Una nuova critica dell’antica pittura italiana.Giovanni Morelli, Emilio Visconti Venosta e l’archeologia del discorso nazionale

A partire dalla celebre recensione di Emilio Visconti Venosta al primo volume di saggi di Giovanni Morelli, il saggio intende dimostrare come, all'indomani dell'unificazione nazionale, la definizione della storia dell'arte come disciplina autonoma partecipi a pieno titolo del discorso nazionalizzante a cui il nuovo stato affida la fabbricazione della sua identità. Il saggio presenta una versione ampliata della relazione al Convegno nazionale della SISCA, Bologna 7,8,9 novembre 2012

Scene per un mondo nuovo. Vanessa Bell, Duncan Grant e il Famous Women Dinner Service

In 1933-34, the Bloomsbury Group painters Duncan Grant and Vanessa Bell honored twelve actresses and dancers from XVIIto XXcentury in The Famous Women Dinner Service, the Wedgewood dinner set which was one of Bell and Grant’s most spectacular joint commissions, the evidence of their dedication to different genres and media and the impressive testament of their close working partnership. Having onlyjust come to light, and first publicly exhibited in 2017 with the whole set, the portraits offer exciting new material for research and discussion: this essay try to unravel the many connections that tie Bell and Grant to the dramatic stage and to explorethe approach of Bloomsbury Group members to theatre as a space of freedom and of experiments of living and working to (try to) change the world

Interpretation Bias in Paranoia: A Systematic Review and Meta-Analysis

More than 10% of the general population regularly experience paranoid thoughts. Persecutory delusions occur in one third of psychiatric patients in the United Kingdom and are associated with severe clinical and social impairment. Furthermore, individuals with elevated vulnerability to paranoia interpret ambiguous environmental information more negatively than those with low vulnerability, a cognitive phenomenon called interpretation bias. We conducted a systematic review and meta-analysis of the association between interpretation bias and paranoia. Twenty studies were included, and our meta-analysis indicated that a negative interpretation bias was associated with paranoia both in clinical (standardized mean difference, or SMD = 1.01; 95% confidence interval [CI] = [0.51, 1.52], p < .001) and nonclinical populations (SMD = 1.06; 95% CI = [0.28, 1.85], p = .008). Our results also showed that higher negative interpretation bias was positively correlated with the severity of paranoia, and results were consistent in nonclinical (r = .32; 95% CI = [.21, .43], p < .001) and clinical samples (r = .38; 95% CI = [.27, .48], p < .001). These findings might orient prevention strategies and psychological interventions for paranoia

The combined cognitive bias hypothesis in anxiety: A systematic review and meta-analysis

Cognitive theories have postulated the relational nature of different cognitive biases in the development and maintenance of anxiety disorders. To test this combined cognitive bias hypothesis, this review addressed the following questions: (i) whether different cognitive biases are associated with each other and (ii) whether one bias influences another bias. We identified 36 articles that studied the relationship between cognitive biases (attention, interpretation and memory bias). Of these, 31 studies were entered into two meta-analyses. Sixteen studies were included in the first meta-analysis of the correlation between cognitive bias indices. A further 15 studies were included in another meta-analysis to examine the transfer effects of cognitive bias modification (CBM) to another bias. Both meta-analyses yielded small but significant overall pooled effect sizes after the removal of outliers (r = 0.11 and g = 0.19 respectively). Moderator analyses revealed that the relationship between interpretation and memory bias was significantly stronger than other types of cognitive bias correlations and CBM is more potent in modifying biases when it was delivered in the laboratory compared with online. Our review quantifies the strength of the relationships between biases and transfer effects following CBM, which serves as a basis to further understand the mechanisms underlying biased information processing

Una experiencia de formación de promotoras contra la violencia de género en los barrios de La Plata y Gran La Plata

En este trabajo presentamos unas primeras reflexiones sobre una experiencia pedagógica realizada en el año 2015 en el marco del Proyecto de Extensión Universitaria: Redescubriendo los lazos sociales del Affidamento. Promotoras para el reposicionamiento subjetivo contra la violencia de género con base en redes cooperativo- comunitarias de la Facultad de Humanidades y Ciencias de la Educación de la UNLP. En el mismo confluimos docentes, graduadas, investigadoras y alumnas de las siguientes Facultades: de Humanidades y Ciencias de la Educación, de Psicología, de Ciencias Jurídicas y Sociales, de Periodismo y Comunicación Social, de Ciencias Naturales y Museo.Eje 4: Prácticas socio-comunitarias en la formación y compromiso social de la universidad. Políticas y estrategias de extensión universitaria: reflexiones y debates.Secretaría de Asuntos Académico

Intrinsically disordered amphiphilic peptides as potential targets in drug delivery vehicles

Intrinsically disordered proteins/peptides play a crucial role in many physiological and pathological events and may assume a precise conformation upon binding to a specific target. Recently, we have described the conformational and functional properties of two linear ester peptides provided with the following sequences: Y-G-E-C-P-C-K-OAllyl (PepK) and Y-G-E-C-P-C-E-OAllyl (PepE). Both peptides are characterized by the presence of the ‘‘CPC’’ motif together with a few amino acids able to promote disorder. The CPC sequence is a binding motif for the CXCR4 receptor that represents a well-known target for cancer therapies. In this paper, we report on synthetic amphiphilic peptides that consist of lipophilic derivatives of PepE and PepK bearing two stearic alkyl chains and/or an ethoxylic spacer. These peptide amphiphiles form stable supramolecular aggregates; they present conformational features that are typical of intrinsically disordered molecules as shown by CD spectroscopy. Solution fluorescence and DLS studies have been performed to evaluate Critical Micellar Concentrations and the dimension of supramolecular aggregates. Moreover, preliminary in vitro cell-based assays have been conducted to investigate the molecular recognition processes involving the CXCR4 receptor. In the end, the results obtained have been compared with the previous data generated by the corresponding non-amphiphilic peptides (PepE and PepK)

En Affidamento: construyendo redes sociales contra la violencia de género

En este trabajo, compartiremos algunas reflexiones sobre nuestra participación en un Proyecto de Extensión Universitaria realizado en el año 2015, titulado: Redescubriendo los lazos sociales del Affidamento. Promotoras para el reposicionamiento subjetivo contra la violencia de género con base en redes cooperativo- comunitaria con continuidad en el año 2016, en la Facultad de Humanidades y Ciencias de la Educación de la UNLP. En el mismo confluimos docentes, graduadas, investigadoras y alumnas de las siguientes Facultades: de Humanidades y Ciencias de la Educación, de Psicología, de Ciencias Jurídicas y Sociales, de Periodismo y Comunicación Social, de Ciencias Naturales y Museo.Mesa 35: ¿Podremos vivir juntos? Ciudadanía, género y culturas urbanas. La perspectiva de género en la producción de conocimiento sociológicoFacultad de Humanidades y Ciencias de la Educació

Conformational Ensembles Explored Dynamically from Disordered Peptides Targeting Chemokine Receptor CXCR4

This work reports on the design and the synthesis of two short linear peptides both containing a few amino acids with disorder propensity and an allylic ester group at the C-terminal end. Their structural properties were firstly analyzed by means of experimental techniques in solution such as CD and NMR methods that highlighted peptide flexibility. These results were further confirmed by MD simulations that demonstrated the ability of the peptides to assume conformational ensembles. They revealed a network of transient and dynamic H-bonds and interactions with water molecules. Binding assays with a well-known drug-target, i.e., the CXCR4 receptor, were also carried out in an attempt to verify their biological function and the possibility to use the assays to develop new specific targets for CXCR4. Moreover, our data indicate that these peptides represent useful tools for molecular recognition processes in which a flexible conformation is required in order to obtain an interaction with a specific target

En Affidamento: construyendo redes sociales contra la violencia de género

En este trabajo, compartiremos algunas reflexiones sobre nuestra participación en un Proyecto de Extensión Universitaria realizado en el año 2015, titulado: Redescubriendo los lazos sociales del Affidamento. Promotoras para el reposicionamiento subjetivo contra la violencia de género con base en redes cooperativo- comunitaria con continuidad en el año 2016, en la Facultad de Humanidades y Ciencias de la Educación de la UNLP. En el mismo confluimos docentes, graduadas, investigadoras y alumnas de las siguientes Facultades: de Humanidades y Ciencias de la Educación, de Psicología, de Ciencias Jurídicas y Sociales, de Periodismo y Comunicación Social, de Ciencias Naturales y Museo.Mesa 35: ¿Podremos vivir juntos? Ciudadanía, género y culturas urbanas. La perspectiva de género en la producción de conocimiento sociológicoFacultad de Humanidades y Ciencias de la Educació

Associations between childhood victimization, inflammatory biomarkers and psychotic phenomena in adolescence: A longitudinal cohort study.

Exposure to victimization in childhood has been linked to the development of psychosis. However, little is known about how childhood victimization is translated into biological risk for psychosis. One possibility is via increased inflammation. This study aimed to investigate the association between childhood victimization, psychotic experiences (PEs) in adolescence and inflammatory markers using data from a general population cohort. Participants were 1,419 British-born children followed from birth to age 18 years as part of the Environmental Risk Longitudinal Twin Study. Childhood victimization was measured prospectively using multiple sources from birth to age 12 years. PEs were assessed during private interviews with participants at age 18 years for the period since age 12. Plasma C-reactive protein (CRP), interleukin-6 (IL-6), and soluble urokinase plasminogen activator receptor (suPAR) levels were measured from plasma samples collected from participants at 18 years. Young people with both PEs and childhood victimization were more likely to belong to a group with elevated suPAR, CRP and IL-6 levels at 18 years of age (OR = 3.34, 95% CI 1.69-6.59, p = 0.001) than those with no childhood victimization and without PEs. However, this association was attenuated when adjusted for other risk factors for elevated inflammation at age 18 (OR = 1.94, 95% CI 0.94-4.04, p = 0.075). In contrast, presence of PEs without childhood victimization was not significantly associated with age-18 inflammatory markers and neither was childhood victimization without PEs (all p's greater than 0.05). The current study highlights that inflammatory dysregulation is mostly present in adolescents reporting PEs who also experienced childhood victimization, though this seemed to be largely due to concurrent inflammation-related risk factors