The monumental submerged Punic harbour of Malfatano and associated Piscinnì quarries: sea level changes and geoarchaeological approach

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Sea level change and vertical land movements since the last two millennia along the coasts of southwestern Turkey and Israel

This paper provides new relative sea-level data inferred from coastal archaeological sites located along the Turkish coasts of the Gulf of Fethye (8 sites), and Israel, between Akziv and Caesarea (5 sites). The structures selected are those that, for effective functioning, can be accurately related to sea level at the time of their construction. Thus their positions with respect to present sea level provide a measure of the relative sea level change since their time of construction. Useful information was obtained from the investigated sites spanning an age range of ~2.3 to ~1.6 ka BP. The inferred changes in relative sea level for the two areas are distinctly different, from a rise of 2.41 to 4.50 m in Turkey and from 0 to 0.18 m in Israel. Sea level change is the combination of several processes, including vertical tectonics, glacio–hydro-isostatic signals associated with the last glacial cycle, and changes in ocean volume. For the Israel section, the present elevations of the MIS 5.5 Tyrrhenian terraces occur at a few meters above present sea level and vertical tectonic displacements are small. Data from GPS and tide gauge measurements also indicate that any recent vertical movements are small. The MIS-5.5 shorelines are absent from the investigated section of the Turkish coast, consistent with crustal subsidence associated with the Hellenic Arc. The isostatic signals for the Israel section of the coast are also small (ranging from -0.11 mm/year to 0.14 mm/year, depending on site and earth model) and the observed (eustatic) average sea level change, corrected for this contribution, is a rise of 13.5±2.6 cm during the past ~2 ka. This is attributed to the time-integrated contribution to sea level from a combination of thermal expansion and other increases in ocean volume. The observed sea levels from the Turkish sites, in contrast, indicate a much greater rise of up to 2.2 mm/yr since 2.3 ka BP occurring in a wide area between Knidos and Kekova. The isostatic signal here is also one of a rising sea level (of up to ~ 1mm/year and site and earth-model dependent) and the corrected tectonic rate of land subsidence is ~1.48 mm/year. This is the primary cause of dramatic relative sea level rise for this part of the coast

On the rehydration of organic layered double hydroxides to form low-ordered carbon/LDH nanocomposites

Low-ordered carbon/layered double hydroxide (LDH) nanocomposites were prepared by rehydration of the oxides produced by calcination of an organic LDH. While the memory effect is a widely recognized effect on oxides produced by inorganic LDH, it is unprecedented from the calcination/rehydration of organic ones. Different temperatures (400, 600, and 1100 °C) were tested on the basis of thermogravimetric data. Water, instead of a carbonate solution, was used for the rehydration, with CO2 available from water itself and/or air to induce a slower process with an easier and better intercalation of the carbonaceous species. The samples were characterized by X-ray powder diffraction (XRPD), infrared in reflection mode (IR), and Raman spectroscopies and scanning electron microscopy (SEM). XRPD indicated the presence of carbonate LDH, and of residuals of unreacted oxides. IR confirmed that the prevailing anion is carbonate, coming from the water used for the rehydration and/or air. Raman data indicated the presence of low-ordered carbonaceous species moieties and SEM and XRPD the absence of separated bulky graphitic sheets, suggesting an intimate mixing of the low ordered carbonaceous phase with reconstructed LDH. Organic LDH gave better memory effect after calcination at 400 °C. Conversely, the carbonaceous species are observed after rehydration of the sample calcined at 600 °C with a reduced memory effect, demonstrating the interference of the carbonaceous phase with LDH reconstruction and the bonding with LDH layers to form a low-ordered carbon/LDH nanocomposite

A 2-year point-prevalence surveillance of healthcare-associated infections and antimicrobial use in Ferrara University Hospital, Italy

Background: Healthcare-Associated Infections (HAIs) represent one of the leading issues to patient safety as well as a significant economic burden. Similarly, Antimicrobial Use (AMU) and Resistance (AMR) represent a growing threat to global public health and the sustainability of healthcare services. Methods: A Point Prevalence Survey (PPS) following the 2016 ECDC protocol for HAI prevalence and AMU was conducted at Ferrara University Hospital (FUH). Data were collected by a team of trained independent surveyors in 2016 and 2018. Risk factors independently associated with HAI were assessed by a multivariate logistic regression model. Results: Of the 1102 patients surveyed, 115 (10.4%) had an active HAI and 487 (44.2%) were on at least 1 systemic antimicrobial agent. Factors independently associated with increased HAI risk were a "Rapidly Fatal" McCabe score (expected fatal outcome within 1 year), presence of medical devices (PVC, CVC, indwelling urinary catheter or mechanically assisted ventilation) and a length of hospital stay of at least 1 week. The most frequent types of HAI were pneumonia, bloodstream infections, and urinary tract infections. Antimicrobial resistance to third-generation cephalosporins was observed in about 60% of Enterobacteriaceae. Conclusions: The survey reports a high prevalence of HAI and AMU in FUH. Repeated PPSs are useful to control HAIs and AMU in large acute-care hospitals, highlighting the main problematic factors and allowing planning for improvement actions

Coseismic deformation and source modeling of the May 2012 Emilia (Northern Italy) earthquakes

On May 20th, 2012, an ML 5.9 earthquake (Table 1) occurred near the town of Finale Emilia, in the Central Po Plain, Northern Italy (Figure 1). The mainshock caused 7 casualties and the collapse of several historical buildings and industrial sheds. The earthquake sequence continued with diminishing aftershock magnitudes until May 29th, when an ML 5.8 earthquake occurred near the town of Mirandola, ~12 km WSW of the mainshock (Scognamiglio et al., 2012). This second mainshock started a new aftershock sequence in this area, and increased structural damage and collapses, causing 19 more casualties and increasing to 15.000 the number of evacuees. Shortly after the first mainshock, the Department of Civil Protection (DPC) activated the Italian Space Agency (ASI), which provided post-seismic SAR Interferometry data coverage with all 4 COSMO-SkyMed SAR satellites. Within the next two weeks, several SAR Interferometry (InSAR) image pairs were processed by the INGV-SIGRIS system (Salvi et al., 2012), to generate displacement maps and preliminary source models for the emergency management. These results included continuous GPS site displacement data, from private and public sources, located in and around the epicentral area. In this paper we present the results of the geodetic data modeling, identifying two main fault planes for the Emilia seismic sequence and computing the corresponding slip distributions. We discuss the implication of this seismic sequence on the activity of the frontal part of the Northern Apennine accretionary wedge by comparing the co-seismic data with the long term (geological) and present day (GPS) velocity fields.Published645-6551.1. TTC - Monitoraggio sismico del territorio nazionale1.9. Rete GPS nazionale1.10. TTC - Telerilevamento3.2. Tettonica attivaJCR Journalrestricte

Sea level changes in the Mediterranean: tectonic implications

The interpretation of sea level variations along the coasts of the Mediterranean region must be accompanied by the evaluation of vertical land movements associated with seismic and volcanic sources. This can be tentatively carried out through seismic strain analysis based on data pertaining the last 2 millennia as well as from the study of maritime archaeological structures.PublishedHersonissos, Crete island, Greece3.3. Geodinamica e struttura dell'interno della Terraope

Carfilzomib plus dexamethasone in patients with relapsed and refractory multiple myeloma: A retro-prospective observational study

Objective: We investigate safety and efficacy in common clinical practice of the combination of carfilzomib and dexamethasone (Kd56) approved for the ENDEAVOR trial for the treatment of relapsed or refractory multiple myeloma. Methods: We retro-prospective analyzed 75 patients in three centers in Tuscany, 48 of whom had a clinically relevant comorbidity and 50 of whom were older than 65 years, treated with a median use in the fourth line of therapy. We assessed the efficacy based on the International Myeloma Working Group criteria. Results: The overall response rate was 60%. Median PFS was 10 months in the general cohort; in patients treated for more than 1 cycle of therapy PFS was 12 months. Quality of response to Kd56 treatment was found to positively impact PFS. Refractory status to previous line of therapy or to lenalidomide or an history of exposure to pomalidomide, seemed to have no impact on survival. We also showed a low adverse events rate, with no neuropathy events, and a relatively small number of cardiovascular events above grade 3 (10%). Conclusion: Kd56 is an effective and well tolerated regimen in highly pretreated and elderly patients with a good safety profile

Potential Use of a Combined Bacteriophage–Probiotic Sanitation System to Control Microbial Contamination and AMR in Healthcare Settings: A Pre-Post Intervention Study

Microbial contamination in the hospital environment is a major concern for public health, since it significantly contributes to the onset of healthcare-associated infections (HAIs), which are further complicated by the alarming level of antimicrobial resistance (AMR) of HAI-associated pathogens. Chemical disinfection to control bioburden has a temporary effect and can favor the selection of resistant pathogens, as observed during the COVID-19 pandemic. Instead, probiotic-based sanitation (probiotic cleaning hygiene system, PCHS) was reported to stably abate pathogens, AMR, and HAIs. PCHS action is not rapid nor specific, being based on competitive exclusion, but the addition of lytic bacteriophages that quickly and specifically kill selected bacteria was shown to improve PCHS effectiveness. This study aimed to investigate the effect of such combined probiotic–phage sanitation (PCHSφ) in two Italian hospitals, targeting staphylococcal contamination. The results showed that PCHSφ could provide a significantly higher removal of staphylococci, including resistant strains, compared with disinfectants (−76%, p < 0.05) and PCHS alone (−50%, p < 0.05). Extraordinary sporadic chlorine disinfection appeared compatible with PCHSφ, while frequent routine chlorine usage inactivated the probiotic/phage components, preventing PCHSφ action. The collected data highlight the potential of a biological sanitation for better control of the infectious risk in healthcare facilities, without worsening pollution and AMR concerns