Estudio morfológico y citotaxonómico de algunos Helicidos de la fauna española, en especial de la región central

Tesis Univ. Complutense de Madrid, 1983.Depto. de Genética, Fisiología y MicrobiologíaFac. de Ciencias BiológicasTRUEProQuestpu

Mollusca and Microvertebrata from the Pleistocene terraces of the Tagus River of Toledo and Fuentidueña de Tajo (Central Spain)

The study of the terraces and its associated faunas from the areas of Toledo and Fuentidueña de Tajo in the Valley of the Tagus River, mainly from a palaeoenvironmental point of view, has been made in this work. Six new sites of fossil microvertebrates and fossil molluscs were found when this work was undertaked. Many of the sites with remains of microvertebrates and all the sites with fossil mollucs that were found in that prospecting are presented for the first time in this work. As regards to the last, it can be remarked that all the shells of the molluscs find out are of a very small size. That could be the consequence of the alloctone origin as it happens in the seasonal river side flooding. This suggestion is supported by the presence of freshwater and terrestrial species mixed in the same sample, as, for example, Succinea putris (characteristic biotope of humid areas near the river side), together with Helicella madritensis with a terrestrial habitat. The conditions of life of the twelve species of mollucs here analyzed suggest a temperate climate in the Middle Pleistocene at the time of the sites deposition, similar to the present day in the area. Besides, the presence of Helicella madritensis, a xerophillus species that lives today in the arid areas of the central plateau of the Iberian Peninsula, suggests a climate with large dry periods not very different from now. The habitat of Truncatellina cylindrica (very dry calcareous grassy or rocky places) and that of Vallonia costata (dry open calcareous places) supports the sames suggestions.Peer reviewe

Malacofauna of the late Middle Pleistocene in the Jarama valley: The Valdocarros site (Madrid, Spain)

Depto. de Prehistoria, Historia Antigua y ArqueologíaFac. de Geografía e HistoriaTRUEsubmitte

Late Middle Pleistocene malacofauna of the Acheulean site of Valdocarros II, Jarama river valley, Madrid, Spain

ing to its geographical position relative to northwestern Europe, the Iberian Peninsula was a refuge for many species during periods of harsh environmental conditions in the Quaternary. Despite this, the Pleistocene history of non-marine molluscs in Spain has been scarcely addressed. In this study, we examine the malacofauna of Valdocarros II, a site within the Complex Terrace of Arganda in the Jarama river valley tributary of the Tagus River in central Spain. This large, minutely-excavated site consists of five flood sequences identified in five archaeological levels and has been dated to the late Middle Pleistocene (end MIS 8–beginning MIS 7). Specimens of twelve freshwater and eighteen land mollusc taxa were identified. The most abundant species observed was Xerotricha madritensis, a land snail endemic to the Iberian Peninsula that today inhabits exposed surfaces with scarce plant cover. The most abundant freshwater species found was Anisus spirorbis, which currently thrives in tributaries of the Jarama River. This malacofauna assemblage features different ecological components, though dry, open-ground terrestrial species predominate. A correspondence analysis of the most frequently appearing land animals and the archaeological levels revealed a slight separation of level 2 from the other levels, indicative of its mesophilous character. However, few differences among these levels were identified in three correspondence analyses performed on the land or freshwater species datasets. Our observations of the malacofauna assemblage of Valdocarros II indicate a site characterized by a temperate climate and open areas with riverside vegetation. Furthermore, we propose the assignment of this site to an interstadial given the observed malacofauna of the five levels

Human occupations palaeoenvironmental context of Coímbre Cave (Peñamellera Alta, Asturias) during the Upper Pleistocene

[ES] En este capítulo presentamos la síntesis paleoecológica y paleoambiental de la cueva de Coímbre obtenido a partir de las diferentes evidencias proporcionadas paleovegetales y paleofaunísticas y siguiendo los resultados de los estudios polínicos, antracológicas, macro- y micofaunísticos. Los resultados muestran un medio con paisajes abiertos y unas condiciones frías más o menos rigurosas según el momento bajo las cuales tuvieron lugar las ocupaciones humanas del Gravetiense y Magdaleniense inferior y medio. La secuencia arqueológica culmina con una fase más húmeda y una mayor diversidad del ecosistema durante el Magdaleniense superior.[ES] In this chapter we offer a paleoecological and paleoenvironmental synthesis of the Coímbre cave using the evidence provided by plant and animal remains, as well as the results of the studies on pollen, wood charcoal, and microfauna. The result shows a milieu characterized by open landscapes and cold conditions of varying degrees of severity, depending on the time when the Gravettian and Lower and Middle Magdalenian human occupations took place. The archaeological sequence culminates in a more humid phase with a greater diversity of ecosystems during the Upper Magdalenian.Peer reviewe

"Escape Seminar": Escápate del seminario

Las "escape room" son juegos de equipo para "escapar" de una sala o una sala virtual. Esta sala está llena de desafíos que se deben superar para ganar (escapar) dentro de un límite de tiempo determinado. Debido a que la enseñanza tradicional está causando problemas en torno a la motivación y el compromiso, y muchos estudiantes la perciben como ineficaz y aburrida, el uso de juegos educativos es muy prometedor porque son una herramienta de enseñanza para mejorar las habilidades no cognitivas, como la resolución de problemas y la colaboración. y comunicación. Los juegos tienen un notable poder motivador debido al uso de una serie de mecanismos que alientan a las personas a participar en ellos, a menudo sin ninguna recompensa, solo por la satisfacción de jugar y la posibilidad de ganar. En el curso 2019-2020, hemos desarrollado actividades basadas en el concepto de la "escape room" en las asignaturas: "Ciencia y Análisis de agua y bebidas" del Grado en Ciencia y Tecnología de Alimentos, "Química Analítica I" y "Físico-Química Farmacéutica" del Grado de Farmacia y “Química” del Grado en Óptica y Optometría de la Universidad Complutense de Madrid. Para el desarrollo del proyecto, todas las características y el progreso de las diferentes fases del seminario de la "escape room" se informaron en el primer día de clase y a través de la plataforma del Campus Virtual. Los estudiantes se agruparon (5-7 personas / grupo) y nombraron un portavoz que fue responsable de responder los retos de la actividad. Al final de esta acción, los estudiantes respondieron voluntariamente a las encuestas Likert para evaluar sus implicaciones y su percepción sobre su aprendizaje, trabajo en equipo y si les gustó la actividad propuesta

Maritime-oriented foragers during the Late Pleistocene on the eastern costa del sol (Southeast Iberia): Cueva Victoria (Málaga, Spain)

The Mediterranean coast of Spain is marked by several clusters of Palaeolithic sites: to the south of the Pyrenees, in the area around the Ebro River, in the central part, and on the south coast, one of the southernmost regions in Europe. The number of sites is small compared with northern Iberia, but like that region, the Palaeolithic occupations are accompanied by several rock art ensembles. The archaeological material (both biotic and abiotic resources) and radiocarbon dates presented here were obtained during archaeological fieldwork of professor J. Fortea in the Late Pleistocene deposits in Cueva Victoria, located near the modern coastline and about 150 km north of the Strait of Gibraltar. In the three occupation phases, marine resources were acquired by shell-fishing (focusing almost exclusively on the clam Ruditapes decussatus), fishing, and the use of beached marine mammals. This contrasts with the limited data about the exploitation of terrestrial resources by hunting and gathering animals and plants. The study is completed by the study of artefacts (lithic and bone industry and objects of adornment) that help to understand the subsistence strategies of the cave occupants and enable a comparison with other groups inhabiting the Mediterranean coasts of the Iberian Peninsula during Greenland Interstadial 1, between ca. 15.1 and 13.6 cal BP.This work was supported by the University of Salamanca GIR PREHUSAL, the Ministry of Science and Innovation-Spanish Government (PaleontheMove-PID2020-114462GB-I00), the Universidad Nacional de Educación a Distancia (Madrid) and Dirección General de Universitat, Investigacio i Ciencia of the Valencian Regional Government (Project Aico/2020/97).Peer reviewe

Validation of mutated <i>CEBPA</i> bZIP as a distinct prognosis entity in acute myeloid leukemia: a study by the Spanish PETHEMA registry

Not available

GPR56/ADGRG1 inhibits mesenchymal differentiation and radioresistance in glioblastoma

A mesenchymal transition occurs both during the natural evolution of glioblastoma (GBM) and in response to therapy. Here, we report that the adhesion G-protein-coupled receptor, GPR56/ADGRG1, inhibits GBM mesenchymal differentiation and radioresistance. GPR56 is enriched in proneural and classical GBMs and is lost during their transition toward a mesenchymal subtype. GPR56 loss of function promotes mesenchymal differentiation and radioresistance of glioma initiating cells both in vitro and in vivo. Accordingly, a low GPR56-associated signature is prognostic of a poor outcome in GBM patients even within non-G-CIMP GBMs. Mechanistically, we reveal GPR56 as an inhibitor of the nuclear factor kappa B (NF-κB) signaling pathway, thereby providing the rationale by which this receptor prevents mesenchymal differentiation and radioresistance. A pan-cancer analysis suggests that GPR56 might be an inhibitor of the mesenchymal transition across multiple tumor types beyond GBM