The helium spread in the Globular cluster 47 Tuc

Spectroscopy has shown the presence of the CN band dicothomy and the Na-O anticorrelations for 50--70% of the investigated samples in the cluster 47 Tuc, otherwise considered a "normal" prototype of high metallicity clusters from the photometric analysis. Very recently, the re-analysis of a large number of archival HST data of the cluster core has been able to put into evidence the presence of structures in the Sub Giant Branch: it has a brighter component with a spread in magnitude by $\sim$0.06 mag and a second one, made of about 10% of stars, a little fainter (by $\sim$0.05 mag). These data also show that the Main Sequence of the cluster has an intrinsic spread in color which, if interpreted as due to a small spread in helium abundance, suggests $\Delta$Y$\sim$0.027. In this work we examine in detail whether the Horizontal Branch morphology and the Sub Giant structure provide further independent indications that a real --although very small-helium spread is present in the cluster. We re--analyze the HST archival data for the Horizontal Branch of 47 Tuc, obtaining a sample of $\sim$500 stars with very small photometric errors, and build population synthesis based on new models to show that its particular morphology can be better explained by taking into account a spread in helium abundance of 2% in mass. The same variation in helium is able to explain the spread in luminosity of the Sub Giant Branch, while a small part of the second generation is characterized by a small C+N+O increase and provides an explanation for the fainter Sub Giant Branch. We conclude that three photometric features concur to form the paradigm that a small but real helium spread is present in a cluster that has no spectacular evidence for multiple populations like those shown by other massive clusters.Comment: Accepted for publication in the MNRAS on 2010 June 8. Received 2010 May 19; in original form 2010 February 9. 7 pages and 3 figures. No table

Recognizable neonatal clinical features of aplasia cutis congenita

Background: Aplasia cutis congenita (ACC), classified in nine groups, is likely to be underreported, since milder isolated lesions in wellbeing newborns could often be undetected, and solitary lesions in the context of polymalformative syndromes could not always be reported. Regardless of form and cause, therapeutic options have in common the aim to restore the deficient mechanical and immunological cutaneous protection and to limit the risk of fluid leakage or rupture of the exposed organs. We aimed to review our institutional prevalence, comorbidities, treatment and outcome of newborns with ACC. Methods: We conducted a retrospective study including all newborns affected by ACC and admitted at the University Mother-Child Department from October 2010 to October 2019. Anthropometric and clinical characteristics of ACC1 versus a non-isolated ACC group were analyzed. Results: We encountered 37 newborns, 16 with ACC1 versus 21 with non-isolated ACC. The incidence rate of 0.1% in ACC1 was higher than expected, while 19% of cases showed intrafamilial autosomal dominant transmission. Higher birth weight centile, though lower than reference population, being adequate for gestational age, normal Apgar score and euglycemia characterizing ACC1 resulted associated to a rapid tissue regeneration. Non-isolated ACC, in relation to concomitant congenital anomalies and higher prematurity rate, showed more surgical and medical complications along with the risk of neonatal death. Specifically, newborns with ACC4 were characterized by the frequent necessity of abdominal wall defect repair, responsible for the occurrence of an abdominal compartment syndrome. Conclusion: Prompt carefully assessment of the newborn with ACC in order to exclude concomitant other congenital malformations, provides clues to the underlying pathophysiology, and to the short-term prognosis. Family should be oriented toward identification of other family members affected by similar pathology, while obstetric history should exclude initial multiple pregnancy with death of a co-twin, placental anomalies and drug assumption. Molecular-genetic diagnosis and genetic counseling are integrative in individualized disease approach

Análise espacial das mudanças na cobertura e uso das terras em Santarém e Belterra, Pará, Brasil: armadilhas metodológicas associadas.

Através de um estudo de caso, indicamos como a delimitação da área de estudo pode influenciar o resultado de análises multiescalares em processos espaciais de mudanças na cobertura e uso da terra na Amazônia. Partindo dos limites dos municípios de Santarém e Belterra no oeste do Estado do Pará, definimos três níveis de delimitação da área de estudo. O primeiro nível abrange uma região que foi arbitrariamente definida e denominada sub-região de Santarém e Belterra. O segundo nível, uma parte do primeiro, corresponde ao limite do entorno de lotes estabelecidos pelo INCRA na década de 1970, tratando-se portanto de uma área de ocupação consolidada. O terceiro nível corresponde às zonas de influência de quatro eixos viários inseridos dentro da área de ocupação consolidada, subdivididos em subáreas norte e sul, num total de oito subáreas do segundo nível de delimitação. Para cada nível, aplicamos métricas de paisagem sobre mapeamentos temáticos do satélite Landsat obtidos para os anos de 1986 a 2005 e as associamos com dados sociodemográficos obtidos em levantamentos realizados em 2003. Os resultados mostram que as peculiaridades da dinâmica de ocupação em cada nível permitem melhor identificar padrões e processos na composição da estrutura da paisagem. Os dados obtidos para os três níveis de delimitação são complementares, possibilitando uma compreensão mais abrangente do que aquela que se poderia obter pelo estudo de um único nível

White Paper: promoting Design for All and e-Accessibility in Europe.

This White Paper results from the collaboration of Design for All (DfA) and e-Accessibility expert bodies representing the European Union member states [ref: the coordination centres of the national European Design for All e-Accessibility network (EDeAN) in 23 European Union Member States, in this document referred to as NCCs]. The objectives of this White Paper are threefold: (1) to present the current state of affairs of EDeAN, active since 2002 as part of the European Commission’s action line supporting the development of the European Information Society; (2) to outline a roadmap for future initiatives, actively reflecting views of the EDeAN network in specific domains related to DfA, e-Accessibility and e-Inclusion; and (3) to bring forward a set of suggestions and recommendations regarding the activities of the network, aiming to support the creation of a fully inclusive European Information Society. The paper is organised as follows: Section 1 provides a short introduction to DfA and Accessibility in Information Society (IS) and Information Society Technology (IST) developments in Europe. Section 2 provides an overview of policy as well as R&D activities related to DfA and accessibility in IST in Europe. Section 3 briefly describes the role of EDeAN and the new challenges that emerge as a result of the changing European policy environment. Section 4 presents current challenges that emerge in five domains directly related to DfA and accessibility, such as policy and legislation, industry, monitoring and evaluation—benchmarking, standardisation, R&D, and education and training. Finally, Sect. 5 puts forward a number of recommendations with regard to future activities for EDeAN. The contents of this paper reflect results from the open discussion forums supported in the EDeAN website (ref: EDeAN Special Interest Groups, SIGs). The draft paper was written by the EDeAN Secretariat for 2005, FORTH-ICS (Greece), and completed with the support of all NCCs. Support was also provided by the European Commission DG Information Society and Media and by the D4ALLnet project (ref: an EC funded project with the code IST-2001-38833)

P02-270 Study of the correlations between theory of mind, symptoms and personality characteristics of a non-psychiatric population

Aims:A deficit in the theory of mind has been identified, although without univocal results, in various pathologies, such as schizophrenia, bipolar disorder and some personality disorders. Aim of the study was to evaluate, in a non- psychiatric population, the correlation of personological characteristics and symptoms with theory of mind and emotion recognition tasks.Methods:The following protocol was administrated to 130 voluntary students from Novara (Italy) School of Medicine: EPQ-R test for personality analysis; an intention-inferencing task for theory of mind (adapted from Happè's version); the emotion recognition test (adapted from Blair's version); and SCL-90 for symptoms evaluation. Spearman correlation coefficient (SC) was calculated; p< 0.05 was considered statistically significant.Results:No statistically significant correlations were found between the EPQ-R (psychoticism, estroversion and nevroticism) and theory of mind test scores. Better performances in the theory of mind test corresponded to lower scores in SCL-90 subscales: obsessive-compulsive disorder (SC:-0.248; p=0.004); depression (SC:-0.280; p=0.001); anxiety (SC:-0.276; p=0.001); hostility (SC:-0.178; p=0.042); phobic anxiety (SC:-0.197;p=0.025); paranoid ideation (SC:-0.191;p=0.03); and psychoticism (SC:-0.189; p=0.032). A lower capacity in the recognition of the happiness emotion corresponded to higher scores in the hostility (CS:-0.194; p=0.027) and phobic anxiety (CS:-0.211; p=0.016) SCL-90 subscales, while higher scores in the EPQ-R subscale psychoticism and somatisation SCL-90 subscales were respectively related to lower skills in the recognition of fear (CS:-0.226; p=0.01) and envy (CS:-0.193; p=0.028) emotions.Conclusions:Theory of mind skills seem independent from personological traits, but are inversely correlated to various symptomatological subscale scores. The recognition of specific emotions correlates selectively with various personological traits and symptomatological subscales

Online Communities for All: The Role of Design for All in the Formation and Support of Inclusive Online Communities

An online community is a virtual community composed of individuals who form and maintain online communication, share common goals, interests and needs that provide the reason of community existence, and use common interactive tools that support their networking and communication activities. The term “networking” is traditionally used to describe the formation and maintenance of connections and relationships between individuals, organizations or other interested parties. Virtual or online networking is a form of interpersonal communication that is characterized by the use of electronic means of communication between the different parties and the exchange of messages and information in electronic forms [11]. Hence, virtual or online communities perform virtual networking. This paper aims to examine how the principles of Design for All can support the formation and operation of online communities that are fully inclusive, multi-cultural and multiplatform, thus providing an infrastructure essentially accessible to all their members to carry out virtual networking activities. Following an introduction to online communities and community formation, the paper briefly builds the case for Design for All and the challenges for new information and communication technologies towards a fully inclusive Information Society. Then, based on practical experience and case studies, the paper examines the benefits and challenges of applying the principles of Design for All in the design, development and support of virtual interaction spaces, in order to cater for the diversity of users-community members, as well as of their environments of use. The paper concludes by proposing a set of design issues to be taken into account in the development of online communities for all

A Case Report of a Woman Affected with Rapid Cycling Bipolar Disorder I and Methabolic Syndrome Improved with Aripiprazole Monotherapy

Introduction We present the case of a 51-years-old Caucasian woman with Bipolar Disorder I (BDI), treated for a long time with typical antipsychotics and mood stabilizers. She referred to our outpatient service because she wished to revise her precriptions, which had caused several side-effects, including metabolic syndrome, gain of body weight, sedation, cognitive impairments, and extrapiramidal symptoms. Moreover, treatment was poorly effective, the patient's compliance was lacking and she experienced frequent relapses. Aims We started treating the patient with aripiprazole at a daily dose of 15 mg. Our aim is to describe the substantial clinical and metabolic improvements of a patient who poorly responded to previous prescriptions. Methods Psychometric measures for the assessment of mood and social functioning were administered at baseline and at the follow-up interviews. Body Mass Index was monitored and blood tests were performed to evaluate the lipid profile (LDL, HDL, total cholesterol, triglycerides), blood glucose, and glycated haemoglobin. Results In the last two years the patient has regularly taken her therapies and attended to follow-up visits. Her social functioning and tolerance to stressful situations have improved, as well as her metabolic profile. Noteworthy, she had not needed further hospitalizations. Conclusions Our clinical observations support the efficacy of aripiprazole in the treatment of BDI. Switching to aripiprazole should be considered in cases similar to the one we have described, characterized by poor compliance, obesity or metabolic syndrome, sensitivity to manifest extrapiramidal syndrome (especially tardive dyskinesia) and other side effects such as sedation and cognitive impairments

THE VALUE OF FENO MEASUREMENT IN CHILDHOOD ASTHMA: UNCERTAINTIES AND PERSPECTIVES.

Asthma is considered an heterogeneous disease, requiring multiple biomarkers for diagnosis and management. Fractional exhaled nitric oxide in exhaled breath (FeNO) was the first useful non-invasive marker of airway inflammation in asthma and still is the most widely used. The non-invasive nature and the relatively easy use of FeNO technique make it an interesting tool to monitor airway inflammation and rationalize corticosteroid therapy in asthmatic patients, together with the traditional clinical tools (history, physical examination and lung function tests), even if some controversies have been published regarding the use of FeNO to support the management of asthma in children. The problem of multiple confounding factors and overlap between healthy and asthmatic populations preclude the routine application of FeNO reference values in clinical practice and suggest that it would be better to consider an individual "best", taking into account the context in which the measurement is obtained and the clinical history of the patient. Besides, there is still disagreement about the role of FeNO as a marker of asthma control, due to the complexity of balance among the different items involved in its determination and the ack of homogeneity in the population groups studied in the few studies conducted so far. Heterogeneity of problematic severe asthma greatly limits utility of FeNO alone as a biomarker of inflammation to optimize the disease management on an individual basis. None of the studies conducted so far demonstrated that the use of FeNO was better than current asthma guidelines in controlling asthma exacerbations. In summary, there is a large variation in FeNO levels between individuals, which may reflect the natural heterogeneity in baseline epithelial nitric oxide synthase activity and/or the contribution of other noneosinophilic factors to epithelial nitric oxide synthase activity. FeNO is a promising biomarker, but at present some limits are highlighted. We would recommend that further research can be carried out by organizing studies aimed to obtain reliable reference values of FeNO and in order to better interpret FeNO measurements in clinical settings, taking also into account the influence of genetic and environmental factor