A
- Koh A
- Kokkinos G
- Kokobelyan AK
- Kokoropoulos P
- Koleva Radica M
- Kolias Angelos
- Kolias Angelos
- Kolla C
- Kollengode VV
- Kolli VS
- Konney Thomas
- Konstadoulakis M
- Konstantinou C
- Konsten J
- Kontovounisios C
- Kornblith LZ
- Kottayasamy Seenivasagam R
- Koukoulis G
- Kourdouli A
- Kovacevic B
- Kowalewski P
- Krarup P
- Krdzic I
- Kredan A
- Kretzmer L
- Krishnan E
- Kristensen HĂ
- Krivokapic Z
- Kroon HM
- Kruijff Schelto
- KrĆĄul D
- Kubiliute E
- Kubyshkin V
- Kucuk GO
- Kudchadkar S
- Kuiper S
- Kulkarni N
- Kulkarni R
- Kulle CB
- Kumar A
- Kumar L
- Kumar S
- Kumar V
- KutkeviÄius J
- Kuttanchettiyar KG
- KwanâFeinberg R
- Kwiatkowski A
- Kyriacou H
- KÀlviÀinen H
- Königsrainer A
- KĂŒĂ§ĂŒk IF
- La Regina D
- La Torre F
- Labib PL
- Lacy AM
- Ladd MR
- Laface L
- Laforest A
- Laharwal A
- Lakkis Z
- Lala AK
- Lalou L
- Lamb Benjamin
- Landaluceâolavarria A
- Lapolla P
- Laporte G
- Larentzakis A
- Larkin J
- Laskar N
- Lasses MartĂnez B
- LatinÄiÄ S
- Lauretta A
- Lauscher J
- Lavy R
- Law J
- Lawani Ismail
- Lawday S
- Lawday Samuel
- Lawday Samuel
- Layton Georgia R
- Le Roy B
- Lecolle K
- Lederhuber Hans
- Lederhuber Hans
- Ledesma FS
- Lee M
- Lee N
- Leede E
- Lenzi E
- Leon R
- Leung Elaine YL
- Leventoglu Sezai
- Leventoglu Sezai
- LewisâLloyd C
- Li Elizabeth
- Li Elizabeth
- Li M
- Li Z
- Liakakos T
- Liao CCL
- Lieske B
- Lim M
- Lim RZM
- Lima Buarque I
- Lima da Cruz L
- Lima da Silva C
- Lima MJ
- Linari C
- Lippa Laura
- Lira dos Santos Leite A
- Litta F
- Litvin A
- Litvin Andrey
- Litvina Y
- Liu J
- Liu T
- Lizzi V
- Locatelli A
- Loch FN
- Loehrer A
- Loehrer Andrew
- Loncar Z
- Long C
- Longhi M
- Longhini A
- Longstaff L
- Lopes L
- Lopez Abad A
- LoraâCumplido P
- Lorena Maria Aguilera
- Lorenzon L
- Losada M
- Lott N
- Loubani M
- Loutzidou L
- Lowery A
- Lozano Lominchar P
- Lucchini SM
- Luglio G
- Lule H
- Lun EWY
- Lunevicius R
- Lunghi EG
- Lynch N
- Lyons A
- LĂĄzaro A
- López Antoñanzas L
- Löffler Markus W
- Löffler MW
- Löfgren N
- M. elghazaly S
- Maa Albared S
- Maccabe TA
- MacDonald L
- Machado D
- Machado N
- Macina S
- Madani Kia T
- Madani R
- Madonini M
- Maffioli A
- Magee C
- Maghrebi H
- Magowan D
- Mahajan A
- Mahendran V
- Mahmood M
- Mahmoud Ali F
- Mahvi D
- Maida P
- Maiga A
- Maimbo Mayaba
- Majbar AM
- Majkowska A
- Major P
- Major Piotr
- Majrashi S
- Majumdar KS
- Mak TWC
- Malapati H
- Malcolm FL
- Malgras B
- Malibary N
- Mall JW
- Maltinti G
- Manatakis DK
- Manfredelli S
- Manku B
- Mann Harvinder S
- Manrique E
- Manso I
- Manson J
- Mantoglu B
- Manu N
- Maqueda GonzĂĄlez R
- Marafante C
- Marano A
- Marchbank Adrian
- MarcosâSantos P
- Marcus Hani J
- Mardare M
- Margalit A
- Mari G
- Marialva J
- Mariani NM
- MarieâMacron L
- Marinello P
- Marino Cosentino L
- Marino M
- Marino MV
- Markaryan D
- Markovic I
- Markovic V
- Marques R
- Marques T
- Marqueta De Salas M
- Marra AA
- Marra E
- Marreiro A
- Marson Ella J
- Marte G
- Martel A
- Martin E
- Martin E
- Martin Janet
- Martin ST
- Martinek L
- Martinez German A
- Martins dos Santos G
- Martins JordĂŁo D
- Martins A
- Martins D
- Martins R
- MartinâPerez B
- MartinâPerez E
- MartĂn Anoro LF
- MartĂn L
- MartĂnez Chicote C
- MartĂnezâHurtado E
- MartĂnezâPinedo C
- MartĂnezâPĂ©rez P
- MartĂnâArĂ©valo J
- Marx W
- Marzi F
- Marçal A
- MarĂn H
- Masciandaro A
- Mashat A
- Mashbari Hassan N
- Massey LH
- Massie E
- Massobrio A
- Mastoridis S
- Math S
- Mathew S
- MatiÄ S
- Matos Costa P
- Matute M
- Maté Mate P
- MatĂasâGarcĂa B
- Maw A
- Mazingi Dennis
- Mazzotta E
- Mazzotti F
- McAleer J
- McAree B
- McCanny A
- Mccluney S
- Mccormick P
- McDermott FD
- McElhinney K
- McEwen R
- McGivern K
- McGrath John S
- McIlmunn C
- McIntosh S
- McIntyre J
- McKay Siobhan
- Mckay Siobhan C
- McKevitt K
- McLean Kenneth A
- McNaught C
- McNeill Alan
- McNicol F
- MdRazali. I null
- Mehigan BJ
- Mehraj A
- Meimaâvan Praag EM
- Mekhael M
- MelchorâRuan J
- Melenhorst J
- Melhem S
- Memon AS
- Memos N
- Mendes F
- Mendes JR
- MendozaâMoreno F
- Meneghini S
- Mercado MĂ
- Merdrignac A
- Merh R
- Meriç S
- Messner F
- Metallidis Symeon
- Metwalli M
- Metzger J
- Michalopoulos N
- Michalski C
- Michel M
- Micic D
- Migliore M
- Mignot G
- Miguel T
- Mihanovic J
- Mihmanli M
- Miladinov M
- MilanoviÄ M
- Milic LJ
- Mills Emily C
- Mills SJ
- Milne K
- Minaya Bravo AM
- MinayaâBravo Ana
- MinayaâBravo Ana
- MinayaâBravo Ana
- Mingoli A
- Minicozzi A
- Minto G
- Mir I
- Mirabella A
- Miranda P
- Mirica RM
- Mirnezami R
- Mishra N
- Mishra S
- Mishra T
- Misra S
- Mitchell D
- Mitchell S
- Mithany R
- Mitra JK
- Mitrofan C
- Mittal R
- Mittal Rohin
- Miu V
- Mochet S
- Modolo Maria Marta
- Modolo Maria Marta
- Moftah M
- Moggia E
- Mohamed Sidek AS
- Mohammad Z
- Mohammed MM
- MohammedJibreel M
- Mohan H
- Mohan Helen M
- Mohan Helen M
- Mohd Azman ZA
- Mohd Yunus MF
- Mohsine R
- Mongelli F
- Montauban P
- Montelatici M
- Monteleone M
- Montella MT
- Montori G
- Montuori M
- Moore Rachel
- Moorthy M
- Morais H
- Moras L
- MoraâGuzmĂĄn I
- Morelli L
- Moretto G
- Morgan R
- Moritani K
- MoroâValdezate D
- Morris A
- Morsi A
- Mosley F
- Moss J
- Moszkowicz David
- Moug S
- Moug Susan
- Moug Susan
- Moura F
- Mourad M
- Mshelbwala P
- Msherghi A
- Mudawi I
- Muduly D
- Muguerza JM
- Muiesan P
- Mukherjee S
- Muller B
- Mulligan CS
- Mungo S
- Muratore A
- Murawa D
- Murgese A
- Murphy C
- Musetti S
- Mustafa A
- Mutter D
- Muzamil J
- Muñoz Camarena JM
- MuñozâAtienza V
- MuñozâBellvis L
- Naar L
- Nacif L
- Nafees Ahmed R
- Nageh MA
- Nahm C
- Najarian M
- Nally D
- Namazov Ä°
- Nankivell Paul
- Narahari Krishna
- Nassa H
- Nassif M
- Natale J
- Naumann D
- Navaratne L
- Nazir S
- Neary P
- Neary PM
- Neely D
- Negoi I
- Negoi Ionut
- Negoita VM
- Nel D
- Nelli T
- Nepogodiev Dmitri
- Nepogodiev Dmitri
- Neri J
- Nespoli LC
- Nessim C
- Neville Iuri
- Newman S
- Newman T
- Newton C
- Newton K
- Ng HJ
- Ng Joe
- Ng S
- Ng V
- Ng V
- Ngo CW
- NgâKamstra Joshua S
- NicolĂĄsâLĂłpez T
- Nikaj H
- Nikolaou S
- Nikolic S
- Niquen Milagros
- Nisar P
- Nitschke C
- Nogueira O
- Nogueiro J
- Nogués A
- Noiret B
- Nolan GJ
- Norcini C
- Nordberg M
- Notte F
- Nouh T
- Novello S
- Novikova A
- Nowak K
- Ntirenganya Faustin
- Nugent E
- Nunes Coelho M
- Nunes R
- NunezâGarcia B
- NunooâMensah JW
- Nuñez Del Barrio H
- Nwabuoku SE
- NĂșñez J
- Obeidat K
- Ocaña J
- OchagavĂa S
- Oguttu B
- Okafor B
- Okunlola A
- Olaogun J
- Olasehinde O
- Oldfield F
- Oliva Mompean F
- Oliveira A
- Olivier J
- Olivieri M
- Olivos Maricarmen
- Olori S
- Olson KA
- Olute A
- Omar W
- Omeroglu S
- Ong SL
- Onos L
- Oosterlinck W
- Oosterling S
- Opocher E
- Ortega VĂĄzquez I
- Ortiz de SolĂłrzano Aurusa FJ
- Ortiz LĂłpez D
- Osagie O
- Oseira A
- Osman N
- Osorio Ramos A
- Otero A
- Otoniel LR
- Oussama Kacimi
- Outani Oumaima
- Ovejero Merino E
- Owen H
- Owens P
- Oyende O
- Ozben V
- Ozcelık MF
- Ozgediz D
- Ozmen BB
- OâBrien H
- OâBrien S
- OâDonnell S
- OâMalley S
- OâRiordan J
- OâShea M
- P Delrio
- Pacheco SĂĄnchez D
- PadillaâValverde D
- Padmore G
- Pagano G
- Pajan H
- Palagi S
- Palma P
- Palmeri M
- Panahi P
- Pandey D
- Paniagua GarcĂa Señorans M
- Papaconstantinou I
- Papadopoulos V
- Papagni V
- Papatheodorou P
- Paquette N
- Parasyris S
- Pareek P
- Pareja Rene
- Parello A
- Parente A
- Parini S
- Parise P
- Park J
- Parkin E
- Parkins K
- Parlanti D
- Parmar C
- Parra Baños PA
- Parray FQ
- Parreira R
- ParreñoâSacdalan Marie Dione
- ParreñoâSacdalan Marie Dione
- Parseliunas A
- Parwaiz I
- Pasini F
- Paspaliari D
- Pata Francesco
- Pata Francesco
- Pata Francesco
- Patel Akshay
- Patel K
- Patel M
- Patel P
- Patil S
- Patrone R
- PatrĂcio B
- Pattyn P
- Pattyn P
- Pavlov M
- Pedrazzani C
- Pedro J
- Pedro V
- Peirce C
- Pejnovic L
- Pejovic I
- Pellegrino L
- Pellino G
- Pellino Gianluca
- Peluso C
- Penumadu P
- Pera R
- Peralta Ferreira M
- Pereca J
- Pereira Rodrigues A
- Pereira A
- Pereira C
- Pereira I
- Pereira R
- Perez Gonzalez M
- Perez D
- Pergolini I
- Perivoliotis K
- Peros G
- Perotto LO
- Perra T
- Perrone G
- Persad A
- Persiani R
- Pertile D
- Peteja M
- Petrillo A
- Peyroteo M
- Pezzuto AP
- Peña Ros E
- Peña Soria MJ
- Pham H
- Phan D
- Phang PT
- Phillips E
- Picardo AL
- Picciariello A
- Picciochi Maria
- Pickett L
- PicĂłn RodrĂguez R
- Pieniowski E
- Piessen G
- Pina S
- Pinilla Morales RE
- Pinkney Thomas D
- Pinotti E
- Pinto J
- Pipara A
- Piper Rory J
- Pipitone Federico NS
- Pirozzolo G
- Pirzada A
- Pisani Ceretti A
- Pisanu A
- Pius Ogolekwu I
- PlaâMarti V
- Pockney P
- Pockney Peter
- Pockney Peter
- Pockney Peter
- Podda M
- Poeze M
- Poggioli G
- Police A
- Polydorou A
- PolâFachin L
- Ponchietti L
- Popoola AA
- Porcu A
- Portinari M
- PosadasâTrujillo OE
- PosmaâBouman L
- Potter R
- Pourcher G
- Powell S
- Pozotou I
- Praetorius C
- Pramesh CS
- Prando D
- Presl J
- Price C
- Price Stephen J
- Prieto Calvo M
- Prieto Nieto MI
- Pronk AJM
- Prosperi P
- Provozina A
- Pruvot FR
- Pujari R
- Pujol Cano N
- PĂ©rez SĂĄnchez MA
- PĂ©rezâSaborido B
- Qadan M
- Qasem A
- Qatora MS
- Quante M
- Quintana Martinic M
- QuirogaâValcĂĄrcel A
- Qureshi Ahmad
- Qureshi AU
- RabyâSmith W
- Radenkovic Dejan
- Raggio E
- Rai L
- Rajan S
- Rajaretnam N
- Rakvin I
- Ramachandran A
- Ramalho de Almeida F
- Ramamoorthy R
- Ramasamy S
- Ramcharan S
- Ramesh P
- Ramirez Faraco M
- Ramirez Romero P
- Ramos Bonilla A
- Ramos D
- RamosâDe la Medina Antonio
- RamosâMartĂn P
- Ramwell A
- Rao S
- Rapaport S
- Rashid A
- Rashid MM
- Rasoaherinomenjanahary F
- Rattizzato S
- Ratto C
- Raval M
- Ravindrakumar S
- Ravindran S
- Rayamajhi S
- Raymond T
- Razafindrahita JB
- Recordare A
- Reddy P
- Redfern J
- Refky B
- Rega D
- Rega D
- Regina de Sampaio L
- Reilly J
- Reim D
- Reinhard T
- Revez T
- Rey Ferro M
- Rey Valcarcel C
- Reynolds IS
- Ribeiro A
- Ribeiro CG
- Ribeiro R
- Ribolla M
- Rice D
- Richards S
- Richards T
- Richards Toby
- Riddell A
- Ridgway PF
- Righini E
- Riley C
- Rimonda R
- Ringressi MN
- RipollĂ©sâMelchor J
- Riquoir Altamirano C
- Risaliti M
- Riva C
- Rivas R
- Rivera Carlos Jose Perez
- RiveraâAlonso D
- Rizk M
- Rizzi A
- Roberts Keith
- Roberts Keith
- Robertson Faith
- Robinson A
- Roca Calvo MJ
- Rodrigo VSD
- Rodrigues K
- Rodriguez Artigas JM
- Rodriguez JL
- RodrĂguez GĂłmez L
- Rodwell H
- Rogers LJ
- Rogers M
- Rojo LĂłpez JA
- RoldĂłn Golet M
- Romano M
- Romero Bañuelos E
- Romero de Diego A
- Ronellenfitsch U
- Rooney SM
- Rosa F
- Rose J
- Roslani AC
- Roslani April C
- Rosseau Gail
- Rossi S
- Roszkowski R
- Rottoli M
- Roux A
- Roxo V
- Roy Mahapatra S
- Royle T
- RubioâPerez I
- Ruivo A
- Ruiz Esquide M
- Ruiz Manzanera JJ
- Ruiz Soriano M
- RuizâEscobar A
- RuizâMarĂn M
- Russ J
- Russo IS
- RutegÄrd M
- RutegÄrd Martin
- RutegÄrd Martin
- Rutherford D
- Ruzgar NM
- Ruzzenente A
- Ryan M
- Ryan ĂJ
- Ryska O
- RĂo Lafuente FD
- S RRR
- Saad MM
- Saafan T
- Saavedra J
- Sabry A
- Saeed S
- Saez Carlin P
- Sagar J
- Sagnotta A
- Sahid Nik Amin
- Sahin I
- Sahnan K
- Saklani A
- Sakr A
- Saksena AR
- Salazar A
- Saleem A
- Saleem A
- Saleh M
- Salem H
- Salem H
- Salem M
- Salerno G
- Sales Mallafré R
- SalgadoâNesme N
- Salim A
- SalimoÄlu S
- Salindera S
- Sallam I
- Samadov E
- Samih A
- Samir Abdelaal A
- Samison LH
- Samkari A
- Sammarco G
- Sammour T
- Sampaio da NĂłvoa Gomes Miguel II
- Sampaio Soares A
- Sampietro GM
- San Miguel C
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- Yousof EA
- Youssef M
- Yurttas C
- YĂĄnez C
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- Zafar SN
- Zakaria AD
- Zakaria Z
- Zakharenko A
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- Zanus G
- Zegarac M
- ZeliÄ M
- Zengin AK
- Zerbib P
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- Zhang H
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- Zmora O
- Zografos C
- Zonta S
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- Zourntou S
- Zubaidi A
- Ăngelo M
- ĂlgĂ„ A
- Ăelebi F
- Ăolak E
- Ăfner D
- Ăhlberger L
- Ăzant A
- Ăzçay N
- ĂÄĂŒcĂŒ H
- ĂberrĂŒck L
- Äoza I
- Ćawnicka A
- ĆœateckĂœ J
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2022
- Field of study
AimThe SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery.MethodsThis was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4âweeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin.ResultsOverall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4âweeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, PÂ =Â 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, PâConclusionOne in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease