354 research outputs found
Development of a novel chlamydia growth-monitoring method and its application for screening anti- and pro-chlamydial compounds
Sexually transmitted infections (STIs) are the most prevalent infectious diseases in the world. Among the STIs, Chlamydia trachomatis (C. trachomatis)-related infections are the most common. C. trachomatis serovars D-K cause pelvic inflammatory diseases and infertility, while the LGV serovars are the pathogens that cause lymphogranuloma venereum, an STI with systemic manifestations. C. trachomatis infections have also been linked to arthritis and spondyloarthritis. C. pneumoniae is a frequent cause of communityacquired pneumonia and is suspected of participating in the pathogenesis of chronic diseases, such as asthma and atherosclerosis.
Human herpes simplex virus-1 (HHSV-1) and preferentially HHSV-2 genital
infections are common viral STIs. The number of HHSV-2 seropositive people (15–49 years) was estimated as 417 million in 2012, with an 11.3% prevalence in the population. Besides the vesicular lesions of the urogenital and anal regions, HSV infections may lead to severe complications including encephalitis, meningitis and neonatal herpes infections. C. trachomatis and HHSV-2 pathogens preferentially cause persistent or latent infections either locally (C. trachomatis) and/or from the site of the primary infection, such as in the
sacral ganglia for HSV-2 and joints for C. trachomatis. Because of the long-term
presence of the pathogens, there is a possibility that their infectious cycles, including the active and persistent growths, are influenced by locally or systematically applied compounds, including nanomaterials.
The standard method for counting chlamydiae is immunofluorescence staining and
manual counting of chlamydial inclusions. High- or medium-throughput estimation of the reduction in chlamydial inclusions should be the basis of testing antichlamydial compounds and other drugs that positively or negatively influence chlamydial growth, yet low-throughput manual counting is the common approach.
Titanium dioxide (TiO2) is the naturally occurring oxide of titanium. TiO2 exists in three most common forms: rutile, anatase and brookite. Titanium dioxide, in the anatase form, is a photocatalyst under ultraviolet (UV) light. The positive holes oxidize water to create hydroxyl radicals, by the strong oxidative potential. TiO2 nanoparticles have a strong bactericidal effect. The TiO2 reacts by photocatalysis with water to release the hydroxyl radical with subsequent formation of superoxide. The reactive oxygen species
can then synergistically act by attacking polyunsaturated phospholipids in bacteria and catalyzed site-specific DNA damage via generation of H2O2. TiO2 NPs are applied as a food additive or a drug delivery vehicle and we wanted to test their interactions with C.trachomatis and HHSV-2 to test their efficacy in non-activated form
Dunaújváros kulturális intézményrendszerének vizsgálata térszemléletben
Napjainkban jellemzĹ‘ tendencia a kulturális intĂ©zmĂ©nyek kĂnálata iránti csökkenĹ‘ kereslet. A kedvezĹ‘tlen folyamatok ok-okozati viszonyainak feltárása, mĂ©rsĂ©klĂ©se Ă©rdekĂ©ben szĂĽksĂ©gessĂ© válik a kulturális intĂ©zmĂ©nyrendszer működĂ©sĂ©nek vizsgálata, feladatok átstrukturálása a fogyasztĂłi igĂ©nyek kielĂ©gĂtĂ©se Ă©rdekĂ©ben. A tanulmány rĂ©szletes helyzetelemzĂ©st ad DunaĂşjváros megyei jogĂş város kulturális intĂ©zmĂ©nyrendszerĂ©nek működĂ©sĂ©rĹ‘l, kulturális Ă©letĂ©nek jellemzĹ‘ tendenciáirĂłl. A kutatás cĂ©lja, hogy a dunaĂşjvárosi lakosság körĂ©ben vĂ©gzett adatgyűjtĂ©sek (2006, 2009) alapján megvizsgálja a város kulturális földrajzi adottságait. Fel kĂvánja tĂ©rkĂ©pezni a lakosság kulturális szokásait, a kulturális intĂ©zmĂ©nyrendszer működĂ©sĂ©nek jellegzetessĂ©geit Ă©s a szolgáltatások minĹ‘sĂ©gĂ©t. A város kulturális intĂ©zmĂ©nyrendszerĂ©t a JĂłzsef Attila Könyvtár, a MunkásművelĹ‘dĂ©si Központ, a BartĂłk KamaraszĂnház Ă©s MűvĂ©szetek Háza, a DĂłzsa Mozicentrum, a Kortárs MűvĂ©szeti IntĂ©zet Ă©s az Intercisa MĂşzeum alkotja (1. ábra). A vizsgálat során komplex kĂ©rdĹ‘Ăv kerĂĽlt felhasználásra, melynek fĹ‘bb pontjai kiterjedtek a kulturális intĂ©zmĂ©nyek általános megĂtĂ©lĂ©sĂ©re, az intĂ©zmĂ©nyek földrajzi hozzáfĂ©rhetĹ‘sĂ©gĂ©re, a látogatási szokások változására, az informáciĂłszerzĂ©s lehetĹ‘sĂ©geire, az intĂ©zmĂ©nyekkel valĂł elĂ©gedettsĂ©g mĂ©rtĂ©kĂ©re, valamint a szolgáltatásokhoz kapcsolĂłdĂł felhasználĂłi igĂ©nyek jellemzĹ‘ire. A tanulmány összegzi a kĂ©rdĹ‘Ăves vizsgálat eredmĂ©nyeit
Az elektromobilitás sajátos nĂ©zĹ‘pontja. A vevĹ‘i igĂ©nyek minĹ‘sĂ©girányĂtási vetĂĽletei
A tanulmány alapvetĹ‘ cĂ©lja az az elektromobilitás által kiváltott vevĹ‘i igĂ©nyek változásának nyomonkövetĂ©se. A károsanyag-kibocsátás csökkentĂ©sĂ©nek igĂ©nye markánsan fogalmazĂłdik meg azonban a felhasználĂłk, potenciális felhasználĂłk, Ă©s elzárkĂłzĂłk nagy rĂ©sze nem rendelkezik megbĂzhatĂł szakszerű informáciĂłkkal a kĂ©rdĂ©sben. A vevĹ‘i igĂ©nyek alakulása mindenkor a szemĂ©lyes attitűd rĂ©szekĂ©nt van jelen. A vevĹ‘kiszolgálás folyamata során a felmerĂĽlĹ‘ kĂ©rdĂ©sek jelentĹ‘s mĂ©rtĂ©kben megválaszoltalanok maradnak. A vevĹ‘k kinyilvánĂtott igĂ©nyei jelenleg nem teljesĂĽlnek maradĂ©ktalanul. A rejtett igĂ©nyek szempontjábĂłl számos nyitott kĂ©rdĂ©s kerĂĽl felszĂnre annak ellenĂ©re, hogy a gyártĂłk saját megĂtĂ©lĂ©sĂĽk szerint törekszenek a vevĹ‘kiszolgálás maximalizálására. A minĹ‘sĂ©gi gyártás alapelvei bizonyĂthatĂłan meghatározzák az iparág jövĹ‘jĂ©t azonban az elektromobilitás tĂ©rnyerĂ©se számos aspektusbĂłl szemlĂ©lve bizonytalan
Centrumok és perifériák : Dunaújváros kulturális intézményrendszerének helye a megyei jogú városok között
From the beginning of the XXI. century, the operation of the institutions is getting to be harder, the attendance is getting to be lower. This fact is certified by numeral datas. The statistical analyses are confined to the operational datas of the cultural institutions. In the course of the preparing the complex analysis was important to consider that the datas - given by the Hungarian Central Statistic Office – didn’t provide comprehensive informations about the attendance, status and relations of the cultural institutions. Despite of the wrong tendency of the external circumstances - according to their possibilities - the institutes calculate with the demand of the users. It is important to maintain and preserve the operability of the cultural institutes in Dunaújváros, because the closing any of them would give an incorrigible deficit in the life of the city. The parts of the system operate properly and independently. After the economic alteration happened a significant realignment in the cultural sector, the trift became the main principle
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