Future glacial lake outburst flood (GLOF) hazard of the South Lhonak Lake, Sikkim Himalaya

The Teesta basin in Sikkim Himalaya hosts numerous glacial lakes in the high altitude glacierized region, including one of the largest and the fastest-growing South Lhonak Lake. While these lakes are mainly located in remote and unsettled mountain valleys, far-reaching glacial lake outburst floods (GLOFs) may claim lives and damage assets up to tens of kilometers downstream. Therefore, evaluating GLOF hazard associated with current and potential future glacier-retreat-driven changes is of high importance. In this work, we assess the future GLOF hazard of the South Lhonak Lake by integrating glacier and hydrodynamic modeling to calculate the lake's future volume and hydraulic GLOF characteristics and impacts along the valley. We identify the increased susceptibility of the lake to potential avalanche impacts as the lake grows in the future. Here we model six avalanche scenarios of varying magnitudes to evaluate the impact-wave generated in the lake and overtopping flow at the dam. Avalanche simulations indicate that the frontal moraine is susceptible to overtopping. The overtopping flow hydraulics is evaluated along the channel assuming no erosion of the moraine. Further, we consider three lake-breach scenarios to model GLOFs originating from the lake, flow propagation, and its downstream impacts. The uncertainty in the breach parameters including breach width and time of failure are calculated to estimate the upper and the lower hydraulic limits of potential future GLOF events. Further, the uncertainty in the flow hydraulics was evaluated using dynamic flood routing of six GLOFs that originate from the lake. Hydrodynamic GLOF modeling resulted in a predicted peak discharge of 4311 m3s−1, 8000 m3s−1, and 12,487 m3s−1 for breach depths of 20 m, 30 m, and 40 m respectively. The large-potential scenario suggests that maximum flow depth and flow velocity at Chungthang, a town proximally located to a major hydropower station built-in 2015, could reach up to 25–30 m and 6–9 m s−1, respectively. Mapping infrastructure exposed to GLOFs in the Teesta valley shows that many settlements and assets located along the river channel at Chungthang are potentially exposed to future GLOFs, indicating the need to conduct a full environmental impact assessment and potentially undertake GLOF risk mitigation measures

Modeling potential glacial lake outburst flood process chains and effects from artificial lake‐level lowering at Gepang Gath lake, Indian Himalaya

Glacial lake outburst floods (GLOFs) are a severe threat to communities in the Himalayas; however, GLOF mitigation strategies have been implemented for only a few lakes, and future changes in hazard are rarely considered. Here, we present a comprehensive assessment of current and future GLOF hazard for Gepang Gath Lake, Western Himalaya, considering rock and/or ice avalanches cascading into the lake. We consider ground surface temperature and topography to define avalanche source zones located in areas of potentially degrading permafrost. GLOF process chains in current and future scenarios, also considering engineered lake lowering of 10 and 30 m, were evaluated. Here, varied avalanche impact waves, erosion patterns, debris flow hydraulics, and GLOF impacts at Sissu village, under 18 different scenarios were assessed. Authors demonstrated that a larger future lake does not necessarily produce larger GLOF events in Sissu, depending, among other factors, on the location from where the triggering avalanche initiates and strikes the lake. For the largest scenarios, 10 m of lowering reduces the high-intensity zone by 54% and 63% for the current and future scenarios, respectively, but has little effect on the medium-intensity flood zone. Even with 30 m of lake lowering, the Sissu helipad falls in the high-intensity zone under all moderate-to-large scenarios, with severe implications for evacuations and other emergency response actions. The approach can be extended to other glacial lakes to demonstrate the efficiency of lake lowering as an option for GLOF mitigation and enable a robust GLOF hazard and risk assessment

Perioperative Probiotics or Synbiotics in Adults Undergoing Elective Abdominal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials

This meta-analysis of 34 randomized controlled trials reporting on 2723 participants has shown that perioperative administration of either probiotics or synbiotics was well tolerated and significantly reduced the risk of infectious complications following elective abdominal surgery. However, there were no differences in non-infectious complications or mortality between the intervention and control groups

Effect of St. John's Wort (Hypericum perforatum) treatment on restraint stress-induced behavioral and biochemical alteration in mice

<p>Abstract</p> <p>Background</p> <p>A stressful stimulus is a crucial determinant of health and disease. Antidepressants are used to manage stress and their related effects. The present study was designed to investigate the effect of St. John's Wort (<it>Hypericum perforatum</it>) in restraint stress-induced behavioral and biochemical alterations in mice.</p> <p>Methods</p> <p>Animals were immobilized for a period of 6 hr. St. John's Wort (50 and 100 mg/kg) was administered 30 minutes before the animals were subjecting to acute immobilized stress. Various behavioral tests parameters for anxiety, locomotor activity and nociceptive threshold were assessed followed by biochemical assessments (malondialdehyde level, glutathione, catalase, nitrite and protein) subsequently.</p> <p>Results</p> <p>6-hr acute restraint stress caused severe anxiety like behavior, antinociception and impaired locomotor activity as compared to unstressed animals. Biochemical analyses revealed an increase in malondialdehyde, nitrites concentration, depletion of reduced glutathione and catalase activity as compared to unstressed animal brain. Five days St. John's Wort treatment in a dose of 50 mg/kg and 100 mg/kg significantly attenuated restraint stress-induced behavioral (improved locomotor activity, reduced tail flick latency and antianxiety like effect) and oxidative damage as compared to control (restraint stress).</p> <p>Conclusion</p> <p>Present study highlights the modest activity of St. John's Wort against acute restraint stress induced modification.</p

Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

BACKGROUND: The Millennium Declaration in 2000 brought special global attention to HIV, tuberculosis, and malaria through the formulation of Millennium Development Goal (MDG) 6. The Global Burden of Disease 2013 study provides a consistent and comprehensive approach to disease estimation for between 1990 and 2013, and an opportunity to assess whether accelerated progress has occured since the Millennium Declaration. METHODS: To estimate incidence and mortality for HIV, we used the UNAIDS Spectrum model appropriately modified based on a systematic review of available studies of mortality with and without antiretroviral therapy (ART). For concentrated epidemics, we calibrated Spectrum models to fit vital registration data corrected for misclassification of HIV deaths. In generalised epidemics, we minimised a loss function to select epidemic curves most consistent with prevalence data and demographic data for all-cause mortality. We analysed counterfactual scenarios for HIV to assess years of life saved through prevention of mother-to-child transmission (PMTCT) and ART. For tuberculosis, we analysed vital registration and verbal autopsy data to estimate mortality using cause of death ensemble modelling. We analysed data for corrected case-notifications, expert opinions on the case-detection rate, prevalence surveys, and estimated cause-specific mortality using Bayesian meta-regression to generate consistent trends in all parameters. We analysed malaria mortality and incidence using an updated cause of death database, a systematic analysis of verbal autopsy validation studies for malaria, and recent studies (2010-13) of incidence, drug resistance, and coverage of insecticide-treated bednets. FINDINGS: Globally in 2013, there were 1·8 million new HIV infections (95% uncertainty interval 1·7 million to 2·1 million), 29·2 million prevalent HIV cases (28·1 to 31·7), and 1·3 million HIV deaths (1·3 to 1·5). At the peak of the epidemic in 2005, HIV caused 1·7 million deaths (1·6 million to 1·9 million). Concentrated epidemics in Latin America and eastern Europe are substantially smaller than previously estimated. Through interventions including PMTCT and ART, 19·1 million life-years (16·6 million to 21·5 million) have been saved, 70·3% (65·4 to 76·1) in developing countries. From 2000 to 2011, the ratio of development assistance for health for HIV to years of life saved through intervention was US$4498 in developing countries. Including in HIV-positive individuals, all-form tuberculosis incidence was 7·5 million (7·4 million to 7·7 million), prevalence was 11·9 million (11·6 million to 12·2 million), and number of deaths was 1·4 million (1·3 million to 1·5 million) in 2013. In the same year and in only individuals who were HIV-negative, all-form tuberculosis incidence was 7·1 million (6·9 million to 7·3 million), prevalence was 11·2 million (10·8 million to 11·6 million), and number of deaths was 1·3 million (1·2 million to 1·4 million). Annualised rates of change (ARC) for incidence, prevalence, and death became negative after 2000. Tuberculosis in HIV-negative individuals disproportionately occurs in men and boys (versus women and girls); 64·0% of cases (63·6 to 64·3) and 64·7% of deaths (60·8 to 70·3). Globally, malaria cases and deaths grew rapidly from 1990 reaching a peak of 232 million cases (143 million to 387 million) in 2003 and 1·2 million deaths (1·1 million to 1·4 million) in 2004. Since 2004, child deaths from malaria in sub-Saharan Africa have decreased by 31·5% (15·7 to 44·1). Outside of Africa, malaria mortality has been steadily decreasing since 1990. INTERPRETATION: Our estimates of the number of people living with HIV are 18·7% smaller than UNAIDS's estimates in 2012. The number of people living with malaria is larger than estimated by WHO. The number of people living with HIV, tuberculosis, or malaria have all decreased since 2000. At the global level, upward trends for malaria and HIV deaths have been reversed and declines in tuberculosis deaths have accelerated. 101 countries (74 of which are developing) still have increasing HIV incidence. Substantial progress since the Millennium Declaration is an encouraging sign of the effect of global action. FUNDING: Bill & Melinda Gates Foundation