Antibacterial, Antioxidant, Collagenase inhibition, Urease inhibition activities and Chemical composition of the Essential oil and extracts of Cinnamomum zeylanicum bark.

Significant biological activities of bacterial infection like antibacterial, antioxidant, urease and collagenase inhibitory activities of the essential oil and various extracts of Cinnamomum zeylanicum were determined. The in vitro antibacterial activity against nine epidermal bacteria and 11 MRSA isolates was conducted. The essential oil of C. zeylanicum exhibited the activity against all bacteria with the Minimum Inhibitory Concentration values (MIC) ranging from 0.15 to 2.5 µl. The extracts showed declined antibacterial activity. The scanning electron microscopic (SEM) studies demonstrated potential detrimental effect of the essential oil on the morphology of tested bacteria. Antioxidant activity of all the samples was also determined and 20% activity was observed in essential oil. Collagenase inhibitory potential  was upto 25% and 30% in aqueous and methanol extracts respectively while upto 35% in essential oil. None of the samples showed urease inhibitory activity. The chemical composition of hydrodistilled essential oil of C. zeylanicum was also analysed by GC-MS. A total of 13 compounds representing 100% of the oil were identified. Therefore, due to different chemical components present in the cinnamon essential oil, further investigation concerned with studied activities of this essential oil to replace the medicines or as supplement in diseases, is recommended

Antibacterial, Antioxidant, Collagenase inhibition, Urease inhibition activities and Chemical composition of the Essential oil and extracts of Cinnamomum zeylanicum bark.

Significant biological activities of bacterial infection like antibacterial, antioxidant, urease and collagenase inhibitory activities of the essential oil and various extracts of Cinnamomum zeylanicum were determined. The in vitro antibacterial activity against nine epidermal bacteria and 11 MRSA isolates was conducted. The essential oil of C. zeylanicum exhibited the activity against all bacteria with the Minimum Inhibitory Concentration values (MIC) ranging from 0.15 to 2.5 µl. The extracts showed declined antibacterial activity. The scanning electron microscopic (SEM) studies demonstrated potential detrimental effect of the essential oil on the morphology of tested bacteria. Antioxidant activity of all the samples was also determined and 20% activity was observed in essential oil. Collagenase inhibitory potential  was upto 25% and 30% in aqueous and methanol extracts respectively while upto 35% in essential oil. None of the samples showed urease inhibitory activity. The chemical composition of hydrodistilled essential oil of C. zeylanicum was also analysed by GC-MS. A total of 13 compounds representing 100% of the oil were identified. Therefore, due to different chemical components present in the cinnamon essential oil, further investigation concerned with studied activities of this essential oil to replace the medicines or as supplement in diseases, is recommended

Free radical scavenging activity, phenolic contents and Phytochemical analysis of seeds of trigonella foenum graecum

The search for sources of potent antioxidants of natural origin derived from plants is very important in the wake of decreasing resistance of human beings to various diseases. In the present study, antioxidant activity, phenolic contents and phytochemical profile of various extracts (methanol, chloroform, ethyl acetate and hexane) of seeds of Trigonella foenum graecum (fenugreek) were investigated. Ethyl acetate extract (100 μg/ml) showed highest inhibitory potential with application of DPPH scavenging (69.70%) and chelating power assay (63.44%). The differences in antioxidant activity of extracts are attributed to the presence of various phytochemicals. The IC50 values of different extracts were also calculated. There was found a positive correlation (R ≥ 0.895) between the total phenolic content and the antioxidant activity of extracts. The phytochemical analysis revealed the presence of alkaloids, flavonoids, saponins, phenols and tannins. Results from different parameters were in agreement with each other. The results reveal that all extracts of the fenugreek exhibit antioxidant activity. These findings suggest that the fenugreek extracts could act as potent source of antioxidants

Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScopeⓇ—Global Registry for Emerging Fungal Infections

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