Higher-order CFD and Interface Tracking Methods on Highly-Parallel MPI and GPU systems

A computational investigation of the effects on parallel performance of higher-order accurate schemes was carried out on two different computational systems: a traditional CPU based MPI cluster and a system of four Graphics Processing Units (GPUs) controlled by a single quad-core CPU. The investigation was based on the solution of the level set equations for interface tracking using a High-Order Upstream Central (HOUC) scheme. Different variants of the HOUC scheme were employed together with a 3rd-order TVD Runge-Kutta time integration. An increase in performance of two orders of magnitude was seen when comparing a single CPU core to a single GPU with a greater increase at higher orders of accuracy and at lower precision

Housing and Mobility Toolkit for San Mateo County

Since the end of the Great Recession, San Mateo County has attracted new workers at a record rate without building anywhere near enough housing. This jobs-housing imbalance drives the cost of housing up and forces many moderate and lower-income employees and their families out of the County. A lack of access to quality affordable housing in the County and the entire Bay Area along with limited transportation options means that an increased number of employees drive in and out of the County every workday. The resultant congestion, gridlock, and long commutes along with other negative environmental, social, and economic impacts create a major concern for communities in the County and beyond. Clearly, this problem has two distinct but interrelated dimensions: housing development and transportation planning. A select group of Mineta Transportation Institute (MTI) Research Associates worked closely with representatives from the San Mateo County Home for All initiative to help address this challenge by developing a toolkit of successful case studies with a holistic approach to housing development and transportation planning

Trends in gabapentinoid prescribing in patients with osteoarthritis: a United Kingdom national cohort study in primary care

Summary Objective To investigate trends in gabapentinoid prescribing in patients with osteoarthritis (OA). Methods Patients aged 40 years and over with a new OA diagnosis recorded between 1995 and 2015 were identified in the Clinical Practice Research Datalink and followed to first prescription of gabapentin or pregabalin, or other censoring event. We estimated the crude and age-standardised annual incidence rates of gabapentinoid prescribing, stratified by patient age, sex, geographical region, and time since OA diagnosis, and the proportion of prescriptions attributable to OA, or to other conditions representing licensed and unlicensed indications for a gabapentinoid prescription. Results Of 383,680 newly diagnosed OA cases, 35,031 were prescribed at least one gabapentinoid. Irrespective of indication, the annual age-standardised incidence rate of first gabapentinoid prescriptions rose from 1.6 (95% CI: 1.3, 2.0) per 1,000 person-years in 2000, to 27.6 (26.7, 28.4) in 2015, a trend seen across all ages and not explained by length of follow-up. Rates were higher among women, younger patients, and in Northern Ireland, Scotland and the North of England. Approximately 9% of first prescriptions could be attributed to OA, a further 13% to comorbid licensed or unlicensed indications. Conclusion Gabapentinoid prescribing in patients with OA increased dramatically between 1995 and 2015. In most cases, diagnostic codes for licensed or unlicensed indications were absent. Gabapentinoid prescribing may be attributable to OA in a significant proportion but evidence for their effectiveness in OA is lacking. Further research to investigate clinical decision making around prescribing these expensive and potentially harmful medicines is recommended

The atmosphere of the soil: its composition and the causes of variation

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Utilizing genotyping-by-sequencing to elucidate Neotropical army ant evolution

The articulation of science and humanism has been from the outset one of the keystones of our programmatic initiative on person centered medicine. This involves the notion that the scientific method is what gives science its foundations and at the same time represents one of the principal strategies and tools to understand, formulate and intervene in crucial and paramount human concerns and activities such as health. A scientific approach to health and health care, from the perspective of person centered medicine, involves not only attending to organs and diseases (preferential topics in much of contemporary medicine), but more broadly to the whole field of human health, including ill health and positive health, within which organs and diseases are inscribed. (aut.ref.

The influence of oil extraction process of different rapeseed varieties on the ileal digestibility of crude protein and amino acids in broiler chickens

The current study assessed the effect of rapeseed variety and oil extraction process on the apparent and standardised ileal digestibility (AID, SID) of crude protein (CP) and amino acids (AA) in rapeseed co-products in broiler chickens. PR46W21 and DK Cabernet rapeseed varieties were de-oiled by soft and standard hexane extraction, producing soft rapeseed meal (SRSM) and rapeseed meal (RSM), respectively. The soft, non-standard hexane extraction method was designed to reduce heat treatment that occurs prior to hexane extraction in order to maximise potential genetic differences in digestibility values of rapeseed co-products. The test meals were incorporated into semi-synthetic diets at a level of 500 g/kg; diets were fed to 14-day old paired chickens (n = 6 pairs) for ten days, when ileal digesta was collected post-slaughter from Meckel’s diverticulum to the ileal-caecal junction. The AID and SID of CP and AA were determined using titanium dioxide as inert dietary marker. The variety PR46W21 showed a greater AID and SID of CP, arginine, leucine, methionine, cysteine, phenylalanine, valine and lysine in RSM compared to the DK Cabernet RSM (p < 0.05). The soft processing increased AID and SID of CP, histidine and lysine in SRSM of PR46W21 and DK Cabernet compared to their RSM counterparts (p < 0.05). An interaction between variety and processing was only observed for AID and SID of tryptophan (p < 0.001), as only in PR46W21 standard processing reduced the tryptophan SID compared to its soft processed counterpart. The data support the view that the selection of rapeseed variety and modification of thermal treatment during the oil extraction might improve nutritional value of rapeseed meals

Spin-dependent thermoelectric transport coefficients in near-perfect quantum wires

Thermoelectric transport coefficients are determined for semiconductor quantum wires with weak thickness fluctuations. Such systems exhibit anomalies in conductance near 1/4 and 3/4 of 2e^2/h on the rising edge to the first conductance plateau, explained by singlet and triplet resonances of conducting electrons with a single weakly bound electron in the wire [T. Rejec, A. Ramsak, and J.H. Jefferson, Phys. Rev. B 62, 12985 (2000)]. We extend this work to study the Seebeck thermopower coefficient and linear thermal conductance within the framework of the Landauer-Buettiker formalism, which also exhibit anomalous structures. These features are generic and robust, surviving to temperatures of a few degrees. It is shown quantitatively how at elevated temperatures thermal conductance progressively deviates from the Wiedemann-Franz law.Comment: To appear in Phys. Rev. B 2002; 3 figure

A large-scale numerical model for computing isochrone geometry

A finite-difference model for the calculation of radar layer geometries in large ice masses is presented. Balance velocities are used as coefficients in the age equation and in the heat equation. Solution of the heat equation allows prediction of sliding areas and computation of basal melt rates. Vertical distributions of velocity are parameterized using shape functions. These can be set uniformly, or allowed to vary in space according to the distribution of sliding. The vertical coordinate can either be uniformly distributed within the thickness of the ice, or be uniformly distributed within the flux. The finite-difference scheme results in a large set of linear equations. These are solved using a nested factorization preconditioned conjugate gradient scheme. The convergence properties of some other iteration solution schemes are studied. The output is computations of age and temperature assuming steady state, in large ice masses at high resolution. Age calculations are used to generate isochrones which show the best fit to observed layers. Comparisons with analytical solutions are made, and the influence of the order of the finite-difference approximation and the choice of vertical coordinate on solution accuracy is considered