Control of heat pumps with CO2 emission intensity forecasts

An optimized heat pump control for building heating was developed for minimizing CO2 emissions from related electrical power generation. The control is using weather and CO2 emission forecasts as input to a Model Predictive Control (MPC) - a multivariate control algorithm using a dynamic process model, constraints and a cost function to be minimized. In a simulation study the control was applied using weather and power grid conditions during a full year period in 2017-2018 for the power bidding zone DK2 (East, Denmark). Two scenarios were studied; one with a family house and one with an office building. The buildings were dimensioned on the basis of standards and building codes. The main results are measured as the CO2 emission savings relative to a classical thermostatic control. Note that this only measures the gain achieved using the MPC control, i.e. the energy flexibility, not the absolute savings. The results show that around 16% savings could have been achieved during the period in well insulated new buildings with floor heating. Further, a sensitivity analysis was carried out to evaluate the effect of various building properties, e.g. level of insulation and thermal capacity. Danish building codes from 1977 and forward was used as benchmarks for insulation levels. It was shown that both insulation and thermal mass influence the achievable flexibility savings, especially for floor heating. Buildings that comply with codes later than 1979 could provide flexibility emission savings of around 10%, while buildings that comply with earlier codes provided savings in the range of 0-5% depending on the heating system and thermal mass.Comment: 16 pages, 12 figures. Submitted to Energie

EFFECT OF FORMING PRESSURE ON THE REACTIVITY AND MICROSTRUCTURE OF ZIRCON POWDER COMPACTS

Preliminary results of a study on the effects of the forming pressure on the reactivity, sintering and microstructure of very fine natural zircon powder compacts. The effects of compaction pressure on the green densities and sintered densities are also discussed. The relationship between the density and the compaction pressure governs the mechanism that occurs in the consolidation process. The investigation has demonstrated changing the compaction pressure in the range 45-180MPa does not influence the onset temperature of sintering of powdered zircon (1150-1170 °C) but does influence the apparent density of the green compacts and consequently the porosity of the sintered specimens. Low relative density values were obtained in these sintering conditions

Exploring the data on femicide across Europe

In recent years, the notion of femicide has expanded in social, criminological and epidemiological research to grasp the basic differences underpinning the killing of a female, as opposed to a male, victim. While femicide research in Australia and the US has been a consolidated trend in criminology and feminist studies since the 1990s (Stout, 1992; Mouzos, 1999; Campbell et al, 2003; Frye et al, 2005), its development in Europe has been much more recent and represents the outcome, primarily, of top-down social pressure. The combined effect of the recent proceedings of the ‘Femicide across Europe’ COST network (active in 30 European countries from 2013 to 2017), together with awareness-raising by the media in many countries and the Resolution adopted by the United Nations General Assembly on 11 February 2014 (United Nations, 2014), inter alia, have acted as catalysts for change, contributing significantly to fostering femicide research in Europe. An extensive analysis of the definition of femicide is presented in Chapter 2 of this book.peer-reviewe

Progress of Induced Pluripotent Stem Cell Technologies to Understand Genetic Epilepsy

The study of the pathomechanisms by which gene mutations lead to neurological diseases has benefit from several cellular and animal models. Recently, induced Pluripotent Stem Cell (iPSC) technologies have made possible the access to human neurons to study nervous system disease-related mechanisms, and are at the forefront of the research into neurological diseases. In this review, we will focalize upon genetic epilepsy, and summarize the most recent studies in which iPSC-based technologies were used to gain insight on the molecular bases of epilepsies. Moreover, we discuss the latest advancements in epilepsy cell modeling. At the two dimensional (2D) level, single-cell models of iPSC-derived neurons lead to a mature neuronal phenotype, and now allow a reliable investigation of synaptic transmission and plasticity. In addition, functional characterization of cerebral organoids enlightens neuronal network dynamics in a three-dimensional (3D) structure. Finally, we discuss the use of iPSCs as the cutting-edge technology for cell therapy in epilepsy

New "Green" approaches to the synthesis of pyrazole derivatives.

A novel approach to the synthesis of pyrazole derivatives from tosylhydrazones of alpha,beta-unsaturated carbonyl compounds possessing a beta-hydrogen is proposed, exploiting microwave (MW) activation coupled with solvent free reaction conditions. The cycloaddition was studied on three ketones (trans-4-phenyl-3-buten-2-one, beta-ionone and trans-chalcone). The corresponding 3,5-disubstituted-1H-pyrazoles were obtained in high yields and after short reaction times. In order to simplify and point out the green chemistry features of the method, a further improvement was achieved under the same catalytic conditions with a "one pot" synthesis of these heterocyclic compounds, starting directly from their carbonyl precursors via tosylhydrazones generated in situ. For an exhaustive study, the dielectric properties of the solid reaction mixtures were also measured, in order to obtain input data for the numerical simulation of their heating behaviour in the single mode MW cavity which was used for experimental work. In order to supply a valid methodology and tool for measuring the environmental impact, a comparative study between the synthetic route proposed and the classical synthetic route has been carried out

Synapsin phosphorylation by SRC tyrosine kinase enhances SRC activity in synaptic vesicles.

Synapsins are synaptic vesicle-associated phosphoproteins implicated in the regulation of neurotransmitter release. Synapsin I is the major binding protein for the SH3 domain of the kinase c-Src in synaptic vesicles. Its binding leads to stimulation of synaptic vesicle-associated c-Src activity. We investigated the mechanism and role of Src activation by synapsins on synaptic vesicles. We found that synapsin is tyrosine phosphorylated by c-Src in vitro and on intact synaptic vesicles independently of its phosphorylation state on serine. Mass spectrometry revealed a single major phosphorylation site at Tyr(301), which is highly conserved in all synapsin isoforms and orthologues. Synapsin tyrosine phosphorylation triggered its binding to the SH2 domains of Src or Fyn. However, synapsin selectively activated and was phosphorylated by Src, consistent with the specific enrichment of c-Src in synaptic vesicles over Fyn or n-Src. The activity of Src on synaptic vesicles was controlled by the amount of vesicle-associated synapsin, which is in turn dependent on synapsin serine phosphorylation. Synaptic vesicles depleted of synapsin in vitro or derived from synapsin null mice exhibited greatly reduced Src activity and tyrosine phosphorylation of other synaptic vesicle proteins. Disruption of the Src-synapsin interaction by internalization of either the Src SH3 or SH2 domains into synaptosomes decreased synapsin tyrosine phosphorylation and concomitantly increased neurotransmitter release in response to Ca(2+)-ionophores. We conclude that synapsin is an endogenous substrate and activator of synaptic vesicle-associated c-Src and that regulation of Src activity on synaptic vesicles participates in the regulation of neurotransmitter release by synapsin

Mmot1, a New Helix-Loop-Helix Transcription Factor Gene Displaying a Sharp Expression Boundary in the Embryonic Mouse Brain

Several genetic factors have been proven to contribute to the specification of the metencephalic-mesencephalic territory, a process that sets the developmental foundation for prospective morphogenesis of the cerebellum and mesencephalon. However, evidence stemming from genetic and developmental studies performed in man and various model organisms suggests the contribution of many additional factors in determining the fine subdivision and differentiation of these central nervous system regions. In man, the cerebellar ataxias/aplasias represent a large and heterogeneous family of genetic disorders. Here, we describe the identification by differential screening and the characterization of Mmot1, a new gene encoding a DNA-binding protein strikingly similar to the helix-loop-helix factor Ebf/Olf1. Throughout midgestation embryogenesis, Mmot1is expressed at high levels in the metencephalon, mesencephalon, and sensory neurons of the nasal cavity. In vitro DNA binding data suggest some functional equivalence of Mmot1 and Ebf/Olf1, possibly accounting for the reported lack of olfactory or neural defects in Ebf −/− knockout mutants. The isolation of Mmot1 and of an additional homolog in the mouse genome defines a novel, phylogenetically conserved mammalian family of transcription factor genes of potential relevance in studies of neural development and its aberrations

A novel methodological approach for land subsidence prediction through data assimilation techniques

AbstractAnthropogenic land subsidence can be evaluated and predicted by numerical models, which are often built over deterministic analyses. However, uncertainties and approximations are present, as in any other modeling activity of real-world phenomena. This study aims at combining data assimilation techniques with a physically-based numerical model of anthropogenic land subsidence in a novel and comprehensive workflow, to overcome the main limitations concerning the way traditional deterministic analyses use the available measurements. The proposed methodology allows to reduce uncertainties affecting the model, identify the most appropriate rock constitutive behavior and characterize the most significant governing geomechanical parameters. The proposed methodological approach has been applied in a synthetic test case representative of the Upper Adriatic basin, Italy. The integration of data assimilation techniques into geomechanical modeling appears to be a useful and effective tool for a more reliable study of anthropogenic land subsidence

Ultrasound- versus landmark-guided subclavian vein catheterization: a prospective observational study from a tertiary referral hospital

This was a single-center, observational, prospective study designed to compare the effectiveness of a real-time, ultrasound- with landmark-guided technique for subclavian vein cannulation. Two groups of 74 consecutive patients each underwent subclavian vein catheterization. One group included patients from intensive care unit, studied by using an ultrasound-guided technique. The other group included patients from surgery or emergency units, studied by using a landmark technique. The primary outcome for comparison between techniques was the success rate of catheterization. Secondary outcomes were the number of attempts, cannulation failure, and mechanical complications. Although there was no difference in total success rate between ultrasound-guided and landmark groups (71 vs. 68, p\u2009=\u20090.464), the ultrasound-guided technique was more frequently successful at first attempt (64 vs. 30, p\u2009<\u20090.001) and required less attempts (1 to 2 vs. 1 to 6, p\u2009<\u20090.001) than landmark technique. Moreover, the ultrasound-guided technique was associated with less complications (2 vs. 13, p\u2009<\u20090.001), interruptions of mechanical ventilation (1 vs. 57, p\u2009<\u20090.001), and post-procedure chest X-ray (43 vs. 62, p\u2009=\u20090.001). In comparison with landmark-guided technique, the use of an ultrasound-guided technique for subclavian catheterization offers advantages in terms of reduced number of attempts and complications