El discurso solidario. Análisis de los mensajes enviados a la telemaratón de tv3 a favor de las personas con enfermedades poco frecuentes

Discourse of solidarity. Analysis of the short messages sent to the TV3 Telethon in favour of people affected by infrequent diseases. The social debate on health and illness has an important presence in mass media. In this debate it is normal to find diverse discourse types from the point of view of valuation. Discourses may offer a positive, negative, non-positive or non-negative valuation of the topic concerning or of the actors involved. One of these types of discourse is that of engagement or the discourse of solidarity. In the present article, we analyse how spectators of the so famous Catalonian Telethon, called La Marató and that took place on the 13th December 2009, express their solidarity. That year the telethon was addressed to the medical investigation of rare diseases (RD), which are those that affect less than 5 for 10.000 inhabitants. Many of them are genetic and scarcely 10 per cent have treatment. 422 short messages (SMS) were sent to the programme. We will analyse all the messages ordered in the following way: those sent by people affected by a RD (28 in total), by relatives of these people (21 in total), by persons without any relation with these types of pathologies (30 from the beginning of the telethon, 30 from the central part and 30 from the end of the programme). In total, 139 SMS will be our last selection. Following the orientations of Critical Discourse Analysis, we will pay particular attention to the discursive materialization of two main dimensions: implication (that includes acts of awareness, of request or offer, of gratefulness or of recognition) and information (that comprises, fundamentally, acts of identification, of location, of greeting and of farewell).El debate social sobre la salud y la enfermedad tiene una presencia importante en los medios de comunicación. En este debate es normal encontrar tipos discursivos diversos desde el punto de vista valorativo; es decir, discursos en los se ofrece una mirada positiva, negativa, no positiva o no negativa en torno al tema del que se habla o a propósito de quienes pueden ser considerados actores protagonistas de ese tema. Uno de esos tipos de discurso es el comprometido o solidario. En el presente artículo, analizamos cómo expresan la solidaridad los espectadores de La Marató emitida por TV3 de Cataluña el día 13 de diciembre de 2009. Ese año, la recaudación fue dirigida a la investigación médica de las enfermedades poco frecuentes (EPF), que son aquellas que afectan a menos de 5 por 10.000 habitantes y que suelen ser crónicas y graves. Muchas de ellas son genéticas y apenas un 10 por ciento tienen tratamiento. Fueron enviados 422 mensajes de texto (SMS) al programa. Analizaremos todos los mensajes mandados por las personas afectadas por una EPF (28 en total) y por familiares de estas personas (21 en total), además de mensajes enviados por personas sin vinculación a este tipo de patologías (30 al comienzo del telemaratón, 30 en la parte central y 30 al final). En total, 139 SMS. Siguiendo las orientaciones del Análisis Crítico del Discurso, prestaremos especial atención a la materialización discursiva de dos dimensiones: la orientada a la implicación (que incluye actos de sensibilización, de petición u ofrecimiento, de agradecimiento o de reconocimiento) y la orientada a la información (que puede incorporar, fundamentalmente, actos de identificación, de localización, de salutación y de despedida)

Empirical Challenges in Organizational Aesthetics Research: Towards a Sensual Methodology

Despite growing scholarly interest in aesthetic dimensions of organizational life, there is a lack of literature expressly engaging with the methodological mechanics of 'doing aesthetics research'. This article addresses that gap. It begins with an overview of the conceptual idiosyncrasies of 'aesthetics' as a facet of human existence and maps out the challenges these pose for empirical research methodology. A review of methodological approaches adopted to date in empirical studies of organizational aesthetics is then presented. The remainder of the article draws on the author's experiences and suggests methods and techniques to address both conceptual and practical challenges encountered during the execution of an organizational aesthetics research project. The article calls for a firmer focus on the aesthetic experiences of organizational members in addition to those of researchers and concludes with some suggestions as to the future of such 'sensual methodologies' </jats:p

Reconstructing the Plinian and co-ignimbrite sources of large volcanic eruptions: a novel approach for the Campanian Ignimbrite

The 39 ka Campanian Ignimbrite (CI) super-eruption was the largest volcanic eruption of the past 200 ka in Europe. Tephra deposits indicate two distinct plume forming phases, Plinian and co-ignimbrite, characteristic of many caldera-forming eruptions. Previous numerical studies have characterized the eruption as a single-phase event, potentially leading to inaccurate assessment of eruption dynamics. To reconstruct the volume, intensity, and duration of the tephra dispersal, we applied a computational inversion method that explicitly accounts for the Plinian and co-ignimbrite phases and for gravitational spreading of the umbrella cloud. To verify the consistency of our results, we performed an additional single-phase inversion using an independent thickness dataset. Our better-fitting two-phase model suggests a higher mass eruption rate than previous studies, and estimates that 3/4 of the total fallout volume is co-ignimbrite in origin. Gravitational spreading of the umbrella cloud dominates tephra transport only within the first hundred kilometres due to strong stratospheric winds in our best-fit wind model. Finally, tephra fallout impacts would have interrupted the westward migration of modern hominid groups in Europe, possibly supporting the hypothesis of prolonged Neanderthal survival in South-Western Europe during the Middle to Upper Palaeolithic transition

A Novel approach to reconstruct the plinian and co-ignimbrite phases of large eruptions - Campanian Ignimbrite

Reconstructing the volume and tephra dispersal from volcanic super-eruptions is necessary to assess the widespread impact of these massive events on climate, ecosystems and humans. Recent studies have demonstrated that volcanic ash transport and dispersion models are unrivaled in accurately constraining the volume of material ejected and provide further insight about the eruption dynamics during these gigantic events. However, the conventional simplified characterization of caldera-forming supereruptions as a single-phase event can lead to inaccurate estimations of the eruption dynamics and its impacts. Here, we apply a novel computational inversion method to reconstruct, for the first time, the two phases of the largest eruption of the last 200 ky in Europe, the Campanian Ignimbrite (CI) super-eruption. Additionally, we discuss the eruption’s contribution to the Middle to Upper Paleolithic transition by evaluating its environmental and climate implications

A Novel approach to reconstruct the plinian and co-ignimbrite phases of large eruptions - Campanian Ignimbrite

Reconstructing the volume and tephra dispersal from volcanic super-eruptions is necessary to assess the widespread impact of these massive events on climate, ecosystems and humans. Recent studies have demonstrated that volcanic ash transport and dispersion models are unrivaled in accurately constraining the volume of material ejected and provide further insight about the eruption dynamics during these gigantic events. However, the conventional simplified characterization of caldera-forming supereruptions as a single-phase event can lead to inaccurate estimations of the eruption dynamics and its impacts. Here, we apply a novel computational inversion method to reconstruct, for the first time, the two phases of the largest eruption of the last 200 ky in Europe, the Campanian Ignimbrite (CI) super-eruption. Additionally, we discuss the eruption’s contribution to the Middle to Upper Paleolithic transition by evaluating its environmental and climate implications

MORBIMORTALIDAD EN RECIÉN NACIDOS PRETÉRMINO MENORES DE 32 SDG CON SÍNDROME DE DIFICULTAD RESPIRATORIA TRATADOS CON SURFACTANTE EXÓGENO EN EL HOSPITAL MATERNO INFANTIL ISSEMYM.

El síndrome de dificultad respiratoria (SDR), consecuencia del déficit de surfactante pulmonar, cursa con mortalidad elevada. La lesión pulmonar aparentemente es mitigada después del reemplazo de surfactante, por lo que su aplicación sugiere una disminución en la mortalidad, tiempo de estancia hospitalaria y posibilidad de comorbilidades. Establecer la morbimortalidad en prematuros con SDR con aplicación de surfactante exógeno, en el periodo Enero 2019-Diciembre 2019. Se realizó un estudio observacional, transversal, retrospectivo, descriptivo de expedientes de pacientes prematuros, con SDR tratados con surfactante en el Hospital Materno Infantil ISSEMYM, Toluca, Estado de México, del 01 de enero 2019 al 31 de diciembre del 2019, en búsqueda de variables como aplicación de maduradores pulmonares, aplicación profiláctica o de rescate de surfactante, mortalidad y morbilidad. El análisis estadístico se realizó con el programa IBM SPSS Statistics, calculando medidas de tendencia central, y comparándose con la estadística reportada. Se incluyeron 24 pacientes, registrando una mortalidad de 29.2%. El 33.3% recibieron surfactante, con mortalidad del 50%; 12.5% recibieron esquema profiláctico, mortalidad de 100%, y 20.8% de rescate, mortalidad de 20%. En pacientes que no recibieron surfactante (66.6%) la mortalidad fue de 18.7%. De los que recibieron esquema de maduradores pulmonares y surfactante egresó por mejoría el 25%, y con esquema de maduradores sin surfactante egresó el 100%. En pacientes con administración de surfactante la mortalidad fue más alta. El uso de maduradores sin aplicación de surfactante representó una mayor sobrevida. La morbilidad principal fue hiperbilirrubinemia, seguido de sepsis neonatal y neumonía congénita.UAEM, la autora

KRAS is a molecular determinant of platinum responsiveness in glioblastoma

Background: KRAS is the undisputed champion of oncogenes, and despite its prominent role in oncogenesis as mutated gene, KRAS mutation appears infrequent in gliomas. Nevertheless, gliomas are considered KRAS-driven cancers due to its essential role in mouse malignant gliomagenesis. Glioblastoma is the most lethal primary brain tumor, often associated with disturbed RAS signaling. For newly diagnosed GBM, the current standard therapy is alkylating agent chemotherapy combined with radiotherapy. Cisplatin is one of the most effective anticancer drugs and is used as a first-line treatment for a wide spectrum of solid tumors (including medulloblastoma and neuroblastoma) and many studies are currently focused on new delivery modalities of effective cisplatin in glioblastoma. Its mechanism of action is mainly based on DNA damage, inducing the formation of DNA adducts, triggering a series of signal-transduction pathways, leading to cell-cycle arrest, DNA repair and apoptosis. Methods: Long-term cultures of human glioblastoma, U87MG and U251MG, were either treated with cis-diamminedichloroplatinum (cisplatin, CDDP) and/or MEK-inhibitor PD98059. Cytotoxic responses were assessed by cell viability (MTT), protein expression (Western Blot), cell cycle (PI staining) and apoptosis (TUNEL) assays. Further, gain-of-function experiments were performed with cells over-expressing mutated hypervariable region (HVR) KRASG12V plasmids. Results: Here, we studied platinum-based chemosensitivity of long-term cultures of human glioblastoma from the perspective of KRAS expression, by using CDDP and MEK-inhibitor. Endogenous high KRAS expression was assessed at transcriptional (qPCR) and translational levels (WB) in a panel of primary and long-term glioblastoma cultures. Firstly, we measured immediate cellular adjustment through direct regulation of protein concentration of K-Ras4B in response to cisplatin treatment. We found increased endogenous protein abundance and involvement of the effector pathway RAF/MEK/ERK mitogen-activated protein kinase (MAPK) cascade. Moreover, as many MEK inhibitors are currently being clinically evaluated for the treatment of high-grade glioma, so we concomitantly tested the effect of the potent and selective non-ATP-competitive MEK1/2 inhibitor (PD98059) on cisplatin-induced chemosensitivity in these cells. Cell-cycle phase distribution was examined using flow cytometry showing a significant cell-cycle arrest in both cultures at different percentage, which is modulated by MEK inhibition. Cisplatin-induced cytotoxicity increased sub-G1 percentage and modulates G2/M checkpoint regulators cyclins D1 and A. Moreover, ectopic expression of a constitutively active KRASG12V rescued CDDP-induced apoptosis and different HVR point mutations (particularly Ala 185) reverted this phenotype. Conclusion: These findings warrant further studies of clinical applications of MEK1/2 inhibitors and KRAS as 'actionable target' of cisplatin-based chemotherapy for glioblastoma

Effect of a low crude protein diet supplemented with different levels of threonine on growth performance, carcass traits, blood parameters, and immune responses of growing broilers

ABSTRACT A study was conducted to evaluate growth performance, carcass traits, blood serum parameters, and immune responses of Ross 308 male broilers fed diets containing 2 different crude protein (CP) levels (97.5 and 100%) and 4 threonine (Thr) levels (100, 110, 120, and 130% of Ross recommendations for starter and grower periods). A completely randomized block design was adopted and main effects (CP and Thr) were arranged in a 2 × 4 factorial approach. Optimum growth performance was achieved when broiler requirements for CP and Thr were 100% satisfied. The 110% Thr inclusion in 97.5% CP diet increased ADG, ADFI, energy intake, and protein intake (Thr,

Effects of supra-nutritional levels of vitamin E and vitamin C on growth performance and egg production traits of Japanese quails

A study was conducted to evaluate growth performance and egg production traits of Japanese quails fed diets containing different supra-nutritional levels of vitamin E and C (600, 800 and 1000 mg/kg). A completely randomised design was adopted and main effects (vitamin E and C) were arranged in a 3 × 3 factorial approach. Throughout the study (42 to 105 d), the highest feed intake (vitamin C, p = .01) and weight gain (vitamin E × C, tendency p = .06) were obtained with vitamin E and/or C at 800 mg/kg whereas the highest dietary efficiency with 600 mg/kg of vitamin E plus 600 or 1000 of C and with 800 mg/kg of E plus 600 or 800 mg/kg of C (vitamin E × C, tendency p = .06). The highest final body weight was achieved with 1000 mg/kg of both the vitamins (vitamin E × C, p = .02). Vitamin E and/or C at 1000 mg/kg increased egg production, weight of produced eggs (vitamin E × C, p = .04), number of produced eggs to feed ratio, weight of produced eggs to feed ratio (vitamin E and C, p < .01), average egg volume (vitamin E × C, p = .03), and egg shape index (vitamin E, p < .01; vitamin C, p = .01). Current findings showed that feeding vitamin E and C at supra-nutritional levels can be a good management practice in Japanese quail nutrition to promote growth performance and egg production traits under thermoneutral condition.Highlights Supra-nutritional levels of vitamin E and C can promote growth performance and egg production traits of Japanese quails. Vitamin E plus C at high doses (1000 mg/kg) can synergistically act in promoting quail growth. Dietary supplementation with vitamin E at 800 or 1000 mg/kg plus vitamin C at 1000 mg/kg can improve egg production traits