Palmis y Oronte : comedia en tres actos, representada por la Compañía del Señor Luis Navarro, año de 1798

Según el "Catálogo de comedias sueltas conservadas en la Biblioteca de la Real Academia Española", 869, el autor es Vicente Rodríguez de Arellano. También Aguilar Piñal, VII, n. 1325, incluye esta obra entre las de Rodríguez de Arellano

Título: Teología catequística

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-201

Saynete nuevo intitulado La elección de novios / compuesto por D.A.R.S.

Precede al tit.: "87"Un grab. en la port. que representa a Cupid

Los toreros de invierno : novela

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 201

Cédula, 1778-07-09

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2012-2013Certifica la copia, Antonio Martinez SalazarTexto fechado en Aranjuez, 9 de Julio de 1778Sign.: [ ]6Port. con esc. real xil

Rhythmic expression of the cycle gene in a hematophagous insect vector

BACKGROUND: A large number of organisms have internal circadian clocks that enable them to adapt to the cyclic changes of the external environment. In the model organism Drosophila melanogaster, feedback loops of transcription and translation are believed to be crucial for the maintenance of the central pacemaker. In this mechanism the cycle (or bmal1) gene, which is constitutively expressed, plays a critical role activating the expression of genes that will later inhibit their own activity, thereby closing the loop. Unlike Drosophila, the molecular clock of insect vectors is poorly understood, despite the importance of circadian behavior in the dynamic of disease transmission. RESULTS: Here we describe the sequence, genomic organization and circadian expression of cycle in the crepuscular/nocturnal hematophagous sandfly Lutzomyia longipalpis, the main vector of visceral leishmaniasis in the Americas. Deduced amino acid sequence revealed that sandfly cycle has a C-terminal transactivation domain highly conserved among eukaryotes but absent in D. melanogaster. Moreover, an alternative form of the transcript was also identified. Interestingly, while cycle expression in Drosophila and other Diptera is constitutive, in sandflies it is rhythmic in males and female heads but constitutive in the female body. Blood-feeding, which causes down-regulation of period and timeless in this species, does not affect cycle expression. CONCLUSION: Sequence and expression analysis of cycle in L. longipalpis show interesting differences compared to Drosophila suggesting that hematophagous vector species might present interesting new models to study the molecular control of insect circadian clocks

Jornada de Tarazona hecha por Felipe II en 1592 pasando por Segovia, Valladolid, Palencia, Burgos, Logroño, Pamplona y Tudela

IndicesCopia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-2010Port. a dos tinta

Saynete nuevo intitulado La variedad en la locura : segunda parte / compuesto por D.A.R.Y. ; para siete hombres solos

Precede al tít.: "157"Texto a 2 colSign.: A