Advances in Bioaccumulation: Reflections from the SETAC Europe 17th Annual Meeting

Different pieces of legislation worldwide, and particularly the European Registration Evaluation Authorisation of Chemicals (REACH) program, which entered into force on 1st June 2007, create an increased demand for more reliable information about different toxicological and fate properties, including bioaccumulation. Bioaccumulation has been the focus of dedicated Working Groups to develop guidance for the endpoint under the umbrella of the REACH Implementation Projects (RIP 3.3), and for overall PBT assessment of chemicals (RIP 3.2). The SETAC Advisory Group on Bioaccumulation Assessment (B-SAG) has a proven record of stimulating the incorporation of sound science within regulatory contexts by providing excellent forums for exchange of information and collaboration between scientists from government, industry and academia, and for creating a friendly environment where novel research and young scientists find warm welcome. For the 17th Annual Meeting, the B-SAG organised two oral sessions and two poster corners, which attracted ~60 abstracts and considerable attention at the meeting. The sessions were logically organised around the main themes of in vitro/modelling approaches and lab/field studies, and gave a forum to presenters from two continents, equally eager to share experience and move the science forward. Here we share top lines from the platform presentations.JRC.I.3-Toxicology and chemical substance

Assessment of Progressive Product Innovation on Key Environmental Indicators: Pampers® Baby Wipes from 2007–2013

Companies are increasingly conducting life cycle assessments (LCA) of their products to understand potential product impacts on the environment, prioritize areas of innovation to create more sustainable products, and determine valid claims. This case study shows the results of product innovation by comparing an older (2007) and new (2013) version of a common hygiene product in Europe and the U.S. The standard methodology follows the ISO 14040/44 Guidelines for LCA. Results are reported for the impact indicators with high relevance for the product category: primary energy, global warming, particulates, agricultural land occupation, fossil fuel depletion, and solid waste generation. Generally, raw material supply chains for product and packaging contribute most (up to 82%) to the calculated environmental impact indicators. Improvements vs. the 2007 baby wipe range between 4% and 14% in Europe and between 15% and 36% in the U.S. The improvement is driven by a new substrate technology that provides more surface area for cleaning, which results in lower use of resources. This case study illustrates three key environmental drivers behind this innovation: the corporate focus on R&D capability to design for environmentally improved products, the increased interest from retailers and consumers requiring accurate and relevant information on the performance and sustainability of products, and the company’s interest in deeper technical understanding of contributions from upstream material and process innovations on a product’s environmental profile

Global guidance on environmental life cycle impact assessment indicators: findings of the scoping phase

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The Rise and Fall of Ziggy Stardust and Natural Law

In Natural Law and Natural Rights, John Finnis delves into the past, attempting to revitalise the Thomist natural law tradition cut short by opposing philosophers such as David Hume. In this article, Finnis’s efforts at revival are assessed by way of comparison with—and, indeed, contrast to—the life and art of musician David Bowie. In spite of their extravagant differences, there exist significant points of connection that allow Bowie to be used in interpreting Finnis’s natural law. Bowie’s work—for all its appeals to a Nietzschean ground zero for normative values—shares Finnis’s concern with ordering affairs in a way that will realise humanity’s great potential. In presenting enchanted worlds and evolved characters as an antidote to all that is drab and pointless, Bowie has something to tell his audience about how human beings can thrive. Likewise, natural law holds that a legal system should include certain content that guides people towards a life of “flourishing”. Bowie and Finnis look to the past, plundering it for inspiration and using it as fuel to boost humankind forward. The analogy of Natural Law and Natural Rights and Bowie’s magpie-like relationship to various popular music traditions ultimately reveals that natural law theory is not merely an objective and unchanging edict to be followed without question, but a legacy that is to be recreated by those who carry it into the future. Law’s instruments of critique must not forget these transformative qualities.Arts, Education & Law Group, School of LawFull Tex

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies.11Nsciescopu