CREATION OF COLLAGEN PRODUCTS FISH RAW MATERIAL

Purposeful use of proteins of connecting fabrics is based first of all on structural and mechanical and physical and chemical properties of collagen, his physiology to a human body. Traditional source of collagen is the split of skins of the cattle, but in view of the objective reasons (spongy encephalopathy, reduction of a livestock of cattle), there was a need for search of alternative sources. The particular interest and popularity represent collagenic proteins in biomedical technologies, when receiving surgical sutural materials, wound healing means, prolongator of medicines, artificial organs and fabrics, implatant. New data on use the collagen containing of sources are directly connected with expansion of a source of raw materials of processing industries of agrarian and industrial complex on the basis of deep processing of biological resources and their maximum involvement in the main and special production with significant growth in an exit of useful products from raw materials unit. In this regard, researches of a microstructure of skins and fractional composition of proteins of objects of research are conducted; data on the general chemical composition and the content of collagen in them are received. Experimental data showed that the most perspective source of collagen from the studied fishes of internal reservoirs is the skin of a silver carp that is caused by the high content of target substance collagen, the low content of fat. The technology of receiving collagenic substances with the high technical characteristics allowing to apply them in production of medical materials is proved and realized in vitro. The comparative analysis showed that substances from a split of skins of cattle and a silver carp have an identical set of amino acids, but are characterized by the different content of separate amino acid s

Cognitive Coherence as the Element of Functional Valence in COVID-19 Terminological System

Background. The relevance of the study is predetermined by the uniqueness of the communicative and discursive field formed during COVID-19 pandemic. The manifestation of COVID-19-related nominative categories occurs spontaneously and depends on pragmatic motives of social interaction at the global international level. The atypicality of COVID-19 terminological system development sets up the research course directed at both the process of diffuse terminological conglomerate formation and its conceptualization based on the mechanisms of cognitive activity implementation viewed through the cultural specificity revealed at the level of terminological functioning and terminological systemic unity. Objective. This article presents the results of a corpus-based research of cognitive and discursive features of COVID-19 terminological system development. Methods. The research material is a sample of Russian and English media texts selected via automatized algorithms of data parsing. Media discourse reflects short-term socially significant fluctuations in global information agenda directly related to semantic shifts in COVID-19 representation that are revealed through the variety of linguistic and extralinguistic discursive means and compared within the linguo-cultural communities under study. Results. As a result of content analysis and subsequent component analysis the peculiarities of COVID-19 terminological system development appear to be predetermined by the parallel structuring and transformation of COVID-19 semantic representation formed in the temporal perspective of pandemic waves on the basis of fundamental mechanisms of cognitive activity. The functional valence of COVID-19 terminological system is explicated through the convergence of cognitive components that result in terminological coherence and gradual formation of the denotative component of meaning through cognitive compilation of occasional semic characteristics. Conclusion. Cognitive coherence as the element of COVID-19 terminological system functional valence contributes to its gradual structuring and determines the features of semantic arrangement of COVID-19 conceptual field

FUNCTIONAL FOOD COMPOSITIONS BASED ON WHEY PROTEIN ISOLATE, FISH OIL AND SOY PHOSPHOLIPIDS

The aim of the research was to study the impact of whey protein isolate on the solubility and oxidative stability of the lipid composition based on soy phosphatidylcholine and fish oil. The relationship between the molecular parameters (density; ζ-potential) of the formed complex particles and their functional properties was found using laser light scattering (static, dynamic, electrophoretic) and spectrophotometry. The studied compositions could be used as the basis for the development of multifunctional food additives with an objective of the enrichment of foods and beverages with omega-3 polyunsaturated fatty acids (PUFAs). The main advantages of such composition are a high level of protection of the lipids against oxidation and degradation, a high solubility in an aqueous medium and the clean label.The aim of the research was to study the impact of whey protein isolate on the solubility and oxidative stability of the lipid composition based on soy phosphatidylcholine and fish oil. The relationship between the molecular parameters (density; ζ-potential) of the formed complex particles and their functional properties was found using laser light scattering (static, dynamic, electrophoretic) and spectrophotometry. The studied compositions could be used as the basis for the development of multifunctional food additives with an objective of the enrichment of foods and beverages with omega-3 polyunsaturated fatty acids (PUFAs). The main advantages of such composition are a high level of protection of the lipids against oxidation and degradation, a high solubility in an aqueous medium and the clean label

Technology for the Industrial Production of K3 Series Vitamins Based on Menadione

Received: 15.04.2020. Accepted: 27.06.2020. Published: 30.06.2020.An improved technology for the industrial production of K3 series vitamins based on menadion is reported. The procedure involves the Cr(VI) — promoted oxidation of the corresponding methyl-naphtahelenes with the following purification by precipitation/recrystallization. The best results were obtained under the process temperature between 20–40 °C, solution pH after dilution of MNB in a range of 5.5–5.7, and MNB content in initial solution of 25–30%

ИССЛЕДОВАНИЕ ЭФФЕКТИВНОСТИ ПРИМЕНЕНИЯ ОТДЕЛЬНЫХ ЗУБНЫХ ПАСТ С РАЗЛИЧНЫМИ АКТИВНЫМИ КОМПОНЕНТАМИ

Introduction. Nowadays, the prevention of dental diseases is very important in dentistry. The main measure aimed at prevention of dental diseases is an individual oral hygiene. Its effectiveness depends on the quality and regularity, as well as the proper selection of means of individual oral hygiene.The objective is to study the effectiveness of using the certain toothpastes with different active ingredients.Material and methods. Toothpastes «А» and «B» were used to study the effectiveness of using the certain toothpastes with different active ingredients. Probantes at the age of 50 to 70 years, with the presence of dental deposits and periodontal disease of moderate and severe degrees of severity took part in the study of the effectiveness of using these toothpastes. They were divided into two groups of 26 people in each group. The study evaluated the following indices: the hygiene index of Green – Vermillion (1964), gingival PMA index (Parma, 1960), the bleeding index of Muhleman and Son (1971). Results. The experiment discovered the decrease of the values of the digital indicators of the hygiene index of Green – Vermillion, gingival PMA index, and the bleeding index of Muhleman and Son in all groups during the whole period. These changes of the values of the indices were accompanied with the simultaneously increase in the values of a cleansing effect, anti-inflammatory and hemostatic efficiency.Conclusions. Toothpastes «А» and «В» are treatment-and-prophylactic toothpastes, acting effectively on the tissues and organs of the oral cavity with prolonged use. Введение. На сегодняшний день важное значение в стоматологии придается профилактике стоматологических заболеваний. Основной мерой, направленной на предотвращение стоматологических заболеваний, является индивидуальная гигиена рта. Ее эффективность напрямую зависит не только от качества и регулярности ее проведения, но и от правильного подбора средств индивидуальной гигиены рта.Цель – исследование эффективности применения отдельных зубных паст с различными активными компонентами.Материал и методы. Для исследования эффективности применения отдельных зубных паст с различными активными компонентами использовались зубные пасты «А» и «Б». В исследовании эффективности применения данных паст принимали участие пробанты в возрасте от 50 до 70 лет, с наличием зубных отложений и заболеваний пародонта средней и тяжелой степени тяжести. Они были разделены на две группы, по 26 человек в каждой. В исследовании оценивались следующие индексы: индекс гигиены Грина – Вермиллиона (1964), пародонтальный индекс PMA (Parma, 1960 г.), индекс кровоточивости Мюхлеман и Сон (1971). Результаты исследования. Установлено, что за весь период в группах происходило снижение значений цифровых показателей индекса гигиены Грина – Вермиллиона, пародонтального индекса PMA и индекса кровоточивости Мюхлеман и Сон. Данные изменения значений показателей индексов сопровождались одновременно увеличением значений очищающего эффекта, противовоспалительной и кровеостанавливающей эффективности.Выводы. Зубные пасты «А» и «Б» являются лечебно-профилактическими зубными пастами, действующими эффективно на ткани и органы полости рта при длительном их применении.

Application of the wax moth (Galeria melonella) larvae extract for correction of the immune status of athletes during the recovery period

Objective: to study dynamics of parameters of system immunity of athletes during the recovery period against the background of the combined reception of antler bathtubs and extract of larvae of a wax moth. Materials and methods: dynamics of parameters of the immune system of 28 athletes (skiers) had been studied during the recovery period. The main group of athletes (14 people) received antler bathtubs in combination with intake of extract of larvae of a wax moth, and group of comparison - only antler bathtubs. Results: the analysis of the results of the survey showed that the combined reception of the extract of the larvae of the wax moth and antler baths by athletes has a pronounced effect on the dynamics of the studied parameters. The significant augmentation of initially lowered subpopulations of lymphocytes became perceptible (CD3+, CD4+, CD8+). There was an essential depression of concentration of pro-inflammatory cytokines of TNF-a and IL-6 in blood serum and depression of spontaneous production of pro-inflammatory cytokines of TNF-a (p =0,010), IL-6 and IL lß by blood cells. Conclusions: the obtained data confirm the expressed immunomodulatory effect of extract of larvae of a wax moth in athletes during the recovery period

ВОЗМОЖНОСТИ ХИРУРГИЧЕСКОГО ЛЕЧЕНИЯ БОЛЬНЫХ МЕСТНО-РАСПРОСТРАНЕННЫМ РАКОМ ПРЯМОЙ КИШКИ С ВОВЛЕЧЕНИЕМ ЗАДНЕЙ СТЕНКИ МОЧЕВОГО ПУЗЫРЯ

The aim of investigation is the optimization of surgical treatment of patients with locally advanced rectal cancer with the involvement of posterior wall of urinary bladder.Materials and methods. The basis of investigation is the analysis of results of combined treatment of 67 patients with locally advanced rectal cancer involving triangle and cervix of urinary bladder. Radical operations of different volume were carried out in the department of common surgery during a period from 2000 till 2010. All patients had Т3–4N0–2M0 rectal cancer. Following types of surgery have been performed:1. Ultra-low anterior resection with coloanal anastomosis or abdomino-perineal excision combined with resection of 2/3 of urinary bladder — main group (44 patients);2. Pelvic exenteration — control group (23 patients).Results. The application of combined surgical intervention with the resection of posterior wall of urinary bladder didn’t lead to the increased post operative complications rate, which were diagnosed in 1 (2.27 %) of 44 patients in the main group. The patients, which had the operativetreatment in the volume of pelvic exenteration (control group), had a complication rate of 4.34 % (1 patient). In both cases, pelvic abscess of with a favorable outcome took place.Three-year disease-free survival rate in main investigated group was 55.3 %, in control group (23 patients) — 74 %.Conclusion. The investigation showed that pelvic exenteration for locally advanced rectal cancer involving posterior wall of the bladder is not always justified. We consider, that it’s more reasonable to save even small part of urinary bladder for the better patients rehabilitation.Цель исследования: оптимизация хирургического лечения больных местно-распространенным колоректальным раком (КРР) с вовлечением задней стенки мочевого пузыря.Материалы и методы исследования. В основу исследования положен анализ результатов комбинированного лечения 67 больных с местно-распространенным раком прямой кишки с вовлечением треугольника и шейки мочевого пузыря, которым в отделенииобщей хирургии ЛОКОД в период с 2000 по 2010 г. выполнены различные по объему радикальные операции. Все больные имели стадию процесса Т3–4N0–2M0. Всем больным выполнены операции в объеме:1. Комбинированная брюшно-анальная резекция или брюшно-промежностная экстирпация прямой кишки с резекцией 2/3 мочевого пузыря (основная группа, 44 пациента).2. Тотальная эвисцерация органов малого таза (контрольная группа, 23 пациента).Результаты. Проведение комбинированного хирургического вмешательства с резекцией стенки мочевого пузыря (основная группа) не привело к увеличению частоты послеоперационных осложнений, которые были диагностированы у 1 (2,27 %) больного из 44.У пациентов, получавших оперативное лечение в объеме эвисцерации органов малого таза (контрольная группа), осложнения составили 4,34 % (1 больной из 23). В обоих случаях имел место абсцесс малого таза с благоприятным исходом.Трехлетняя безрецидивная выживаемость в основной группе составила 55,3 %, в контрольной — 74 %.Заключение. Проведение эвисцерации органов малого таза при вовлечении в опухолевый процесс задней стенки мочевого пузыря не всегда оправданно. Мы считаем более целесообразным сохранять даже небольшую часть мочевого пузыря для лучшей реабилитации больного