To Evaluate Efficient Use of Nitrogen and Sulphuric Acid Application Towards Increase in Seed Cotton Yield and Soil Health

Present study was study at Agronomic Research area BahauddinZakariya University, Multan to evaluate efficient use of nitrogen and sulphuric acid application towards increase in seed cotton yield and soil health during Kharif 2013. Experiment was laid out in split plot arrangement having three replications. Nitrogen levels (N1= 50 kg ha-1, N2=100 kg ha-1, N3=150 kg ha-1) were kept in main plots while sulphuric acid (S1= 0 kg ha-1, S2= 125 kg ha-1, S3= 250 kg ha-1 and S4= 375 kg ha-1) was randomized in sub plots respectively.Statistical analysis of the data also revealed that maximumLAI, CGR, NAR, plant height (127.22 cm), matured bolls per plant (47.68), mean boll weight (2.94 g), seed cotton yield (3.11 t ha-1), biological yield (26.81 t ha-1) and soil organic matter (5.58%) was noted from the plots fertilized with 150 kg N ha-1. Analysis of the data recorded from the sulfuric acid treatments showed that maximum LAI, CGR, NAR, average boll weight (3.02 g), seed cotton yield (3.13 t ha-1), biological yield (27.16 t ha-1) and changes in soil pH (5.26%) was noted from the plots which were supplied of 375 Kg ha-1 sulfuric acid. From the above results, it is concluded the nitrogen rate N­3­ (150 kg ha-1) with 375 kg ha-1 H2SO4 is recommended for achieving higher yield of cotton under the agro-ecological conditions of Multan. Keywords:  Nitrogen, Cotton, Yields, sulfuric aci

Mathematical Modeling and Review of Pine Wilt Disease

Pine Wilt Disease (PWD), caused by the pinewood nematode (PWN) Bursaphelenchus xylophilus, causes significant losses in coniferous forests in eastern Asia, including Japan, China, and South Korea, as well as western Europe, including Portugal. The results of the research papers given at the International Symposium on Pine Wilt Disease (IUFRO Working Party Meeting 4.04.03) in Nanjing, China, in July 2009 are summarized in this article. The basic themes discussed included pine wilt disease (PWD), the pinewood nematode (PWN) Bursaphelenchus xylophilus, and other PWN-associated microorganisms that play a significant role in PWD, such as bacteria (e.g., Pseudomonas fluorescens). The majority of the papers are based on PWD-PWN research in East Asia and Russia. The following are some of the specific topics covered: 1) fundamental concepts of PWD development, 2) pathogenicity, 3) host-parasite relationships, including histopathology of diseased conifers and the role of toxins from bacteria-nematode ecto-symbionts, 4) PWN life cycle and transmission, 5) B. xylophilus dissemination models, 6) associations (with other nematodes), 7) diagnostics, 8) quarantine and control of the PWN and 9) biocontrol of the PWN

Agent-based Simulation Model for Long-term Carpooling: Effect of Activity Planning Constraints

AbstractIn order to commute by carpooling, individuals need to communicate, negotiate and coordinate, and in most cases adapt their daily schedule to enable cooperation. Through negotiation, agents (individuals) can reach complex agreements in an iterative way, which meets the criteria for the successful negotiation. The procedure of negotiation and trip execution in the long-term carpooling consists of a number of steps namely; (i) decision to carpool, (ii) exploration and communication, (iii) negotiation, (iv) coordination and schedule adaptation, (v) long term trip execution (carpooling), (vi) negotiation during carpooling and (vii) carpool termination and exploration for new carpool. This paper presents a conceptual design of an agent-based model (ABM) of a set of candidate carpoolers. A proof of concept implementation is presented. The proposed model is used for simulating the interactions between autonomous agents. The model enables communication to trigger the negotiation process; it measures the effect of pick-drop and shopping activities on the carpooling trips. Carpooling for commuting is simulated: we consider a set of two intermediate trips (home-to-work and work-to-home) for the long-term carpooling. Schedule adaptation during negotiation depends on personal preferences. Trip timing and duration are crucial factors. We carried out a validation study of our results with real data (partial) collected in Flanders, Belgium. Simulation results show the effect of constraining activities on the carpooling trips. The future research will mainly focus on enhancing the mechanisms for communication and negotiation between agents

Smart Dynamic Traffic Monitoring and Enforcement System

Enforcement of traffic rules and regulations involves a wide range of complex tasks, many of which demand the use of modern technologies. variable speed limits (VSL) control is to change the current speed limit according to the current traffic situation based on the observed traffic conditions. The aim of this study is to provide a simulation-based methodological framework to evaluate (VSL) as an effective Intelligent Transportation System (ITS) enforcement system. The focus of the study is on measuring the effectiveness of the dynamic traffic control strategy on traffic performance and safety considering various performance indicators such as total travel time, average delay, and average number of stops. United Arab Emirates (UAE) was selected as a case study to evaluate the effectiveness of this strategy. A micro simulation software package VISSIM with add-on module VisVAP is used to evaluate the impacts of VSL. It has been observed that VSL control strategy reduced the average delay time per vehicle to around 7%, travel time by 3.2%, and number of stops by 48.5%. Dynamic traffic control strategies also alleviated congestion by increasing the capacity of the bottleneck section and improving safety. Results of this study would act as a guidance for engineers and decision makers to new traffic control system implementation

Systemically administered central nervous system drugs induced ocular side effects: a review

Several systemic drugs have reported ocular and visual side effects that affect patient management. It is imperative to be familiar with the associated side effects which can be mild or transient and may seriously threaten vision. This article deals briefly with the mechanisms and reasons that account for the impact that systemically administered central nervous system (CNS) drugs can exert on the visual or ocular system. The eye care practitioner can be instrumental in detecting and reporting ocular side effects, advising patients and collaborating with other members of the patient’s healthcare team. One of the difficulties include becoming familiar with the countless systemic medications prescribed to patients. Another is being able to correlate a particular side effect with a suspected drug. Several of the ocular adverse effects such as glaucoma, cataract, blurred vision, color vision, optic neuritis, maculopathy, dry eye, etc., are vision threatening and often patients fail to recognize or describe the symptoms appropriately. Therefore, physicians and paramedical members like staff nurses, clinical pharmacists and other members must make adequate observations while recommending these drugs to patients

Exposure to low concentrations of heavy metals alone and in combination induces histopathological and genotoxic effects in fish (Labeo rohita)

Background: The terrestrial and agro-aquatic ecosystems are continuously at the pity of human's negative impacts. Extensive and indiscriminate application of agrochemicals like heavy metals, industrial wastes, germicides, drug residues and different feed additives has become serious threats to public health. The current experimental trial was executed to investigate genotoxic potential of different heavy metals in fresh water fish (Labeo rohita).Methods: A total of 120 active, healthy, free from  disease and internal parasites fish having three months of age were procured from local fish breeding center and were kept in glass aquarium having 100 liter water. After two weeks of acclimatization, fish were arbitrarily distributed and placed in different eight groups (A-H). Prior to start of experiment, acute toxicity of various heavy metals alone such as lead, cadmium, chromium and in combination (Pb +Cr), (Cr+Cd), (Cd+Pb) and (Pb+Cr+Cd) mixture were determined in-term of 96-h LC50 and lethal doses for Labeo rohita. After assessment of acute toxicity, all the fish were exposed to three sub-lethal concentrations (5, 7 and 9%) of heavy metals alone and in combinations for a period of 30 days in triplicate experiments.Results: Different clinical ailments like, increased surface breathing, loss of coordination, rapid opercular movement, erratic swimming, air gulping, jerking movement and tremors were noted in fish. Histopathological observations of gills of various fish exhibited severe microscopic alterations. Results on micronucleus assay exhibited increased frequency of formation of micronuclei in red blood cells, while comet assays showed significantly increased DNA damage in peripheral erythrocytes in-term of arbitrary units of comets, average percentile rate of damaged cell and genomic damage index.Conclusion: From the results of our experimental study, it can be concluded that fresh water fish are useful and reliable bio-indicators of heavy metal toxicity. Micronucleus and comet assays showed that heavy metals alone and in combination induced DNA damage in fish.Keywords: Labeo rohita; Heavy metals; Histopathology; Erythrocytes; DNA damag

Evaluation of the spermatogenic activity of polyherbal formulation in oligospermic males

The therapeutic use of natural herbs is an ancient human civilization act and the numbers of people have reliance on their pharmacological properties and preferred to use the natural herbs. People also use to consume these herbs as supplements to energize, bolster, and eventually enhance sexual ability. Polyherbal formulation (PHF) is one of these herbal amalgams that can be used to treat sexual dysfunction including erectile dysfunction, impotence, ejaculation dysfunction, and hypogonadism. The pilot study was aimed at evaluating the capacity of PHF in enhancing the spermatogenic potential of oligospermic patients. Thirty-six male patients with oligospermia were enrolled and randomized either to treatment (n = 23) with PHF (750 mg/d in three doses for 90 days) or to placebo (n = 13) in the same protocol. The preintervention semen analysis was compared with posttreatment semen analysis. Based on the postintervention semen analysis, patients were advised to undergo either in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) to assess their fertility status. After polyherbal treatment, there was a 256% increase in sperm concentration (9.59 +/- 4.37 x 106/mL to 25.61 +/- 8.6 x 10(6)/mL;

Mutation in NSUN2, which Encodes an RNA Methyltransferase, Causes Autosomal-Recessive Intellectual Disability

Causes of autosomal-recessive intellectual disability (ID) have, until very recently, been under researched because of the high degree of genetic heterogeneity. However, now that genome-wide approaches can be applied to single multiplex consanguineous families, the identification of genes harboring disease-causing mutations by autozygosity mapping is expanding rapidly. Here, we have mapped a disease locus in a consanguineous Pakistani family affected by ID and distal myopathy. We genotyped family members on genome-wide SNP microarrays and used the data to determine a single 2.5 Mb homozygosity-by-descent (HBD) locus in region 5p15.32–p15.31; we identified the missense change c.2035G>A (p.Gly679Arg) at a conserved residue within NSUN2. This gene encodes a methyltransferase that catalyzes formation of 5-methylcytosine at C34 of tRNA-leu(CAA) and plays a role in spindle assembly during mitosis as well as chromosome segregation. In mouse brains, we show that NSUN2 localizes to the nucleolus of Purkinje cells in the cerebellum. The effects of the mutation were confirmed by the transfection of wild-type and mutant constructs into cells and subsequent immunohistochemistry. We show that mutation to arginine at this residue causes NSUN2 to fail to localize within the nucleolus. The ID combined with a unique profile of comorbid features presented here makes this an important genetic discovery, and the involvement of NSUN2 highlights the role of RNA methyltransferase in human neurocognitive development