Potential synergies between existing multilateral environmental agreements in the implementation of Land Use, Land Use Change and Forestry activities

There is potential for synergy between the global environmental conventions on climate change, biodiversity and desertification: changes in land management and land use undertaken to reduce net greenhouse gas emissions can simultaneously deliver positive outcomes for conservation of biodiversity, and mitigation of desertification and land degradation. However, while there can be complementarities between the three environmental goals, there are often tradeoffs. Thus, the challenge lies in developing land use policies that promote optimal environmental outcomes, and in implementing these locally to promote sustainable development. The paper considers synergies and tradeoffs in implementing land use measures to address the objectives of the three global environmental conventions, both from an environmental and economic perspective. The intention is to provide environmental scientists and policy makers with a broad overview of these considerations, and the benefits of addressing the conventions simultaneously.Climate change, LULUCF, Biodiversity, Desertification, Sustainable development.

Leading from within: Distributing leadership to enhance eLearning at ACU

Research on academic leaders of Australian and international higher education institutions has shown how “the broader societal change forces that have unfolded over the past quarter century have generated a set of higher education specific pressures on universities to change, which, in turn, are testing the extent to which these institutions and their leaders are ‘change capable’” (Scott, Coates and Anderson, 2008, p. xiii). Australian Catholic University (ACU) which has six campuses across Queensland, New South Wales, Victoria and the Australian Capital Territory, is responding to these change forces in accord with its mission to provide quality teaching, research and service. ACU has focussed on the development of policy, procedures and strategic initiatives related to eLearning. This paper reports on embedding of an initial Australian Learning and Teaching Council (ALTC) project designed “to develop distributed leadership capacity in the pedagogical and evaluative dimensions of online teaching and learning” in which six academic staff members were funded for a new role as Online Advisers (OAs). The paper highlights the leadership learning which has occurred for the OAs, identifies ongoing challenges in terms of distributing leadership in a sustainable way for the enhancement of online teaching and learning (OTL) and offers eight insights and challenges into how such projects can be implemented by like institutions

Chicken Toll-like Receptor 3 Recognizes Its Cognate Ligand When Ectopically Expressed in Human Cells

Recognition of pathogens by toll-like receptors (TLRs) causes activation of signaling cascades that trigger cytokine secretion and, ultimately, innate immunity. Genes encoding proteins with substantial homology to mammalian TLR1, TLR2, TLR3, TLR4, TLR5, and TLR7 are present in the chicken genome, whereas orthologs of TLR8, TLR9, and TLR10 seem to be defective or missing. Except for chicken TLR2 (ChTLR2), which was previously shown to recognize lipopeptides and lipopolysaccharides (LPS), the ligand specificity of ChTLRs had not been determined. We found that polyI:C, LPS, R848, S-28463, and ODN2006, which are specifically recognized by TLR3, TLR4, TLR7/8, and TLR9 in mammals, induced substantial amounts of type I interferon (IFN) and interleukin-6 (IL-6) in freshly prepared chicken splenocytes. To determine the ligand specificity of ChTLR3 and ChTLR7, we used a standard reporter assay frequently employed for analysis of mammalian TLRs. Neither S-28463 nor any other TLR ligand induced reporter activity in human 293 cells expressing ChTLR7. However, human 293 cells expressing ChTLR3 strongly and specifically responded to polyI:C, demonstrating that this chicken receptor represents a true ortholog of mammalian TLR3

Sicherheit und Effektivität der Endoskopischen Submukosadissektion von Magenfrühkarzinomen nach erweiterten Resektionskriterien

Zusammenfassend zeigt sich, dass die Durchführung einer ESD bei westlichen Patienten mit einem Magenfrühkarzinom der EC- Gruppe sicher ist, zu einer hohen Rate kurativer endoskopischer Behandlungen führt und hinsichtlich des krankheitsspezifischen Überlebens den Ergebnissen der GC- Frühkarzinome nicht unterlegen ist, wenngleich die Rate an Lokalrezidiven durch den höheren Anteil an piecemeal- Resektionen und die Komplikationsrate (Perforationen) erhöht ist. Diese Aussage kann zumindest für die EC- Frühkarzinome getroffen werden, die eine Läsionsgröße > 20 mm ohne weitere Risikofaktoren aufweisen. Aufgrund dessen erscheint eine primäre endoskopische Therapie dieser Frühkarzinome auch in der westlichen Welt gerechtfertigt. Zur ESD bei Frühkarzinomen mit anderen EC- Kriterien als dem der Läsionsgröße kann aufgrund der geringen Fallzahlen in diesen Subgruppen keine Empfehlung abgeleitet werden. Die Ergebnisse des follow up hinsichtlich metachroner Neoplasien zeigen, dass neben dem Erreichen einer kurativen Resektion der koordinierten endoskopischen Nachsorge der entscheidende Stellenwert zu kommt, um langfristig ein krankheitsspezifisches Überleben aller Patienten zu erreichen. Gegenüber dem Risiko eine metachrone Neoplasie zu entwickeln ist das Risiko eines metastatischen Rezidivs gering. Die koordinierte endoskopische Nachsorge auch nach kurativer Resektion sollte im ersten Jahr nach jeweils sechs Monaten, im Folgenden jährlich durchgeführt werden. Hinsichtlich einer Dauer der endoskopischen Nachsorge über fünf Jahre hinaus lassen die Ergebnisse dieser Studie keine Empfehlung zu; vermutlich ist eine längere Dauer sinnvoll und kann das Auftreten fortgeschrittener metachroner Karzinome reduzieren oder verhindern

Air temperature and inflammatory and coagulation responses in men with coronary or pulmonary disease during the winter season

Background and Objective Air temperature changes are associated with increased cardiovascular and respiratory risk, but the roles of inflammatory and coagulation markers are not well understood. We investigated the associations between temperature and several blood markers in patients with coronary heart disease (CHD) and pulmonary disease (PD). Methods Two studies were conducted in Erfurt, Germany, over two successive winters. 578 and 381 repeated blood measurements were collected from 57 CHD and 38 PD patients, respectively. Data on patient characteristics and disease history were gathered at baseline. Meteorological data were collected from existing networks. Associations were analysed using additive mixed models with random patient effects. Effect modification by diabetes status was investigated only in CHD patients, as only two PD patients had diabetes. Results Mean daily air temperature varied between -13 degrees C and 16 degrees C in both study periods. A 10 degrees C decrease in the 5-day temperature average before blood withdrawal led to an increase in platelet counts (% change from the mean: 3.0%, 95% CI 0.6% to 5.5%) and fibrinogen (5.5%, 1.3% to 9.7%), no change in C-reactive protein in PD patients, and a decrease in C-reactive protein in CHD patients. A 2-day delayed increase in factor VII associated with temperature decrease was seen in CHD patients (4.9%; 0.7% to 9.2%), while PD patients showed no effect. `Effects in CHD patients without diabetes' into `Effects on factor VII in CHD patients without diabetes'. Conclusions This study suggests that temperature decrease is associated with change in several blood parameters. The complex interplay of blood markers at low temperature may contribute to the observed association between cold and cardiovascular mortality and morbidity

Benefits of listening to a recording of euphoric joint music making in polydrug abusers

Background and Aims: Listening to music can have powerful physiological and therapeutic effects. Some essential features of the mental mechanism underlying beneficial effects of music are probably strong physiological and emotional associations with music created during the act of music making. Here we tested this hypothesis in a clinical population of polydrug abusers in rehabilitation listening to a previously performed act of physiologically and emotionally intense music making. Methods: Psychological effects of listening to self-made music that was created in a previous musical feedback intervention were assessed. In this procedure, participants produced music with exercise machines (Jymmin) which modulate musical sounds. Results: The data showed a positive effect of listening to the recording of joint music making on self-efficacy, mood, and a readiness to engage socially. Furthermore, the data showed the powerful influence of context on how the recording evoked psychological benefits. The effects of listening to the self-made music were only observable when participants listened to their own performance first; listening to a control music piece first caused effects to deteriorate. We observed a positive correlation between participants' mood and their desire to engage in social activities with their former training partners after listening to the self-made music. This shows that the observed effects of listening to the recording of the single musical feedback intervention are influenced by participants recapitulating intense pleasant social interactions during the Jymmin intervention. Conclusions: Listening to music that was the outcome of a previous musical feedback (Jymmin) intervention has beneficial psychological and probably social effects in patients that had suffered from polydrug addiction, increasing self-efficacy, mood, and a readiness to engage socially. These intervention effects, however, depend on the context in which the music recordings are presented

The blood-brain barrier studied in vitro across species

The blood-brain barrier (BBB) is formed by brain capillary endothelial cells (BECs) supported by pericytes and astrocytes. The BBB maintains homeostasis and protects the brain against toxic substances circulating in the blood, meaning that only a few drugs can pass the BBB. Thus, for drug screening, understanding cell interactions, and pathology, in vitro BBB models have been developed using BECs from various animal sources. When comparing models of different species, differences exist especially in regards to the transendothelial electrical resistance (TEER). Thus, we compared primary mice, rat, and porcine BECs (mBECs, rBECs, and pBECs) cultured in mono- and co-culture with astrocytes, to identify species-dependent differences that could explain the variations in TEER and aid to the selection of models for future BBB studies. The BBB models based on primary mBECs, rBECs, and pBECs were evaluated and compared in regards to major BBB characteristics. The barrier integrity was evaluated by the expression of tight junction proteins and measurements of TEER and apparent permeability (Papp). Additionally, the cell size, the functionality of the P-glycoprotein (P-gp) efflux transporter, and the expression of the transferrin receptor were evaluated and compared. Expression and organization of tight junction proteins were in all three species influenced by co-culturing, supporting the findings, that TEER increases after co-culturing with astrocytes. All models had functional polarised P-gp efflux transporters and expressed the transferrin receptor. The most interesting discovery was that even though the pBECs had higher TEER than rBECs and mBECs, the Papp did not show the same variation between species, which could be explained by a significantly larger cell size of pBECs. In conclusion, our results imply that the choice of species for a given BBB study should be defined from its purpose, instead of aiming to reach the highest TEER, as the models studied here revealed similar BBB properties

The Association Between Particulate Air Pollution and Respiratory Mortality in Beijing Before, During, and After the 2008 Olympic and Paralympic Games

To improve ambient air quality during the 2008 Summer Olympic and Paralympic Games, the Chinese Government and Beijing’s municipal government implemented comprehensive emission control policies in Beijing and its neighboring regions before and during this period. The goal of this study was to investigate the association between particulate air pollution and cause-specific respiratory mortality before, during and after the period of the Olympic Games. Further, we wanted to assess whether changes in pollutant concentrations were linked to changes in respiratory mortality. We obtained daily data on mortality due to respiratory diseases (coded as J00-J99 according to the International Classification of Diseases and Related Health Problems 10th revision [ICD10]) and pneumonia (ICD10: J12–18), meteorology, particulate matter less than 10 µm or 2.5 μm in diameter (PM10, PM2.5) and particle number size distribution from official monitoring networks and sites located on the Peking University campus between May 20 and December 1, 2008. We assessed the effects of particulate air pollution on daily respiratory mortality using confounder-adjusted Quasi-Poisson regression models. Furthermore, we estimated air pollution effects for three periods—before (May 20 to July 20, 2008), during (August 1 to September 20, 2008) and after (October 1 to December 1, 2008)—by including interaction terms in the models. We found associations between different particle metrics and respiratory and pneumonia mortality, with more pronounced effects in smaller particle size ranges. For example, an interquartile range increase of 7,958 particles/cm3 in ultrafine particles (particles <100 nm in diameter) led to a 16.3% (95% confidence interval 4.3%; 26.5%) increase in respiratory mortality with a delay of seven days. When investigating the sub-periods, results indicate that a reduction in air pollution during the Olympics resulted in reduced (cause-specific) respiratory mortality. This reduction was especially pronounced for pneumonia mortality. The findings suggest that even a short-term reduction in pollution concentrations may lead to health benefits and that smaller particles in the ultrafine size range may be particularly important for respiratory health