A Cultural-Historical Interpretation of Resilience: the implications for practice

Recent attempts at preventing the social exclusion of vulnerable children in England have been driven by notions of resilience which centre primarily on changing children so that they may be better able to cope with adversity. Drawing on the concepts of Cultural Historical Activity Theory (CHAT), we suggest that the idea of resilience should be expanded to include developing a capacity to act on and reshape the social conditions of one’s development. We use evidence from two studies of practices in recent re-configurations of children’s services in England to examine whether practitioners are seeing resilience in these terms. We present examples of work which embody these views but suggest that they are not easily incorporated into practices where expertise is centred on care and clear communication. The care and communication model of practice reflects the emphases given to evolutionary notions of child development while a CHAT view of resilience reflects Vygotsky’s concerns with a dialectic between individuals and the social situations of their development

Moduli spaces of polarized irreducible symplectic manifolds are not necessarily connected

We show that the moduli space of polarized irreducible symplectic manifolds of $K3^{[n]}$-type, of fixed polarization type, is not always connected. This can be derived as a consequence of Eyal Markman's characterization of polarized parallel-transport operators of $K3^{[n]}$-type.Comment: 17 pages, minor changes following referee's comment

The benthic harpacticoids (Crustacea, Copepoda) of Budakskyi (Shabolatskyi) Lagoon, North-West coast of the Black Sea, Ukraine

The present study gives new data on a poorly studied group of brackish harpacticoids from the North-West coast of the Black Sea, Ukraine. Seven harpacticoids species (Crustacea, Copepoda) collected in July 1988 from the Budakskyi (Shabolatskyi) Lagoon are reported

First study on the zooplankton of the Kerid (Kerið) Crater Lake, Iceland

We studied the qualitative composition of zooplankton of the Kerid Crater Lake. We found 10 taxa from which five rotifers and two lower crustaceans. Three of the recorded species are new to the freshwater fauna of Iceland: the rotifer species Keratella cf. americana Carlin, 1943 and Colurella sulcata (Stenroos, 1898), and the crustacean harpacticoid Bryocamptus (Bryocamptus) minutus (Claus, 1863)

On irreducible symplectic varieties of K3 [n]-type

[no abstract

Data on the distribution of freshwater harpacticoids (Crustacea, Copepoda) in Tierra del Fuego (Argentina)

All available data on the distribution of freshwater harpacticoids (Copepoda) in Grande de Tierra del Fuego Island are summarized. Attheyella (Delachauxiella) nuda Lëffler, 1961 inhabiting wet mosses in the valley of Martial Glacier near Ushuaia is newly established. The site marks the southernmost distribution of the species in Argentina

A Cultural-Historical Interpretation of Resilience: the implications for practice

Recent attempts at preventing the social exclusion of vulnerable children in England have been driven by notions of resilience which centre primarily on changing children so that they may be better able to cope with adversity. Drawing on the concepts of Cultural Historical Activity Theory (CHAT), we suggest that the idea of resilience should be expanded to include developing a capacity to act on and reshape the social conditions of one’s development. We use evidence from two studies of practices in recent re-configurations of children’s services in England to examine whether practitioners are seeing resilience in these terms. We present examples of work which embody these views but suggest that they are not easily incorporated into practices where expertise is centred on care and clear communication. The care and communication model of practice reflects the emphases given to evolutionary notions of child development while a CHAT view of resilience reflects Vygotsky’s concerns with a dialectic between individuals and the social situations of their development

Phytol: A review of biomedical activities

© 2018 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license: http://creativecommons.org/licenses/by-nc-nd/4.0/ This author accepted manuscript is made available following 12 month embargo from date of publication (Auguist 2018) in accordance with the publisher’s archiving policyPhytol (PYT) is a diterpene member of the long-chain unsaturated acyclic alcohols. PYT and some of its derivatives, including phytanic acid (PA), exert a wide range of biological effects. PYT is a valuable essential oil (EO) used as a fragrance and a potential candidate for a broad range of applications in the pharmaceutical and biotechnological industry. There is ample evidence that PA may play a crucial role in the development of pathophysiological states. Focusing on PYT and some of its most relevant derivatives, here we present a systematic review of reported biological activities, along with their underlying mechanism of action. Recent investigations with PYT demonstrated anxiolytic, metabolism-modulating, cytotoxic, antioxidant, autophagy- and apoptosis-inducing, antinociceptive, anti-inflammatory, immune-modulating, and antimicrobial effects. PPARs- and NF-κB-mediated activities are also discussed as mechanisms responsible for some of the bioactivities of PYT. The overall goal of this review is to discuss recent findings pertaining to PYT biological activities and its possible applications

New data and notes on the distribution of Nitokra spinipes spinipes Boeck, 1865 (Crustacea: Copepoda: Harpacticoida) in Bulgaria

The present study reports a new locality of Nitokra spinipes spinipes Boeck, 1865. During 1988-1989 a large number of Nitokra spinipes spinipes were found in the biofilter at the aquaculture station in Pomorie Town, on the Pomorie Lake coast. This is the first record of the Nitokra spinipes spinipes found trapped in the technical equipment for water purification used in aquaculture

Etude des modifications post-traductionnelles de facteur de transcription Ikaros et leur rôle pour son fonctionnement

Le but de mon travail était d’étudier les modifications post-traductionnelles et plus précisément la sumoylation d’Ikaros. Mes études ont montré que le facteur de transcription Ikaros est modifié non seulement par SUMO-1 mais aussi par SUMO-2/3 sur plusieurs sites consensus. Cette modification est conditionnelle et dépendante du stade de développement des cellules T. J’ai trouvé un site consensus en plus des sites déjà décrits dans l’étude de Gómez-del Arco et al., 2005. En accord avec les résultats publiés, dans mon système expérimental, l’absence de sumoylation augmente les propriétés anti-prolifératives d’Ikaros, car ses mutants qui ne peuvent pas être sumoylés inhibent mieux la prolifération des cellules leucémiques. Un effet surprenant est l’absence d’un effet cumulatif de l’absence de sumoylation sur la prolifération des cellules. Par exemple, des mutants ponctuels qui ne perdent pas complètement leur sumoylation sont les meilleurs répresseurs de la prolifération, comparés avec le mutant où tous les sites modifiés sont mutés. Ce résultat est en contradiction avec les données publiées, parce qu’il suggère un rôle différent de la sumoylation, et non seulement comme un interrupteur physique des complexes Ikaros – NURD. J’ai fait des expériences utilisant l’expression d’un gène rapporteur comme un moyen de révéler des différences subtiles entre les propriétés répressives d’Ikaros et ses mutants sumo-déficients. Pour ces essais j’ai utilisé des cellules HeLa, un type cellulaire qui n’exprime pas Ikaros endogène et qu’il est donc théoriquement convenable pour étudier son effet sur l’expression d’un gène rapporteur. Mes résultats ont démontré que dans des cellules HeLa, il n’y pas de différence significative entre les propriétés répressives d’Ikaros et ses mutants sumo-déficients. Ces différences par rapport aux résultats obtenues avec la lignée de cellule T suggèrent une grande importance de contexte du système utilisé et que certains effets peuvent être observés uniquement dans des cellules T. Pour mieux comprendre le rôle de la sumoylation dans le fonctionnement d’Ikaros, j’ai analysé les transcriptomes des lignées cellulaires T qui surexpriment IK1-ER ou ses mutants. L’analyse des puces d’ADN a démontré un phénotype de dérégulation d’expression des gènes cibles d’Ikaros, différent entre la protéine WT et les mutants, ainsi qu’entre les mutants mêmes. Ce résultat suggère un rôle de la sumoylation d’Ikaros beaucoup plus complexe que l’interruption mécanique de son interaction avec le complexe NURD. Mes résultats ont aussi démontré que les autres membres de la famille d’Ikaros (Helios, Aiolos et Eos) sont également sumoylés, un événement qui pourrait être important pour la régulation de leurs fonctions.The main topic of my PhD studies was to investigate the role of sumoylation in the function of Ikaros transcription factor, that regulates the lymphocyte differentiation and function. Sumoylation is a posttranslational modification that can change the properties and regulate the function of a given protein. Up to now, one study addressed the question of how sumoylationmodulates Ikaros function. It shows that Ikaros is sumoylated in total primary thymocytes, and that this dynamic event modulates Ikaros' repressive function. It also describes two consensus sumoylation sites on Ikaros (K58 and K240), the sumoylation of which leads to loss of Ikaros repressive function in ectopic reporter gene assays. The final conclusion of the study is that sumoylation does not alter the nuclear localization of Ikaros but acts as a mechanism disrupting its participation in both histone deacetylase (HDAC) dependent and independent repression. My work shows the presence of additional sumoylation site on Ikaros and demonstrates that sumoylation does not significantly alter its interaction with the nucleosome remodelling and histone deacetylase (NURD) complex in T-cell lines. The functional analysis of sumo-deficientmutants indicates a complex role of this modification in regulating Ikaros' transcriptional properties. The identification of this new sumoylation site contributes to a better understanding of Ikaros' dual repressive - activating function and suggests the existence of conditional Ikaros' interacting partners. Moreover, the different Ikaros splicing isoforms would have differentsumoylation profiles, which would complete the knowledge of their functional diversity