Parameter test ideals of Cohen Macaulay rings

We describe an algorithm for computing parameter-test-ideals in certain local Cohen-Macaulay rings. The algorithm is based on the study of a Frobenius map on the injective hull of the residue field of the ring and on the application of Rodney Sharp's notion of ``special ideals''. Our techniques also provide an algorithm for computing indices of nilpotency of Frobenius actions on top local cohomology modules of the ring and on the injective hull of its residue field. The study of nilpotent elements on injective hulls of residue fields also yields a great simplification of the proof of the fact that for a power series ring $R$ of prime characteristic, for all nonzero $f\in R$, $1/f$ generates $R_f$ as a $D_R$-module.Comment: 16 pages To appear in Compositio Mathematic

Sex differences in the pituitary TGFβ1 system: the role of TGFβ1 in prolactinoma development

Prolactinomas are the most frequent functioning pituitary adenomas, and sex differences in tumor size, behavior and incidence have been described. These differences have been associated with earlier diagnosis in woman, as well as with serum estradiol levels. Experimental models of prolactinomas in rodents also show a higher incidence in females, and recent findings suggest that gender differences in the transforming growth factor beta 1 (TGFbeta1) system might be involved in the sex-specific development of prolactinomas in these models. The aim of this review is to summarize the literature supporting the important role of TGFbeta1 as a local modulator of pituitary lactotroph function and to provide recent evidencefor TGF1 involvement in the sex differences found in prolactinoma development in animal models.Fil: Recouvreux, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Sanford Burnham Prebys Medical Discovery Institute; Estados UnidosFil: Faraoni, Erika Yanil. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Camilletti, María Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Ratner, Laura Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Abeledo Machado, Alejandra Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Diaz, Graciela Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentin

Selection of attributes for modelling Bach chorales by a genetic algorithm

A genetic algorithm selected combinations of attributes for a machine learning system. The algorithm used 90 Bach chorale melodies to train models and randomly selected sets of 10 chorales for evaluation. Compression of pitch was used as the fitness evaluation criterion. The best models were used to compress a different test set of chorales and their performance compared to human generate models. G.A. models outperformed the human models, improving compression by 10 percent

The pituitary TGFb1 system as a novel target for the treatment of resistant prolactinomas

Prolactinomas are the most frequently observed pituitary adenomas and most of themrespond well to conventional treatment with dopamine agonists (DAs). However, a subsetof prolactinomas fails to respond to such therapies and is considered as DA-resistantprolactinomas (DARPs). New therapeutic approaches are necessary for these tumors.Transforming growth factor b1 (TGFb1) is a known inhibitor of lactotroph cell proliferationand prolactin secretion, and it partly mediates dopamine inhibitory action. TGFb1 is secretedto the extracellular matrix as an inactive latent complex, and its bioavailability is tightlyregulated by different components of the TGFb1 system including latent binding proteins,local activators (thrombospondin-1, matrix metalloproteases, integrins, among others), andTGFb receptors. Pituitary TGFb1 activity and the expression of different components of theTGFb1 system are regulated by dopamine and estradiol. Prolactinomas (animal models andhumans) present reduced TGFb1 activity as well as reduced expression of several componentsof the TGFb1 system. Therefore, restoration of TGFb1 inhibitory activity represents a noveltherapeutic approach to bypass dopamine action in DARPs. The aim of this review is tosummarize the large literature supporting TGFb1 important role as a local modulator ofpituitary lactotroph function and to provide recent evidence of the restoration of TGFb1activity as an effective treatment in experimental prolactinomasFil: Recouvreux, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Cedars Sinai Medical Center; Estados UnidosFil: Camilletti, María Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Rifkin, Daniel B.. University of New York; Estados UnidosFil: Diaz, Graciela Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentin

Affecting affect: making sense of the challenges - Australian non-native English speaker students in Australian universities

Multiple streams of influence, including cultural policy and societal goals, and theories of the mind, have affected the global non-English speaking background (NESB) community over the last couple of decades. The evolution of culture perceptibly influences directly or indirectly the rapid change of higher educational system in Australia. To improve approaches to Australian non-native English speakers (ANNES) students substantially, solutions to current concerns address integrating ANNES into the mainstream of NES. If such solutions can be implemented, the landscape of educational novelty will be very different and much improved at the end of the Australian university education. Reviewing the past century of ANNES gives rise to some critical questions. Where did the community of ANNES stand at the close of the university admission? Is this a comfortable and useful place? What needs to change and why? Meaningful answers to these questions we tried to find thorough this study. Thus, ANNES students can become part of the solution rather than be part of the problem as many appear to believe at the current turbulent time. More than what one thinks, less than what we need

The Courier, Volume 15, Issue 27, May 14, 1982

Stories: Food Costs To Rise 10% Propose PE Center Mural 8 Seek Support For 6 SG Posts Track Team Takes State By Landslide People: Jim Annes Mike Kristofek Sally Getwil

Queer Farmers: Sexuality and the Transition to Sustainable Agriculture

Intimate relationships are foundational to farm viability. Such relationships affect how farmers share tasks, earn income, and access land, yet the role of sexuality and heteronormativity in agriculture remains understudied. Furthermore, queers are largely ignored as potential farmers by the sustainable agriculture and LGBT movements. Through participant observation and interviews with 30 sustainable farmers of various genders and sexualities in New England, I document the lived experiences of queer sustainable farmers, an under-researched group, and examine whether sexuality and gender affects why they farm. Whereas the perception of rural heterosexism can discourage queer participation in agriculture, queer farmers faced less overt heterosexism than expected. However, they did experience heterosexism particular to sustainable agriculture, and confronting it jeopardized relationships important for economic and environmental sustainability and land access. Some were attracted to sustainable agriculture for reasons specific to gender, sexuality, and anti-consumerist values. I offer the sustainable agriculture movement a lens for observing how sexuality and heteronormativity are embedded in farmer recruitment, retention, and land acquisition