胸部特異的肋骨形成における組織間相互作用とその分子機構

研究期間:平成14-17年度 ; 研究種目: 基盤研究B ; 課題番号:14370006原著には既発表論文の別刷を含む

Hematogenous extraneural metastasis of the germinomatous component of a pineal mixed germ cell tumor

A 23-year-old man presented with a mass in the pineal region and obstructive hydrocephalus. A neuroendoscopic biopsy for the lesion, ventriculoperitoneal (VP) shunting, and focal irradiation were conducted as initial treatment. Histological diagnosis of the biopsy specimen was germinoma. He underwent further irradiation and two tumor resections. Histological diagnosis was mature teratoma without a germinomatous component. After serial treatments, the intracranial lesion was controlled. However, 14 months after presentation, extraneural lesions were confirmed in the posterior mediastinum and retroperitoneal space. The biopsy specimen of the retroperitoneal space lesion was histologically diagnosed as germinoma. Although chemotherapy with cisplatin and etoposide was undertaken, extraneural lesions ware uncontrollable and he died. At autopsy, extraneural lesions were confirmed in the posterior mediastinum, retroperitoneal space, and right lung. Histological diagnosis of extraneural lesions was germinoma. This case was considered to be a pineal mixed germ cell tumor mainly consisting of germinoma and mature teratoma, which caused hematogenous metastasis of the germinoma component. Systemic chemotherapy and irradiation for primary lesions as an initial treatment is important to cure the primary lesion and prevent extraneural metastasis.ArticleBRAIN TUMOR PATHOLOGY. 29(4):245-250 (2012)journal articl

Performance of a newly developed SDCCD for X-ray use

A Scintillator Deposited CCD (SDCCD) is a wide-band X-ray detector consisting of a CCD and a scintillator directly attached to each other. We assembled the newly developed SDCCD that the scintillator CsI(Tl) is below the fully depleted CCD. The incident X-rays enter the CCD depletion layer first. Then, X-rays passing through the depletion layer are absorbed in the CsI(Tl). The contact surface of the CCD is a back-illuminated side so that we can have good light collection efficiency. In our experimental setup, we confirmed good performance of our SDCCD detecting many emission lines up to 88\,keV that comes from $^{109}$Cd.Comment: 4 pages, 6 figures, accepted publication for Nucl. Instr. and Meth. (2010

Difference in the homology of two nuclear nonhistone protein fractions as compared by polyacrylamide gel electrophoresis.

The extent of homology between two protein fractions was compared by simple electrophoretic analysis. Nuclear proteins of several rodent cells of different origins were fractionated into acid-soluble and acid-insoluble fractions. The two protein fractions were subjected to polyacrylamide gel electrophoresis in separate gel systems, and protein bands with identical mobilities were sought either in all possible combinational pairs of cell types or in all cell types. The paired and overall homology indices calculated from these data and chi-square testing of the results indicated that acid-soluble nuclear nonhistone proteins are more homologous than acid-insoluble nuclear proteins. Several factors which might have affected the results were discussed.</p