Magnetic losses in Si-Fe alloys for avionic applications

This paper presents an experimental analysis of the rotational power losses of the magnetic materials of transformers, motors and actuators used in avionic environment. A large frequency range is investigated using a suitable experimental test frame developed to measure the power losses for a circular magnetization. The results about different silicon iron alloys with different textures and thickness are considered and compared

New perspectives on the management of the Spanish national health system

Ao longo dos últimos vinte e cinco anos, a organização do sistema de saúde na Espanha vem adotando diversas medidas que reorientaram seu gerenciamento, melhoraram sua eficiência e aprimoraram seu sistema de financiamento, resultado de profundas reformas e da introdução de novos instrumentos de gestão. Este artigo é resultado de uma análise documental que objetivou descrever a trajetória de conformação do sistema de saúde espanhol e sua organização na contemporaneidade. Apresenta alguns determinantes históricos que tornaram possíveis as reformas no setor sanitário, como a descentralização para o nível das Comunidades Autônomas, a incorporação de mecanismos de coordenação e a integração e o financiamento dos novos e distintos formatos organizativos coexistentes no país. Além disso, identifica desafios que emergem no cenário atual do Sistema Nacional de Saúde, como o fenômeno da imigração, o avançado processo de transição demográfica, a crescente demanda por melhorias na qualidade da atenção e de incorporação tecnológica. Todos esses fatores influem na sustentabilidade do sistema, o que motivou a criação de mais um espaço para estabelecimentos de consensos sobre o papel fundamental do sistema sanitário para o Estado de Bem-Estar espanhol.During the last twenty-five years, the organization of the health system in Spain has adopted diverse measures that reoriented its management and improved its efficiency and financing system as a result of deep reforms and introduction of new management instruments. This paper is a result of a documental analysis that aimed to describe the trajectory of conformation of the Spanish health system and its current organization. The paper presents some historical determinants that enabled the reforms in the sanitary sector, such as the decentralization to the Autonomous Communities level, the incorporation of coordination mechanisms, and the integration and financing of the new and distinct organizational formats that coexist in the country. Furthermore, it identifies challenges that emerge in the current scenario of the National Health System, as the immigration phenomenon, the advanced process of demographic transition, and the growing demand for improvements in the quality of care and of technological incorporation. All these factors influence the sustainability of the system, which motivated the creation of one more space for the establishment of a consensus on the fundamental role of the sanitary system for the Welfare State in Spain

“Every day that I stay at home, it's another day blaming myself for not being at #Frontline”–Understanding medical students' sacrifices during COVID-19 Pandemic

COVID-19 struck the world and stretched the healthcare system and professionals. Medical students engaged in the pandemic effort, making personal and professional sacrifices. However, the impact of these sacrifices on students` professional development is still unknown. We applied constructivist grounded theory to individual audio diaries (total time = 5h38 min) and interviews (total time = 11h57min) performed with 18 last-year medical students during the first wave of COVID-19 pandemic in Brazil. The perspective of making sacrifices caused initial emotional distress in medical students, followed by a negotiation process revolving around three themes: predisposition to sacrifice, sense of competence, and sense of belonging. This negotiation process led to three response patterns: Pattern A: “No sense of duty”–the sacrifice was perceived as meaningless, and students showed intense anger and a desire to flee; Pattern B: “Sense of duty with hesitation to act”–the sacrifice was acknowledged as legitime, but students felt unprepared to contribute, leading to feelings of frustration and shame; and, Pattern C: “Sense of duty with readiness to act”–the engagement with the sacrifice was perceived as an opportunity to grow as a doctor, leading to fulfillment and proudness. Students ready to engage with the COVID-19 effort experienced identity consonance, reinforcing their professional identities. Students who felt incompetent or found the sacrifice meaningless experienced identity dissonance, which led to emotional suffering and the consideration of abandoning the course. Monitoring students' emotional reactions when facing professional challenges creates opportunities to problematize the role of sacrifice in the medical profession and scaffold professional identity development.</p

A New Approach in the Management of Triangular Fossa Auricular Defects: The Posterior Auricular Artery Perforator Antihelix-Conchal Flap (PAAP Flap).

Background: The reconstruction of extensive scapha or triangular fossa defects to the ear still represents a challenge considering the lack of local simple surgical procedures. Objective: To present a new perforator flap which is a modification of the Elsahy and Ladocsi chondrocutaneous rotation flaps. Patients and Methods: Ten patients, in whom the oncological resection to the triangular fossa did not include cartilage, but skin and perichondrium. Defects no larger than 3 cm in diameter were treated. The dissection of the flap was carried out from lateral to medial on the anterior subperichondral plane. The flap was thus raised without the cartilage component but with the anterior perichondrium branched with the perforating vessels. Results: All flaps survived and treated patients presented good aesthetic results. Conclusions: We think that this procedure represents a valuable option to be considered in reconstructing well selected composite defects to upper ear

In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses

Abstract BACKGROUND: Rhinovirus infections do not only cause common colds, but may also trigger severe exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Even though rhinoviruses have been the focus of extensive drug development efforts in the past, an anti-rhinoviral drug still has to make it to the market. In the past, the viral capsid protein VP1 has been shown to be an important target for the development of antiviral molecules. Furthermore, many different chemical scaffolds appear to possess the properties that are required to inhibit virus replication by this mechanism of action. I-6602, an analogue of the rhinovirus inhibitor pirodavir, was previously identified as a potent inhibitor of rhinovirus infection. Here, we describe the antiviral activity of its analogue ca603, a molecule with a modified linker structure, and corroborate its mechanism of action as a capsid binder. FINDINGS: The molecule ca603 shows antiviral activity against a panel of rhino-and enteroviruses. Cross-resistance is observed against viruses with mutations that render them resistant to the inhibitory effect of the capsid binder pleconaril and thermostability assays demonstrate that the compound binds and stabilizes the viral capsid. Binding of the molecule to the VP1 protein is corroborated by in silico modeling. CONCLUSIONS: It is confirmed that ca603 inhibits rhinovirus replication by interaction with the VP1 protein and, by this, allows to further expand the chemical diversity of capsid-binding molecules

Novas perspectivas na gestão do sistema de saúde da Espanha

Ao longo dos últimos vinte e cinco anos, a organização do sistema de saúde na Espanha vem adotando diversas medidas que reorientaram seu gerenciamento, melhoraram sua eficiência e aprimoraram seu sistema de financiamento, resultado de profundas reformas e da introdução de novos instrumentos de gestão. Este artigo é resultado de uma análise documental que objetivou descrever a trajetória de conformação do sistema de saúde espanhol e sua organização na contemporaneidade. Apresenta alguns determinantes históricos que tornaram possíveis as reformas no setor sanitário, como a descentralização para o nível das Comunidades Autônomas, a incorporação de mecanismos de coordenação e a integração e o financiamento dos novos e distintos formatos organizativos coexistentes no país. Além disso, identifica desafios que emergem no cenário atual do Sistema Nacional de Saúde, como o fenômeno da imigração, o avançado processo de transição demográfica, a crescente demanda por melhorias na qualidade da atenção e de incorporação tecnológica. Todos esses fatores influem na sustentabilidade do sistema, o que motivou a criação de mais um espaço para estabelecimentos de consensos sobre o papel fundamental do sistema sanitário para o Estado de Bem-Estar espanhol.During the last twenty-five years, the organization of the health system in Spain has adopted diverse measures that reoriented its management and improved its efficiency and financing system as a result of deep reforms and introduction of new management instruments. This paper is a result of a documental analysis that aimed to describe the trajectory of conformation of the Spanish health system and its current organization. The paper presents some historical determinants that enabled the reforms in the sanitary sector, such as the decentralization to the Autonomous Communities level, the incorporation of coordination mechanisms, and the integration and financing of the new and distinct organizational formats that coexist in the country. Furthermore, it identifies challenges that emerge in the current scenario of the National Health System, as the immigration phenomenon, the advanced process of demographic transition, and the growing demand for improvements in the quality of care and of technological incorporation. All these factors influence the sustainability of the system, which motivated the creation of one more space for the establishment of a consensus on the fundamental role of the sanitary system for the Welfare State in Spain

TCT-709 Early and Mid-term Outcomes Of 1904 Patients Undergoing Transcatheter Balloon-Expandable Valve Implantation: results the ITER Registry

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Appraisal of antivenom production in public laboratories in Latin America during the first semester of 2020: The impact of COVID-19.

VIEWPOINT

Planning the integration and test of a space telescope with a 1 m aluminum primary mirror: the Ariel mission case

Ariel (Atmospheric Remote-Sensing Infrared Exoplanet Large Survey) is ESA’s M4 mission of the “Cosmic Vision” program, with launch scheduled for 2029. Its purpose is to conduct a survey of the atmospheres of known exoplanets through transit spectroscopy. Ariel is based on a 1 m class telescope optimized for spectroscopy in the waveband between 1.95 and 7.8 µm, operating at cryogenic temperatures in the range 40–50 K. The Ariel Telescope is an off-axis, unobscured Cassegrain design, with a parabolic recollimating tertiary mirror and a flat folding mirror directing the output beam parallel to the optical bench. The secondary mirror is mounted on a roto-translating stage for adjustments during the mission. The mirrors and supporting structures are all realized in an aerospace-grade aluminum alloy T6061 for ease of manufacturing and thermalization. The low stiffness of the material, however, poses unique challenges to integration and alignment. Care must be therefore employed when designing and planning the assembly and alignment procedures, necessarily performed at room temperature and with gravity, and the optical performance tests at cryogenic temperatures. This paper provides a high-level description of the Assembly, Integration and Test (AIT) plan for the Ariel telescope and gives an overview of the analyses and reasoning that led to the specific choices and solutions adopted