Influence of myocardial oxygen demand on the coronary vascular response to arterial blood gas changes in humans

It remains unclear if the human coronary vasculature is inherently sensitive to changes in arterial PO2 and PCO2 or if coronary vascular responses are the result of concomitant increases in myocardial O2 consumption/demand (MVO2). We hypothesized that the coronary vascular response to PO2 and PCO2 would be attenuated in healthy men when MVO2 was attenuated with β1-adrenergic receptor blockade. Healthy men (n=11; age: 25 {plus minus} 1 years) received intravenous esmolol (β1-adrenergic receptor antagonist) or volume-matched saline in a double-blind, randomized, crossover study, and were exposed to poikilocapnic hypoxia, isocapnic hypoxia, and hypercapnic hypoxia. Measurements made at baseline and following 5-min of steady state at each gas manipulation included left anterior descending coronary blood velocity (LADV; Doppler echocardiography), heart rate and arterial blood pressure. LADV values at the end of each hypoxic condition were compared between esmolol and placebo. Rate pressure product (RPP) and left-ventricular mechanical energy (MELV) were calculated as indices of MVO2. All gas manipulations augmented RPP, MELV, and LADV but only RPP and MELV were attenuated (4-18%) following β1-adrenergic receptor blockade (P<0.05). Despite attenuated RPP and MELV responses, β1-adrenergic receptor blockade did not attenuate the mean LADV vasodilatory response when compared to placebo during poikilocapnic hypoxia (29.4{plus minus}2.2 vs. 27.3{plus minus}1.6 cm/s) and isocapnic hypoxia (29.5{plus minus}1.5 vs. 30.3{plus minus}2.2 cm/s). Hypercapnic hypoxia elicited a feed-forward coronary dilation that was blocked by β1-adrenergic receptor blockade. These results indicate a direct influence of arterial PO2 on coronary vascular regulation that is independent of MVO2

Generalized Approach to Translating Exercise Tests and Prescribing Exercise

[EN] Although there is evidence supporting the benefit of regular exercise, and recommendations about exercise and physical activity, the process of individually prescribing exercise following exercise testing is more difficult. Guidelines like % heart rate (HR) reserve (HRR) require an anchoring maximal test and do not always provide a homogenous training experience. When prescribing HR on the basis of % HRR, rating of perceived exertion or Talk Test, cardiovascular/perceptual drift during sustained exercise makes prescription of the actual workload difficult. To overcome this issue, we have demonstrated a strategy for “translating” exercise test responses to steady state exercise training on the basis of % HRR or the Talk Test that appeared adequate for individuals ranging from cardiac patients to athletes. However, these methods depended on the nature of the exercise test details. In this viewpoint, we combine these data with workload expressed as Metabolic Equivalent Task (METs). We demonstrate that there is a regular stepdown between the METs during training to achieve the same degree of homeostatic disturbance during testing. The relationship was linear, was highly-correlated (r = 0.89), and averaged 71.8% (Training METs/Test METs). We conclude that it appears possible to generate a generalized approach to correctly translate exercise test responses to exercise training

Optimal strategies for gravitational wave stochastic background searches in pulsar timing data

A low frequency stochastic background of gravitational waves may be detected by pulsar timing experiments in the next five to ten years. Using methods developed to analyze interferometric gravitational wave data, in this paper we lay out the optimal techniques to detect a background of gravitational waves using a pulsar timing array. We show that for pulsar distances and gravitational wave frequencies typical of pulsar timing experiments, neglecting the effect of the metric perturbation at the pulsar does not result in a significant deviation from optimality. We discuss methods for setting upper limits using the optimal statistic, show how to construct skymaps using the pulsar timing array, and consider several issues associated with realistic analysis of pulsar timing data.Comment: 20 pages, 6 figures. Added figure with sky sensitivity for Parkes Pulsar Timing Array, included dipole overlap reduction function and derivation in appendix, extended likelihood discussio

On detection of the stochastic gravitational-wave background using the Parkes pulsar timing array

We search for the signature of an isotropic stochastic gravitational-wave background in pulsar timing observations using a frequency-domain correlation technique. These observations, which span roughly 12 yr, were obtained with the 64-m Parkes radio telescope augmented by public domain observations from the Arecibo Observatory. A wide range of signal processing issues unique to pulsar timing and not previously presented in the literature are discussed. These include the effects of quadratic removal, irregular sampling, and variable errors which exacerbate the spectral leakage inherent in estimating the steep red spectrum of the gravitational-wave background. These observations are found to be consistent with the null hypothesis, that no gravitational-wave background is present, with 76 percent confidence. We show that the detection statistic is dominated by the contributions of only a few pulsars because of the inhomogeneity of this data set. The issues of detecting the signature of a gravitational-wave background with future observations are discussed.Comment: 12 pages, 8 figures, 7 tables, accepted for publication in MNRA

Scientific discovery and its role in sports science

Scientific discovery is about a search for the Truth, for the consistent and predictable in how the universe works. Using a particular method of inquiry, the scientific method, and with acknowledgement of the inherently self-correcting nature of science, scientific inquiry moves forward incrementally to ever closer approximations of the Truth. This paper reviews the history of scientific inquiry, the methodology of the scientific method, including the necessity for hypothesis testing and development of the probability that a particular answer is a closer approximation of the Truth than previous answers have been. It also discusses some of the pitfalls of scientific inquiry, and areas in which the search for Truth may be corrupted

UBC-Nepal Expedition: An experimental overview of the 2016 University of British Columbia Scientific Expedition to Nepal Himalaya

The University of British Columbia Nepal Expedition took place over several months in the fall of 2016 and was comprised of an international team of 37 researchers. This paper describes the objectives, study characteristics, organization and management of this expedition, and presents novel blood gas data during acclimatization in both lowlanders and Sherpa. An overview and framework for the forthcoming publications is provided. The expedition conducted 17 major studies with two principal goals—to identify physiological differences in: 1) acclimatization; and 2) responses to sustained high-altitude exposure between lowland natives and people of Tibetan descent. We performed observational cohort studies of human responses to progressive hypobaric hypoxia (during ascent), and to sustained exposure to 5050 m over 3 weeks comparing lowlander adults (n = 30) with Sherpa adults (n = 24). Sherpa were tested both with (n = 12) and without (n = 12) descent to Kathmandu. Data collected from lowlander children (n = 30) in Canada were compared with those collected from Sherpa children (n = 57; 3400–3900m). Studies were conducted in Canada (344m) and the following locations in Nepal: Kathmandu (1400m), Namche Bazaar (3440m), Kunde Hospital (3480m), Pheriche (4371m) and the Ev-K2-CNR Research Pyramid Laboratory (5050m). The core studies focused on the mechanisms of cerebral blood flow regulation, the role of iron in cardiopulmonary regulation, pulmonary pressures, intra-ocular pressures, cardiac function, neuromuscular fatigue and function, blood volume regulation, autonomic control, and micro and macro vascular function. A total of 335 study sessions were conducted over three weeks at 5050m. In addition to an overview of this expedition and arterial blood gas data from Sherpa, suggestions for scientists aiming to perform field-based altitude research are also presented. Together, these findings will contribute to our understanding of human acclimatization and adaptation to the stress of residence at high-altitude

Physics beyond the standard model with trapped atoms in the LHC era

Experiments carried out with the TRINAT trap system are described. These lead to limits on scalar interactions and on right-handed currents in the weak interaction process of β decay that are beyond the standard model of weak interactions. An upgraded experimental system and its improved capabilities are described

Unilateral cross bite treated by corticotomy-assisted expansion: two case reports

<p>Abstract</p> <p>Background</p> <p>True unilateral posterior crossbite in adults is a challenging malocclusion to treat. Conventional expansion methods are expected to have some shortcomings. The aim of this paper is to introduce a new technique for treating unilateral posterior crossbite in adults, namely, corticotomy-assisted expansion (CAE) applied on two adult patients: one with a true unilateral crossbite and the other with an asymmetrical bilateral crossbite, both treated via modified corticotomy techniques and fixed orthodontic appliances.</p> <p>Methods</p> <p>Two cases with asymmetric maxillary constriction were treated using CAE.</p> <p>Results</p> <p>In both cases, effective asymmetrical expansion was achieved using CAE, and functional occlusion was established as well.</p> <p>Conclusions</p> <p>Unilateral CAE presents an effective and reliable technique to treat true unilateral crossbite.</p